VEGF Antibody (26503) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Vascular Endothelial Growth Factor (VEGF or VEGF-A), also known as Vascular Permeability Factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. Human VEGF165 is an approximately 44 kDa molecular weight homodimer sharing 88% aa sequence identity with corresponding regions of mouse and rat, 96% with porcine, 95% with canine, and 93% with feline, equine and bovine VEGF, respectively. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt-1) and VEGF R2 (Flk-1/KDR) on endothelial cells. Although VEGF affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. VEGF165 binds the Semaphorin receptor, Neuropilin-1 and promotes complex formation with VEGF R2. VEGF is required during embryogenesis and functions to regulate the proliferation, migration, and survival of endothelial cells. In adults, VEGF functions mainly in wound healing and the female reproductive cycle. Pathologically, it is involved in tumor angiogenesis and vascular leakage. Circulating VEGF levels correlate with disease activity in autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. VEGF is induced by hypoxia and cytokines such as IL-1, IL-6, IL-8, Oncostatin M (OSM) and TNF-alpha.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 8 confirmed species: Human, Mouse, Rat, Bovine, Complex Species Category, Porcine, Primate, Rhesus Macaque.

We have publications tested in 12 applications: Array Development, Bioassay, Cell Culture, ELISA Development, ELISA Microarray Development, Flow Cytometry, ICC, IHC, IHC-Fr, IHC-P, Neutralization, Western Blot.

Showing Publications 1 - 10 of 113. Show All 113 Publications. Collapse Publications.

Publications using MAB293	Applications	Species
Lim, SJ;Gan, SC;Ong, HT;Ngeow, YF; In vitro analysis of VEGF-mediated endothelial permeability and the potential therapeutic role of Anti-VEGF in severe dengue Biochemistry and biophysics reports 2024-09-01 [PMID: 39263317] (Bioassay, Human)	Bioassay	Human
Harary Søndergaard, R;Drozd Højgaard, L;Haack-Sørensen, M;Hoeeg, C;Mønsted Johansen, E;Follin, B;Kastrup, J;Ekblond, A;Juhl, M; Investigating the paracrine and juxtacrine abilities of adipose-derived stromal cells in angiogenesis triple cell co-cultures Stem cell research 2024-04-09 [PMID: 38608355] (Neutralization, Human)	Neutralization	Human
Dutta Gupta, S;Ta, M; ADAMTS13 regulates angiogenic markers via Ephrin/Eph signaling in human mesenchymal stem cells under serum-deprivation stress Scientific reports 2024-01-04 [PMID: 38177376] (Western Blot, Human)	Western Blot	Human
Urban, L;Novák, Š;?oma, M;Dvo?ánková, B;Lacina, L;Šáchová, J;Hradilová, M;Svato?ová, P;Kolá?, M;Strnad, H;B?ezinová, J;Smetana, K;Gál, P;Szabo, P; Unravelling heterogeneous effects of cancer?associated fibroblasts on poor prognosis markers in breast cancer EM?G3 cell line: In vitro?targeted treatment (anti?IL-6, anti?VEGF-A, anti?MFGE8) based on transcriptomic profiling Oncology reports 2024-01-01 [PMID: 37975220] (Neutralization, Human)	Neutralization	Human
Abu El-Asrar, AM;Nawaz, MI;Ahmad, A;Dillemans, L;Siddiquei, M;Allegaert, E;Gikandi, PW;De Hertogh, G;Opdenakker, G;Struyf, S; CD40 Ligand-CD40 Interaction Is an Intermediary between Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy International journal of molecular sciences 2023-10-25 [PMID: 37958563] (Western Blot, Human)	Western Blot	Human
Samuel Wan Ki Wong, Sze Keong Tey, Xiaowen Mao, Hiu Ling Fung, Zhi‐Jie Xiao, Danny Ka Ho Wong et al. Small Extracellular Vesicle‐Derived vWF Induces a Positive Feedback Loop between Tumor and Endothelial Cells to Promote Angiogenesis and Metastasis in Hepatocellular Carcinoma Advanced Science 6/30/2023 [PMID: 37387563]
Dilara Z. Gatina, Ilnaz M. Gazizov, Margarita N. Zhuravleva, Svetlana S. Arkhipova, Maria A. Golubenko, Marina O. Gomzikova et al. Induction of Angiogenesis by Genetically Modified Human Umbilical Cord Blood Mononuclear Cells International Journal of Molecular Sciences 2/23/2023 [PMID: 36901831]
