The enzymes of the Matrix Metalloproteinase (MMP) family assist in the degradation of the extracellular matrix, under both normal and pathological conditions. MMP antibodies have identified roles in a number of physiological processes, such as embryonic development and tissue remodelling. They also regulate enzyme cascades, expression of various proteins and the migration of both normal and malignant cells.
The MMP2 antibody is used in a number of research areas, including metastasis, angiogenesis, apoptosis and tumor suppression. MMP2 antibody studies have shown MMP2 plays a specific role in the degradation of collagens and Gelatin 1. It also functions in angiogenesis, tissue repair, vascularization, inflammation, atherosclerotic plaque rupture, endometrial menstrual breakdown and tumour metastasis. It is secreted in inactive form, being activated by proteinase cleavage via the Ras signalling pathway.
In 2001, S. Papadopoulou et al. published MMP2 antibody research which used immunohistochemical staining techniques to compare MMP2 levels in both normal human colon mucosa and colorectal cancer cells. Both tissues showed immunohistological localization of MMP2. However, antigen levels were significantly higher in the tumour cells, with staining intensity higher in malignant adenocarcinomas than benign adenomas.
K.S Park et al. also used MMP2, MMP9 and TIMP2 (tissue inhibitor of metalloproteinase-2) antibodies to identify gene profiles which may increase the risk of colorectal cancer. Specific SNPs (single-nucleotide polymorphisms) were identified in both TIMP2 and MMP2, which were associated with tumourigenesis. M.J Kang. et al have also used MMP2 antibody products to probe the relationship of MMP2 SNPs to SNPs in VEGF and HIF1A, but no association was found.
Novus Biologicals offers many MMP2 reagents for your research needs including:
