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SOX11 Antibody

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Western Blot: SOX11 Antibody [NBP1-85823] - Analysis in human cell line SH-SY5Y.
Immunohistochemistry-Paraffin: SOX11 Antibody [NBP1-85823] - Staining of human chronic lymphocytic leukemia shows no nuclear positivity in tumor cells as expected.
Immunohistochemistry-Paraffin: SOX11 Antibody [NBP1-85823] - Staining of human mantle cell lymphoma shows moderate to strong nuclear positivity in tumor cells.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, ChIP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

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SOX11 Antibody Summary

Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: FMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLKDSEKIPFIREAERLRLKHMADYPDYKYRPRKKPKMDPSAKPSASQSPEKSAAGGGGGSAGGGAGGAKTSKGSSKK
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SOX11
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Chromatin Immunoprecipitation (ChIP) Reported in scientific literature (PMID: 24681958)
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
  • Western Blot 0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Control Peptide
SOX11 Protein (NBP1-85823PEP)
Publications
Read Publications using
NBP1-85823 in the following applications:

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (82%), Rat (82%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for SOX11 Antibody

  • SOX11
  • SRY (sex determining region Y)-box 11
  • SRY (sex-determining region Y)-box 11
  • SRY-related HMG-box gene 11
  • transcription factor SOX-11

Background

SOX11 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOX11 Antibody (NBP1-85823)(20)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 3 applications: Chemotaxis, IF/IHC, WB.


Filter By Application
Chemotaxis
(1)
IF/IHC
(4)
WB
(1)
All Applications
Filter By Species
Human
(3)
All Species
Showing Publications 1 - 10 of 20. Show All 20 Publications.
Publications using NBP1-85823 Applications Species
Righi S, Pileri S, Agostinelli C et al. Reproducibility of SOX-11 detection in decalcified bone marrow tissue in mantle cell lymphoma patients. Hum. Pathol. 2016-10-05 [PMID: 27720733] (IF/IHC) IF/IHC
Inmaculada Ribera-Cortada, Daniel Martinez, Virginia Amador et al. Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype. Modern Pathology 2015-09-11 [PMID: 26360498] (IF/IHC, Human) IF/IHC Human
Davidson B, Holth A, Hellesylt E et al. The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions. Hum Pathol 2015-01-01 [PMID: 25455994] (IF/IHC, Human) IF/IHC Human
Kuo PY, Leshchenko VV, Fazzari MJ et al. High resolution Chromatin Immunoprecipitation (Chromatin Immunoprecipitation) sequencing reveals novel bindings targets and prognostic role for SOX11 in Mantle cell lymphoma. Oncogene 2015-03-05 [PMID: 24681958] (IF/IHC, WB, Chemotaxis, Human) IF/IHC, WB, Chemotaxis Human
Nygren L, Baumgartner Wennerholm S, Klimkowska M et al. Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma. Blood 2012-05-01 [PMID: 22431568]
Carvajal-Cuenca A, Sua LF, Silva NM et al. In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior. Haematologica 2012-02-01 [PMID: 22058203]
Sernbo S, Gustavsson E, Brennan DJ et al. The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation. BMC Cancer 2011-09-01 [PMID: 21943380]
Kimura Y, Sato K, Imamura Y et al. Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index. Cancer Sci 2011-09-01 [PMID: 21609366]
Ondrejka SL, Lai R, Smith SD et al. Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis. Haematologica 2011-08-01 [PMID: 21508124]
Cao X, Fan L, Fang C et al. The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases. Med Oncol 2012-06-01 [PMID: 21479697]
Show All 20 Publications.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional SOX11 Products

Blogs on SOX11.

SOX-11 seals your fate
The SOX-11 transcription factor is a member of the SOX family known to be involved in embryonic development regulation and cell fate determination. The protein acts as a transcriptional regulator and appears to modulate fundamental aspects of normal e...  Read full blog post.

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Bioinformatics

Gene Symbol SOX11