R Kunimatsu, T Hiraki, K Rikitake, K Nakajima, NAR Putranti, T Abe, K Ando, A Nakatani, S Sakata, K Tanimoto Effects of Human Deciduous Dental Pulp-Derived Mesenchymal Stem Cell-Derived Conditioned Medium on the Metabolism of HUVECs, Osteoblasts, and BMSCs Cells, 2022-10-14;11(20):. 2022-10-14 [PMID: 36291089] (ELISA Development, Neutralization, Human)	ELISA Development, Neutralization	Human
A Weigert, X Zheng, A Nenzel, K Turkowski, S Günther, E Strack, E Sirait-Fis, E Elwakeel, IM Kur, VS Nikam, C Valasaraja, H Winter, A Wissgott, R Voswinkel, F Grimminger, B Brüne, W Seeger, SS Pullamsett, R Savai Fibrocytes boost tumor-supportive phenotypic switches in the lung cancer niche via the endothelin system Nature Communications, 2022-10-14;13(1):6078. 2022-10-14 [PMID: 36241617] (Neutralization, Human)	Neutralization	Human
Hyejin Park, Ki-Seok Nam, Hae-June Lee, Kwang Seok Kim Ionizing Radiation-Induced GDF15 Promotes Angiogenesis in Human Glioblastoma Models by Promoting VEGFA Expression Through p-MAPK1/SP1 Signaling Frontiers in Oncology 2/25/2022 [PMID: 35280749]
S Okikawa, Y Morine, Y Saito, S Yamada, K Tokuda, H Teraoku, K Miyazaki, S Yamashita, T Ikemoto, S Imura, M Shimada Inhibition of the VEGF signaling pathway attenuates tumor?associated macrophage activity in liver cancer Oncology reports, 2022-02-16;47(4):. 2022-02-16 [PMID: 35169858] (Cell Culture, Human)	Cell Culture	Human
AM Abu El-Asr, A Ahmad, MI Nawaz, MM Siddiquei, A De Zutter, L Vanbrabant, PW Gikandi, G Opdenakker, S Struyf Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation Frontiers in Physiology, 2022-01-10;12(0):807747. 2022-01-10 [PMID: 35082694] (Western Blot, Rat)	Western Blot	Rat
AM Abu El-Asr, MI Nawaz, A Ahmad, MM Siddiquei, E Allegaert, PW Gikandi, G De Hertogh, G Opdenakker CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy Investigative Ophthalmology & Visual Science, 2021-07-01;62(9):32. 2021-07-01 [PMID: 34293080] (Western Blot, Human)	Western Blot	Human
Vera C. Keil, Gerrit H. Gielen, Bogdan Pintea, Peter Baumgarten, Angeliki Datsi, Kanishka Hittatiya et al. DCE-MRI in Glioma, Infiltration Zone and Healthy Brain to Assess Angiogenesis: A Biopsy Study Clinical Neuroradiology 12/1/2021 [PMID: 33900414]
KV Manian, CA Galloway, S Dalvi, AA Emanuel, JA Mereness, W Black, L Winschel, C Soto, Y Li, Y Song, W DeMaria, A Kumar, I Slukvin, MP Schwartz, WL Murphy, B Anand-Apte, M Chung, DSW Benoit, R Singh 3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration Cell Stem Cell, 2021-03-29;0(0):. 2021-03-29 [PMID: 33784497] (ICC, Human)	ICC	Human
Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Ajmal Ahmad, Alexandra De Zutter, Mohammad Mairaj Siddiquei, Marfa Blanter et al. Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy Frontiers in Immunology 1/20/2021 [PMID: 33552057]
Simon Bernatz, Daniel Monden, Florian Gessler, Tijana Radic, Elke Hattingen, Christian Senft et al. Influence of VEGF-A, VEGFR-1-3, and neuropilin 1-2 on progression-free: and overall survival in WHO grade II and III meningioma patients Journal of Molecular Histology 4/1/2021 [PMID: 33528717]
ZY Liao, IC Liang, HJ Li, CC Wu, HM Lo, DC Chang, CF Hung Chrysin Inhibits High Glucose-Induced Migration on Chorioretinal Endothelial Cells via VEGF and VEGFR Down-Regulation Int J Mol Sci, 2020-08-02;21(15):. 2020-08-02 [PMID: 32748894] (Western Blot, Primate, Rhesus Macaque)	Western Blot	Primate, Rhesus Macaque
Jinhee Lee, Atsuro Tatsumi, Kaori Tsukakoshi, Ellie D. Wilson, Koichi Abe, Koji Sode et al. Application of a Glucose Dehydrogenase-Fused with Zinc Finger Protein to Label DNA Aptamers for the Electrochemical Detection of VEGF Sensors (Basel) 7/11/2020 [PMID: 32664558]
Z Chang, Y Zhang, J Liu, Y Zheng, H Li, Y Kong, P Li, H Peng, Y Shi, B Cao, F Ran, Y Chen, Y Song, Q Ye, L Ding Snail promotes the generation of vascular endothelium by breast cancer cells Cell Death Dis, 2020-06-15;11(6):457. 2020-06-15 [PMID: 32541667] (Neutralization, Human)	Neutralization	Human
HA Oh, J Kwak, BJ Kim, HJ Jin, WS Park, SJ Choi, W Oh, S Um Migration Inhibitory Factor in Conditioned Medium from Human Umbilical Cord Blood-Derived Mesenchymal Stromal Cells Stimulates Hair Growth Cells, 2020-05-28;9(6):. 2020-05-28 [PMID: 32481584] (Neutralization, Human)	Neutralization	Human
