CD160 Antibody (342713)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CD160 (also Natural killer cell receptor BY55) is a 16 kDa (predicted) member of the Ig superfamily (1‑4). In mouse, it is expressed principally on nonmyeloid hematopoietic cells. These include CD3⁺ NK1.1 cells, CD8⁺ TEM and TCM T cells, CD8 alpha ⁺ IELs, NKT cells, CD8‑ gamma δ TCR T cells, and vascular endothelial cells (1, 5‑7). Mouse CD160 has been identified as a 20‑21 kDa GPI‑linked glycoprotein (4, 5). It is synthesized as a preproprotein that is 185 amino acids (aa) in length. The precursor contains a 27 aa signal sequence, a 133 aa mature molecule that shows one 98 aa V‑type Ig‑like domain (aa 28‑125), and a 25 aa prosegment that is cleaved to generate a GPI‑linkage at Ser160. Mouse GPI‑linked CD160 is known to be cleaved by phospholipase C, and this generates a 40 kDa (presumably dimeric) band in SDS‑PAGE (5). One alternative splice form for mouse CD160 is reported that appears to show a deletion of aa 137‑180. This may generate a soluble molecule (5; GenBank Accession # NP_001156969). Mature mouse CD160 shares 63% and 88% aa identity with human and rat CD160, respectively. In mouse, CD160 is reported to bind to bind to HVEM/TNFRSF14, and both classical and non‑classical MHC Class I molecules (5, 8). MHC‑I proteins recognized by CD160 include Dd, Kb, Qa‑1b and CD1d (5). Upon engagement, the effects of CD160 ligation appear to be context dependent. When expressed on endothelial cells, CD160 binding to human HLA‑G1 initiates apoptosis, and thus impacts angiogenesis (6). When expressed on NK1.1 cells, mouse CD160 ligation alone has no effect; when combined with NK1.1 antigen stimulation, CD160 decreases NK cell IFN‑ gamma secretion. Relative to cytotoxicity, NK cell activity is positively correlated with the presence of CD160 (5).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Array MAB3899

• CD160 Antibodies
• CD160 Antibody Pair
• CD160 ELISA Kits
• CD160 Lysate
• CD160 Proteins and Enzymes