Human IL-1ra/IL-1F3 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Interleukin-1 receptor antagonist (IL-1ra; also known as IL-1F3) is a 22-25 kDa member of the IL-1 family of cytokines. Currently, there are 11 family members (IL-1F1-F11), nine of which form an IL-1 gene cluster on human Ch2 (1-3). Each IL-1 family member contains an IL-1 fold. This fold is generated by 12 packed beta -sheets that interact to form a beta -trefoil structure. Little amino acid (aa) homology is required to achieve this structure, and this explains the low aa identity among IL-1 family members. IL-1ra is a pure cytokine receptor antagonist that has no signal transduction-initiating activity (4). It is an acute phase protein that exists to dampen inflammation. IL-1( beta ) is initially produced by monocytes in response to a variety of stimuli. Circulating IL-1 then binds to widely expressed IL-1 type I receptors (IL-1 RI) and initiates a number of pro-inflammatory events. On endothelial cells (EC), IL-1 induces PGE2 and IL-6 release, generating fever, thrombocytosis, and hepatic acute phase protein production. In synovial joints, IL-1 induces chondrocyte NO production, an event that leads to reduced collagen synthesis and chondrocyte apoptosis. Finally, IL-1 increases neutrophil counts, both in blood and tissue, and thus is able to promote a pro-inflammatory environment in multiple locations (5-8). IL-1ra blocks IL-1 action through competitive inhibition. More correctly, although IL-1ra fills the IL-1 binding site in IL-1 RI, it is also unable to orchestrate the creation of a signal-transducing IL-1 RI:IL-1 R Accessory protein (IL-1 R AcP) heterodimer complex. Effective IL-1ra concentrations are generally 100-fold greater than local IL-1 concentrations. This is because the IL-1ra half-life is but 6 minutes, and very few IL-1 type I receptors need to be engaged by IL-1 to elicit a cellular response (5, 7, 9). 

We have publications tested in 7 confirmed species: Human, Mouse, Rat, Ovine, Primate, Primate - Macaca mulatta (Rhesus Macaque), Primate - Papio hamadryas (Hamadyras Baboon).

We have publications tested in 1 application: ELISA Capture.

Showing Publications 1 - 10 of 100. Show All 100 Publications. Collapse Publications.

Publications using DRA00B	Applications	Species
Scovino, AM;Dahab, EC;Diniz-Lima, I;de Senna Silveira, E;Barroso, SPC;Cardoso, KM;Nico, D;Makhoul, GJ;da Silva-Junior, EB;Freire-de-Lima, CG;Freire-de-Lima, L;Fonseca, LMD;Valente, N;Nacife, V;Machado, A;Araújo, M;Vieira, GF;Pauvolid-Corrêa, A;Siqueira, M;Morrot, A; A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants Microorganisms 2024-04-02 [PMID: 38674664] (Human)		Human
Mochizuki, T;Ushiki, T;Suzuki, K;Sato, M;Ishiguro, H;Suwabe, T;Watanabe, S;Edama, M;Omori, G;Yamamoto, N;Kawase, T; Elevated IL-1? and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players International journal of molecular sciences 2023-12-14 [PMID: 38139317] (Human)		Human
Kurahashi, T;Nishime, C;Nishinaka, E;Komaki, Y;Seki, F;Urano, K;Harada, Y;Yoshikawa, T;Dai, P; Transplantation of Chemical Compound-Induced Cells from Human Fibroblasts Improves Locomotor Recovery in a Spinal Cord Injury Rat Model International journal of molecular sciences 2023-09-08 [PMID: 37762156] (Human)		Human
Lischka, J;Schanzer, A;de Gier, C;Greber-Platzer, S;Zeyda, M; Macrophage-associated markers of metaflammation are linked to metabolic dysfunction in pediatric obesity Cytokine 2023-09-18 [PMID: 37729736] (Human)		Human
Mochizuki, T;Ushiki, T;Suzuki, K;Sato, M;Ishiguro, H;Suwabe, T;Edama, M;Omori, G;Yamamoto, N;Kawase, T; Characterization of Leukocyte- and Platelet-Rich Plasma Derived from Female Collage Athletes: A Cross-Sectional Cohort Study Focusing on Growth Factor, Inflammatory Cytokines, and Anti-Inflammatory Cytokine Levels International journal of molecular sciences 2023-09-02 [PMID: 37686398] (Human)		Human
