Neurokinin B Antibody - BSA Free

Neurokinin B (NKB) belongs to tachykinin family of peptides that also includes substance P, NKA, neuropeptide K, neuropeptide-gamma, and hemokinin-1, and NKB is the only tachykinin synthesized from preprotachykinin-B gene (designated as TAC3 in mammals, except for rodents where it is named Tac2). Tachykinins are characterized by a common carboxyl-terminal amino acid sequence of FXGLM-NH2 , X being a hydrophobic residue and are active peptides which stimulates neurons, evoke behavioral responses, are potent vasodilators and secretagogues (secretion stimulators), and contract directly or indirectly smooth muscles. NKB is the cleaved product of neurokinin B-like protein Zneurok1 (also called preprotachykinin-B or tachykinin-3) and act as an endogenous agonist ligand for its receptor, the NK3 receptor (NKB receptor). NKB signaling has been reported to play critical role in pre-eclampsia which is a potentially life threatening disease and is essential to neuroprotection in neurodegenerative diseases as well as to normal reproductive development.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 4 applications: ICC/IF, IF/IHC, IHC-Fr, WB.

Showing Publications 1 - 10 of 25. Show All 25 Publications. Collapse Publications.

Publications using NB300-201	Applications	Species
L Naulé, A Mancini, SA Pereira, BM Gassaway, JR Lydeard, JC Magnotto, HK Kim, J Liang, C Matos, SP Gygi, FT Merkle, RS Carroll, AP Abreu, UB Kaiser MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity JCI Insight, 2023-04-24;8(8):. 2023-04-24 [PMID: 37092553]
Roberts SA, NaulE L, Chouman S et al. Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice Endocrinology 2022-08-17 [PMID: 35974456]
Senft RA, Freret ME, Sturrock N, Dymecki SM Neurochemically and hodologically distinct ascending VGLUT3 versus serotonin subsystems comprise the r2-Pet1 median raphe The Journal of neuroscience : the official journal of the Society for Neuroscience 2021-02-05 [PMID: 33547164]
Liu, X, Yeo, S H Et al. Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendron. Elife 2021-01-19 [PMID: 33464205] (WB, Human)	WB	Human
Chen S, Gao XF, Zhou Y et al. A spinal neural circuitry for converting touch to itch sensation Nat Commun 2020-10-08 [PMID: 33033265] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Gao Z, Ma X, et al. Troxerutin protects against DHT-induced polycystic ovary syndrome in rats. J Ovarian Res 2020-09-13 [PMID: 32921318] (IF/IHC, Rat)	IF/IHC	Rat
Dees WL, Hiney JK, Srivastava VK Regulation of prepubertal dynorphin secretion in the medial basal hypothalamus of the female rat J. Neuroendocrinol. 2019-12-01 [PMID: 31715027] (WB, Rat)	WB	Rat
Sakata D, Uruno T et al. Selective role of neurokinin B in IL-31-induced itch response in mice. J Allergy Clin Immunol 2019-01-10 [PMID: 31405606] (IF/IHC, Mouse)	IF/IHC	Mouse
Fergani C, Leon S, Padilla SL et al. NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice Elife 2018-12-19 [PMID: 30565563] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Srivastava Vinod K, Hiney Jill K, Dees William L et al. Alcohol Delays the Onset of Puberty in the Female Rat by Altering Key Hypothalamic Events. Alcoholism, Clinical and Experimental Research 2018-07-01 [PMID: 29689132] (WB, Rat)	WB	Rat
Kanaya M, Iwata K, Ozawa H. Distinct dynorphin expression patterns with low- and high-dose estrogen treatment in the arcuate nucleus of female rats. Biol. Reprod. 2017-10-24 [PMID: 29069289] (Rat)		Rat
