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SCP3/SYCP3 Antibody [Unconjugated]

 (13 Publications)
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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Conjugate Size Price
Biotin
BAF3750
View Available Formulations
Catalog# & Formulation Size Price
Carrier Free
AF3750-SP
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SCP3/SYCP3 Antibody [Unconjugated] Summary

Immunogen
E. coli-derived recombinant human SCP3/SYCP3
Met1-Phe236
Accession # Q8IZU3
Specificity
Detects human SCP3/SYCP3 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SYCP3
Purity Statement
Antigen Affinity-purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
Publications
Read Publications using
AF3750 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SCP3/SYCP3 Antibody [Unconjugated]

  • COR1
  • MGC71888
  • SCP3 chromosome 3 open reading frame 8
  • SCP3 COR1
  • SCP3
  • SCP-3
  • SYCP3
  • synaptonemal complex protein 3

Background

SCP3 is a component of the synaptonemal complex, which is a meiosis-specific proteinaceous structure required for the pairing and segregation of homologous chromosomes. Human SCP3 is a 236 amino acid protein with a centrally located nuclear localization signal (NLS) and two C-terminal coiled coil domains. Human and mouse SCP3 share 71% amino acid sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SCP3/SYCP3 Antibody (AF3750)(13)

We have publications tested in 3 confirmed species: Human, Mouse, Porcine.

We have publications tested in 3 applications: ICC, IHC, Western Blot.


Filter By Application
ICC
(4)
IHC
(4)
Western Blot
(1)
All Applications
Filter By Species
Human
(2)
Mouse
(5)
Porcine
(2)
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using AF3750 Applications Species
Shao, Q;Zhang, Y;Liu, Y;Shang, Y;Li, S;Liu, L;Wang, G;Zhou, X;Wang, P;Gao, J;Zhou, J;Zhang, L;Wang, S; ATF7IP2, a meiosis-specific partner of SETDB1, is required for proper chromosome remodeling and crossover formation during spermatogenesis Cell reports 2023-08-04 [PMID: 37542719] (ICC, Mouse) ICC Mouse
X You, T Li, Y Cui, W Liu, Z Cheng, W Zeng, P Wang, Y Zheng Retinoic acid-induced differentiation of porcine prospermatogonia in�vitro Theriogenology, 2023-01-07;198(0):344-355. 2023-01-07 [PMID: 36640739] (ICC, Porcine) ICC Porcine
H Abe, YH Yeh, Y Munakata, KI Ishiguro, PR Andreassen, SH Namekawa Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation Nature Communications, 2022-11-28;13(1):7212. 2022-11-28 [PMID: 36443288] (ICC, Mouse) ICC Mouse
Y Huang, R Tian, J Xu, Z Ji, Y Zhang, L Zhao, C Yang, P Li, E Zhi, H Bai, S Han, J Luo, J Zhao, J Zhang, Z Zhou, Z Li, C Yao Novel copy number variations within SYCE1 caused meiotic arrest and non-obstructive azoospermia BMC medical genomics, 2022-06-19;15(1):137. 2022-06-19 [PMID: 35718780] (IHC, Human) IHC Human
R Liu, Z Liu, M Guo, W Zeng, Y Zheng SETDB1 Regulates Porcine Spermatogonial Adhesion and Proliferation through Modulating MMP3/10 Transcription Cells, 2022-01-22;11(3):. 2022-01-22 [PMID: 35159180] (IHC, Porcine) IHC Porcine
Peng Li, Zhiyong Ji, Erlei Zhi, Yuxiang Zhang, Sha Han, Liangyu Zhao et al. Novel bi-allelic MSH4 variants causes meiotic arrest and non-obstructive azoospermia Reproductive Biology and Endocrinology 12/1/2022 [PMID: 35090489]
Zhiyong Ji, Chencheng Yao, Chao Yang, Chuan Huang, Liangyu Zhao, Xia Han et al. Novel Hemizygous Mutations of TEX11 Cause Meiotic Arrest and Non-obstructive Azoospermia in Chinese Han Population Frontiers in Genetics 9/21/2021 [PMID: 34621296]
Chencheng Yao, Chao Yang, Liangyu Zhao, Peng Li, Ruhui Tian, Huixing Chen et al. Bi-allelic SHOC1 loss-of-function mutations cause meiotic arrest and non-obstructive azoospermia Journal of Medical Genetics 10/1/2021 [PMID: 32900840]
JA Slotman, MW Paul, F Carofiglio, HM de Gruiter, T Vergroesen, L Koornneef, WA van Cappel, AB Houtsmulle, WM Baarends Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase PLoS Genet., 2020-06-05;16(6):e1008595. 2020-06-05 [PMID: 32502153] (IHC, Mouse) IHC Mouse
I Brandsma, K Sato, SE van Rossum, N van Vliet, E Sleddens, M Reuter, H Odijk, N van den Te, DHW Dekkers, K Bezstarost, JAA Demmers, A Maas, J Lebbink, C Wyman, J Essers, DC van Gent, WM Baarends, P Knipscheer, R Kanaar, AN Zelensky HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis Cell Rep, 2019-06-25;27(13):3790-3798.e7. 2019-06-25 [PMID: 31242413] (Western Blot, Human) Western Blot Human
Show All 13 Publications.

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SCP3: A Key to Meiotic Recombination, Sterility and Cancer
Synaptonemal Complex Protein 3 (SCP3), which is a protein present in the synaptonemal complex which is responsible for pairing, synapsis, and recombination of homologous chromosomes during meiosis. Meiosis, in basic terms, is where germ cells divide t...  Read full blog post.
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Bioinformatics

Gene Symbol SYCP3
Uniprot