IL-1 beta/IL-1F2 Antibody [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

IL-1 is a name that designates two pleiotropic cytokines, IL-1 alpha (IL-1F1) and IL-1 beta (IL-1F2, IL1B), which are the products of distinct genes. IL-1 alpha and IL-1 beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL-1 alpha and IL-1 beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1 RI binds directly to IL-1 alpha or IL-1 beta and then associates with IL-1 R accessory protein (IL-1 R3/IL-1 R AcP) to form a high-affinity receptor complex that is competent for signal transduction. IL-1 RII has high affinity for IL-1 beta but functions as a decoy receptor and negative regulator of IL-1 beta activity. IL-1ra functions as a competitive antagonist by preventing IL-1 alpha and IL-1 beta from interacting with IL-1 RI. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. The 17 kDa molecular weight mature human IL-1 beta shares 96% aa sequence identity with rhesus and 67%-78% with canine, cotton rat, equine, feline, mouse, porcine, and rat IL-1 beta . IL-1 beta functions in a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 6 confirmed species: Human, Mouse, Amphibian, Canine, Lizard, Primate - Macaca mulatta (Rhesus Macaque).

We have publications tested in 10 applications: Bioassay, Blocking/Neutralizing, Dot Blot, Functional Assay, ICC, IHC, IHC-P, Immunohistochemistry, Neutralization, Western Blot.

Showing Publications 1 - 10 of 88. Show All 88 Publications. Collapse Publications.

Publications using AF-201-NA	Applications	Species
Szymanska, I;Bauernfried, S;Komar, T;Hornung, V; Vaccinia virus F1L blocks the ribotoxic stress response to subvert ZAK?-dependent NLRP1 inflammasome activation European journal of immunology 2024-07-31 [PMID: 39086059] (Western Blot, Human)	Western Blot	Human
Li, Y;Zhuang, Y;Chen, Y;Wang, G;Tang, Z;Zhong, Y;Zhang, Y;Wu, L;Ji, X;Zhang, Q;Pan, B;Luo, Y; Euphorbia factor L2 alleviated gouty inflammation by specifically suppressing both the priming and activation of NLRP3 inflammasome International immunopharmacology 2024-07-08 [PMID: 38981223] (Western Blot, Mouse)	Western Blot	Mouse
Schmauch, E;Severin, Y;Xing, X;Mangold, A;Conrad, C;Johannsen, P;Kahlenberg, JM;Mellett, M;Navarini, A;Nobbe, S;Sarkar, MK;Satyam, A;Tsoi, LC;French, LE;Nilsson, J;Linna-Kuosmanen, S;Kaikkonen, MU;Snijder, B;Kellis, M;Gudjonsson, JE;Tsokos, GC;Contassot, E;Kolios, AGA; Targeting IL-1 controls refractory pityriasis rubra pilaris Science advances 2024-07-05 [PMID: 38959302] (Immunohistochemistry, Human)	Immunohistochemistry	Human
Vukovic, M;Chamlati, JM;Hennenlotter, J;Todenhöfer, T;Lütfrenk, T;Jersinovic, S;Tsaur, I;Stenzl, A;Rausch, S; Interleukin-1?/Interleukin (IL)-1-Receptor-Antagonist (IL1-RA) Axis in Invasive Bladder Cancer-An Exploratory Analysis of Clinical and Tumor Biological Significance International journal of molecular sciences 2024-02-19 [PMID: 38397123] (IHC, Human)	IHC	Human
Lee, S;Yun, S;Yang, H;Lee, N;Kim, Y;Lee, S;Zamora, NA;Montero, SS;Yi, DK;Kim, SY;Choi, S;Choi, T;Kim, MS;Lee, Y;Park, YH; Guarea microcarpa C. DC. extract inhibits NLRP3 inflammasome by suppressing its ATPase activity Journal of ethnopharmacology 2024-01-03 [PMID: 38176663] (Western Blot, Human)	Western Blot	Human
