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Substance P Antibody (266815)

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Substance P was detected in immersion fixed paraffin-embedded sections of human spinal cord using 8 µg/mL Human/Mouse/Rat Substance P Monoclonal Antibody (Catalog # MAB4375) overnight at 4 °C. Tissue was ...read more

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clone
266815
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

Substance P Antibody (266815) Summary

Immunogen
KLH-coupled mouse Substance P synthetic peptide
RPKPQQFFGLM
Specificity
Detects human, mouse, and rat Substance P.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
TAC1
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
Reviewed Applications
Read 1 Review rated 4
using
MAB4375 in the following application:

Publications
Read Publications using
MAB4375 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Substance P Antibody (266815)

  • neurokinin 1
  • neurokinin 2
  • neurokinin A
  • Neurokinin-1
  • neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
  • neuropeptide gamma
  • neuropeptide K
  • NK2
  • NKA
  • NKNAneurokinin alpha
  • NPK
  • PPT
  • protachykinin-1
  • substance K
  • Substance P
  • TAC1
  • TAC2neuromedin L
  • tachykinin 2
  • tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2
  • tachykinin, precursor 1

Background

Substance P (Neurokinin-1), is member of the tachykinin peptide family. Processing of preprotachykinin isoforms generates Substance P and other tachykinins. Active Substance P is an 11 amino acid peptide, RPKPQQFFGLM, that is identical across all mammalian species. Substance P is mainly secreted from C-type fibers of primary sensory afferent neurons after stimulation through protease-activated receptor 2 (PAR2). Substance P binds primarily to the neurokinin 1 receptor on neurons in the dorsal horn, transmitting pain signals through the central nervous system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Substance P Antibody (MAB4375)(9)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 3 applications: IHC, IHC-Fr, IHC-P.


Filter By Application
IHC
(3)
IHC-Fr
(2)
IHC-P
(1)
All Applications
Filter By Species
Human
(1)
Mouse
(3)
Rat
(2)
All Species
Showing Publications 1 - 9 of 9.
Publications using MAB4375 Applications Species
S Frase, F Löffler, JA Hosp Enhancing Post-Stroke Rehabilitation and Preventing Exo-Focal Dopaminergic Degeneration in Rats-A Role for Substance P International Journal of Molecular Sciences, 2022-03-31;23(7):. 2022-03-31 [PMID: 35409207] (IHC, Rat) IHC Rat
Y Xu, C Huang, H Deng, J Jia, Y Wu, J Yang, W Tu TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model Turk J Gastroenterol, 2018-11-01;29(6):692-700. 2018-11-01 [PMID: 30381276] (IHC-P, Mouse) IHC-P Mouse
L Xiao, M Ding, A Fernandez, P Zhao, L Jin, X Li Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors Eur Cell Mater, 2017-05-09;33(0):279-293. 2017-05-09 [PMID: 28485773] (IHC, Mouse) IHC Mouse
Y Okamura, S Mishima, JI Kashiwakur, T Sasaki-Sak, S Toyoshima, K Kuroda, S Saito, Y Tokuhashi, Y Okayama The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis Allergol Int, 2017-03-31;0(0):. 2017-03-31 [PMID: 28366675] (IHC, Human) IHC Human
Siomara Hernandez, Myrella L. Cruz, Annelyn Torres-Reveron, Caroline B. Appleyard Impact of Physical Activity on Pain Perception in an Animal Model of Endometriosis Journal of Endometriosis and Pelvic Pain Disorders 12/24/2015 [PMID: 28217664]
Siomara Hernandez, Myrella L. Cruz, Inevy I. Seguinot, Annelyn Torres-Reveron, Caroline B. Appleyard Impact of Psychological Stress on Pain Perception in an Animal Model of Endometriosis Reproductive Sciences 10/1/2017 [PMID: 28093054]
Cosker , Katharin, Pazyra-Murphy , Maria F, Fenstermacher , Sara J, Segal , Rosalind Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration. J Neurosci, 2013-03-20;33(12):5195-207. 2013-03-20 [PMID: 23516285] (IHC-Fr, Mouse) IHC-Fr Mouse
E. Matthew Hoffman, Zijia Zhang, Michael B. Anderson, Ruben Schechter, Kenneth E. Miller Potential mechanisms for hypoalgesia induced by anti-nerve growth factor immunoglobulin are identified using autoimmune nerve growth factor deprivation Neuroscience 10/13/2011 [PMID: 21802499]
Xu JT, Zhao X, Yaster M, Tao YX Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn. Brain Res., 2010-04-24;1336(0):46-57. 2010-04-24 [PMID: 20399760] (IHC-Fr, Rat) IHC-Fr Rat

Review for Substance P Antibody (MAB4375) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Mouse.

Reviews using MAB4375:
Filter by Applications
IF
(1)
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Filter by Species
Mouse
(1)
All Species
Images Ratings Applications Species Date Details
  4
reviewed by:
Verified Customer
IF Mouse 02/20/2015
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Summary

ApplicationImmunofluorescence
Sample TestedSee PMID 23232501
SpeciesMouse

FAQs for Substance P Antibody (MAB4375) (0)

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Verified Customer
02/20/2015
Application: IF
Species: Mouse

Bioinformatics

Gene Symbol TAC1