Glut1 Antibody [PE]

Glucose transporter 1 (GLUT1) or solute carrier family 2 (SLC2A1) is a member of the GLUT family of monosaccharides and polyols transporters. GLUT proteins transport glucose across cellular membranes through facilitative mechanisms and play a key role in glucose homeostasis (1). Fourteen GLUT proteins have been identified in the human, which are encoded by SLC2A genes 1-14 and are broadly expressed in many cell types and tissues. GLUT family members differ in sequence homology, substrate specificity and expression patterns. Based on sequence homology, GLUT family members are classified into Class I (GLUT1, 2, 3, 4, and GLUT14), Class II (GLUT5, 7, 9, and 11), and Class III (GLUT6, 8, 10, 12 and 13) (1). Structurally, GLUT transporters are integral membrane glycoproteins consisting of 12 membrane spanning helical domains, a single N-linked glycosylation site, and having cytoplasmic facing carboxy and amino terminal domains (2).

GLUT1 (Human glycosylated form theoretical molecular weight 55kDa) functions primarily as a glucose transporter but can transport other substrates including mannose, galactose and glucosamine across the membrane (3). Like other GLUT family members, GLUT1 is broadly expressed, nevertheless it is the predominant glucose transporter expressed in red blood cells and brain endothelial cells (1). SLC2A1 mutations underscore the autosomal dominant disorder GLUT1 deficiency syndrome (GLUTI-DS) which is characterized by low glucose levels in the brain or hypoglycorrhachia due to insufficient glucose transport across the blood brain barrier (2, 4, 5). Phenotypically, GLUT1-DS is characterized by early onset seizures, neurologic developmental delay, microcephaly, and ataxia (4). GLUT1 is highly expressed in the endothelium of cutaneous vascular lesions and serves as a marker for the diagnosis of juvenile or infantile hemangiomas (6).

References

1. Augustin, R. (2010). The protein family of glucose transport facilitators: It's not only about glucose after all. IUBMB Life. https://doi.org/10.1002/iub.315

2. Mueckler, M., & Thorens, B. (2013). The SLC2 (GLUT) family of membrane transporters. Molecular Aspects of Medicine. https://doi.org/10.1016/j.mam.2012.07.001

3. Stein, W. D., & Litman, T. (2015). Carrier-Mediated Transport. In Channels, Carriers, and Pumps. https://doi.org/10.1016/b978-0-12-416579-3.00004-6

4. Pearson, T. S., Akman, C., Hinton, V. J., Engelstad, K., & De Vivo, D. C. (2013). Phenotypic spectrum of glucose transporter type 1 deficiency syndrome (Glut1 DS). Current Neurology and Neuroscience Reports. https://doi.org/10.1007/s11910-013-0342-7

5. Messana, T., Russo, A., Vergaro, R., Boni, A., Santucci, M., & Pini, A. (2018). Glucose transporter type 1 deficiency syndrome: Developmental delay and early-onset ataxia in a novel mutation of the SLC2A1 gene. Journal of Pediatric Neurosciences. https://doi.org/10.4103/JPN.JPN_169_17

6. van Vugt, L. J., van der Vleuten, C. J. M., Flucke, U., & Blokx, W. A. M. (2017). The utility of GLUT1 as a diagnostic marker in cutaneous vascular anomalies: A review of literature and recommendations for daily practice. Pathology Research and Practice. https://doi.org/10.1016/j.prp.2017.04.023

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 2 applications: FLOW, In vitro.

Showing Publications 1 - 9 of 9.

Publications using NB110-39113PE	Applications	Species
Artico LL, Ruas JS, Teixeira Júnior JR et al. IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis International journal of molecular sciences 2023-06-02 [PMID: 37298628] (FLOW)	FLOW
Jaiswal AK, Yadav J, Makhija S Et al. Short palate, lung, and nasal epithelial clone 1 (SPLUNC1) level determines steroid-resistant airway inflammation in aging Am J Physiol Lung Cell Mol Physiol 2021-12-01 [PMID: 34851736] (FLOW, Mouse) Details: Citation using the PE version of this antibody.	FLOW	Mouse
Pacella I, Procaccini C, Focaccetti C et al. Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth Proc Proc Natl Acad Sci U S A. 2018-07-10 [PMID: 29941600] (FLOW, Mouse) Details: Citation using the PE form of this antibody.	FLOW	Mouse
Trompette A, Gollwitzer ES, Pattaroni C et al. Dietary Fiber Confers Protection against Flu by Shaping Ly6c- Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism Immunity 2018-05-15 [PMID: 29768180]
Trachsel V In vitro fate mapping of stem cell development at the single cell level Thesis 2018-01-01 (FLOW, In vitro, Human)	FLOW, In vitro	Human
Girotra M, Trachsel V, Roch A, Lutolf MP In Vivo Pre-Instructed HSCs Robustly Execute Asymmetric Cell Divisions In Vitro Int J Mol Sci 2020-11-06 [PMID: 33153113] (Mouse) Details: Citation using the PE version of this antibody.		Mouse
Jaiswal AK, Makhija S, Stahr N Et al. Pyruvate kinase M2 in lung APCs regulates Alternaria-induced airway inflammation Immunobiology 2020-08-05 [PMID: 32747016] Details: Citation using the PE version of this antibody.
Cheung KCP, Fanti S, Mauro C et al. Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming Nat Commun 2020-07-17 [PMID: 32681081] Details: Citation using the PE/Cy7 format of this antibody.
Kishore M, Cheung KCP, Fu H et al. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis Immunity. 2017-11-21 [PMID: 29669254] (FLOW, Mouse) Details: The Phycoerythrin conjugated version of this antibody was used as part of this experiment, NB110-39113PE.	FLOW	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	Flow	Mouse	02/26/2015	View Summary Application Flow Cytometry Sample Tested Murine CD4+ T cells Species Mouse Lot E-3-PE

Array NB110-39113PE

• Glut1 Antibodies
• Glut1 ELISA Kits
• Glut1 Lysate
• Glut1 Proteins