Exconde, PM;Hernandez-Chavez, C;Bourne, CM;Richards, RM;Bray, MB;Lopez, JL;Srivastava, T;Egan, MS;Zhang, J;Yoo, W;Shin, S;Discher, BM;Taabazuing, CY; The tetrapeptide sequence of IL-18 and IL-1? regulates their recruitment and activation by inflammatory caspases Cell reports 2023-12-15 [PMID: 38103201] (Western Blot, Bioassay, Human)	Western Blot, Bioassay	Human
Coralie Guy, Marcin Baran, Pau Ribó-Molina, Bernadette G. van den Hoogen, Andrew G. Bowie Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores iScience 9/15/2023 [PMID: 37680489]
Chen Li, Tianli Chen, Jialiang Liu, Yue Wang, Chunhuan Zhang, Lu Guo et al. FGF19‐Induced Inflammatory CAF Promoted Neutrophil Extracellular Trap Formation in the Liver Metastasis of Colorectal Cancer Advanced Science 8/1/2023 [PMID: 37345586]
Ito M, Ducasa GM, Molina JD et al. ABCA1 deficiency contributes to podocyte pyroptosis priming via the APE1/IRF1 axis in diabetic kidney disease Scientific reports 6/14/2023 [PMID: 37316538] Details: 1:500 dilution, fresh sections used
Damien Bierschenk, Nikolina Papac-Milicevic, Ian P. Bresch, Valentina Kovacic, Serena Bettoni, Mateusz Dziedzic et al. C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation Frontiers in Immunology 5/22/2023 [PMID: 37283747]
Yen-Ju Lin, Annette Jamin, Sonja Wolfheimer, Anna Fiedler, Ann-Christine Junker, Alexandra Goretzki et al. A flagellin-conjugate protein induces dual NLRC4- and NLRP3-inflammasome activation which modulates inflammatory cytokine secretion from macrophages Frontiers in Immunology 3/21/2023 [PMID: 37026001]
J Li, Q Lin, X Shao, S Li, X Zhu, J Wu, S Mou, L Gu, Q Wang, M Zhang, K Zhang, J Lu, Z Ni HIF1alpha-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome Cell Death & Disease, 2023-03-17;14(3):200. 2023-03-17 [PMID: 36928344] (ICC, Western Blot, Human)	ICC, Western Blot	Human
PM Exconde, C Hernandez-, MB Bray, JL Lopez, T Srivastava, MS Egan, J Zhang, S Shin, BM Discher, CY Taabazuing The tetrapeptide sequence of IL-1beta regulates its recruitment and activation by inflammatory caspases bioRxiv : the preprint server for biology, 2023-02-16;0(0):. 2/16/2023 [PMID: 36824844]
SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs Nature Immunology, 2022-12-01;0(0):. 2022-12-01 [PMID: 36456734] (Neutralization, Human)	Neutralization	Human
Niklas A. Schmacke, Fionan O’Duill, Moritz M. Gaidt, Inga Szymanska, Julia M. Kamper, Jonathan L. Schmid-Burgk et al. IKK beta primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network Immunity 12/13/2022 [PMID: 36384135]
A Gritsenko, R Díaz-Pino, G Lopez-Cast NLRP3 inflammasome triggers interleukin-37 release from human monocytes European Journal of Immunology, 2022-04-28;0(0):. 2022-04-28 [PMID: 35429346] (Western Blot, Human)	Western Blot	Human
V Mercier, G Boucher, D Devost, K Bourque, A Alikashani, C Beauchamp, A Bitton, S Foisy, P Goyette, G Charron, TE Hébert, JD Rioux IBD-associated G protein-coupled receptor 65 variant compromises signalling and impairs key functions involved in inflammation Cellular Signalling, 2022-02-24;93(0):110294. 2022-02-24 [PMID: 35218908] (Western Blot, Human)	Western Blot	Human
