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Mouse CCL11/Eotaxin Quantikine ELISA Kit, 2 Plate

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Summary
Reactivity MuSpecies Glossary
Applications ELISA
Conjugate
HRP

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Mouse CCL11/Eotaxin Quantikine ELISA Kit, 2 Plate Summary

Background
The Quantikine Mouse Eotaxin Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse Eotaxin in cell culture supernates, serum, and plasma. It contains recombinant mouse Eotaxin and antibodies raised against the recombinant protein. This immunoassay has been shown to quantitate the recombinant protein accurately. Results obtained using natural mouse Eotaxin showed dose curves t...hat were parallel to the standard curves obtained using the E. coli-expressed kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse Eotaxin.
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Specificity
Natural and recombinant mouse Eotaxin.  This assay cross-reacts 0.062% with Human Eotaxin and recognizes Rat Eotaxin.
Source
N/A
Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
Ccl11

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using MME00.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse CCL11/Eotaxin Quantikine ELISA Kit, 2 Plate

  • C-C motif chemokine 11
  • CCL11
  • chemokine (C-C motif) ligand 11
  • Eosinophil chemotactic protein
  • Eotaxin
  • eotaxin-1
  • MGC22554
  • SCYA11Small-inducible cytokine A11
  • small inducible cytokine subfamily A (Cys-Cys), member 11 (eotaxin)

Background

CCL11/Eotaxin is a chemokine that interacts with CCR3 to induce eosinophil, basophil, dendritic cell, and Th2 cell chemoattraction during inflammatory and allergic reactions. Its production is upregulated in airway epithelium, alveolar macrophages, eosinophils, smooth muscle cells, chondrocytes, and fibroblasts following allergen or inflammatory challenge. CCL11 is also involved in the growth of myeloid cell progenitors and the differentiation of mast cells.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for CCL11/Eotaxin (MME00)(57)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.


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Human
(1)
Mouse
(53)
Rat
(3)
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Showing Publications 1 - 10 of 57. Show All 57 Publications.
Publications using MME00 Applications Species
G Scabia, G Testa, M Scali, S Del Turco, G Desiato, N Berardi, A Sale, M Matteoli, L Maffei, M Maffei, M Mainardi, “Train the Reduced ccl11/eotaxin mediates the beneficial effects of environmental stimulation on the aged hippocampus Brain, Behavior, and Immunity, 2021-08-19;98(0):234-244. 2021-08-19 [PMID: 34418501] (Mouse) Mouse
W Gao, Z Jin, Y Zheng, Y Xu Psoralen inhibits the inflammatory response and mucus production in allergic rhinitis by inhibiting the activator protein�1 pathway and the downstream expression of cystatin?SN Molecular Medicine Reports, 2021-07-19;24(3):. 2021-07-19 [PMID: 34278468] (Human) Human
SJ Wu, CJ Liou, YL Chen, SC Cheng, WC Huang Fucoxanthin Ameliorates Oxidative Stress and Airway Inflammation in Tracheal Epithelial Cells and Asthmatic Mice Cells, 2021-05-25;10(6):. 2021-05-25 [PMID: 34070405] (Mouse) Mouse
ME Kotas, J Dion, S Van Dyken, RR Ricardo-Go, CJ Danel, C Taillé, L Mouthon, RM Locksley, B Terrier A role for IL-33-activated ILC2s in eosinophilic vasculitis JCI Insight, 2021-06-22;0(0):. 2021-06-22 [PMID: 33974563] (Mouse) Mouse
S Piñeiro-He, P Martínez, MA Blasco Short and dysfunctional telomeres protect from allergen-induced airway inflammation Aging Cell, 2021-05-04;20(5):e13352. 2021-05-04 [PMID: 33942458] (Mouse) Mouse
R Wang, K Huang CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL?2 and TGF?&beta by CD4+ T�cells via the STAT5 signaling pathway Mol Med Rep, 2020-04-01;0(0):. 2020-04-01 [PMID: 32323817] (Mouse) Mouse
HS Choi, T Won, X Hou, G Chen, W Bracamonte, MV Talor, I Jur?ová, O Szárszoi, L ?urnova, I St?íž, JE Hooper, V Melenovský, D ?iháková Innate Lymphoid Cells Play a Pathogenic Role in Pericarditis Cell Rep, 2020-03-03;30(9):2989-3003.e6. 2020-03-03 [PMID: 32130902] (Mouse) Mouse
I Sulaiman, K Tan, N Mohtarrudi, JC Woei Lim, J Stanslas Andrographolide prevented toluene diisocyanate-induced occupational asthma and aberrant airway E-cadherin distribution via p38 MAPK-dependent Nrf2 induction Pulm Pharmacol Ther, 2018-09-21;0(0):. 2018-09-21 [PMID: 30244166] (Mouse) Mouse
A Aguilar-Va, N Haji, D De Gregori, E Matta-Cama, MJ Eslamizade, J Popic, V Sharma, R Cao, C Rummel, A Tanti, S Wiebe, N Nuñez, S Comai, R Nadon, G Luheshi, N Mechawar, G Turecki, JC Lacaille, G Gobbi, N Sonenberg Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E Nat Commun, 2018-06-25;9(1):2459. 2018-06-25 [PMID: 29941989] (Mouse) Mouse
Macrophages and cardiac fibroblasts are the main producers of eotaxins and regulate eosinophil trafficking to the heart Eur J Immunol, 2016-10-25;0(0):. 2016-10-25 [PMID: 27621211] (Mouse) Mouse
Show All 57 Publications.

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Blogs on CCL11/Eotaxin.

Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation
By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...  Read full blog post.

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Bioinformatics

Gene Symbol Ccl11