Fan, YC;Fong, YC;Kuo, CT;Li, CW;Chen, WY;Lin, JD;Bürtin, F;Linnebacher, M;Bui, QT;Lee, KD;Tsai, YC; Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer Cell & bioscience 2023-08-10 [PMID: 37563620]
Burrows, K;Figueroa-Hall, L;Stewart, J;Alarbi, A;Kuplicki, R;Hannafon, B;Tan, C;Risbrough, V;McKinney, B;Ramesh, R;Victor, T;Aupperle, R;Savitz, J;Teague, K;Khalsa, S;Paulus, M; Exploring the role of neuronal-enriched extracellular vesicle miR-93 and interoception in major depressive disorder Research square 2023-06-16 [PMID: 37398092] (Human)		Human
Buchheit, T;Huh, Y;Breglio, A;Bang, S;Xu, J;Matsuoka, Y;Guo, R;Bortsov, A;Reinecke, J;Wehling, P;Jun Huang, T;Ji, RR; Intrathecal Administration of Conditioned Serum from Different Species Resolves Chemotherapy-Induced Neuropathic Pain in Mice via Secretory Exosomes Brain, behavior, and immunity 2023-05-05 [PMID: 37150265] (Human)		Human
LH Willems, LMC Jacobs, LA Groh, H Ten Cate, HMH Spronk, B Wilson-Sto, G Hannink, SMJ van Kuijk, C Ghossein-D, M Nagy, DHJ Thijssen, AS van Peters, MC Warlé Vascular Function, Systemic Inflammation, and Coagulation Activation 18 Months after COVID-19 Infection: An Observational Cohort Study Journal of Clinical Medicine, 2023-02-10;12(4):. 2023-02-10 [PMID: 36835948] (Human)		Human
H Hallihan, P Tsai, N Lv, L Xiao, B Peñalver B, Y Wu, GN Pandey, LM Williams, OA Ajilore, J Ma Affective neural circuits and inflammatory markers linked to depression and anxiety symptoms in patients with comorbid obesity Journal of psychiatric research, 2023-02-03;160(0):9-18. 2023-02-03 [PMID: 36764197] (Human)		Human
G Della Came, T Liu, W Yang, Y Li, VF Puntes, S Gioria, P Italiani, D Boraschi Induction of Innate Memory in Human Monocytes Exposed to Mixtures of Bacterial Agents and Nanoparticles International Journal of Molecular Sciences, 2022-11-24;23(23):. 2022-11-24 [PMID: 36498992] (Human)		Human
D Chaar, BL Dumont, B Vulesevic, PE Neagoe, A Räkel, M White, MG Sirois Neutrophils and Circulating Inflammatory Biomarkers in Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction The American journal of cardiology, 2022-07-08;0(0):. 2022-07-08 [PMID: 35811144] (Human)		Human
DB Rosen, EA Murphy, RS Gejman, A Capili, RL Friedlande, S Rand, KA Cagino, SM Glynn, KC Matthews, JM Kubiak, J Yee, M Prabhu, LE Riley, YJ Yang Cytokine response over the course of COVID-19 infection in pregnant women Cytokine, 2022-04-25;154(0):155894. 2022-04-25 [PMID: 35490452] (Human)		Human
D Martins, O Dipasquale, K Davies, E Cooper, J Tibble, M Veronese, M Frigo, SCR Williams, F Turkheimer, M Cercignani, NA Harrison Transcriptomic and cellular decoding of functional brain connectivity changes reveal regional brain vulnerability to pro- and anti-inflammatory therapies Brain, Behavior, and Immunity, 2022-03-05;102(0):312-323. 2022-03-05 [PMID: 35259429] (Human)		Human
M Archer, O Niemelä, M Hämäläinen, E Moilanen, E Leinonen, O Kampman The role of alcohol use and adiposity in serum levels of IL-1RA in depressed patients BMC Psychiatry, 2022-03-02;22(1):158. 2022-03-02 [PMID: 35232419] (Human)		Human
C Gar, B Thorand, C Herder, C Sujana, M Heier, C Meisinger, A Peters, W Koenig, W Rathmann, M Roden, M Stumvoll, H Maalmi, T Meitinger, H Then, J Seissler, C Then Association of circulating MR-proADM with all-cause and cardiovascular mortality in the general population: Results from the KORA F4 cohort study PLoS ONE, 2022-01-06;17(1):e0262330. 2022-01-06 [PMID: 34990470] (Human)		Human
Tominaga T, Ikemura T, Yada K, Kanda K, Sugama K, Ma S, Choi W, Araya M, Huang J, Nakamura N, Suzuki K The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males. Antioxidants (Basel), 2021-05-28;10(6):. 2021-05-28 [PMID: 34071378] (Human)		Human
K Burrows, JL Stewart, R Kuplicki, L Figueroa-H, PA Spechler, H Zheng, SM Guinjoan, Tulsa 1000, JB Savitz, T Kent Teagu, MP Paulus Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder Brain, Behavior, and Immunity, 2021-01-26;0(0):. 2021-01-26 [PMID: 33508469] (Human)		Human