SD Rao, Q Chen, Q Wang, EL Orth-He, M Saoi, AR Griswold, A Bhattachar, DP Ball, HC Huang, AJ Chui, DJ Covelli, S You, JR Cross, DA Bachovchin M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome Nature Chemical Biology, 2022-02-14;0(0):. 2022-02-14 [PMID: 35165443] (Western Blot, Human)	Western Blot	Human
G Theocharid, BE Thomas, D Sarkar, HL Mumme, WJR Pilcher, B Dwivedi, T Sandoval-S, RF Sîrbulescu, A Kafanas, I Mezghani, P Wang, A Lobao, IS Vlachos, B Dash, HC Hsia, V Horsley, SS Bhasin, A Veves, M Bhasin Single cell transcriptomic landscape of diabetic foot ulcers Nature Communications, 2022-01-10;13(1):181. 2022-01-10 [PMID: 35013299] (IHC, Human)	IHC	Human
GK Annarapu, D Nolfi-Done, M Reynolds, Y Wang, L Kohut, B Zuckerbrau, S Shiva Heme stimulates platelet mitochondrial oxidant production to induce targeted granule secretion Redox Biology, 2021-12-05;48(0):102205. 2021-12-05 [PMID: 34891098] (Dot Blot, Human)	Dot Blot	Human
Benjamin Krämer, Rainer Knoll, Lorenzo Bonaguro, Michael ToVinh, Jan Raabe, Rosario Astaburuaga-García et al. Early IFN-alpha signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19 Immunity 11/1/2021 [PMID: 34592166]
H Yu, M Xie, Z Meng, CY Lo, FL Chan, L Jiang, X Meng, X Yao Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1beta/NF-kappaB pathway British Journal of Cancer, 2021-09-21;0(0):. 2021-09-21 [PMID: 34548638] (Neutralization, Human)	Neutralization	Human
Marrocco A, Frawley K, Pearce LL et al. Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica The Journal of Immunology 9/15/2021 [PMID: 34433619]
Marrocco A, Frawley K, Pearce LL et al. Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica The Journal of Immunology 2021-09-15 [PMID: 34433619]
Gota Sudo, Hironori Aoki, Eiichiro Yamamoto, Akira Takasawa, Takeshi Niinuma, Ayano Yoshido et al. Activated macrophages promote invasion by early colorectal cancer via an interleukin 1 beta ‐serum amyloid A1 axis Cancer Science 10/1/2021 [PMID: 34293235]
NG Díaz-Marot, G Garcia-Vic, G Polcaro, M Bañuls, N Albert, A Villanueva, DG Molleví The Blockade of Tumoral IL1&beta-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation International Journal of Molecular Sciences, 2021-05-07;22(9):. 2021-05-07 [PMID: 34066976] (Neutralization, Human)	Neutralization	Human
B Zhou, DW Abbott Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases Cell Reports, 2021-04-13;35(2):108998. 2021-04-13 [PMID: 33852854] (Western Blot, Mouse)	Western Blot	Mouse
Scott A Read, Brian S Gloss, Christopher Liddle, Jacob George, Golo Ahlenstiel Interferon-lambda 3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis Journal of Inflammation Research 4/1/2021 [PMID: 33833547]
P Gowda, S Patrick, SD Joshi, RK Kumawat, E Sen Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication Cytokine, 2021-03-12;142(0):155496. 2021-03-12 [PMID: 33773396] (Western Blot, Human)	Western Blot	Human
Adrianne F. Pike, Tatiana Varanita, Maaike A. C. Herrebout, Bonnie C. Plug, Jeroen Kole, René J. P. Musters et al. alpha ‐Synuclein evokes NLRP3 inflammasome‐mediated IL ‐1 beta secretion from primary human microglia Glia 6/1/2021 [PMID: 33506583]
