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SREBP1 Antibody [Biotin]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ha, Pl, ChHaSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC, MA
Clonality
Polyclonal
Host
Rabbit
Conjugate
Biotin

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SREBP1 Antibody [Biotin] Summary

Immunogen
A synthetic peptide made to a portion of the human SREBP1 protein sequence (between residues 300-400). [Uniprot: P36956]
Localization
Membranes of ER, Golgi and Cytoplasmic Vesicles. Processed SREBP1 (1-490 a.a.) translocates to the nucleus.
Predicted Species
Chinese Hamster (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SREBF1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Microarray
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Readout System

Reactivity Notes

Use in Human reported in scientific literature (PMID:33842305).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for SREBP1 Antibody [Biotin]

  • bHLHd1
  • Class D basic helix-loop-helix protein 1
  • SREBF1
  • SREBP 1c
  • SREBP1
  • SREBP-1
  • SREBP1bHLHd1SREBP-1c
  • sterol regulatory element binding protein-1
  • sterol regulatory element binding transcription factor 1
  • sterol regulatory element-binding protein 1
  • Sterol regulatory element-binding transcription factor 1

Background

SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. SREBPs may also play some role in the apoptotic processes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for SREBP1 Antibody (NB100-2215B) (0)

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Secondary Antibodies

 

Isotype Controls

Additional SREBP1 Products

Research Areas for SREBP1 Antibody (NB100-2215B)

Find related products by research area.

Blogs on SREBP1.

Metabolic Syndrome: Symptoms and associated disease states
By Jamshed Arslan, Pharm. D., PhD. What is metabolic syndrome?It was 1988 when, after decades of research, Dr. GM Reaven    of the Stanford University, CA, explained the relationship between four diseases:...  Read full blog post.

SREBP2 - regulating cholesterol homeostasis and lipid metabolism
Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...  Read full blog post.

SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. ...  Read full blog post.

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Bioinformatics

Gene Symbol SREBF1