CCR2 Antibody (48607) [Allophycocyanin]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Flow Cytometry.

Showing Publications 1 - 10 of 12. Show All 12 Publications. Collapse Publications.

Publications using FAB151A	Applications	Species
JS Castleman, GYH Lip, E Shantsila Monocytes are increased in pregnancy after gestational hypertensive disease Oncogene, 2022-06-20;12(1):10358. 2022-06-20 [PMID: 35725746] (Flow Cytometry, Human)	Flow Cytometry	Human
J Zhuang, Y Han, D Xu, G Zhu, S Singh, L Chen, M Zhu, W Chen, Y Xu, X Li Comparison of circulating dendritic cell and monocyte subsets at different stages of atherosclerosis: insights from optical coherence tomography BMC Cardiovasc Disord, 2017-10-18;17(1):270. 2017-10-18 [PMID: 29047360] (Flow Cytometry, Human)	Flow Cytometry	Human
Lee Faulkner Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity Toxicol. Sci, 2016-09-16;154(2):416-429. 2016-09-16 [PMID: 27637899] (Flow Cytometry, Human)	Flow Cytometry	Human
Adam J. Wells, Jay R. Hoffman, Adam R. Jajtner, Alyssa N. Varanoske, David D. Church, Adam M. Gonzalez et al. The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression Nutrients 2016-07-02 [PMID: 27384580]
Victoria L Gadd Altered Peripheral Blood Monocyte Phenotype and Function in Chronic Liver Disease: Implications for Hepatic Recruitment and Systemic Inflammation PLoS ONE, 2016-06-16;11(6):e0157771. 2016-06-16 [PMID: 27309850] (Flow Cytometry, Human)	Flow Cytometry	Human
Martinez-Martin N, Viejo-Borbolla A, Martin R, Blanco S, Benovic J, Thelen M, Alcami A Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. Nat Commun, 2015-01-27;6(0):6163. 2015-01-27 [PMID: 25625471] (Flow Cytometry, Human)	Flow Cytometry	Human
Falk M, Singh A, Faber C, Nissen M, Hviid T, Sorensen T CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD. PLoS ONE, 2014-12-15;9(12):e112473. 2014-12-15 [PMID: 25503251] (Flow Cytometry, Human)	Flow Cytometry	Human
CXCR4 positive and angiogenic monocytes in myocardial infarction. Thromb Haemost, 2012-12-06;109(2):255-62. 2012-12-06 [PMID: 23223950] (Flow Cytometry, Human)	Flow Cytometry	Human
Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro-Garcia S, Drayson MT, Lip GY Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology. J. Thromb. Haemost., 2011-05-01;9(5):1056-66. 2011-05-01 [PMID: 21342432] (Flow Cytometry, Human)	Flow Cytometry	Human
Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J. Immunol., 2010-10-27;185(11):6646-63. 2010-10-27 [PMID: 20980630] (Flow Cytometry, Human)	Flow Cytometry	Human
Ahern D, Lloyd CM, Robinson DS Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors. Allergy, 2009-02-07;64(8):1121-9. 2009-02-07 [PMID: 19208087] (Flow Cytometry, Human)	Flow Cytometry	Human
Chang WL, Baumgarth N, Yu D, Barry PA Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality. J. Virol., 2004-08-01;78(16):8720-31. 2004-08-01 [PMID: 15280480] (Flow Cytometry, Human)	Flow Cytometry	Human
Show All 12 Publications. Collapse Publications.

Array FAB151A

• CCR2 Antibodies
• CCR2 ELISA Kit
• CCR2 Lysates
• CCR2 Proteins