TR4/NR2C2 Antibody (H0107B) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Human Testicular Receptor 4 (TR4, TAK1; NR2C2) is a member of the Orphan Nuclear Receptor family. TR4 was originally cloned from lymphoblastoma Raji cells or mouse brain cDNA library. No ligand has been reported. Northern blot shows TR4 is transcribed as a 9 kb mRNA in many tissues and as a 2.8 kb mRNA in testis, mainly in spermatocytes. TR4 has two isoforms called TR4 alpha 1 and TR4 alpha 2 that differ in 19 amino acids coded by two separate exons. Both products translated from the 9 kb transcript are ubiquitously expressed. Since TR4 binds to the same elements for the RAR-RXR or TR-RXR heterodimers, TR4 may have an inhibitory effect for retinoic acid-mediated transactivation.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: IHC-P.

Showing Publications 1 - 3 of 3.

Publications using PP-H0107B-00	Applications	Species
Barroso-GonzAlez J, GarcIa-ExpOsito L, Galaviz P et al. Anti-recombination function of MutS alpha restricts telomere extension by ALT-associated homology-directed repair Cell reports 2021-12-07 [PMID: 34879271]
Porreca RM, Herrera-Moyano E, Skourti E et al. TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres Elife 2020-01-14 [PMID: 31934863]
Ding X, Yang D, Xia L, Chen B, Yu S, Niu Y, Wang M, Li G, Chang C Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals. Mol Cancer, 2015-01-27;14(0):16. 2015-01-27 [PMID: 25623427] (IHC-P, Human)	IHC-P	Human

Array PP-H0107B-00

• TR4/NR2C2 Antibodies
• TR4/NR2C2 Lysate
• TR4/NR2C2 Protein