S Frankova, M Lunova, H Gottfriedo, R Senkerikov, M Neroldova, J Kovac, E Kieslichov, V Lanska, P Urbanek, J Spicak, M Jirsa, J Sperl Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis PLoS ONE, 2021-01-07;16(1):e0244934. 2021-01-07 [PMID: 33411729] (Human)		Human
N Kashiwagi, F Saito, H Maegawa, K Kaneda Granulocyte and monocyte adsorptive apheresis induces apoptosis of neutrophils and release of a novel chemoattractant for desensitization of interleukin-8 response - In vitro and in vivo results Cytokine, 2021-01-01;139(0):155410. 2021-01-01 [PMID: 33395614] (Human)		Human
S Ballikaya, S Sadeghi, E Niebergall, L Nimtz, J Frindert, A Norrick, N Stemler, N Bauer, Y Rosche, V Kratzenber, J Pieper, T Ficek, MH Frank, C Ganss, J Esterlechn, MA Kluth Process data of allogeneic ex vivo-expanded ABCB5+ mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP Stem Cell Res Ther, 2020-11-16;11(1):482. 2020-11-16 [PMID: 33198791] (Human)		Human
DM de Graaf, M Jaeger, ICL van den Mu, RT Horst, K Schraa, J Zwaag, M Kox, M Fujita, T Yamauchi, L Mercurio, S Madonna, JHW Rutten, J de Graaf, NP Riksen, FL van de Vee, MG Netea, LAB Joosten, CA Dinarello Reduced concentrations of the B cell cytokine Interleukin 38 are associated with cardiovascular disease risk in overweight subjects Eur J Immunol, 2020-11-19;0(0):. 2020-11-19 [PMID: 33125159] (Human)		Human
T Peeters, S Martens, V D'Onofrio, MHT Stappers, JCH van der Hi, B Houben, R Achten, LAB Joosten, IC Gyssens An observational study of innate immune responses in patients with acute appendicitis Sci Rep, 2020-10-15;10(1):17352. 2020-10-15 [PMID: 33060696] (Human)		Human
R Li, Y Li, X Dong Preconditioning mesenchymal stromal cells with flagellin enhances the anti?inflammatory ability of their secretome against lipopolysaccharide?induced acute lung injury Molecular Medicine Reports, 2020-07-28;0(0):. 2020-07-28 [PMID: 32945411] (Human)		Human
T Reichel, TK Bo beta lau, J Palmowski, K Eder, R Ringseis, FC Mooren, R Walscheid, E Bothur, S Samel, T Frech, M Philippe, K Krüger Reliability and suitability of physiological exercise response and recovery markers Sci Rep, 2020-07-17;10(1):11924. 2020-07-17 [PMID: 32681124] (Human)		Human
KA Davies, E Cooper, V Voon, J Tibble, M Cercignani, NA Harrison Interferon and anti-TNF therapies differentially modulate amygdala reactivity which predicts associated bidirectional changes in depressive symptoms Mol. Psychiatry, 2020-05-26;0(0):. 2020-05-26 [PMID: 32457424] (Human)		Human
T Sarabhai, S Kahl, J Szendroedi, DF Markgraf, OP Zaharia, C Barosa, C Herder, F Wickrath, P Bobrov, JH Hwang, JG Jones, M Roden Monounsaturated fat rapidly induces hepatic gluconeogenesis and whole-body insulin resistance JCI Insight, 2020-05-21;5(10):. 2020-05-21 [PMID: 32434996] (Human)		Human
S Xiong, Z Hong, LS Huang, Y Tsukasaki, S Nepal, A Di, M Zhong, W Wu, Z Ye, X Gao, GN Rao, D Mehta, J Rehman, AB Malik IL-1beta suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury J. Clin. Invest., 2020-07-01;130(7):3684-3698. 2020-07-01 [PMID: 32298238] (Human)		Human
A Hedbrant, L Andersson, IL Bryngelsso, D Eklund, H Westberg, E Särndahl, A Persson Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers Mediators Inflamm., 2020-01-07;2020(0):8490908. 2020-01-07 [PMID: 32256196] (Human)		Human
S Ma, T Tominaga, K Kanda, K Sugama, C Omae, S Hashimoto, K Aoyama, Y Yoshikai, K Suzuki Effects of an 8-Week Protein Supplementation Regimen with Hyperimmunized Cow Milk on Exercise-Induced Organ Damage and Inflammation in Male Runners: A Randomized, Placebo Controlled, Cross-Over Study Biomedicines, 2020-03-04;8(3):. 2020-03-04 [PMID: 32143279] (Human)		Human
A Rajamanick, S Munisankar, C Dolla, PA Menon, K Thiruvenga, TB Nutman, S Babu Helminth infection modulates systemic pro-inflammatory cytokines and chemokines implicated in type 2 diabetes mellitus pathogenesis PLoS Negl Trop Dis, 2020-03-03;14(3):e0008101. 2020-03-03 [PMID: 32126084] (Human)		Human
