CD161/NK1.1 Antibody (PK136) - BSA Free

NK-1.1 surface antigen is encoded by the NKR-P1B/NKR-P1C gene, also known as CD161b/CD161c and Ly-55. It is expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129. Expression of NKR-P1C antigen has been correlated with lysis of tumor cells in vitro and rejection of bone marrow allografts in vivo. NK-1.1 has also been shown to play a role in NK cell activation, IFN- gamma production, and cytotoxic granule release. NK-1.1 and DX5 are commonly used as mouse NK cell markers. The PK136 antibody has been reported to deplete NK cells, induce redirected lysis, block NK cell function, and induce NK cell proliferation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: FLOW, IF/IHC, IHC, IHC-Fr, IHC-P.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using NB100-77528	Applications	Species
Cheng LS, Zhu M, Gao Y et al. An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity Cellular & molecular biology letters 2023-05-31 [PMID: 37259060] (IHC, Mouse) Details: Multiplexed immunohistochemistry	IHC	Mouse
Peng JM, Chiu CF, Cheng JH et al. Evasion of NK cell immune surveillance via the vimentin-mediated cytoskeleton remodeling Frontiers in immunology 2022-08-11 [PMID: 36032170] (IHC-P, Human)	IHC-P	Human
Salman S, Meyers DJ, Wicks EE Et al. HIF inhibitor 32-134D eradicates murine hepatocellular carcinoma in combination with anti-PD1 therapy J Clin Invest 2022-05-02 [PMID: 35499076] (FLOW, Mouse) Details: Citation using the Alexa Fluor 488 version of this antibody.	FLOW	Mouse
Rai V, Wood MB, Feng H et al. The immune response after noise damage in the cochlea is characterized by a heterogeneous mix of adaptive and innate immune cells Scientific reports 2020-09-16 [PMID: 32938973] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Samanta D, Huang T, Shah R et al. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy Cell Rep [PMID: 32846130] (FLOW, Mouse) Details: Citation using the PE format of this antibody.	FLOW	Mouse
Chai C, Cox B, Yaish D et al. Agonist of RORA Attenuates Nonalcoholic Fatty Liver Progression in Mice via Up-regulation of MicroRNA 122 Gastroenterology 2020-09-01 [PMID: 32450149] (IHC-Fr)	IHC-Fr
Potez M, Fernandez-Palomo C, Bouchet A et al. Synchrotron microbeam radiation therapy as a new approach for treatment of radio-resistant melanoma: potential underlying mechanisms Int. J. Radiat. Oncol. Biol. Phys. 2019-08-25 [PMID: 31461675] (Mouse)		Mouse
X Wu, A Tommasi di, Q Zhou, PJ Michel-Dzi, F Bai, J Mi, J Qin, T Zu, GFL Hofbauer The ARE-binding protein Tristetraprolin (TTP) is a novel target and mediator of calcineurin tumor suppressing function in the skin PLoS Genet., 2018-05-03;14(5):e1007366. 2018-05-03 [PMID: 29723192]
Hu B, Elinav E, Huber S et al. Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci U S A 2010-12-14 [PMID: 21118981] (IHC-P, Mouse)	IHC-P	Mouse
Sun J, Hartvigsen K et al. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation 2010-08-24 [PMID: 20697023] (IF/IHC, Mouse)	IF/IHC	Mouse
Kanwar JR, Shen WP, Kanwar RK et al. Effects of survivin antagonists on growth of established tumors and B7-1 immunogene therapy. J Natl Cancer Inst. 93(20):1541-52. 2001-10-17 [PMID: 11604477]
Show All 11 Publications. Collapse Publications.

Array NB100-77528

• CD161/NK1.1 Antibodies