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TREX1 Antibody [mFluor Violet 500 SE]

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Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
mFluor Violet 500 SE

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NBP1-76977AF350
Alexa Fluor 405
NBP1-76977AF405
Alexa Fluor 488
NBP1-76977AF488
Alexa Fluor 532
NBP1-76977AF532
Alexa Fluor 594
NBP1-76977AF594
Alexa Fluor 647
NBP1-76977AF647
Alexa Fluor 700
NBP1-76977AF700
Alexa Fluor 750
NBP1-76977AF750
Biotin
NBP1-76977B
CoraFluor 1
NBP1-76977CL1
DyLight 350
NBP1-76977UV
DyLight 405
NBP1-76977V
DyLight 488
NBP1-76977G
DyLight 550
NBP1-76977R
DyLight 594
NBP1-76977DL594
DyLight 650
NBP1-76977C
DyLight 680
NBP1-76977FR
DyLight 755
NBP1-76977IR
FITC
NBP1-76977F
HRP
NBP1-76977H
Janelia Fluor 525
NBP1-76977JF525
Janelia Fluor 549
NBP1-76977JF549
Janelia Fluor 585
NBP1-76977JF585
Janelia Fluor 635
NBP1-76977JF635
Janelia Fluor 646
NBP1-76977JF646
Janelia Fluor 669
NBP1-76977JF669
PerCP
NBP1-76977PCP
Unconjugated
NBP1-76977
mFluor Violet 450 SE
NBP1-76977MFV450
mFluor Violet 610 SE
NBP1-76977MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NBP1-76977
BSA Free
NBP1-76977
BSA Free
NBP1-76977-0.025mg
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TREX1 Antibody [mFluor Violet 500 SE] Summary

Immunogen
Antibody was raised against a 15 amino acid synthetic peptide near the center of human TREX1. The immunogen is located within amino acids 220 - 270 of TREX1. Amino Acid Squence: TRLYGQSPPDSHT
Specificity
TREX1 antibody will not cross-react with the related protein TREX2. At least three isoforms of TREX1 are known to exist; this antibody will recognize all three isoforms.
Predicted Species
Bovine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TREX1
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Peptide affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for TREX1 Antibody [mFluor Violet 500 SE]

  • 3'-5' exonuclease TREX1
  • AGS1
  • Aicardi-Goutieres syndrome 1
  • CRV
  • DKFZp434J0310
  • DNase III
  • DRN3
  • EC 3.1.11.2
  • HERNS
  • three prime repair exonuclease 1,3' repair exonuclease 1

Background

TREX1 encodes the major 3'->5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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TREX2 Antibody -
BSA Free
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Applications: ELISA, ICC/IF, IHC, IHC-P, WB
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Chk1 Antibody
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SAMHD1 Antibody
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AF2905
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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on TREX1.

Check out the latest blog posts on TREX1.
Dinosaur Protein Names: Infographic
Trex1 the protein is involved in DNA damage response. Tyrannosaurus rex (T. rex) the dinosaur lived during the Cretaceous Period. Raptor the protein is a regulator of mTOR activity. Velociraptors the dinosaurs lived during the Cretaceous Period. Learn...  Read full blog post.
Trex1 (3'-5' exonuclease TREX1, DNase III)
This gene encodes the major 3' to 5' DNA exonuclease in human cells. The protein is a non-processive exonuclease that appears to provide proofreading for checkpoint signaling after DNA damage in response to oxidative stress and apoptosis. It is ubiqui...  Read full blog post.
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Bioinformatics

Gene Symbol TREX1