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HSP90 beta Antibody [HRP]

 
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Product Details

Summary
Reactivity Hu, Mu, Rt, PmSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
HRP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-77563AF350
Alexa Fluor 405
NBP1-77563AF405
Alexa Fluor 488
NBP1-77563AF488
Alexa Fluor 532
NBP1-77563AF532
Alexa Fluor 594
NBP1-77563AF594
Alexa Fluor 647
NBP1-77563AF647
Alexa Fluor 700
NBP1-77563AF700
Alexa Fluor 750
NBP1-77563AF750
Allophycocyanin
NBP1-77563APC
Biotin
NBP1-77563B
CoraFluor 1
NBP1-77563CL1
DyLight 350
NBP1-77563UV
DyLight 405
NBP1-77563V
DyLight 488
NBP1-77563G
DyLight 550
NBP1-77563R
DyLight 594
NBP1-77563DL594
DyLight 650
NBP1-77563C
DyLight 680
NBP1-77563FR
DyLight 755
NBP1-77563IR
FITC
NBP1-77563F
Janelia Fluor 525
NBP1-77563JF525
Janelia Fluor 549
NBP1-77563JF549
Janelia Fluor 585
NBP1-77563JF585
Janelia Fluor 635
NBP1-77563JF635
Janelia Fluor 646
NBP1-77563JF646
Janelia Fluor 669
NBP1-77563JF669
PE
NBP1-77563PE
PerCP
NBP1-77563PCP
Unconjugated
NBP1-77563
mFluor Violet 450 SE
NBP1-77563MFV450
mFluor Violet 500 SE
NBP1-77563MFV500
mFluor Violet 610 SE
NBP1-77563MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-77563
BSA Free
NBP1-77563SS
BSA Free
NBP1-77563
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HSP90 beta Antibody [HRP] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human Hsp90B protein (between residues 650-724) [UniProt P08238]
Localization
Cytoplasm. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HSP90AB1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Knockdown Validated
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Readout System

Reactivity Notes

Immunogen has 86% identity to cow.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for HSP90 beta Antibody [HRP]

  • D6S182
  • Heat shock 84 kDa
  • heat shock 90kD protein 1, beta
  • heat shock 90kDa protein 1, beta
  • heat shock protein 90kDa alpha (cytosolic), class B member 1
  • heat shock protein beta
  • heat shock protein HSP 90-beta
  • HSP 84
  • HSP84
  • HSP90 beta
  • HSP90AB1
  • HSP90B
  • HSP90-BETA
  • HSP90BHSP 90
  • HSPC2
  • HSPC2D6S182
  • HSPCB
  • HSPCBFLJ26984

Background

HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 (HSP90AB1), also known as HSPC2, HSPCB and HSP90B, is a chaperone that plays an integral part in signal transduction, protein folding and degradation, cell cycle regulation, and protein maturation. Specifically, HSP90AB1 is a highly conserved chaperone which interacts with other cochaperones to assist in either the folding or refolding of proteins. HSP90AB1 is a constitutive form of the two major HSP90 proteins and is found primarily in the cytosol along with the inducible form, HSP90AA1. HSP90B is a target molecule for treatment of Helicobacter pylori (H. pylori)-induced gastric injury due to an interaction of HSP90B1 with Rac1 ultimately leading to increased production in reactive oxygen species (ROS) in gastric epithelial cells (PMID: 20451655). HSP90B in conjunction with HSP70 also plays a role in HIF-1alpha stability via ubiquitin and O(2)-independent regulation (PMID: 19802386). HSP90 antibodies are useful tools for studying cancer or other diseases brought on by cellular stress.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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BSA Free
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Video Protocols

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ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol HSP90AB1