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SOCS-7/Nck/NAP4 Antibody (23E4)

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Immunohistochemistry: SOCS-7/Nck/NAP4 Antibody (23E4) [NBP3-26310] - Image of SOCS-7/Nck/NAP4 Antibody (23E4) diluted at 1:50 and staining in paraffin-embedded human testis tissue performed. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.43% DAB.
Immunohistochemistry: SOCS-7/Nck/NAP4 Antibody (23E4) [NBP3-26310] - Image of SOCS-7/Nck/NAP4 Antibody (23E4) diluted at 1:50 and staining in paraffin-embedded human testis tissue performed. After dewaxing and ...read more
Flow Cytometry: SOCS-7/Nck/NAP4 Antibody (23E4) [NBP3-26310] - Overlay Peak curve showing HepG2 cells stained with SOCS-7/Nck/NAP4 Antibody (23E4) (red line) at 1:50. The cells were fixed in 4% formaldehyde and ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA, Flow, IHC
Clone
23E4
Clonality
Monoclonal
Host
Rabbit
Conjugate
Unconjugated

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SOCS-7/Nck/NAP4 Antibody (23E4) Summary

Additional Information
Recombinant monoclonal antibody expressed in HEK293F cells
Immunogen
A synthesized peptide derived from Human SOCS-7/Nck/NAP4 [UniProt O14512]
Isotype
IgG
Clonality
Monoclonal
Host
Rabbit
Gene
SOCS7
Purity
Affinity purified
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Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry 1:50-1:200
  • Immunohistochemistry 1:50-1:200

Packaging, Storage & Formulations

Storage
Store at -20 to -70C. Avoid freeze-thaw cycles.
Buffer
PBS, pH 7.4, 150mM NaCl, and 50% glycerol
Preservative
0.02% Sodium Azide
Purity
Affinity purified

Alternate Names for SOCS-7/Nck/NAP4 Antibody (23E4)

  • NAP4
  • NAP-4
  • NAP4SOCS-7
  • Nck
  • Nck, Ash and phospholipase C binding protein
  • Nck, Ash and phospholipase C gamma-binding protein
  • NCKAP4
  • Nck-associated protein 4
  • SOCS6
  • SOCS7
  • SOCS-7
  • suppressor of cytokine signaling 7

Background

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol SOCS7