Q Gong, K Robinson, C Xu, PT Huynh, KHC Chong, EYJ Tan, J Zhang, ZZ Boo, DET Teo, K Lay, Y Zhang, JSY Lim, WI Goh, G Wright, FL Zhong, B Reversade, B Wu Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8 Nature Communications, 2021-01-08;12(1):188. 2021-01-08 [PMID: 33420028] (Western Blot, Human)	Western Blot	Human
Gritsenko, A, Yu, S Et al. Priming Is Dispensable for NLRP3 Inflammasome Activation in Human Monocytes In Vitro. Front Immunol 10/27/2020 [PMID: 33101286]
PS Mitchell, JL Roncaioli, EA Turcotte, L Goers, RA Chavez, AY Lee, CF Lesser, I Rauch, RE Vance NAIP-NLRC4-deficient mice are susceptible to shigellosis Elife, 2020-10-19;9(0):. 10/19/2020 [PMID: 33074100]
Haitao Guo, Jenny P.‐Y. Ting Inflammasome Assays In Vitro and in Mouse Models Current Protocols in Immunology 12/15/2020 [PMID: 33017103]
Z Zhai, JM Samson, T Yamauchi, PK Vaddi, Y Matsumoto, CA Dinarello, D Ravindran, M Fujita Inflammasome Sensor NLRP1 Confers Acquired Drug Resistance to Temozolomide in Human Melanoma Cancers (Basel), 2020-09-04;12(9):. 2020-09-04 [PMID: 32899791] (IHC, Human)	IHC	Human
Nogiec A, Bzowska M, Demczuk A Phenotype and Response to PAMPs of Human Monocyte-Derived Foam Cells Obtained by Long-Term Culture in the Presence of oxLDLs Front Immunol 8/4/2020 [PMID: 32849539]
Linder A, Bauernfried S, Cheng Y et al. CARD8 inflammasome activation triggers pyroptosis in human T cells EMBO J. 8/25/2020 [PMID: 32840892]
V Rolfes, LS Ribeiro, I Hawwari, L Böttcher, N Rosero, S Maasewerd, MLS Santos, T Próchnicki, CMS Silva, CWS Wanderley, M Rothe, SV Schmidt, HJ Stunden, D Bertheloot, MN Rivas, CJ Fontes, LH Carvalho, FQ Cunha, E Latz, M Arditi, BS Franklin Platelets Fuel the Inflammasome Activation of Innate Immune Cells Cell Rep, 2020-05-12;31(6):107615. 2020-05-12 [PMID: 32402278] (Blocking/Neutralizing, Human)	Blocking/Neutralizing	Human
Y Chen, Z Yang, B Deng, D Wu, Y Quan, Z Min Interleukin 1&beta/1RA axis in colorectal cancer regulates tumor invasion, proliferation and apoptosis via autophagy Oncol. Rep., 2020-01-22;43(3):908-918. 2020-01-22 [PMID: 32020215] (IHC, Western Blot, Human)	IHC, Western Blot	Human
Z Wang, H Zhou, H Zheng, X Zhou, G Shen, X Teng, X Liu, J Zhang, X Wei, Z Hu, F Zeng, Y Hu, J Hu, X Wang, S Chen, J Cheng, C Zhang, Y Gui, S Zou, Y Hao, Q Zhao, W Wu, Y Zhou, K Cui, N Huang, Y Wei, W Li, J Li Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin in?ammation Autophagy, 2020-02-16;0(0):1-24. 2020-02-16 [PMID: 32019420] (Neutralization, Human)	Neutralization	Human
R Cheng, S Billet, C Liu, S Haldar, D Choudhury, M Tripathi, M Hav, A Merchant, T Hu, H Huang, H Zhou, NA Bhowmick Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells Oncogene, 2019-11-04;0(0):. 2019-11-04 [PMID: 31685946] (IHC, Western Blot, Human, Mouse)	IHC, Western Blot	Human, Mouse
Jeeyoung Kim, Woo Jin Kim, Kwon-Soo Ha, Eun-Taek Han, Won Sun Park, Se-Ran Yang et al. Perivascular Stem Cells Suppress Inflammasome Activation during Inflammatory Responses in Macrophages International Journal of Stem Cells 11/30/2019 [PMID: 31658511]
