HIF-2 alpha is a member of the heterodimeric hypoxia-inducible factors/HIFs family (HIF-1,HIF-2, and HIF-3) which contains a common beta subunit but differ in their alpha subunits.
Glucose is the principal fuel source for the brain and GLUT1 is the only vehicle by which glucose enters the brain. In case of GLUT1 deficiency, the risk of clinical manifestations is increased in infancy and childhood, when the brain glucose demand is maximal.
