AgRP/ART Antibody

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Agouti-Related Protein (AgRP), the protein product of the Agouti-Related Transcript (ART), is a neuropeptide that regulates energy metabolism and the development of obesity by antagonizing alpha -melanocyte stimulating hormone ( alpha -MSH) on MC-3 and MC-4 receptors (1 - 4). AgRP is predominantly expressed in the hypothalamus and adrenal medulla (5). Mature human AgRP is a 112 amino acid (aa) peptide; its C-terminal portion contains ten conserved cysteines that form five disulfide bonds (5, 6). Human AgRP shares 82% and 72% aa sequence identity with mouse and rat AgRP, respectively. It shares 32% aa sequence identity with Agouti. As in the case of Agouti, the C-terminal cysteine-rich region is sufficient for biological activity (7). AgRP is 100 times more potent than Agouti in antagonizing MC-3 and MC-4 receptors (8). AgRP also induces the beta -arrestin dependent endocytosis of MC-3 and MC-4 (9). Hypothalamic expression of AgRP is upregulated in obesity and diabetes (5, 10), and chronic AgRP administration increases food intake and weight gain in rats (11). Genetically-linked polymorphisms of AgRP in humans are associated with susceptibility to anorexia nervosa (12, 13). In addition, AgRP inhibits the ACTH-induced synthesis of steroid hormones in a mechanism that does not involve melanocortin receptors (14).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publication using AF704	Applications	Species
Minghao Liu, Diane Hamele-Bena, John Ausiello, Gabrielle Page-Wilson Ectopic ACTH Syndrome Emerging 5 Years after the Diagnosis of Neuroendocrine Tumor Case Reports in Endocrinology 2019-05-28 [PMID: 31275666]

Array AF704

• AgRP/ART Antibodies
• AgRP/ART ELISA Kits
• AgRP/ART Lysates
• AgRP/ART Proteins
• AgRP/ART Proteins and Enzymes
• AgRP/ART ELISAs