SOCS-4 Antibody (517331) [Unconjugated]

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Suppressor of cytokine signaling 4 (SOCS-4) is a 51 kDa (predicted) member of the SOCS family of proteins, which are Src homology-2 (SH2)-containing proteins originally identified as negative regulators of cytokine signaling. Human SOCS-4 is 440 amino acids (aa) in length. It contains an SH2 domain (aa 289‑381) and a SOCS box domain (aa 376‑425). Human SOCS-4 shares 93% and 86% aa sequence identity with bovine and mouse SOCS-4, respectively. The biological function of SOCS-4 remains poorly understood, but it has been found to be elevated in cells following treatment with EGF, acting perhaps in a feedback loop inhibiting STAT3.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.

Showing Publications 1 - 4 of 4.

Publications using MAB5628	Applications	Species
Yuan, X;Liu, P;Xu, L;Liang, L;Dong, Q;Fan, T;Yue, W;Qu, M;Pei, X;Xie, X; miR-1915-3p regulates megakaryocytic and erythroid differentiation by targeting SOCS4 Thrombosis journal 2024-08-09 [PMID: 39123189] (Western Blot, Human)	Western Blot	Human
Chiao‐Fang Teng, Hong‐Yi Chang, Hung‐Wen Tsai, Wen‐Chuan Hsieh, Yu‐Hao Kuo, Ih‐Jen Su et al. Liver regeneration accelerates hepatitis B virus‐related tumorigenesis of hepatocellular carcinoma Molecular Oncology 6/1/2018 [PMID: 29729074]
Y Feng, AJ Sanders, LD Morgan, S Owen, F Ruge, KG Harding, WG Jiang In vitro significance of SOCS-3 and SOCS-4 and potential mechanistic links to wound healing Sci Rep, 2017-07-27;7(1):6715. 2017-07-27 [PMID: 28751715] (Western Blot, Human)	Western Blot	Human
D.G. Walker, A.M. Whetzel, L.-F. Lue Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer’s disease brains and human microglia Neuroscience 8/27/2015 [PMID: 25286386]

Array MAB5628

• SOCS-4 Antibodies
• SOCS-4 Proteins