TLR10 Antibody (670719)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Toll-like receptor 10 (TLR10, CD290) is a 91-100 kDa member of the Toll-like receptor family. Human TLR10 is synthesized as a precursor with a 19 amino acid (aa) signal sequence and a 792 aa mature chain. The mature chain constitutes a single-pass type I transmembrane protein. The extracellular domain (ECD) extends from aa 20-576 and the cytoplasmic region consists of aa 598-811. Human TLR10 contains 15 leucine-rich repeats plus eight potential sites for N-linked glycosylation. In addition, it contains one cytoplasmic TIR domain. Functionally, TLR10 is involved in the innate immune response to microbial agents. Specifically, it acts via MYD88 and TRAF6, which leads to NF-kappa-B activation, cytokine secretion, and an inflammatory response. Human TLR10 shares 71% aa sequence identity with rat TLR10.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 2 of 2.

Publications using MAB6619	Applications	Species
Shuainan Zhu, Ying Yu, Mengdi Qu, Zhiyun Qiu, Hao Zhang, Changhong Miao et al. Neutrophil extracellular traps contribute to immunothrombosis formation via the STING pathway in sepsis-associated lung injury Cell Death Discovery 8/25/2023 [PMID: 37626060]
Y Fan, L Yang, Q Wei, Y Ding, Z Tang, P Tan, T Lin, D Guo, S Qiu Toll-like receptor 10 (TLR10) exhibits suppressive effects on inflammation of prostate epithelial cells Asian J. Androl., 2019-07-01;0(0):. 2019-07-01 [PMID: 30618413] (Western Blot, Human)	Western Blot	Human

Array MAB6619

• TLR10 Antibodies
• TLR10 ELISA Kits
• TLR10 Lysates
• TLR10 Protein
• TLR10 Proteins and Enzyme