GATA-3 Antibody (634919) [Alexa Fluor® 594] Summary
Immunogen |
E. coli-derived recombinant human GATA-3 Pro135-Ser258 Accession # P23771 |
Specificity |
Detects human GATA-3 in flow cytometry. |
Source |
N/A |
Isotype |
IgG2b |
Clonality |
Monoclonal |
Host |
Mouse |
Gene |
GATA3 |
Purity Statement |
Protein A or G purified from hybridoma culture supernatant |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Intracellular Staining by Flow Cytometry 5 uL/10^6 cells
|
Packaging, Storage & Formulations
Storage |
Protect from light. Do not freeze.- 12 months from date of receipt, 2 to 8 °C as supplied.
|
Buffer |
Supplied in a saline solution containing BSA and Sodium Azide. |
Preservative |
Sodium Azide |
Notes
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for GATA-3 Antibody (634919) [Alexa Fluor® 594]
Background
GATA-3 is a 54-60 kDa member of the GATA family of
transcription regulating factors. There
are currently six mammalian members, each of which binds to a G-A-T-A motif
found in gene promoters. Although GATA-3
is traditionally described as being a hematopoietic transcriptional regulator,
it has been found in multiple cell types, both embryonic and adult. Postnatal cells reported to express GATA-3
include NK cells, ILCs, NKT cells, B cells, thymocytes (DN, CD4 SP, and CD8 SP)
and T cells, plus keratinocytes, sympathetic neurons, renal distal convoluted
tubule and mammary duct epithelium.
Human GATA-3 is 443 amino acids (aa) in length. It contains two GAGA-type Zn finger domains
(aa 263-287 and 317-341) and multiple phosphorylation sites. GATAs as a group are known to either activate,
or repress, gene expression, maintain transcriptional activity, and regulate
gene expression levels. Within this
framework, GATA-3 is best known to drive naïve CD4+ T cells into a Th2
phenotype, induce Th2 proliferation, and inhibit Th1 cell development via T-bet
repression. Other effects attributed to
GATA-33 include the promotion of Th9 and Treg formation, and the inhibition of
Th1, TH17 and B cell development. Over
aa 135-258, human and mouse GATA-3 share 94% aa sequence identity.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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