Tola A. Faraj, Cordula Stover, Clett Erridge Dietary Toll-Like Receptor Stimulants Promote Hepatic Inflammation and Impair Reverse Cholesterol Transport in Mice via Macrophage-Dependent Interleukin-1 Production Frontiers in Immunology 6/20/2019 [PMID: 31316501]
Q Lin, S Li, N Jiang, X Shao, M Zhang, H Jin, Z Zhang, J Shen, Y Zhou, W Zhou, L Gu, R Lu, Z Ni PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation Redox Biol, 2019-06-11;26(0):101254. 2019-06-11 [PMID: 31229841] (ICC, Human)	ICC	Human
C De Witte, K Demeyere, S De Bruycke, B Taminiau, G Daube, R Ducatelle, E Meyer, F Haesebrouc Characterization of the non-glandular gastric region microbiota in Helicobacter suis-infected versus non-infected pigs identifies a potential role for Fusobacterium gastrosuis in gastric ulceration Vet. Res., 2019-05-24;50(1):39. 2019-05-24 [PMID: 31126330] (Western Blot, Human)	Western Blot	Human
PJ Goddard, J Sanchez-Ga, SL Slater, M Kalyan, D Ruano-Gall, O Marchès, LÁ Fernández, G Frankel, AR Shenoy Enteropathogenic Escherichia coli Stimulates Effector-Driven Rapid Caspase-4 Activation in Human Macrophages Cell Rep, 2019-04-23;27(4):1008-1017.e6. 2019-04-23 [PMID: 31018119] (Western Blot, Human)	Western Blot	Human
Jaya Talreja, Harvinder Talwar, Christian Bauerfeld, Lawrence I Grossman, Kezhong Zhang, Paul Tranchida et al. HIF-1 alpha regulates IL-1 beta and IL-17 in sarcoidosis eLife 5/1/2019 [PMID: 30946009]
S Botto, J Abraham, N Mizuno, K Pryke, B Gall, I Landais, DN Streblow, KJ Fruh, VR DeFilippis Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1? Protein during Virion-Mediated Activation of the AIM2 Inflammasome MBio, 2019-02-12;10(1):. 2019-02-12 [PMID: 30755509] (Western Blot, Human)	Western Blot	Human
Yao Xu, Jingjing Wang, Wangjie Xu, Feng Ding, Wei Ding Prohibitin 2-mediated mitophagy attenuates renal tubular epithelial cells injury by regulating mitochondrial dysfunction and NLRP3 inflammasome activation American Journal of Physiology-Renal Physiology 2/1/2019 [PMID: 30539655]
N Nejati Moh, E Bjørkøy Ta, L Ryan, T Espevik, V Boyartchuk ROR? controls inflammatory state of human macrophages PLoS ONE, 2018-11-28;13(11):e0207374. 2018-11-28 [PMID: 30485323] (Western Blot, Human)	Western Blot	Human
L Kasper, A König, PA Koenig, MS Gresnigt, J Westman, RA Drummond, MS Lionakis, O Gro beta , J Ruland, JR Naglik, B Hube The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes Nat Commun, 2018-10-15;9(1):4260. 2018-10-15 [PMID: 30323213]
Pablo Palazón‐Riquelme, Jonathan D Worboys, Jack Green, Ana Valera, Fatima Martín‐Sánchez, Carolina Pellegrini et al. USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation EMBO reports 10/1/2018 [PMID: 30206189]
Moritz M. Gaidt, Thomas S. Ebert, Dhruv Chauhan, Katharina Ramshorn, Francesca Pinci, Sarah Zuber et al. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3 Cell 11/16/2017 [PMID: 29033128]
Byung-Cheol Han, Huijeong Ahn, Jiseon Lee, Eunsaem Jeon, Sanghoon Seo, Kyoung Hwa Jang et al. Nonsaponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome Journal of Ginseng Research 10/1/2017 [PMID: 29021698]
Alex G. Baldwin, Jack Rivers-Auty, Michael J.D. Daniels, Claire S. White, Carl H. Schwalbe, Tom Schilling et al. Boron-Based Inhibitors of the NLRP3 Inflammasome Cell Chemical Biology 11/16/2017 [PMID: 28943355]
