TXNIP Antibody

Thioredoxin-interacting protein belongs to the arrestin family. It acts as an oxidative stress mediator by inhibiting thioredoxin activity or by inhibiting thioredoxin activity or by limiting its bioavailability. It functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. It is required for the maturation of natural killer cells. Recently reported, TXNIP deficiency led to the impairment of NLRP3 inflammasome activation to innate immune responses and reduced secretion of interleukin IL-1Beta .

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Monkery.

We have publications tested in 4 applications: IF/IHC, IHC-P, IP, WB.

Showing Publications 1 - 4 of 4.

Publications using NBP2-27095	Applications	Species
Singatulina AS, Hamon L, Sukhanova MV et al. Evaluation of the Effect of Carvedilol on the Thioredoxin Pathway in H9C2 Rat Cardiomyocytes Thesis (IP, WB, Rat, Monkery)	IP, WB	Rat, Monkery
Karmi O, Sohn YS, Zandalinas SI et al. Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression Free Radical Biology and Medicine 2021-11-01 [PMID: 34547371]
Lim Jo, Shin Nr, Seo Ys et Al. Silibinin Attenuates Silica Dioxide Nanoparticles-Induced Inflammation by Suppressing TXNIP/MAPKs/AP-1 Signaling Cells 2020-03-10 [PMID: 32164364] (IHC-P, IF/IHC, WB, Mouse)	IHC-P, IF/IHC, WB	Mouse
Lee H, Lee S, Bae H, Kang HS, Kim SJ. Genome-wide identification of target genes for miR-204 and miR-211 identifies their proliferation stimulatory role in breast cancer cells. Nature.com. 2016-04-28 [PMID: 27121770] (WB, Human)	WB	Human

Array NBP2-27095

• TXNIP Antibodies
• TXNIP ELISA Kits
• TXNIP Lysate
• TXNIP Protein