TREX1 Antibody - BSA Free

Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. TREX1 antibody will not cross-react with the related protein TREX2.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC/IF.

Showing Publication 1 - 1 of 1.

Publication using NBP1-76977	Applications	Species
Takahashi A, Loo TM, Okada R et al. Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells. Nat Commun. 2018-03-28 [PMID: 29593264] (ICC/IF, Human)	ICC/IF	Human

Images	Ratings	Applications	Species	Date	Details
Enlarge	4 reviewed by: Prashant Rai	WB	Mouse	07/17/2019	View Summary Application Western Blot Sample Tested MEFs whole cell lysate Species Mouse Lot 7463-1404 Comments Comments Cell lysates run on Bis-Tris 4-12% gradient gel

Array NBP1-76977

• TREX1 Antibodies
• TREX1 Lysate
• TREX1 Proteins