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UCH-L1/PGP9.5 Antibody (BH7) [FITC]

 
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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, EqSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC, IHC
Clone
BH7
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB110-58869AF350
Alexa Fluor 405
NB110-58869AF405
Alexa Fluor 488
NB110-58869AF488
Alexa Fluor 532
NB110-58869AF532
Alexa Fluor 594
NB110-58869AF594
Alexa Fluor 647
NB110-58869AF647
Alexa Fluor 700
NB110-58869AF700
Alexa Fluor 750
NB110-58869AF750
Allophycocyanin
NB110-58869APC
Biotin
NB110-58869B
CoraFluor 1
NB110-58869CL1
DyLight 350
NB110-58869UV
DyLight 405
NB110-58869V
DyLight 488
NB110-58869G
DyLight 550
NB110-58869R
DyLight 594
NB110-58869DL594
DyLight 650
NB110-58869C
DyLight 680
NB110-58869FR
DyLight 755
NB110-58869IR
HRP
NB110-58869H
Janelia Fluor 525
NB110-58869JF525
Janelia Fluor 549
NB110-58869JF549
Janelia Fluor 646
NB110-58869JF646
Janelia Fluor 669
NB110-58869JF669
PE
NB110-58869PE
PerCP
NB110-58869PCP
Unconjugated
NB110-58869
mFluor Violet 450 SE
NB110-58869MFV450
mFluor Violet 500 SE
NB110-58869MFV500
mFluor Violet 610 SE
NB110-58869MFV610
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UCH-L1/PGP9.5 Antibody (BH7) [FITC] Summary

Immunogen
Recombinant full length human UCHL1 purified from E. coli. [Swiss-Prot# P09936]
Localization
Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor. Note: About 30% of total UCHL1 is associated with membranes in brain.
Marker
pan-Neuronal Marker
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
UCHL1
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovator's Reward

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry Free-Floating
  • Immunohistochemistry
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Affinity purified

Alternate Names for UCH-L1/PGP9.5 Antibody (BH7) [FITC]

  • EC 3.4.19.12
  • EC 6.-
  • Neuron cytoplasmic protein 9.5
  • PARK5
  • PGP 9.5
  • PGP9.5
  • PGP9.5Uch-L1
  • PGP95
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
  • ubiquitin carboxyl-terminal hydrolase isozyme L1
  • ubiquitin C-terminal hydrolase
  • Ubiquitin thioesterase L1
  • UCHL1
  • UCH-L1

Background

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a soluble cytoplasmic protein found in neurons and in cells of the diffuse neuroendocrine system, and their respective tumors. Therefore, UCH-L1 has been widely used as a peripheral nerve fiber marker. UCHL-1 functions as a tissue-specific ubiquitin carboxyl terminal hydrolase isoenzyme involved in the processing of both ubiquitin precursors and ubiquitinated proteins.

UCH L1 is down-regulated in brains from Parkinson disease and Alzheimer disease patients, and certian site specific mutations in the UCHL1 gene can either increase or decrese the risk of Parkinson's and/or Alzheimer's neurodegenerative diseases.

Human UCHL 1 and the closely related UCHL3 protein have one of the most complicated knot structures ever discovered, with five knot crossings. This knot structure is expected to help the protein resist degradation in the proteasome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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UCH-L1/PGP9.5
Antibody (BH7) [FITC]
NB110-58869F
UCH-L1/PGP9.5 Antibody (BH7) [FITC]
Species: Hu, Mu, Rt, Po, Bv, Eq
Applications: WB, Simple Western, ICC/IF, IHC, IHC

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol UCHL1