SR-AI/MSR Antibody - BSA Free

Macrophage Scavenger Receptor I (MSR1, also called CD204 or scavenger receptor A) belongs to scavenger receptor A family and represents phagocytic pattern-recognition receptors (PRRs) expressed predominantly on macrophages and dendritic cells. MSR1 is a single-pass type II membrane glycoprotein capable of binding to a wide range of polyanionic ligands (e.g., modified low density lipoproteins, pathogen-derived molecules), and is implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis, innate immune response as well as Alzheimer's disease. MSR1 mediates the endocytosis of a diverse group of macromolecules including modified LDLs, and scavenger receptors MSR1, CD36 and LOX-1 are three main receptors for oxidized LDL on macrophage membrane wherein MSR1/CD36 account for more than 9/10 of the lipid accumulation in macrophages exposed to oxidized LDL. Defects in MSR1 have also been linked to prostate cancer and Barrett esophagus (BE).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 6 applications: ICC/IF, IF/IHC, IHC-Fr, Immunohistochemistry, PLA, WB.

Showing Publications 1 - 8 of 8.

Publications using NBP1-00092	Applications	Species
Wang P, Li M, Gao T et al. Vascular Electrical Stimulation with Wireless, Battery-Free, and Fully Implantable Features Reduces Atherosclerotic Plaque Formation Through Sirt1-Mediated Autophagy Small (Weinheim an der Bergstrasse, Germany) 2023-06-02 [PMID: 37267941] (WB, Mouse)	WB	Mouse
Ma C, Feng K, Yang X, et al. Targeting macrophage liver X receptor by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis British journal of pharmacology 2021-01-28 [PMID: 33506494]
Bhandari, S, Li, R Et al. Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages. BMC Mol Cell Biol 2020-11-27 [PMID: 33246411] (WB, Mouse)	WB	Mouse
Chen J, Koduri S, Dai S et al. Intra-hematomal White Matter Tracts Act As a Scaffold for Macrophage Infiltration After Intracerebral Hemorrhage Translational Stroke Research 2021-10-01 [PMID: 33094829] (Immunohistochemistry)	Immunohistochemistry
Cao L, Sun PL, He Y et al. Immune stromal features in cervical squamous cell carcinoma are prognostic factors for distant metastasis: A retrospective study Pathol. Res. Pract. 2019-11-18 [PMID: 31776057] (IF/IHC, Human)	IF/IHC	Human
Komai K, Ito M, Kanamori M et al. Role of scavenger receptors as damage-associated molecular pattern receptors in Toll-like receptor activation. International Immunology. 2017-02-24 [PMID: 28338748] (PLA, Mouse)	PLA	Mouse
Bartels ED, Christoffersen C, Lindholm MW, Nielsen LB. Altered Metabolism of LDL in the Arterial Wall Precedes Atherosclerosis Regression. Circ. Res. 2015-09-10 [PMID: 26358193] (IF/IHC, Mouse)	IF/IHC	Mouse
Piccolo P, Vetrini F, Mithbaokar P et al. SR-A and SREC-I Are Kupffer and Endothelial Cell Receptors for Helper-dependent Adenoviral Vectors. Mol Ther 2013-01-29 [PMID: 23358188] (ICC/IF, IHC-Fr, Mouse)	ICC/IF, IHC-Fr	Mouse

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	ICC	Canine	06/13/2017	View Summary Application Immunocytochemistry Sample Tested Dog blood cells on slide Species Canine Lot b-9
Enlarge	5 reviewed by: A G	ICC	Canine	03/24/2017	View Summary Application Immunocytochemistry Sample Tested Peripheral blood leukocytes Species Canine Lot B9

Array NBP1-00092

• SR-AI/MSR Antibodies
• SR-AI/MSR Antibody Pair
• SR-AI/MSR ELISA Kits
• SR-AI/MSR Lysates
• SR-AI/MSR Proteins
• SR-AI/MSR Proteins and Enzymes