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SREBP1 Antibody [DyLight 550]

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Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ha, Pl, ChHaSpecies Glossary
Applications WB, Simple Western, ICC/IF, IHC, MA
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 550

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price
Alexa Fluor 350
NB100-2215AF350
Alexa Fluor 405
NB100-2215AF405
Alexa Fluor 488
NB100-2215AF488
Alexa Fluor 532
NB100-2215AF532
Alexa Fluor 594
NB100-2215AF594
Alexa Fluor 647
NB100-2215AF647
Alexa Fluor 700
NB100-2215AF700
Alexa Fluor 750
NB100-2215AF750
Allophycocyanin
NB100-2215APC
Biotin
NB100-2215B
CoraFluor 1
NB100-2215CL1
DyLight 350
NB100-2215UV
DyLight 405
NB100-2215V
DyLight 488
NB100-2215G
DyLight 594
NB100-2215DL594
DyLight 650
NB100-2215C
DyLight 680
NB100-2215FR
DyLight 755
NB100-2215IR
FITC
NB100-2215F
HRP
NB100-2215H
Janelia Fluor 525
NB100-2215JF525
Janelia Fluor 549
NB100-2215JF549
Janelia Fluor 585
NB100-2215JF585
Janelia Fluor 635
NB100-2215JF635
Janelia Fluor 646
NB100-2215JF646
Janelia Fluor 669
NB100-2215JF669
PE
NB100-2215PE
PerCP
NB100-2215PCP
Unconjugated
NB100-2215
mFluor Violet 450 SE
NB100-2215MFV450
mFluor Violet 500 SE
NB100-2215MFV500
mFluor Violet 610 SE
NB100-2215MFV610
View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
NB100-2215
BSA Free
NB100-2215SS
BSA Free
NB100-2215
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SREBP1 Antibody [DyLight 550] Summary

Immunogen
A synthetic peptide made to a portion of the human SREBP1 protein sequence (between residues 300-400). [Uniprot: P36956]
Localization
Membranes of ER, Golgi and Cytoplasmic Vesicles. Processed SREBP1 (1-490 a.a.) translocates to the nucleus.
Predicted Species
Chinese Hamster (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SREBF1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.
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Applications/Dilutions

Dilutions
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Microarray
  • Simple Western
  • Western Blot
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Publications
Read Publication using
NB100-2215R in the following applications:

  • WB
    1 publication

Reactivity Notes

Use in Human reported in scientific literature (PMID:33842305).

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes



DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SREBP1 Antibody [DyLight 550]

  • bHLHd1
  • Class D basic helix-loop-helix protein 1
  • SREBF1
  • SREBP 1c
  • SREBP1
  • SREBP-1
  • SREBP1bHLHd1SREBP-1c
  • sterol regulatory element binding protein-1
  • sterol regulatory element binding transcription factor 1
  • sterol regulatory element-binding protein 1
  • Sterol regulatory element-binding transcription factor 1

Background

SREBP (Sterol Regulatory Element Binding Protein) 1 and 2 are transcription factors which participate in the control of cholesterol homeostasis. SREBP proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. SREBPs may also play some role in the apoptotic processes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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SREBP1 Antibody
[DyLight 550]
NB100-2215R
SREBP1 Antibody [DyLight 550]
Species: Hu, Mu, Rt, Po, Bv, Ha, Pl, ChHa
Applications: WB, Simple Western, ICC/IF, IHC, MA

Publications for SREBP1 Antibody (NB100-2215R)(1)

We have publications tested in 1 confirmed species: Rat.

We have publications tested in 1 application: WB.


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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Blogs on SREBP1.

Check out the latest blog posts on SREBP1.
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By Jamshed Arslan, Pharm. D., PhD. What is metabolic syndrome?It was 1988 when, after decades of research, Dr. GM Reaven    of the Stanford University, CA, explained the relationship between four diseases:...  Read full blog post.
SREBP2 - regulating cholesterol homeostasis and lipid metabolism
Sterol regulatory element-binding proteins (SREBP) are important transcription factors regulating the synthesis and uptake of lipids including cholesterol. This essential role in lipid metabolism makes investigations into the functions SREBPs im...  Read full blog post.
SREBP: Gatekeeper of Cholesterol Homeostasis
SREBP1 (sterol-regulatory-element-binding protein 2) is a basic-helix-loop-helix-leucine zipper (bHLH-ZIP) transcription factor. It regulates sterol and cholesterol homeostasis by controlling enzymes involved in cholesterol synthesis and uptake, e.g. ...  Read full blog post.
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Bioinformatics

Gene Symbol SREBF1