DJ Perdicaro, C Rodriguez, J Gambarte T, RM Miatello, PI Oteiza, MA Vazquez Pr Quercetin attenuates adipose hypertrophy, in part through activation of adipogenesis in rats fed a high-fat diet J. Nutr. Biochem., 2020-02-04;79(0):108352. 2020-02-04 [PMID: 32145471] (Western Blot, Rat)	Western Blot	Rat
Ruoqin Wang, Yanchao Ma, Shenghua Zhan, Guangbo Zhang, Lei Cao, Xueguang Zhang et al. B7-H3 promotes colorectal cancer angiogenesis through activating the NF-kappa B pathway to induce VEGFA expression Cell Death & Disease 1/23/2020 [PMID: 31974361]
Ahmed M. Abu El-Asrar, Ajmal Ahmad, Mohammad Mairaj Siddiquei, Alexandra De Zutter, Eef Allegaert, Priscilla W. Gikandi et al. The Proinflammatory and Proangiogenic Macrophage Migration Inhibitory Factor Is a Potential Regulator in Proliferative Diabetic Retinopathy Frontiers in Immunology 12/4/2019 [PMID: 31866994]
Song Yi Ko, WonJae Lee, Hilary A. Kenny, Long H. Dang, Lee M. Ellis, Eric Jonasch et al. Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake Communications Biology 10/18/2019 [PMID: 31646189]
AF Stassi, F Gasser, MML Velázquez, EM Belotti, NC Gareis, F Rey, HH Ortega, NR Salvetti, ME Baravalle Contribution of the VEGF system to the follicular persistence associated with bovine cystic ovaries Theriogenology, 2019-07-03;138(0):52-65. 2019-07-03 [PMID: 31301448] (IHC, IHC-P, Western Blot, Bovine, Mouse)	IHC, IHC-P, Western Blot	Bovine, Mouse
Andrew C. Little, Pragathi Pathanjeli, Zhifen Wu, Liwei Bao, Laura E. Goo, Joel A. Yates et al. IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling Frontiers in Oncology 5/31/2019 [PMID: 31214501]
Jing Jia, Haibao Zhang, Hongke Zhang, Huicong Du, Wenbo Liu, Maoguo Shu Activated androgen receptor accelerates angiogenesis in cutaneous neurofibroma by regulating VEGFA transcription International Journal of Oncology 5/6/2019 [PMID: 31059067]
J Ren, C Gu, Y Yang, J Xue, Y Sun, F Jian, D Chen, L Bian, Q Sun TSP-1 is downregulated and inversely correlates with miR-449c expression in Cushing's disease J. Cell. Mol. Med., 2019-04-23;0(0):. 2019-04-23 [PMID: 31016850] (Western Blot, Mouse)	Western Blot	Mouse
Giane Sumner, Camille Georgaros, Ashique Rafique, Thomas DiCioccio, Joel Martin, Nicholas Papadopoulos et al. Anti-VEGF drug interference with VEGF quantitation in the R&D systems human quantikine VEGF ELISA kit Bioanalysis 3/21/2019 [PMID: 30892063]
P Zizza, R Dinami, M Porru, C Cingolani, E Salvati, A Rizzo, C D'Angelo, E Petti, CA Amoreo, M Mottolese, I Sperduti, A Chambery, R Russo, P Ostano, G Chiorino, G Blandino, A Sacconi, J Cherfils-V, C Leonetti, E Gilson, A Biroccio TRF2 positively regulates SULF2 expression increasing VEGF-A release and activity in tumor microenvironment Nucleic Acids Res., 2019-04-23;0(0):. 2019-04-23 [PMID: 30698737] (Neutralization, Human, Mouse)	Neutralization	Human, Mouse
Daniel Grun, Gautam Adhikary, Richard L. Eckert NRP-1 interacts with GIPC1 and SYX to activate p38 MAPK signaling and cancer stem cell survival Molecular Carcinogenesis 4/1/2019 [PMID: 30456845]
HK Kim, SG Lee, SW Lee, BJ Oh, JH Kim, JA Kim, G Lee, JD Jang, YA Joe A Subset of Paracrine Factors as Efficient Biomarkers for Predicting Vascular Regenerative Efficacy of Mesenchymal Stromal/Stem Cells Stem Cells, 2018-10-08;0(0):. 2018-10-08 [PMID: 30281870] (Neutralization, Human)	Neutralization	Human
Jason Stein, Quangang Xu, Kayla C. Jackson, Elena Romm, Simone C. Wuest, Peter Kosa et al. Intrathecal B Cells in MS Have Significantly Greater Lymphangiogenic Potential Compared to B Cells Derived From Non-MS Subjects Frontiers in Neurology 7/20/2018 [PMID: 30079049]
Y Zhao, J Song, X Bi, J Gao, Z Shen, J Zhu, G Fu Thymosin ?4 promotes endothelial progenitor cell angiogenesis via a vascular endothelial growth factor?dependent mechanism Mol Med Rep, 2018-06-20;18(2):2314-2320. 6/20/2018 [PMID: 29956769]
MKS Tang, PYK Yue, PP Ip, RL Huang, HC Lai, ANY Cheung, KY Tse, HYS Ngan, AST Wong Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface Nat Commun, 2018-06-11;9(1):2270. 2018-06-11 [PMID: 29891938] (Neutralization, Mouse)	Neutralization	Mouse
