TRAF-6 Antibody

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Mouse, Rat.

We have publications tested in 4 applications: IF/IHC, IHC-P, IP, WB.

Showing Publications 1 - 5 of 5.

Publications using NB100-56179	Applications	Species
Wei F, Ba S, Jin M et al. RNF180 Inhibits Proliferation and Promotes Apoptosis of Colorectal Cancer Through Ubiquitination of WISP1 Frontiers in Cell and Developmental Biology 2021-01-22 [PMID: 33553163] (IP, WB)	IP, WB
Wang P, Liu BY, Wu MM et al. Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats Neurosci. Lett. 2019-01-30 [PMID: 30710662] (WB, IF/IHC, Rat)	WB, IF/IHC	Rat
Wei W, Wan H, Peng X et al. Antiviral effects of Ma Huang Tang against H1N1 influenza virus infection in vitro and in an ICR pneumonia mouse model Biomedicine & Pharmacotherapy 2018-06-01 [PMID: 29710534] (IF/IHC, Mouse)	IF/IHC	Mouse
Ye Y, Yang Y, Chen C et al. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway Stem Cells Int. 2017-08-06 [PMID: 28848607] (WB, Mouse)	WB	Mouse
Zapata JM, Krajewska M, Krajewski S et al. TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies. J Immunol. 2000-11-01 [PMID: 11046039] (WB, IHC-P) Details: WB: Figs 1, 2, 4, 5; IHC-paraffin: Fig 3.	WB, IHC-P

Array NB100-56179

• TRAF-6 Antibodies
• TRAF-6 Inhibitor
• TRAF-6 Lysates
• TRAF-6 Proteins