S Lucht, F Hennig, S Moebus, S Ohlwein, C Herder, B Kowall, KH Jöckel, B Hoffmann All-source and source-specific air pollution and 10-year diabetes Incidence: Total effect and mediation analyses in the Heinz Nixdorf recall study Environ Int, 2020-01-25;136(0):105493. 2020-01-25 [PMID: 31991234] (Human)		Human
XS Wang, Q Shi, N Bhadkamkar, CS Cleeland, A Garcia-Gon, J Aguilar, C Heijnen, C Eng Minocycline for Symptom Reduction during Oxaliplatin-Based Chemotherapy for Colorectal Cancer: A Phase II Randomized Clinical Trial J Pain Symptom Manage, 2019-06-26;0(0):. 2019-06-26 [PMID: 31254639] (Human)		Human
E Bournazou, J Samuels, H Zhou, S Krasnokuts, J Patel, T Han, J Bencardino, L Rybak, SB Abramson, U Junker, KS Brown, M Attur Vascular Adhesion Protein-1 (VAP-1) as Predictor of Radiographic Severity in Symptomatic Knee Osteoarthritis in the New York University Cohort Int J Mol Sci, 2019-05-29;20(11):. 2019-05-29 [PMID: 31146362] (Human)		Human
S Lucht, F Hennig, S Moebus, D Führer-Sak, C Herder, KH Jöckel, B Hoffmann Air pollution and diabetes-related biomarkers in non-diabetic adults: A pathway to impaired glucose metabolism? Environ Int, 2019-01-17;124(0):370-392. 2019-01-17 [PMID: 30660850] (Human)		Human
W Coryell, H Wilcox, SJ Evans, GN Pandey, L Jones-Bran, F Dickerson, R Yolken Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior J Psychiatr Res, 2018-09-11;106(0):38-42. 2018-09-11 [PMID: 30261413] (Human)		Human
DT Skelly, ÉW Griffin, CL Murray, S Harney, C O'Boyle, E Hennessy, MA Dansereau, A Nazmi, L Tortorelli, JN Rawlins, DM Bannerman, C Cunningham Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms Mol. Psychiatry, 2018-06-06;24(10):1533-1548. 2018-06-06 [PMID: 29875474] (Mouse)		Mouse
KC El Kasmi, PM Vue, AL Anderson, MW Devereaux, S Ghosh, N Balasubram, SA Fillon, C Dahrenmoel, A Allawzi, C Woods, S McKenna, CJ Wright, L Johnson, A D'Alessand, JA Reisz, E Nozik-Gray, FJ Suchy, RJ Sokol Macrophage-derived IL-1?/NF-?B signaling mediates parenteral nutrition-associated cholestasis Nat Commun, 2018-04-11;9(1):1393. 2018-04-11 [PMID: 29643332] (Human)		Human
P Presicce, CW Park, P Senthamara, S Bhattachar, C Jackson, F Kong, CM Rueda, E DeFranco, LA Miller, DA Hildeman, N Salomonis, CA Chougnet, AH Jobe, SG Kallapur IL-1 signaling mediates intrauterine inflammation and chorio-decidua neutrophil recruitment and activation JCI Insight, 2018-03-22;3(6):. 2018-03-22 [PMID: 29563340] (Primate - Macaca mulatta (Rhesus Macaque))		Primate - Macaca mulatta (Rhesus Macaque)
C Herder, A Schmitt, F Budden, A Reimer, B Kulzer, M Roden, T Haak, N Hermanns Association between pro- and anti-inflammatory cytokines and depressive symptoms in patients with diabetes-potential differences by diabetes type and depression scores Transl Psychiatry, 2018-03-09;7(11):1. 2018-03-09 [PMID: 29520075] (Human)		Human
PM Macedo, R Almeida-Pa, MA Almeida, RA Coelho, MA Oliveira F, DM Medeiros, A Gomes-Silv, JR Lima, AM Da-Cruz, RM Zancopé-Ol, ACFD Valle Fatal septic shock caused by Paracoccidioides brasiliensis phylogenetic species S1 in a young immunocompetent patient: a case report Rev. Soc. Bras. Med. Trop., 2018-01-01;51(1):111-114. 2018-01-01 [PMID: 29513831] (Human)		Human
N Schofer, S Ludwig, N Rübsamen, R Schnabel, KJ Lackner, HJ Ruprecht, C Bickel, U Landmesser, S Blankenber, T Zeller Prognostic impact of Interleukin-1 receptor antagonist in patients with documented coronary artery disease Int. J. Cardiol., 2018-02-01;0(0):. 2018-02-01 [PMID: 29395365] (ELISA Capture, Human)	ELISA Capture	Human
A Abrahamsso, A Capodanno, A Rzepecka, C Dabrosin Downregulation of tumor suppressive microRNAs in vivo in dense breast tissue of postmenopausal women Oncotarget, 2017-09-15;8(54):92134-92142. 2017-09-15 [PMID: 29190903] (Human)		Human