C Rodriguez, DJ Perdicaro, MS Landa, A Fontana, A Antoniolli, RM Miatello, PI Oteiza, MA Vazquez Pr Grape pomace extract induced beige cells in white adipose tissue from rats and in 3T3-L1 adipocytes J. Nutr. Biochem., 2018-03-10;56(0):224-233. 2018-03-10 [PMID: 29631143] (Western Blot, Rat)	Western Blot	Rat
L Rao, K De Veirman, D Giannico, I Saltarella, V Desantis, MA Frassanito, AG Solimando, D Ribatti, M Prete, A Harstrick, U Fiedler, H De Raeve, V Racanelli, K Vanderkerk, A Vacca Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin� protein MP0250: a preclinical study Oncotarget, 2018-01-30;9(17):13366-13381. 2018-01-30 [PMID: 29568363] (Neutralization, Human)	Neutralization	Human
X Xu, N Cui, E Wang Application of an acellular dermal matrix to a rabbit model of oral mucosal defects Exp Ther Med, 2018-01-05;15(3):2450-2456. 2018-01-05 [PMID: 29456650] (Western Blot, Human)	Western Blot	Human
S Gogalic, U Sauer, S Doppler, C Preininger Investigating Colorimetric Protein Array Assay Schemes for Detection of Recurrence of Bladder Cancer Biosensors (Basel), 2018-01-24;8(1):. 2018-01-24 [PMID: 29364182] (Array Development, Human)	Array Development	Human
Patrícia Matos Biselli-Chicote, Joice Matos Biselli, Bianca R Cunha, Rodrigo Castro, José Victor Maniglia, Dalísio de Santi Neto et al. Overexpression of Antiangiogenic Vascular Endothelial Growth Factor Isoform and Splicing Regulatory Factors in Oral, Laryngeal and Pharyngeal Squamous Cell Carcinomas Asian Pac. J. Cancer Prev 8/28/2017 [PMID: 28843252]
J. Konen, E. Summerbell, B. Dwivedi, K. Galior, Y. Hou, L. Rusnak et al. Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion Nature Communications 5/12/2017 [PMID: 28497793]
McDonald G, Tabellini L, Storer B, Martin P, Lawler R, Rosinski S, Schoch H, Hansen J Predictive Value of Clinical Findings and Plasma Biomarkers after Fourteen Days of Prednisone Treatment for Acute Graft-versus-host Disease. Biol Blood Marrow Transplant, 2017-05-03;23(8):1257-1263. 2017-05-03 [PMID: 28478120] (Human)		Human
LB Strickland, S Brem, AM Rojiani, MV Rojiani Vessel morphometric parameters-correlation with histologic grade and VEGF expression in oligodendroglioma Am J Cancer Res, 2017-04-01;7(4):973-981. 2017-04-01 [PMID: 28469969] (IHC, Human)	IHC	Human
P Wang, C Lan, S Xiong, X Zhao, Y Shan, R Hu, W Wan, S Yu, B Liao, G Li, J Wang, D Zou, B Chen, H Feng, N Wu HIF1? regulates single differentiated glioma cell dedifferentiation to stem-like cell phenotypes with high tumorigenic potential under hypoxia Oncotarget, 2017-04-25;8(17):28074-28092. 2017-04-25 [PMID: 28427209] (ICC, Western Blot, Human)	ICC, Western Blot	Human
W Katagiri, T Kawai, M Osugi, Y Sugimura-W, K Sakaguchi, T Kojima, T Kobayashi Angiogenesis in newly regenerated bone by secretomes of human mesenchymal stem cells Maxillofac Plast Reconstr Surg, 2017-03-25;39(1):8. 2017-03-25 [PMID: 28405581] (Neutralization, Human)	Neutralization	Human
C Thej, B Ramadasse, A Walvekar, AS Majumdar, S Balasubram Development of a surrogate potency assay to determine the angiogenic activity of Stempeucel�, a pooled, ex-vivo expanded, allogeneic human bone marrow mesenchymal stromal cell product Stem Cell Res Ther, 2017-02-28;8(1):47. 2017-02-28 [PMID: 28245882] (Neutralization, Human)	Neutralization	Human
Lopa Leach Transendothelial migration of human umbilical mesenchymal stem cells across uterine endothelial monolayers: Junctional dynamics and putative mechanisms Placenta, 2016-10-21;48(0):87-98. 2016-10-21 [PMID: 27871478] (ICC, Neutralization, Human)	ICC, Neutralization	Human
Suneetha Amara, Dalal Alotaibi, Venkataswarup Tiriveedhi NFAT5/STAT3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells Oncology Letters 8/1/2016 [PMID: 27446373]
Compound 49b Restores Retinal Thickness and Reduces Degenerate Capillaries in the Rat Retina following Ischemia/Reperfusion PLoS ONE, 2016-07-20;11(7):e0159532. 7/20/2016 [PMID: 27439004]
Ahmed M. Abu El-Asrar, Kaiser Alam, Mohd Imtiaz Nawaz, Ghulam Mohammad, Kathleen Van den Eynde, Mohammad Mairaj Siddiquei et al. Upregulation of Thrombin/Matrix Metalloproteinase-1/Protease-Activated Receptor-1 Chain in Proliferative Diabetic Retinopathy Current Eye Research 12/1/2016 [PMID: 27261371]