Osuka S, Iwase A, Nakahara T et al. Kisspeptin in the hypothalamus of two rat models of polycystic ovary syndrome. Endocrinology. 2016-12-16 [PMID: 27983870] (Rat)		Rat
Obata K, Shimo T, Okui T et al. Tachykinin Receptor 3 Distribution in Human Oral Squamous Cell Carcinoma. Anticancer Res. 2016-12-01 [PMID: 27919954] (IF/IHC, Human)	IF/IHC	Human
Kunimura Y, Iwata K, Ishigami A, Ozawa H. Age-related alterations in hypothalamic kisspeptin, neurokinin B, and dynorphin neurons and in pulsatile LH release in female and male rats. Neurobiol. Aging. 2016-10-19 [PMID: 27842268] (IF/IHC, Rat)	IF/IHC	Rat
Mittelman-Smith MA, Krajewski-Hall SJ, McMullen NT, Rance NE Ablation of KNDy Neurons Results in Hypogonadotropic Hypogonadism and Amplifies the Steroid-Induced LH Surge in Female Rats. Endocrinology 2016-05-01 [PMID: 26937713]
Pineda Reyes R, Sabatier N, Ludwig M et al. A direct neurokinin B projection from the arcuate nucleus regulates magnocellular vasopressin cells of the supraoptic nucleus. J. Neuroendocrinol. 2015-11-27 [PMID: 26610724] (IHC-Fr, Rat)	IHC-Fr	Rat
Helena CV, Toporikova N, Kalil B et al. KNDy neurons modulate the magnitude of the steroid-induced luteinizing hormone surges in ovariectomized rats. Endocrinology 2015-08-24 [PMID: 26302111]
Mittelman-Smith MA, Krajewski-Hall SJ, McMullen NT, Rance NE. Neurokinin 3 Receptor-Expressing Neurons in the Median Preoptic Nucleus Modulate Heat-Dissipation Effectors in the Female Rat Endocrinology 2015-03-31 [PMID: 25825817] (IHC-Fr, Rat)	IHC-Fr	Rat
True C, Nasrin Alam S, Cox K et al. Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. Endocrinology 2015-04-01 [PMID: 25574869] (Mouse)		Mouse
Cholanian M, Krajewski-Hall SJ, Levine RB et al. Electrophysiology of Arcuate Neurokinin B Neurons in Female Tac2-EGFP Transgenic Mice. Endocrinology 2014-04-15 [PMID: 24735328] (IHC-Fr, Mouse)	IHC-Fr	Mouse
Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, Lai J, Ciofi P, McMullen NT, Rance NE. Arcuate Kisspeptin/Neurokinin B/Dynorphin (KNDy) Neurons Mediate the Estrogen Suppression of Gonadotropin Secretion and Body Weight. Endocrinology;153(6):2800-12. 2012-06-01 [PMID: 22508514] (IF/IHC, Rat)	IF/IHC	Rat
Krajewski SJ, Burke MC, Anderson MJ et al. Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat. Neuroscience. 2010-03-17 [PMID: 20038444] (ICC/IF, IF/IHC, Rat)	ICC/IF, IF/IHC	Rat
Halasz J, Zelena D, Toth M et al. Substance P neurotransmission and violent aggression: the role of tachykinin NK(1) receptors in the hypothalamic attack area. Eur J Pharmacol. 2009-06-02 [PMID: 19344710] (IHC-Fr, Rat)	IHC-Fr	Rat
Burke MC, Letts PA, Krajewski SJ, Rance NE. Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleus. J Comp Neurol;498(5):712-26. 2006-10-10 [PMID: 16917850]
Krajewski SJ, Anderson MJ, Iles-Shih L Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence. J Comp Neurol. 2005-08-29 [PMID: 16025449] (IHC-Fr, Rat)	IHC-Fr	Rat
Show All 25 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Andree Lessard	IHC	Rat	06/22/2012	View Summary Application Immunohistochemistry Sample Tested rat tissue fixed with PFA and acrolein Species Rat
Enlarge	4 reviewed by: Christina Merkley	IF	Mouse	05/15/2012	View Summary Application Immunofluorescence Sample Tested Mouse hypothalamus Species Mouse Lot A3

Array NB300-201

• Neurokinin B Antibodies
• Neurokinin B ELISA Kit
• Neurokinin B Lysate
• Neurokinin B Proteins