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UCH-L1/PGP9.5 Antibody [PerCP]

 
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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Eq, PmSpecies Glossary
Applications WB, Simple Western, Flow, ICC/IF, IHC, KO
Clonality
Polyclonal
Host
Rabbit
Conjugate
PerCP

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB300-676AF350
Alexa Fluor 405
NB300-676AF405
Alexa Fluor 488
NB300-676AF488
Alexa Fluor 532
NB300-676AF532
Alexa Fluor 594
NB300-676AF594
Alexa Fluor 647
NB300-676AF647
Alexa Fluor 700
NB300-676AF700
Alexa Fluor 750
NB300-676AF750
Allophycocyanin
NB300-676APC
Biotin
NB300-676B
CoraFluor 1
NB300-676CL1
DyLight 350
NB300-676UV
DyLight 405
NB300-676V
DyLight 488
NB300-676G
DyLight 550
NB300-676R
DyLight 594
NB300-676DL594
DyLight 650
NB300-676C
DyLight 680
NB300-676FR
DyLight 755
NB300-676IR
FITC
NB300-676F
HRP
NB300-676H
Janelia Fluor 525
NB300-676JF525
Janelia Fluor 549
NB300-676JF549
Janelia Fluor 635
NB300-676JF635
Janelia Fluor 646
NB300-676JF646
Janelia Fluor 669
NB300-676JF669
PE
NB300-676PE
Unconjugated
NB300-676
mFluor Violet 450 SE
NB300-676MFV450
mFluor Violet 500 SE
NB300-676MFV500
mFluor Violet 610 SE
NB300-676MFV610
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UCH-L1/PGP9.5 Antibody [PerCP] Summary

Immunogen
A synthetic peptide made to a C-terminal portion of the human UCHL1 protein (between residues 200-220). [UniProt# P09936]
Localization
Cytoplasmic
Marker
pan-Neuronal Marker
Predicted Species
Rat (100%), Porcine (100%), Equine (100%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
UCHL1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
  • Knockout Validated
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for UCH-L1/PGP9.5 Antibody [PerCP]

  • EC 3.4.19.12
  • EC 6.-
  • Neuron cytoplasmic protein 9.5
  • PARK5
  • PGP 9.5
  • PGP9.5
  • PGP9.5Uch-L1
  • PGP95
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
  • ubiquitin carboxyl-terminal hydrolase isozyme L1
  • ubiquitin C-terminal hydrolase
  • Ubiquitin thioesterase L1
  • UCHL1
  • UCH-L1

Background

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.

UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certian site specific mutations in the UCHL1 gene can either increase or decrese the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.

Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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(3 Reviews)
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Enolase
2/Neuron-specific Eno ...
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DBD00
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UCH-L1/PGP9.5
Antibody [PerCP]
NB300-676PCP
UCH-L1/PGP9.5 Antibody [PerCP]
Species: Hu, Mu, Rt, Po, Eq, Pm
Applications: WB, Simple Western, Flow, ICC/IF, IHC, KO

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Video Protocols

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Bioinformatics

Gene Symbol UCHL1