Goodwin G Jinesh, Ashish M Kamat Endocytosis and serpentine filopodia drive blebbishield-mediated resurrection of apoptotic cancer stem cells Cell Death Discovery 5/27/2016 [PMID: 27226900]
XUEYING ZHANG, JUNXIA CAO, YUJUN PEI, JIYAN ZHANG, QINGYANG WANG Smad4 inhibits cell migration via suppression of JNK activity in human pancreatic carcinoma PANC-1 cells Oncology Letters 5/1/2016 [PMID: 27123137]
Z Jing, H Xu, X Chen, Q Zhong, J Huang, Y Zhang, W Guo, Z Yang, S Ding, P Chen, Z Huang The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer PLoS ONE, 2016-04-14;11(4):e0152789. 2016-04-14 [PMID: 27078157] (Neutralization, Human)	Neutralization	Human
Yanan Zhang, Jie Liu, Shibin Wang, Xiaoli Luo, Yang Li, Zhaohui Lv et al. The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1 alpha -dependent and -independent manners Oncotarget 4/26/2016 [PMID: 26988756]
ZHI-FEI ZHAO, JIAN-XIONG LI, RUI YE, XUAN WU, LING-LING GAO, BAO-LONG NIU Interleukin-6 as a potential molecular target in esophageal squamous cell carcinoma Oncology Letters 2/1/2016 [PMID: 26893670]
Li-Xia Zhao, Hui Liu, Qing Wei, Guang Xu, Jian Wu, Hui-Xiong Xu et al. Contrast-Enhanced Ultrasonography Features of Breast Malignancies with Different Sizes: Correlation with Prognostic Factors BioMed Research International 12/31/2015 [PMID: 26881202]
Yanan Zhang, Jie Liu, Jing Lin, Lei Zhou, Yuhua Song, Bo Wei et al. The transcription factor GATA1 and the histone methyltransferase SET7 interact to promote VEGF-mediated angiogenesis and tumor growth and predict clinical outcome of breast cancer Oncotarget 3/1/2016 [PMID: 26848522]
D Grun, G Adhikary, RL Eckert VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors Oncogene, 2016-01-25;35(33):4379-87. 2016-01-25 [PMID: 26804163] (Western Blot, Human)	Western Blot	Human
Nalwoga H, Ahmed L, Arnes J, Wabinga H, Akslen L Strong Expression of Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Is Associated with Axl Expression and Features of Aggressive Tumors in African Breast Cancer. PLoS ONE, 2016-01-13;11(1):e0146823. 1/13/2016 [PMID: 26760782]
Yang Gao, Kaijie Wu, Yule Chen, Jiancheng Zhou, Chong Du, Qi Shi et al. Beyond proliferation: KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription Oncotarget 12/22/2015 [PMID: 26544730]
Mar A, Chu C, Lee H, Chien C, Cheng J, Yang S, Jiang J, Lee T Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis. J Biol Chem, 2015-07-24;290(36):22212-24. 2015-07-24 [PMID: 26209639] (Neutralization, Mouse)	Neutralization	Mouse
Bai Y, Zhu X, Chao J, Zhang Y, Qian C, Li P, Liu D, Han B, Zhao L, Zhang J, Buch S, Teng G, Hu G, Yao H Pericytes contribute to the disruption of the cerebral endothelial barrier via increasing VEGF expression: implications for stroke. PLoS ONE, 2015-04-17;10(4):e0124362. 2015-04-17 [PMID: 25884837] (Neutralization, Mouse)	Neutralization	Mouse
Heng Cai, Yixue Xue, Zhen Li, Yi Hu, Zhenhua Wang, Wenjing Liu et al. Roundabout4 Suppresses Glioma-Induced Endothelial Cell Proliferation, Migration and Tube Formation in Vitro by Inhibiting VEGR2-Mediated PI3K/AKT and FAK Signaling Pathways Cellular Physiology and Biochemistry 1/21/2015 [PMID: 25833462]
FEI YUAN, HAILONG SHI, JUN JI, QU CAI, XUEHUA CHEN, YINGYAN YU et al. Capecitabine metronomic chemotherapy inhibits the proliferation of gastric cancer cells through anti-angiogenesis Oncology Reports 4/1/2015 [PMID: 25634241]
Fernandez J, Rodriguez D, Valenzuela M, Calderon C, Urzua U, Munroe D, Rosas C, Lemus D, Diaz N, Wright M, Leyton L, Tapia J, Quest A Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription. Mol Cancer, 2014-09-09;13(0):209. 2014-09-09 [PMID: 25204429] (Neutralization, Human)	Neutralization	Human
Lee E, Fertig E, Jin K, Sukumar S, Pandey N, Popel A Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. Nat Commun, 2014-09-02;5(0):4715. 2014-09-02 [PMID: 25178650] (IHC, Neutralization, Human)	IHC, Neutralization	Human
Aderhold C, Grobschmidt G, Sauter A, Faber A, Hormann K, Schultz J Interleukin 4, interleukin 6 and osteopontin-serological markers of head and neck malignancy in primary diagnostics: A pilot study. Oncol Lett, 2014-07-04;8(3):1112-1118. 2014-07-04 [PMID: 25120668] (Bioassay, Human)	Bioassay	Human