L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis Autophagy, 2017-01-01;0(0):0. 2017-01-01 [PMID: 28933598] (Neutralization, Human)	Neutralization	Human
Jeeyoung Kim, Haengseok Song, Hye-Ryeon Heo, Jung Woon Kim, Hye-Ryun Kim, Yoonki Hong et al. Cadmium-induced ER stress and inflammation are mediated through C/EBP–DDIT3 signaling in human bronchial epithelial cells Experimental & Molecular Medicine 9/1/2017 [PMID: 28860664]
Hiroshi Nakanishi, Yoshiyuki Kawashima, Kiyoto Kurima, Jae Jin Chae, Astin M. Ross, Gineth Pinto-Patarroyo et al. NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA34 responsive to anakinra therapy Proceedings of the National Academy of Sciences 9/12/2017 [PMID: 28847925]
JH Jeong, J Kim, J Kim, HR Heo, JS Jeong, YJ Ryu, Y Hong, SS Han, SH Hong, SJ Lee, WJ Kim ACN9 Regulates the Inflammatory Responses in Human Bronchial Epithelial Cells Tuberc Respir Dis (Seoul), 2017-07-03;80(3):247-254. 2017-07-03 [PMID: 28747957] (Western Blot, Human)	Western Blot	Human
Zhirong Zhang, Gergö Meszaros, Wan-ting He, Yanfang Xu, Helena de Fatima Magliarelli, Laurent Mailly et al. Protein kinase D at the Golgi controls NLRP3 inflammasome activation Journal of Experimental Medicine 9/4/2017 [PMID: 28716882]
HL Young, EJ Rowling, M Bugatti, E Giurisato, N Luheshi, I Arozarena, JC Acosta, J Kamarashev, DT Frederick, ZA Cooper, A Reuben, J Gil, KT Flaherty, JA Wargo, W Vermi, MP Smith, C Wellbrock, A Hurlstone An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition J. Exp. Med., 2017-04-27;0(0):. 2017-04-27 [PMID: 28450382] (Neutralization, Human)	Neutralization	Human
K Hendrawan, CM Whittingto, MC Brandley, K Belov, MB Thompson The Regulation of Uterine Proinflammatory Gene Expression during Pregnancy in the Live-Bearing Lizard, Pseudemoia entrecasteauxii J. Exp. Zool. B Mol. Dev. Evol, 2017-03-10;0(0):. 2017-03-10 [PMID: 28296138] (Western Blot, Lizard)	Western Blot	Lizard
Beckerman P, Bi-Karchin J, Park AS et al. Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat. Med. 2/20/2017 [PMID: 28218918]
17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome Sci Rep, 2016-11-24;6(0):37625. 2016-11-24 [PMID: 27883019] (Western Blot, Human)	Western Blot	Human
Efficacy and Pharmacology of the NLRP3 Inflammasome Inhibitor CP-456,773 (CRID3) in Murine Models of Dermal and Pulmonary Inflammation J Immunol, 2016-08-12;0(0):. 2016-08-12 [PMID: 27521339] (Western Blot, Mouse)	Western Blot	Mouse
Yong Hwan Park Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS Nat Immunol, 2016-06-06;0(0):. 2016-06-06 [PMID: 27270401] (Western Blot, Human)	Western Blot	Human
Huijeong Ahn, Seung Goo Kang, Sung-il Yoon, Pyeung-Hyeun Kim, Doo Kim, Geun-Shik Lee Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation Cellular & Molecular Immunology 2/1/2018 [PMID: 27133472]
Edye M, Brough D, Allan S Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1beta for Caspase-1 Cleavage. J Biol Chem, 2015-08-31;290(42):25374-81. 2015-08-31 [PMID: 26324708] (Western Blot, Human)	Western Blot	Human
Kortmann J, Brubaker S, Monack D Cutting Edge: Inflammasome Activation in Primary Human Macrophages Is Dependent on Flagellin. J Immunol, 2015-06-24;195(3):815-9. 2015-06-24 [PMID: 26109648] (Western Blot, Human)	Western Blot	Human
Sokolowska M, Chen L, Liu Y, Martinez-Anton A, Qi H, Logun C, Alsaaty S, Park Y, Kastner D, Chae J, Shelhamer J Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages. J Immunol, 2015-04-27;194(11):5472-87. 2015-04-27 [PMID: 25917098] (Western Blot, Human)	Western Blot	Human
Coll R, Robertson A, Chae J, Higgins S, Munoz-Planillo R, Inserra M, Vetter I, Dungan L, Monks B, Stutz A, Croker D, Butler M, Haneklaus M, Sutton C, Nunez G, Latz E, Kastner D, Mills K, Masters S, Schroder K, Cooper M, O'Neill L A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med, 2015-02-16;21(3):248-55. 2015-02-16 [PMID: 25686105] (Western Blot, Mouse)	Western Blot	Mouse
Foucher E, Blanchard S, Preisser L, Descamps P, Ifrah N, Delneste Y, Jeannin P IL-34- and M-CSF-induced macrophages switch memory T cells into Th17 cells via membrane IL-1alpha. Eur J Immunol, 2015-01-19;45(4):1092-102. 2015-01-19 [PMID: 25545357] (Bioassay, Human)	Bioassay	Human
Ahn H, Kim J, Lee M, Kim Y, Cho Y, Lee G Methylsulfonylmethane inhibits NLRP3 inflammasome activation. Cytokine, 2014-11-21;71(2):223-31. 2014-11-21 [PMID: 25461402] (Western Blot, Human)	Western Blot	Human
Jae Jin Chae, Yong Hwan Park, Chung Park, Il‐Young Hwang, Patrycja Hoffmann, John H. Kehrl et al. Brief Report: Connecting Two Pathways Through Ca2+Signaling: NLRP3 Inflammasome Activation Induced by a HypermorphicPLCG2Mutation Arthritis & Rheumatology 2/1/2015 [PMID: 25418813]
An L, Mehta P, Xu L, Turman S, Reimer T, Naiman B, Connor J, Sanjuan M, Kolbeck R, Fung M Complement C5a potentiates uric acid crystal-induced IL-1beta production. Eur J Immunol, 2014-10-28;44(12):3669-79. 2014-10-28 [PMID: 25229885] (Western Blot, Human)	Western Blot	Human
Hirao L, Grishina I, Bourry O, Hu W, Somrit M, Sankaran-Walters S, Gaulke C, Fenton A, Li J, Crawford R, Chuang F, Tarara R, Marco M, Baumler A, Cheng H, Dandekar S Early mucosal sensing of SIV infection by paneth cells induces IL-1beta production and initiates gut epithelial disruption. PLoS Pathog, 2014-08-28;10(8):e1004311. 2014-08-28 [PMID: 25166758] (IHC, Primate - Macaca mulatta (Rhesus Macaque))	IHC	Primate - Macaca mulatta (Rhesus Macaque)
Mao C, Mou X, Zhou Y, Yuan G, Xu C, Liu H, Zheng T, Tong J, Wang S, Chen D Tumor-activated TCRgammadelta(+) T cells from gastric cancer patients induce the antitumor immune response of TCRalphabeta(+) T cells via their antigen-presenting cell-like effects. J Immunol Res, 2014-03-31;2014(0):593562. 2014-03-31 [PMID: 24741609] (Functional Assay, Human)	Functional Assay	Human
L'homme L, Esser N, Riva L, Scheen A, Paquot N, Piette J, Legrand-Poels S Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages. J Lipid Res, 2013-09-03;54(11):2998-3008. 2013-09-03 [PMID: 24006511] (Western Blot, Human)	Western Blot	Human
María C. de Andrés, Emmajayne Kingham, Kei Imagawa, Antonio Gonzalez, Helmtrud I. Roach, David I. Wilson et al. Epigenetic Regulation during Fetal Femur Development: DNA Methylation Matters PLoS ONE 1/28/2013 [PMID: 23383012]
