STAT6 Antibody (177C322.1) - BSA Free

Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the Janus family tyrosine kinases (Jak)/ STAT signal transduction pathway and mediates cytokine signaling by IL 4 and IL-13 (1). STAT6 (predicted molecular weight 94kDa) has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT6 is tyrosine phosphorylated (Tyr641) in response to cellular interaction with IL-4. STAT6 mRNA has been detected in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 and Th9 immune response (2). Loss of STAT6 impairs IL-4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation. Diseases associated with STAT6 include malignant hemangiopericytoma and nut allergies.

References

1. Waqas, S. F. H., Ampem, G., & Roszer, T. (2019). Analysis of IL-4/STAT6 Signaling in Macrophages. Methods Mol Biol, 1966, 211-224. doi:10.1007/978-1-4939-9195-2_17

2. Goenka, S., & Kaplan, M. H. (2011). Transcriptional regulation by STAT6. Immunol Res, 50(1), 87-96. doi:10.1007/s12026-011-8205-2

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 1 application: WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-25241	Applications	Species
Bortolotti D, Gentili V, Caselli E et al. DNA Sensors Signaling in NK Cells During HHV-6A, HHV-6B and HHV-7 Infection Front. Microbiol. 2020-02-19 [PMID: 32140147] (WB, Human)	WB	Human
Knosp C A, Carroll H P et al. SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses. J Exp Med 2011-04-07 [PMID: 21646394] (WB, Mouse)	WB	Mouse
Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI et al. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2010 Dec 28 [PMID: 21149710] (WB) Details: WB: Fig 1A (mouse liver, muscle, adipose tissue), Fig 1B (primary heptaocytes from wildtype (WT) and STAT6 knockout mice). The antibody was used at 0.5 ug/ml. Note: The specificity of the 177C322 mAb clone for STAT6 was validated in WT/knockout mice by WB	WB
Thieu VT, Nguyen ET, McCarthy BP et al. IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol. 2007 Aug [PMID: 17513694] (WB) Details: WB: Fig 5A (Nuclear extracts from B220+ primary mouse spenocytes), Fig 5B (Whole cell extracts from B220+ primary mouse splenocytes), Fig 6A (nuclear extracts from purified primary mouse B cells).	WB

Array NBP2-25241

• STAT6 Antibodies
• STAT6 Lysate
• STAT6 Proteins