Lavinia Raimondi, Nicola Amodio, Maria Teresa Di Martino, Emanuela Altomare, Marzia Leotta, Daniele Caracciolo et al. Targeting of multiple myeloma-related angiogenesis by miR-199a-5p mimics: in vitro and in vivo anti-tumor activity Oncotarget 3/14/2014 [PMID: 24839982]
Etulain J, Negrotto S, Tribulatti M, Croci D, Carabelli J, Campetella O, Rabinovich G, Schattner M Control of angiogenesis by galectins involves the release of platelet-derived proangiogenic factors. PLoS ONE, 2014-04-30;9(4):e96402. 2014-04-30 [PMID: 24788652] (Neutralization, Human)	Neutralization	Human
He S, Wu Q, Gong C, Luo S, Zhang S, Li M, Lu L, Wei Y, Yang L Enhanced efficacy of combination therapy with adenoassociated virus-delivered pigment epithelium-derived factor and cisplatin in a mouse model of Lewis lung carcinoma. Mol Med Rep, 2014-04-04;9(6):2069-76. 2014-04-04 [PMID: 24714917] (IHC-P, Mouse)	IHC-P	Mouse
Smith A, Bowers S, Stratman A, Davis G Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions. PLoS ONE, 2013-12-31;8(12):e85147. 2013-12-31 [PMID: 24391990] (Neutralization, Human)	Neutralization	Human
Townsend , Katelin, Spowart , Jaeline, Huwait , Hassan, Eshragh , Sima, West , Nathan R, Elrick , Mary A, Kalloger , Steve E, Anglesio , Michael, Watson , Peter H, Huntsman , David G, Lum , Julian J Markers of T cell infiltration and function associate with favorable outcome in vascularized high-grade serous ovarian carcinoma. PLoS ONE, 2013-12-23;8(12):e82406. 2013-12-23 [PMID: 24376535] (IHC-P, Human)	IHC-P	Human
Ma X, Hibbert B, McNulty M, Hu T, Zhao X, Ramirez F, Simard T, de Belleroche J, O'Brien E Heat shock protein 27 attenuates neointima formation and accelerates reendothelialization after arterial injury and stent implantation: importance of vascular endothelial growth factor up-regulation. FASEB J, 2013-10-18;28(2):594-602. 2013-10-18 [PMID: 24142570] (Neutralization, Human)	Neutralization	Human
Tan J, Prosser H, Vanags L, Monger S, Ng M, Bursill C High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1alpha. FASEB J, 2013-09-10;28(1):206-17. 2013-09-10 [PMID: 24022405] (Neutralization, Human)	Neutralization	Human
María Luisa Pérez-Lozano, Pilar Sandoval, Ángela Rynne-Vidal, Abelardo Aguilera, José Antonio Jiménez-Heffernan, Patricia Albar-Vizcaíno et al. Functional Relevance of the Switch of VEGF Receptors/Co-Receptors during Peritoneal Dialysis-Induced Mesothelial to Mesenchymal Transition PLoS ONE 4/9/2013 [PMID: 23585849]
Richard M Taylor, Takeshi G Kashima, Helen J Knowles, Nicholas A Athanasou VEGF, FLT3 ligand, PlGF and HGF can substitute for M-CSF to induce human osteoclast formation: implications for giant cell tumour pathobiology Laboratory Investigation 10/1/2012 [PMID: 22906984]
Berrin Erdag, B Koray Koray Balcioglu, Aylin Ozdemir Ozdemir Bahadir, Muge Serhatli, Omer Kacar, Aydin Bahar et al. Identification of novel neutralizing single-chain antibodies against vascular endothelial growth factor receptor 2 Biotechnology and Applied Biochemistry 11/1/2011 [PMID: 22172104]
Naoya Ikeda, Soichiro Murata, Takehito Maruyama, Takafumi Tamura, Reiji Nozaki, Takuya Kawasaki et al. Platelet-derived adenosine 5′-triphosphate suppresses activation of human hepatic stellate cell: In vitro study Hepatology Research 1/1/2012 [PMID: 21988364]
Tania Marchbank, Asif Mahmood, Sarah Harten, Patrick H Maxwell, Raymond J Playford Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms Laboratory Investigation 12/1/2011 [PMID: 21876537]
Dan Liu, Vanesa Martin, Juan Fueyo, Ok-Hee Lee, Jing Xu, Nahir Cortes-Santiago et al. Tie2/TEK Modulates the Interaction of Glioma and Brain Tumor Stem Cells with Endothelial Cells and Promotes an Invasive Phenotype ImpactJ 12/30/2010 [PMID: 21321379]
Merdzhanova G, Gout S, Keramidas M, Edmond V, Coll JL, Brambilla C, Brambilla E, Gazzeri S, Eymin B The transcription factor E2F1 and the SR protein SC35 control the ratio of pro-angiogenic versus antiangiogenic isoforms of vascular endothelial growth factor-A to inhibit neovascularization in vivo. Oncogene, 2010-07-19;29(39):5392-403. 2010-07-19 [PMID: 20639906] (Western Blot, Human)	Western Blot	Human