A Barreto A short report on the effect of decreased incubation time on the architectural profile of autologous conditioned serum (ACS) Cytokine, 2017-04-11;0(0):. 2017-04-11 [PMID: 28411044] (Human)		Human
E Peyster, J Chen, HI Feldman, AS Go, J Gupta, N Mitra, Q Pan, A Porter, M Rahman, D Raj, M Reilly, MR Wing, W Yang, RR Townsend Inflammation and Arterial Stiffness in Chronic Kidney Disease: Findings From the CRIC Study Am. J. Hypertens., 2017-04-01;30(4):400-408. 2017-04-01 [PMID: 28391349] (Human)		Human
M Civelek, Y Wu, C Pan, CK Raulerson, A Ko, A He, C Tilford, NK Saleem, A Stan?áková, LJ Scott, C Fuchsberge, HM Stringham, AU Jackson, N Narisu, PS Chines, KS Small, J Kuusisto, BW Parks, P Pajukanta, T Kirchgessn, FS Collins, PS Gargalovic, M Boehnke, M Laakso, KL Mohlke, AJ Lusis Genetic Regulation of Adipose Gene Expression and Cardio-Metabolic Traits Am. J. Hum. Genet, 2017-03-02;100(3):428-443. 2017-03-02 [PMID: 28257690] (Human)		Human
J Nouhin, P Pean, Y Madec, MF Chevalier, C Didier, L Borand, FX Blanc, D Scott-Alga, D Laureillar, L Weiss Interleukin-1 receptor antagonist, a biomarker of response to anti-TB treatment in HIV/TB co-infected patients J. Infect, 2017-02-09;0(0):. 2017-02-09 [PMID: 28189712] (Human)		Human
E Leinonen Association study of arcuate nucleus neuropeptide Y neuron receptor gene variation and serum NPY levels in clozapine treated patients with schizophrenia Eur. Psychiatry, 2016-11-10;40(0):13-19. 2016-11-10 [PMID: 27837667] (Human)		Human
JH Lee, EH Kam, JM Kim, SY Kim, EJ Kim, SY Cheon, BN Koo Intranasal Administration of Interleukin-1 Receptor Antagonist in a Transient Focal Cerebral Ischemia Rat Model Biomol Ther (Seoul), 2017-03-01;25(2):149-157. 2017-03-01 [PMID: 27530114] (Rat)		Rat
Stability of cytokines, chemokines and soluble activation markers in unprocessed blood stored under different conditions Cytokine, 2016-05-18;84(0):17-24. 2016-05-18 [PMID: 27208752] (Human)		Human
CM Rueda, P Presicce, CM Jackson, LA Miller, SG Kallapur, AH Jobe, CA Chougnet Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque J Immunol, 2016-04-01;0(0):. 2016-04-01 [PMID: 27036917] (Primate - Macaca mulatta (Rhesus Macaque))		Primate - Macaca mulatta (Rhesus Macaque)
JR North, S Takenaka, A Rozek, A Kielczewsk, S Opal, LA Morici, BB Finlay, CJ Schaber, R Straube, O Donini A novel approach for emerging and antibiotic resistant infections: Innate defense regulators as an agnostic therapy J. Biotechnol., 2016-03-23;226(0):24-34. 2016-03-23 [PMID: 27015977] (Primate)		Primate
Gupta J, Dominic E, Fink J, Ojo A, Barrows I, Reilly M, Townsend R, Joffe M, Rosas S, Wolman M, Patel S, Keane M, Feldman H, Kusek J, Raj D Association between Inflammation and Cardiac Geometry in Chronic Kidney Disease: Findings from the CRIC Study. PLoS ONE, 2015-04-24;10(4):e0124772. 2015-04-24 [PMID: 25909952] (Human)		Human
Ziegler D, Strom A, Strassburger K, Nowotny B, Zahiragic L, Nowotny P, Carstensen-Kirberg M, Herder C, Szendroedi J, Roden M Differential Patterns and Determinants of Cardiac Autonomic Nerve Dysfunction during Endotoxemia and Oral Fat Load in Humans. PLoS ONE, 2015-04-20;10(4):e0124242. 2015-04-20 [PMID: 25893426] (Human)		Human
Hermanns N, Schmitt A, Gahr A, Herder C, Nowotny B, Roden M, Ohmann C, Kruse J, Haak T, Kulzer B The effect of a Diabetes-Specific Cognitive Behavioral Treatment Program (DIAMOS) for patients with diabetes and subclinical depression: results of a randomized controlled trial. Diabetes Care, 2015-01-20;38(4):551-60. 2015-01-20 [PMID: 25605812] (Human)		Human
Hengartner N, Fiedler J, Schrezenmeier H, Huber-Lang M, Brenner R Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma. PLoS ONE, 2015-01-06;10(1):e0116772. 2015-01-06 [PMID: 25562599] (Human)		Human
Chou C, Lin F, Tsai H, Chang S The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia. BMC Pulm Med, 2014-11-19;14(0):182. 2014-11-19 [PMID: 25409888] (Human)		Human
