TGIF1 Antibody (790707)

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TGIF1 (5'-TG[TCA]-3' Interacting Protein 1; also Transforming growth factor beta-induced factor and HPE4) is a 43 kDa (predicted) member of the TALE/TGIF homeobox family of proteins. It is widely expressed, and serves as a transcriptional corepressor for SMAD2-induced gene activation. Evidence suggests that it either complexes with c-jun and cPML, or interacts with HDAC in the nucleus to perform this function. It also binds to RXR response elements, blocking RXR-mediated gene activation. Such interactions are of considerable importance during fetal and neonatal development. Human TGIF1 is 401 amino acids (aa) in length. It contains a DNA-binding homeobox domain (aa 164-226) and two consecutive repressor domains (aa 267-401). There are multiple splice variants. One is very well characterized, is 33-35 kDa in size, and shows a four aa substitution for aa 1-133. This is most active when phosphorylated, which adds approximately 2-4 kDa to its SDS-PAGE MW. Two other splice forms contain a 19 aa substitution for aa 1-134, and utilize an alternative start site at Met150, respectively. Over aa 245-359, human TGIF1 shares 81% aa identity with mouse TGIF1.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publication 1 - 1 of 1.

Publication using MAB7555	Applications	Species
X He, W Yuan, CQ Yang, L Zhu, F Liu, J Feng, YX Xue Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells Neural regeneration research, 2022-01-01;17(1):170-177. 2022-01-01 [PMID: 34100453] (Western Blot, Human)	Western Blot	Human

Array MAB7555

• TGIF1 Antibodies
• TGIF1 Lysates
• TGIF1 Proteins