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Recombinant Mouse CCL17/TARC Protein

 (13 Publications)
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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Bioactivity

Order Details

View Available Formulations
Catalog# & Formulation Size Price
Standard Formulation
529-TR-025/CF
Carrier Free
529-TR-025/CF
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Recombinant Mouse CCL17/TARC Protein Summary

Details of Functionality
Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR4. The ED50 for this effect is 2‑8 ng/mL.
Source
E. coli-derived mouse CCL17/TARC protein
Ala24-Pro93
Accession #
N-terminal Sequence
Ala24
Protein/Peptide Type
Recombinant Proteins
Gene
Ccl17
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity2
Theoretical MW
7.9 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
529-TR in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse CCL17/TARC Protein

  • ABCD-2
  • CC chemokine TARC
  • C-C motif chemokine 17
  • CCL17
  • chemokine (C-C motif) ligand 17
  • MGC138273
  • SCYA17
  • SCYA17MGC138271
  • small inducible cytokine subfamily A (Cys-Cys), member 17
  • Small-inducible cytokine A17
  • T cell-directed CC chemokine
  • TARC
  • TARCA-152E5.3
  • Thymus and activation-regulated chemokine

Background

Human thymus and activation-regulated chemokine (TARC) also known as CCL17, is a novel CC chemokine identified using a signal sequence trap method. Mouse TARC was discovered as a dendritic cell (DC) specific gene by differentiation RNA display. Mouse TARC cDNA encodes a highly basic 93 amino acid (aa) residue precursor protein with a 23 aa residue putative signal peptide that is cleaved to generate the 70 aa residue mature secreted protein. Among CC chemokine family members, TARC has approximately 24 - 29% amino acid sequence identity with RANTES, MIP-1 alpha , MIP-1 beta , MCP-1, MCP-2, MCP-3 and I-309. The gene for human TARC has been mapped to chromosome 16q13 rather than chromosome 17 where the genes for many human CC chemokines are clustered. Mouse TARC is constitutively expressed in thymic DC, and at a lower level in lymph node DC in the lung. Recombinant TARC has been shown to be chemotactic for T cell lines and antigen-primed T helper cells. In humans, TARC was identified to be a specific functional ligand for CCR-4 and CCR-8, receptors that are selectively expressed on T cells.

  1. Imai, T. et al. (1997) J. Biol. Chem. 272:15036.
  2. Imai, T. et al. (1996) J. Biol. Chem. 271:21514.
  3. Nomiyama, H. et al. (1997) Genomics 40:211.
  4. Lieberam, I. et al. (1999) Eur. J. Immunol. 29:2684.

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Recombinant Mouse
CCL17/TARC Protein
529-TR
Recombinant Mouse CCL17/TARC Protein
Species: Mu
Applications: Bioactivity

Publications for CCL17/TARC (529-TR)(13)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 4 applications: Bioassay, ELISA (Standard), In Vivo, Western Blot.


Filter By Application
Bioassay
(6)
ELISA (Standard)
(3)
In Vivo
(4)
Western Blot
(1)
All Applications
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Human
(1)
Mouse
(9)
All Species
Showing Publications 1 - 10 of 13. Show All 13 Publications.
Publications using 529-TR Applications Species
CH Pai, SR Lin, CH Liu, SY Pan, H Hsu, YT Chen, CT Yen, IS Yu, HL Wu, SL Lin, SW Lin Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis Sci Rep, 2020-10-08;10(1):16772. 2020-10-08 [PMID: 33033277] (Bioassay, Mouse) Bioassay Mouse
KM Lee, Z Zhang, A Achuthan, AJ Fleetwood, JE Smith, JA Hamilton, AD Cook IL-23 in arthritic and inflammatory pain development in mice Arthritis Res. Ther., 2020-05-29;22(1):123. 2020-05-29 [PMID: 32471485] (In Vivo, Mouse) In Vivo Mouse
S Usuki, N Tamura, T Tamura, S Higashiyam, K Tanji, S Mitsutake, A Inoue, J Aoki, K Mukai, Y Igarashi Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism Biochem Biophys Rep, 2019-01-03;17(0):132-138. 2019-01-03 [PMID: 30623117] (Bioassay, Human) Bioassay Human
AD Cook, MC Lee, R Saleh, HW Khiew, AD Christense, A Achuthan, AJ Fleetwood, DC Lacey, JE Smith, I Förster, JA Hamilton TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17 JCI Insight, 2018-03-22;3(6):. 2018-03-22 [PMID: 29563337] (In Vivo, Mouse) In Vivo Mouse
Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation J Clin Invest, 2016-08-15;0(0):. 2016-08-15 [PMID: 27525438] (In Vivo, Mouse) In Vivo Mouse
SA Geherin, D Gómez, RA Glabman, G Ruthel, A Hamann, GF Debes IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require ?4?1 Integrin To Migrate between the Peritoneum and Inflamed Skin J. Immunol, 2016-02-05;196(6):2514-25. 2016-02-05 [PMID: 26851219] (Bioassay, Mouse) Bioassay Mouse
Loebbermann , Jens, Durant , Lydia, Thornton , Hannah, Johansson , Cecilia, Openshaw , Peter J Defective immunoregulation in RSV vaccine-augmented viral lung disease restored by selective chemoattraction of regulatory T cells. Proc Natl Acad Sci U S A, 2013-02-04;110(8):2987-92. 2013-02-04 [PMID: 23382205] (In Vivo, Mouse) In Vivo Mouse
Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Forster I, Kurts C Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell-licensed DCs. Nat. Immunol., 2010-02-28;11(4):313-20. 2010-02-28 [PMID: 20190758] (Bioassay, Mouse) Bioassay Mouse
Kearley J, Buckland KF, Mathie SA, Lloyd CM Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am. J. Respir. Crit. Care Med., 2009-01-29;179(9):772-81. 2009-01-29 [PMID: 19179489] (ELISA (Standard)) ELISA (Standard)
Kearley J, Robinson DS, Lloyd CM CD4+CD25+ regulatory T cells reverse established allergic airway inflammation and prevent airway remodeling. J. Allergy Clin. Immunol., 2008-07-30;122(3):617-24.e6. 2008-07-30 [PMID: 18672278] (ELISA (Standard)) ELISA (Standard)
Show All 13 Publications.

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Bioinformatics

Gene Symbol Ccl17
Uniprot