Bonfim-Mendonca P, Ratti B, Godoy J, Negri M, Lima N, Fiorini A, Hatanaka E, Consolaro M, de Oliveira Silva S, Svidzinski T beta-glucan induces reactive oxygen species production in human neutrophils to improve the killing of Candida albicans and Candida glabrata isolates from vulvovaginal candidiasis. PLoS ONE, 2014-09-17;9(9):e107805. 2014-09-17 [PMID: 25229476] (Human)		Human
Hernandez M, Mills K, Almond M, Todoric K, Aleman M, Zhang H, Zhou H, Peden D IL-1 receptor antagonist reduces endotoxin-induced airway inflammation in healthy volunteers. J Allergy Clin Immunol, 2014-09-05;135(2):379-85. 2014-09-05 [PMID: 25195169] (Human)		Human
Pisetsky D, Trace S, Brownley K, Hamer R, Zucker N, Roux-Lombard P, Dayer J, Bulik C The expression of cytokines and chemokines in the blood of patients with severe weight loss from anorexia nervosa: an exploratory study. Cytokine, 2014-06-14;69(1):110-5. 2014-06-14 [PMID: 25022969] (Human)		Human
Szendroedi J, Yoshimura T, Phielix E, Koliaki C, Marcucci M, Zhang D, Jelenik T, Muller J, Herder C, Nowotny P, Shulman G, Roden M Role of diacylglycerol activation of PKCtheta in lipid-induced muscle insulin resistance in humans. Proc Natl Acad Sci U S A, 2014-06-16;111(26):9597-602. 2014-06-16 [PMID: 24979806] (Human)		Human
Dominy , Stephen, Brown , Joseph N, Ryder , Mark I, Gritsenko , Marina, Jacobs , Jon M, Smith , Richard Proteomic analysis of saliva in HIV-positive heroin addicts reveals proteins correlated with cognition. PLoS ONE, 2014-04-09;9(4):e89366. 2014-04-09 [PMID: 24717448] (Human)		Human
Lin J, Chang Y, Yang W, Yu A, Wong C The multifaceted effects of polysaccharides isolated from Dendrobium huoshanense on immune functions with the induction of interleukin-1 receptor antagonist (IL-1ra) in monocytes. PLoS ONE, 2014-04-04;9(4):e94040. 2014-04-04 [PMID: 24705413] (Human)		Human
Vistisen D, Witte D, Tabak A, Herder C, Brunner E, Kivimaki M, Faerch K Patterns of obesity development before the diagnosis of type 2 diabetes: the Whitehall II cohort study. PLoS Med, 2014-02-11;11(2):e1001602. 2014-02-11 [PMID: 24523667] (Human)		Human
Wing M, Yang W, Teal V, Navaneethan S, Tao K, Ojo A, Guzman N, Reilly M, Wolman M, Rosas S, Cuevas M, Fischer M, Lustigova E, Master S, Xie D, Appleby D, Joffe M, Kusek J, Feldman H, Raj D Race modifies the association between adiposity and inflammation in patients with chronic kidney disease: findings from the chronic renal insufficiency cohort study. Obesity (Silver Spring), 2014-02-11;22(5):1359-66. 2014-02-11 [PMID: 24415732] (Human)		Human
Teichert T, Vossoughi M, Vierkotter A, Sugiri D, Schikowski T, Schulte T, Roden M, Luckhaus C, Herder C, Kramer U Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. PLoS ONE, 2013-12-10;8(12):e83042. 2013-12-10 [PMID: 24340078] (Human)		Human
Leifler K, Svensson S, Abrahamsson A, Bendrik C, Robertson J, Gauldie J, Olsson A, Dabrosin C Inflammation induced by MMP-9 enhances tumor regression of experimental breast cancer. J Immunol, 2013-03-15;190(8):4420-30. 2013-03-15 [PMID: 23509357] (Human)		Human
Saadat , Habiboll, Ziai , Seyed Al, Ghanemnia , Maryam, Namazi , Mohammad, Safi , Morteza, Vakili , Hosein, Dabbagh , Ali, Gholami , Omid Opium addiction increases interleukin 1 receptor antagonist (IL-1Ra) in the coronary artery disease patients. PLoS ONE, 2012-09-19;7(9):e44939. 2012-09-19 [PMID: 23028694] (Human)		Human
Matz J, Krause DL, Dehning S, Riedel M, Gruber R, Schwarz MJ, Muller N Altered monocyte activation markers in Tourette's syndrome: a case-control study. BMC Psychiatry, 2012-05-18;12(0):29. 2012-05-18 [PMID: 22471395] (Human)		Human
Pournot H, Bieuzen F, Louis J, Fillard JR, Barbiche E, Hausswirth C Time-course of changes in inflammatory response after whole-body cryotherapy multi exposures following severe exercise. PLoS ONE, 2011-07-28;6(7):e22748. 2011-07-28 [PMID: 21829501] (Human)		Human
