DDB1 Antibody Summary
Immunogen |
A portion of amino acids 385-435 from human DDB1 was used as the immunogen for this antibody. |
Predicted Species |
Chinese Hamster (94%), Rhesus Macaque (100%), Chimpanzee (100%), Orangutan (100%), Guinea Pig (94%). Backed by our 100% Guarantee. |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Rabbit |
Gene |
DDB1 |
Purity |
Protein A purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Flow Cytometry 0.2ug/10^6cells
- Western Blot 2-4ug/ml~
|
Reactivity Notes
The amino acid sequence used as immunogen for this antibody is 100% homologous in Crab-eating Macaque, and 89% in Zebrafish, Cichlid fish, 83% in Chicken and Xenopus.
Packaging, Storage & Formulations
Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Buffer |
0.2 ml PBS and 0.05% BSA |
Preservative |
0.05% Sodium Azide |
Concentration |
0.5 mg/ml |
Purity |
Protein A purified |
Alternate Names for DDB1 Antibody
Background
DNA Damage Binding protein 1 (DDB1) binds with CUL4 to form an ubiquitin E3 ligase that targets protein substrates for ubiquitin-dependent proteolysis (1, 2). Loss of DDB1 impedes the proteolysis of a grouping of CUL4 substrates at least in response to UV (3, 4) and CUL4 ubiquitinylation (5). DDB1 is highly conserved from yeast to mammals (3, 6). DDB1 specific antibody probes might be useful in identifying CUL4-DDB1 substrates in epigenetics applications and ubiquitin modification dependent protein function.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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