M-H Chen, C-H Tzeng, P-M Chen, J-K Lin, T-C Lin, W-S Chen et al. VEGF −460T → C polymorphism and its association with VEGF expression and outcome to FOLFOX-4 treatment in patients with colorectal carcinoma The Pharmacogenomics Journal 6/1/2011 [PMID: 20531372]
Jing Hua, Christine Spee, Satoru Kase, Emma S. Rennel, Anette L. Magnussen, Yan Qiu et al. Recombinant Human VEGF165b Inhibits Experimental Choroidal Neovascularization Investigative Opthalmology & Visual Science 8/1/2010 [PMID: 20237252]
Varet J, Varet , Julia, Douglas SK, Douglas , Samantha, Gilmartin L, Gilmartin , Laura, Medford , Andrew R, Bates , David O, Harper , Steven J, Millar , Ann B VEGF in the lung: a role for novel isoforms. Am J Physiol Lung Cell Mol Physiol, 2010-03-12;298(6):L768-74. 2010-03-12 [PMID: 20228180] (Western Blot, Human)	Western Blot	Human
Hashizume H, Falcon BL, Kuroda T, Baluk P, Coxon A, Yu D, Bready JV, Oliner JD, McDonald DM Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res., 2010-03-02;70(6):2213-23. 2010-03-02 [PMID: 20197469] (Neutralization, Human)	Neutralization	Human
Rakesh K. Srivastava, Terry G. Unterman, Sharmila Shankar FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol Molecular and Cellular Biochemistry 4/1/2010 [PMID: 20012470]
Junji Moriya, Tohru Minamino, Kaoru Tateno, Sho Okada, Akiyoshi Uemura, Ippei Shimizu et al. Inhibition of Semaphorin As a Novel Strategy for Therapeutic Angiogenesis Circulation Research 2/5/2010 [PMID: 19940264]
Giorgos A. Margaritopoulos, Katerina M. Antoniou, Giannoula Soufla, Konstantinos Karagiannis, Athanasia Proklou, Ismini Lasithiotaki et al. Upregulation of stromal cell derived factor-1alpha in collagen vascular diseases-associated interstitial pneumonias (CVDs-IPs) Pulmonary Pharmacology & Therapeutics 4/1/2010 [PMID: 19878731]
Chris M. van der Loos, Lorine B. Meijer-Jorna, Marloes E.C. Broekmans, Hanneke P.H.M. Ploegmakers, Peter Teeling, Onno J. de Boer et al. Anti-human Vascular Endothelial Growth Factor (VEGF) Antibody Selection for Immunohistochemical Staining of Proliferating Blood Vessels Journal of Histochemistry & Cytochemistry 2/1/2010 [PMID: 19786611]
Choudhury KR, Yagle KJ, Swanson PE et al. A robust automated measure of average antibody staining in immunohistochemistry images. J Histochem Cytochem 2/1/2010 [PMID: 19687472]
Akiyoshi Komuro, Masakazu Yashiro, Caname Iwata, Yasuyuki Morishita, Erik Johansson, Yoshiko Matsumoto et al. Diffuse-type gastric carcinoma: progression, angiogenesis, and transforming growth factor beta signaling JNCI: Journal of the National Cancer Institute 4/15/2009 [PMID: 19351925]
Zhu W, Ou Y, Li Y, Xiao R, Shu M, Zhou Y, Xie J, He S, Qiu P, Yan G A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway. Mol. Pharmacol., 2009-01-21;75(4):812-9. 2009-01-21 [PMID: 19158360] (Western Blot, Human)	Western Blot	Human
Gonzalez RM, Seurynck-Servoss SL, Crowley SA Development and validation of sandwich ELISA microarrays with minimal assay interference. J. Proteome Res., 2008-04-19;7(6):2406-14. 2008-04-19 [PMID: 18422355] (ELISA Microarray Development, Human)	ELISA Microarray Development	Human
Allerstorfer S, Sonvilla G, Fischer H, Spiegl-Kreinecker S, Gauglhofer C, Setinek U, Czech T, Marosi C, Buchroithner J, Pichler J, Silye R, Mohr T, Holzmann K, Grasl-Kraupp B, Marian B, Grusch M, Fischer J, Micksche M, Berger W FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities. Oncogene, 2008-03-24;27(30):4180-90. 2008-03-24 [PMID: 18362893] (Neutralization, Human)	Neutralization	Human
Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P Ultrasensitive flow-based immunoassays using single-molecule counting. Clin. Chem., 2007-09-21;53(11):1990-5. 2007-09-21 [PMID: 17890441] (ELISA Development, Human)	ELISA Development	Human
Ball SG, Shuttleworth CA, Kielty CM Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 2007-04-30;177(3):489-500. 2007-04-30 [PMID: 17470632] (Western Blot, Human)	Western Blot	Human
Cianfarani F, Zambruno G, Brogelli L, Sera F, Lacal PM, Pesce M, Capogrossi MC, Failla CM, Napolitano M, Odorisio T Placenta growth factor in diabetic wound healing: altered expression and therapeutic potential. Am. J. Pathol., 2006-10-01;169(4):1167-82. 2006-10-01 [PMID: 17003476] (Neutralization, Human)	Neutralization	Human