Thacker SG, Berthier CC, Mattinzoli D, Rastaldi MP, Kretzler M, Kaplan MJ The detrimental effects of IFN-alpha on vasculogenesis in lupus are mediated by repression of IL-1 pathways: potential role in atherogenesis and renal vascular rarefaction. J. Immunol., 2010-08-30;185(7):4457-69. 2010-08-30 [PMID: 20805419] (Human)		Human
Carstensen M, Herder C, Kivimaki M, Jokela M, Roden M, Shipley MJ, Witte DR, Brunner EJ, Tabak AG Accelerated increase in serum interleukin-1 receptor antagonist starts 6 years before diagnosis of type 2 diabetes: Whitehall II prospective cohort study. Diabetes, 2010-02-25;59(5):1222-7. 2010-02-25 [PMID: 20185814] (Human)		Human
Rutanen J, Yaluri N, Modi S, Pihlajamaki J, Vanttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes, 2010-01-27;59(4):829-35. 2010-01-27 [PMID: 20107110] (Human)		Human
Ruotsalainen E, Stancakova A, Vauhkonen I, Salmenniemi U, Pihlajamaki J, Punnonen K, Laakso M Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects. Atherosclerosis, 2009-12-02;210(2):536-41. 2009-12-02 [PMID: 20031127] (Human)		Human
Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria. Transplantation, 2009-11-15;88(9):1109-16. 2009-11-15 [PMID: 19898207] (Human)		Human
Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Res., 2009-09-29;69(20):8191-9. 2009-09-29 [PMID: 19789336] (Human)		Human
Dossus L, Becker S, Achaintre D, Kaaks R, Rinaldi S Validity of multiplex-based assays for cytokine measurements in serum and plasma from "non-diseased" subjects: comparison with ELISA. J. Immunol. Methods, 2009-09-10;350(1):125-32. 2009-09-10 [PMID: 19748508] (Human)		Human
Lachmann HJ, Lowe P, Felix SD, Rordorf C, Leslie K, Madhoo S, Wittkowski H, Bek S, Hartmann N, Bosset S, Hawkins PN, Jung T In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes. J. Exp. Med., 2009-04-13;206(5):1029-36. 2009-04-13 [PMID: 19364880] (Human)		Human
Kallapur SG, Nitsos I, Moss TJ, Polglase GR, Pillow JJ, Cheah FC, Kramer BW, Newnham JP, Ikegami M, Jobe AH IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide. Am. J. Respir. Crit. Care Med., 2009-02-20;179(10):955-61. 2009-02-20 [PMID: 19234101] (Ovine)		Ovine
Rehani K, Wang H, Garcia CA, Kinane DF, Martin M Toll-like receptor-mediated production of IL-1Ra is negatively regulated by GSK3 via the MAPK ERK1/2. J. Immunol., 2009-01-01;182(1):547-53. 2009-01-01 [PMID: 19109187] (Human)		Human
Wang D, Drenker M, Eiz-Vesper B, Werfel T, Wittmann M Evidence for a pathogenetic role of interleukin-18 in cutaneous lupus erythematosus. Arthritis Rheum., 2008-10-01;58(10):3205-15. 2008-10-01 [PMID: 18821674] (Human)		Human
O'Donnell K, Brydon L, Wright CE, Steptoe A Self-esteem levels and cardiovascular and inflammatory responses to acute stress. Brain Behav. Immun., 2008-07-08;0(0):. 2008-07-08 [PMID: 18644432] (Human)		Human
Quesnel C, Marchand-Adam S, Fabre A, Marchal-Somme J, Philip I, Lasocki S, Lecon V, Crestani B, Dehoux M Regulation of hepatocyte growth factor secretion by fibroblasts in patients with acute lung injury. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-12-07;294(2):L334-43. 2007-12-07 [PMID: 18065658] (Human)		Human
Dudek AZ, Yunis C, Harrison LI, Kumar S, Hawkinson R, Cooley S, Vasilakos JP, Gorski KS, Miller JS First in human phase I trial of 852A, a novel systemic toll-like receptor 7 agonist, to activate innate immune responses in patients with advanced cancer. Clin. Cancer Res., 2007-12-01;13(23):7119-25. 2007-12-01 [PMID: 18056192] (Human)		Human
Sadeghi M, Susal C, Daniel V, Naujokat C, Zimmermann R, Huth-Kuhne A, Opelz G Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy. AIDS Res. Hum. Retroviruses, 2007-07-01;23(7):886-90. 2007-07-01 [PMID: 17678471] (Human)		Human
Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells. Br. J. Pharmacol., 2007-03-12;151(1):115-27. 2007-03-12 [PMID: 17351655] (Human)		Human
