CART/CARTPT Antibody (113612)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

CART, also known as cocaine and amphetamine-related transcript, is a 10 kDa secreted polypeptide produced by neuronal cell types in a variety of locations.  In human, the molecule is synthesized as a 116 amino acid (aa) precursor with a 27 aa signal sequence an 89 aa mature segment.  There are six C-terminal cysteines that form three intrachain disulfide bonds, and the potential exists for both sulfation and phosphorylation in the N-terminal region.  There are numerous monobasic and dibasic sites for enzyme cleavage, and multiple, presumably proteolytically-generated short forms are known to exist.  These include a 5K, 48 aa peptide (CART 42‑89), and a 4.3K, 40 aa peptide (CART 49-89).  Human CART is 98% aa identical to both moyuse and rat CART (1-89).  Although CART suppresses feeding and increases pain tolerance, there would appear to be differences between the various forms of CART on other functions.   In addition, anatomical location is associated with differing lengths of CART.  For example, 89 aa and 79 aa forms are found in the adrenal, while 48 aa and 44 aa forms are found in the hypothalamus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Rat, Guinea Pig, Porcine,  Human.

We have publications tested in 5 applications: ICC, IHC, IHC-Fr, Immunohistochemistry, Western Blot.

Showing Publications 1 - 10 of 11. Show All 11 Publications. Collapse Publications.

Publications using MAB163	Applications	Species
Mazur, U;Lepiarczyk, E;Janikiewicz, P;?opie?ska-Biernat, E;Majewski, MK;Bossowska, A; Distribution and Chemistry of Phoenixin-14, a Newly Discovered Sensory Transmission Molecule in Porcine Afferent Neurons International journal of molecular sciences 2023-11-23 [PMID: 38068975] (Immunohistochemistry, Porcine)	Immunohistochemistry	Porcine
Kobori, N;Moore, AN;Redell, JB;Dash, PK; Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function Journal of neuroinflammation 2023-07-04 [PMID: 37403174] (Western Blot, Human)	Western Blot	Human
Kobori, N;Moore, AN;Redell, JB;Dash, PK; Caudal DMN neurons innervate the spleen and release CART peptide to regulate neuroimmune function Journal of neuroinflammation 2023-07-04 [PMID: 37403174] ( Human)		Human
Arpan G. Mazumder, Amélie M. Julé, Paul F. Cullen, Daniel Sun Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes iScience 2022-12-22 [PMID: 36465110]
L Rytel, S Gonkowski The Influence of Bisphenol a on the Nitrergic Nervous Structures in the Domestic Porcine Uterus Int J Mol Sci, 2020-06-26;21(12):. 2020-06-26 [PMID: 32604714] (IHC, Porcine)	IHC	Porcine
K Palus, M Bulc, M Czajkowska, B Mici?ski, J Ca?ka Neurochemical characteristics of calbindin-like immunoreactive coeliac-cranial mesenteric ganglion complex (CCMG) neurons supplying the pre-pyloric region of the porcine stomach Tissue Cell, 2017-12-05;50(0):8-14. 2017-12-05 [PMID: 29429522] (ICC, Porcine)	ICC	Porcine
Janusz Najdzion Cocaine- and amphetamine-regulated transcript peptide and calcium binding proteins immunoreactivity in the superficial layers of the superior colliculus in the guinea pig: Implications for visual sensory processing J. Chem. Neuroanat, 2016-11-28;79(0):66-79. 2016-11-28 [PMID: 27908658] (IHC, Guinea Pig)	IHC	Guinea Pig
Malgorzata Radzimirska, Krystyna Bogus-Nowakowska, Tadeusz Kuder, Anna Robak Distribution of cocaine- and amphetamine-regulated transcript (CART), neuropeptide Y (NPY) and galanin (GAL) in the pterygopalatine ganglion of the domestic duck (Anas platyrhynchos f. domestica) Folia Histochemica et Cytobiologica 2015-09-01 [PMID: 27044589]
Isensee J, Wenzel C, Buschow R, Weissmann R, Kuss A, Hucho T Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS ONE, 2014-12-31;9(12):e115731. 2014-12-31 [PMID: 25551770] (IHC-Fr, Rat)	IHC-Fr	Rat
Romke Bron, Lei Yin, Domenico Russo, John B. Furness Expression of the ghrelin receptor gene in neurons of the medulla oblongata of the rat Journal of Comparative Neurology 2013-08-15 [PMID: 23348715]
Gonsalvez DG, Kerman IA, McAllen RM Chemical coding for cardiovascular sympathetic preganglionic neurons in rats. J. Neurosci., 2010-09-01;30(35):11781-91. 2010-09-01 [PMID: 20810898] (IHC-Fr, Rat)	IHC-Fr	Rat
Show All 11 Publications. Collapse Publications.

Array MAB163

• CART/CARTPT Antibodies
• CART/CARTPT ELISA Kit
• CART/CARTPT Lysate
• CART/CARTPT Protein
• CART/CARTPT Proteins and Enzyme