Lucerna M, Zernecke A, de Nooijer R, de Jager SC, Bot I, van der Lans C, Kholova I, Liehn EA, van Berkel TJ, Yla-Herttuala S, Weber C, Biessen EA Vascular endothelial growth factor-A induces plaque expansion in ApoE knock-out mice by promoting de novo leukocyte recruitment. Blood, 2006-09-21;109(1):122-9. 2006-09-21 [PMID: 16990600] (Neutralization, Human)	Neutralization	Human
Hatfield K, Ryningen A, Corbascio M, Bruserud O Microvascular endothelial cells increase proliferation and inhibit apoptosis of native human acute myelogenous leukemia blasts. Int. J. Cancer, 2006-11-15;119(10):2313-21. 2006-11-15 [PMID: 16921487] (Neutralization, Human)	Neutralization	Human
Rofstad EK, Mathiesen B, Kindem K, Galappathi K Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res., 2006-07-01;66(13):6699-707. 2006-07-01 [PMID: 16818644] (Neutralization, Complex Species Category)	Neutralization	Complex Species Category
Feltis BN, Wignarajah D, Zheng L, Ward C, Reid D, Harding R, Walters EH Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma. Am. J. Respir. Crit. Care Med., 2006-03-09;173(11):1201-7. 2006-03-09 [PMID: 16528018] (IHC-P, Human)	IHC-P	Human
Bates DO, MacMillan PP, Manjaly JG, Qiu Y, Hudson SJ, Bevan HS, Hunter AJ, Soothill PW, Read M, Donaldson LF, Harper SJ The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term. Clin. Sci., 2006-05-01;110(5):575-85. 2006-05-01 [PMID: 16451124] (Western Blot, Human)	Western Blot	Human
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis. J. Immunol., 2005-11-01;175(9):6177-89. 2005-11-01 [PMID: 16237115] (Neutralization, Human)	Neutralization	Human
Rodriguez-Porcel M, Zhu XY, Chade AR, Amores-Arriaga B, Caplice NM, Ritman EL, Lerman A, Lerman LO Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension. Am. J. Physiol. Heart Circ. Physiol., 2005-10-07;290(3):H978-84. 2005-10-07 [PMID: 16214846] (IHC-Fr, Porcine)	IHC-Fr	Porcine
Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik SW, Shen Y Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo. Cancer Res., 2005-08-15;65(16):7249-58. 2005-08-15 [PMID: 16103076] (IHC, Human)	IHC	Human
Shikada Y, Yonemitsu Y, Koga T, Onimaru M, Nakano T, Okano S, Sata S, Nakagawa K, Yoshino I, Maehara Y, Sueishi K Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas. Cancer Res., 2005-08-15;65(16):7241-8. 2005-08-15 [PMID: 16103075] (IHC-P, Human)	IHC-P	Human
Tamaki M, Saito R, Ogawa O, Yoshimura N, Ueda T Possible mechanisms inducing glomerulations in interstitial cystitis: relationship between endoscopic findings and expression of angiogenic growth factors. J. Urol., 2004-09-01;172(3):945-8. 2004-09-01 [PMID: 15311005] (ICC, Human)	ICC	Human
Caine GJ, Blann AD, Stonelake PS, Ryan P, Lip GY Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1. Eur. J. Clin. Invest., 2003-10-01;33(10):883-90. 2003-10-01 [PMID: 14511360] (ELISA Development, Human)	ELISA Development	Human
Barbour AP, Reeder JA, Walsh MD, Fawcett J, Antalis TM, Gotley DC Expression of the CD44v2-10 isoform confers a metastatic phenotype: importance of the heparan sulfate attachment site CD44v3. Cancer Res., 2003-02-15;63(4):887-92. 2003-02-15 [PMID: 12591743] (Flow Cytometry, Human)	Flow Cytometry	Human
Zhou Y, 2019, McMaster M, Woo K, Janatpour M, Perry J, Karpanen T, Alitalo K, Damsky C, Fisher SJ Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome. 2002-04-01;160(4):1405-23. 2002-04-01 [PMID: 11943725] (IHC-P, Human)	IHC-P	Human
Takayama K, Suzuki J, Kawauchi M, Tsukioka K, Wada Y, Zhang T, Endoh M, Takamoto S, Amano J, Isobe M Hepatocyte growth factor and vascular endothelial growth factor expression in pig-to-primate xenotransplanted hearts. Transplant. Proc., 2000-08-01;32(5):987-9. 2000-08-01 [PMID: 10936314] (IHC-P, Porcine)	IHC-P	Porcine
Gu JW, Adair TH Hypoxia-induced expression of VEGF is reversible in myocardial vascular smooth muscle cells. Am. J. Physiol., 1997-08-01;273(2):H628-33. 1997-08-01 [PMID: 9277477] (Neutralization, Human)	Neutralization	Human
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