Keller MJ, Guzman E, Hazrati E, Kasowitz A, Cheshenko N, Wallenstein S, Cole AL, Cole AM, Profy AT, Wira CR, Hogarty K, Herold BC PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity. AIDS, 2007-02-19;21(4):467-76. 2007-02-19 [PMID: 17301565] (Human)		Human
Zhang X, Wen J, Deng L, Lin J Decreased levels of peritoneal interleukin-1 receptor antagonist in patients with endometriosis and disease-related dysmenorrhea. Fertil. Steril., 2007-02-12;88(3):594-9. 2007-02-12 [PMID: 17292896] (Human)		Human
Maedler K, Schumann DM, Sauter N, Ellingsgaard H, Bosco D, Baertschiger R, Iwakura Y, Oberholzer J, Wollheim CB, Gauthier BR, Donath MY Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets. Diabetes, 2006-10-01;55(10):2713-22. 2006-10-01 [PMID: 17003335] (Human)		Human
Fichorova RN Guiding the vaginal microbicide trials with biomarkers of inflammation. J. Acquir. Immune Defic. Syndr., 2004-10-01;37(0):S184-93. 2004-10-01 [PMID: 16419271] (Human)		Human
Bouchama A, Ollivier V, Roberts G, Al Mohanna F, de Prost D, Eldali A, Saussereau E, El-Sayed R, Chollet-Martin S Experimental heatstroke in baboon: analysis of the systemic inflammatory response. Shock, 2005-10-01;24(4):332-5. 2005-10-01 [PMID: 16205317] (Primate - Papio hamadryas (Hamadyras Baboon))		Primate - Papio hamadryas (Hamadyras Baboon)
Vergne-Salle</LastName><F P</Initial, Vergne-Salle P, Leger DY, Bertin P, Treves R, Beneytout JL, Liagre B Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes. Cytokine, 2005-09-07;31(5):335-48. 2005-09-07 [PMID: 16099671] (Human)		Human
Kaneyama K, Segami N, Sun W, Sato J, Fujimura K Levels of soluble cytokine factors in temporomandibular joint effusions seen on magnetic resonance images. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2005-04-01;99(4):411-8. 2005-04-01 [PMID: 15772591] (Human)		Human
Pagura SM, Thomas SG, Woodhouse LJ, Ezzat S, Marks P Circulating and synovial levels of IGF-I, cytokines, physical function and anthropometry differ in women awaiting total knee arthroplasty when compared to men. J. Orthop. Res., 2005-03-01;23(2):397-405. 2005-03-01 [PMID: 15734254] (Human)		Human
Sadeghi M, Daniel V, Naujokat C, Wiesel M, Hergesell O, Opelz G Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection. Transpl. Int., 2005-02-01;18(2):177-85. 2005-02-01 [PMID: 15691270] (Human)		Human
Yoshinari N, Kawase H, Mitani A, Ito M, Sugiishi S, Matsuoka M, Shirozu N, Ishihara Y, Bito B, Hiraga M, Arakawa K, Noguchi T Effects of scaling and root planing on the amounts of interleukin-1 and interleukin-1 receptor antagonist and the mRNA expression of interleukin-1beta in gingival crevicular fluid and gingival tissues. J. Periodont. Res., 2004-06-01;39(3):158-67. 2004-06-01 [PMID: 15102044] (Human)		Human
Tominaga K, Habu M, Sukedai M, Hirota Y, Takahashi T, Fukuda J IL-1 beta, IL-1 receptor antagonist and soluble type II IL-1 receptor in synovial fluid of patients with temporomandibular disorders. Arch. Oral Biol., 2004-06-01;49(6):493-9. 2004-06-01 [PMID: 15099807] (Human)		Human
Brooks-Asplund EM, Tupper CE, Daun JM, Kenney WL, Cannon JG Determinants of plasma leptin concentration in postmenopausal women. Mech. Ageing Dev., 2004-02-01;125(2):117-9. 2004-02-01 [PMID: 15037014] (Human)		Human
Bas S, Gauthier BR, Spenato U, Stingelin S, Gabay C CD14 is an acute-phase protein. J. Immunol., 2004-04-01;172(7):4470-9. 2004-04-01 [PMID: 15034063] (Human)		Human
McDevitt MJ, Russell CM, Schmid MJ, Reinhardt RA Impact of increased occlusal contact, interleukin-1 genotype, and periodontitis severity on gingival crevicular fluid IL-1beta levels. J. Periodontol., 2003-09-01;74(9):1302-7. 2003-09-01 [PMID: 14584862] (Human)		Human
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Array DRA00B

• IL-1ra/IL-1F3/IL1RN Antibodies
• IL-1ra/IL-1F3/IL1RN ELISA Kits
• IL-1ra/IL-1F3/IL1RN Lysates
• IL-1ra/IL-1F3/IL1RN Proteins
• IL-1ra/IL-1F3/IL1RN Proteins and Enzymes
• IL-1ra/IL-1F3/IL1RN ELISAs