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature, 2012-11-11;492(7427):123-7. 2012-11-11 [PMID: 23143333] (Western Blot, Mouse)	Western Blot	Mouse
H J M A A Zijlmans, S Punt, G J Fleuren, J B Trimbos, G G Kenter, A Gorter Role of IL-12p40 in cervical carcinoma British Journal of Cancer 12/4/2012 [PMID: 23099807]
Atanackovic D, Panse J, Hildebrandt Y, Jadczak A, Kobold S, Cao Y, Templin J, Meyer S, Reinhard H, Bartels K, Lajmi N, Zander AR, Marx AH, Luetkens T, Bokemeyer C, Kroger N Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma. Haematologica, 2011-05-23;0(0):. 2011-05-23 [PMID: 21606160] (Neutralization, Human)	Neutralization	Human
Cunin P, Caillon A, Corvaisier M, Garo E, Scotet M, Blanchard S, Delneste Y, Jeannin P The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1beta, IL-23, and TNF-like 1A expression by monocytes. J. Immunol., 2011-03-02;186(7):4175-82. 2011-03-02 [PMID: 21368235] (Neutralization, Human)	Neutralization	Human
Rocks N, Paulissen G, Quesada-Calvo F, Munaut C, Gonzalez ML, Gueders M, Hacha J, Gilles C, Foidart JM, Noel A, Cataldo DD ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo. Cancer Res., 2008-11-15;68(22):9541-50. 2008-11-15 [PMID: 19010931] (Neutralization, Human)	Neutralization	Human
Kiczak L, Paslawska U, Bania J, Ugorski M, Sambor I, Kochman A, Blach J, Chelmonska-Soyta A Increased expression of interleukin-1beta and its novel splice variant in canine hearts with volume overload. Cytokine, 2008-11-12;44(3):352-60. 2008-11-12 [PMID: 19008121] (IHC-P, Canine)	IHC-P	Canine
Jantra S, Bigliardi E, Brizzi R, Ietta F, Bechi N, Paulesu L Interleukin 1 in oviductal tissues of viviparous, oviparous, and ovuliparous species of amphibians. Biol. Reprod., 2007-02-21;76(6):1009-15. 2007-02-21 [PMID: 17314310] (IHC-P, Western Blot, Amphibian)	IHC-P, Western Blot	Amphibian
Shahbakhti H, Watson RE, Azurdia RM, Ferreira CZ, Garmyn M, Rhodes LE Influence of eicosapentaenoic acid, an omega-3 fatty acid, on ultraviolet-B generation of prostaglandin-E2 and proinflammatory cytokines interleukin-1 beta, tumor necrosis factor-alpha, interleukin-6 and interleukin-8 in human skin in vivo. Photochem. Photobiol., 2004-09-01;80(2):231-5. 2004-09-01 [PMID: 15362934] (IHC, Human)	IHC	Human
Sengupta J, Dhawan L, Ghosh D Immunohistochemical localization of leukemia inhibitory factor, interleukins 1 and 6 at the primary implantation site in the rhesus monkey. Cytokine, 2003-12-21;24(6):277-85. 2003-12-21 [PMID: 14609569] (IHC-P, Primate - Macaca mulatta (Rhesus Macaque))	IHC-P	Primate - Macaca mulatta (Rhesus Macaque)
Show All 88 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Verified Customer	WB	Human	02/19/2020	View Summary Application Western Blot Sample Tested KO cells Species Human Lot N/A
	4 reviewed by: Verified Customer	WB	Human	01/06/2015	View Summary Application Western Blot Sample Tested See PMID 24006511 Species Human
	4 reviewed by: Verified Customer	WB	Human	01/06/2015	View Summary Application Western Blot Sample Tested See PMID 23221073 Species Human

Array AF-201-NA

• IL-1 beta/IL-1F2 Antibodies
• IL-1 beta/IL-1F2 ELISA Kit
• IL-1 beta/IL-1F2 Lysate
• IL-1 beta/IL-1F2 Proteins
• IL-1 beta/IL-1F2 ELISAs
• IL-1 beta/IL-1F2 Proteins and Enzymes