| Li, Y;Wang, W;Liu, C;Zeng, M;Xu, L;Du, R;Wang, C; Adiponectin C1q/Tumor Necrosis Factor-Related Protein 13 (CTRP13) Protects against Renal Inflammation and Fibrosis in Obstructive Nephropathy Biomedicines 2023-12-25 [PMID: 38255158] (Bioassay, Rat) |
Bioassay |
Rat |
| Rezi, CK;Aslanyan, MG;Diwan, GD;Cheng, T;Chamlali, M;Junger, K;Anvarian, Z;Lorentzen, E;Pauly, KB;Afshar-Bahadori, Y;Fernandes, EFA;Qian, F;Tosi, S;Christensen, ST;Pedersen, SF;Strømgaard, K;Russell, RB;Miner, JH;Mahjoub, MR;Boldt, K;Roepman, R;Pedersen, LB; DLG1 functions upstream of SDCCAG3 and IFT20 to control targeting of polycystin-2 to the primary cilium bioRxiv : the preprint server for biology 2023-11-10 [PMID: 37987012] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Harmange, G;Hueros, RAR;Schaff, DL;Emert, B;Saint-Antoine, M;Kim, LC;Niu, Z;Nellore, S;Fane, ME;Alicea, GM;Weeraratna, AT;Simon, MC;Singh, A;Shaffer, SM; Disrupting cellular memory to overcome drug resistance Nature communications 2023-11-06 [PMID: 37932277] (Bioassay, Human) |
Bioassay |
Human |
| Gu, M;Jiang, H;Tan, M;Yu, L;Xu, N;Li, Y;Wu, H;Hou, Q;Dai, C; Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating ?-catenin palmitoylation Nature communications 2023-10-21 [PMID: 37865665] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Do, NT;Lee, SY;Lee, YS;Shin, C;Kim, D;Lee, TG;Son, JG;Kim, SH; Time-sequential fibroblast-to-myofibroblast transition in elastin-variable 3D hydrogel environments by collagen networks Biomaterials research 2023-10-17 [PMID: 37848974] (Bioassay, Human) |
Bioassay |
Human |
| Lee, JH;Kim, KM;Jung, EH;Lee, HR;Yang, JH;Cho, SS;Ki, SH; Parkin-Mediated Mitophagy by TGF-? Is Connected with Hepatic Stellate Cell Activation International journal of molecular sciences 2023-10-02 [PMID: 37834275] (Bioassay, Human) |
Bioassay |
Human |
| Sandoval, S;Malany, K;Thongphanh, K;Martinez, CA;Goodson, ML;Souza, FDC;Lin, LW;Pennington, J;Lein, PJ;Kerkvliet, NI;Ehrlich, AK; Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4 + T cells bioRxiv : the preprint server for biology 2023-09-28 [PMID: 37808764] (Bioassay, Human) |
Bioassay |
Human |
| Cai, D;Fraunfelder, M;Fujise, K;Chen, SY; ADAR1 exacerbates ischemic brain injury via astrocyte-mediated neuron apoptosis Redox biology 2023-09-29 [PMID: 37801857] (Bioassay, Huma) |
Bioassay |
Huma |
| Ramesh, V;Gollavilli, PN;Pinna, L;Siddiqui, MA;Turtos, AM;Napoli, F;Antonelli, Y;Leal-Egaña, A;Havelund, JF;Jakobsen, ST;Boiteux, EL;Volante, M;Faergeman, NJ;Jensen, ON;Siersbaek, R;Somyajit, K;Ceppi, P; Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma EMBO molecular medicine 2023-09-28 [PMID: 37766669] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Dirand, Z;Tissot, M;Chatelain, B;Viennet, C;Rolin, G; Is Spheroid a Relevant Model to Address Fibrogenesis in Keloid Research? Biomedicines 2023-08-23 [PMID: 37760792] (Bioassay, Human) |
Bioassay |
Human |
| Barbayianni, I;Kanellopoulou, P;Fanidis, D;Nastos, D;Ntouskou, ED;Galaris, A;Harokopos, V;Hatzis, P;Tsitoura, E;Homer, R;Kaminski, N;Antoniou, KM;Crestani, B;Tzouvelekis, A;Aidinis, V; SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis Nature communications 2023-09-21 [PMID: 37735172] (Cell Culture, Mouse, Human) |
Cell Culture |
Mouse, Human |
| Jalan-Sakrikar, N;Anwar, A;Yaqoob, U;Gan, C;Lagnado, AB;Wixom, AQ;Jurk, D;Huebert, RC; Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in Primary Sclerosing Cholangitis JCI insight 2023-09-14 [PMID: 37707950] (Bioassay, Human) |
Bioassay |
Human |
| Suzuki, M;Sakai, S;Ota, K;Bando, Y;Uchida, C;Niida, H;Kitagawa, M;Ohhata, T; CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions Scientific reports 2023-09-08 [PMID: 37684517] (Cell Culture, Human) |
Cell Culture |
Human |
| Vaikunthanathan, T;Landmann, E;Correa, DM;Romano, M;Trevelin, SC;Peng, Q;Crespo, E;Corrado, M;Lozano, JJ;Pearce, EL;Perpinan, E;Zoccarato, A;Siew, L;Edwards-Hicks, J;Khan, R;Luu, NT;Thursz, MR;Newsome, PN;Martinez-Llordella, M;Shah, N;Lechler, RI;Shah, AM;Sanchez-Fueyo, A;Lombardi, G;Safinia, N; Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease EBioMedicine 2023-08-30 [PMID: 37657135] (Bioassay, Human) |
Bioassay |
Human |
| Fonseca, VC;Van, V;Ip, BC; Primary Human Cell-Derived Extracellular Matrix from Decellularized Fibroblast Microtissues with Tissue-Dependent Composition and Microstructure bioRxiv : the preprint server for biology 2023-08-17 [PMID: 37645710] (Bioassay, Human) |
Bioassay |
Human |
| Mercader-Barceló, J;Martín-Medina, A;Truyols-Vives, J;Escarrer-Garau, G;Elowsson, L;Montes-Worboys, A;Río-Bocos, C;Muncunill-Farreny, J;Velasco-Roca, J;Cederberg, A;Kadefors, M;Molina-Molina, M;Westergren-Thorsson, G;Sala-Llinàs, E; Mitochondrial Dysfunction in Lung Resident Mesenchymal Stem Cells from Idiopathic Pulmonary Fibrosis Patients Cells 2023-08-17 [PMID: 37626894] (Cell Culture, Human) |
Cell Culture |
Human |
| Zhou, L;Fang, L;Tamm, M;Stolz, D;Roth, M; Extracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual-Specificity Phosphatase 1 via Toll-like Receptor 4 and Attenuates Inflammation in Airway Epithelial Cells International journal of molecular sciences 2023-07-20 [PMID: 37511459] (Bioassay, Human) |
Bioassay |
Human |
| Hall, C;Law, JP;Reyat, JS;Cumberland, MJ;Hang, S;Vo, NTN;Raniga, K;Weston, CJ;O'Shea, C;Townend, JN;Gehmlich, K;Ferro, CJ;Denning, C;Pavlovic, D; Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype Scientific reports 2023-07-26 [PMID: 37495732] (Bioassay, Human) |
Bioassay |
Human |
| Koncina, E;Nurmik, M;Pozdeev, VI;Gilson, C;Tsenkova, M;Begaj, R;Stang, S;Gaigneaux, A;Weindorfer, C;Rodriguez, F;Schmoetten, M;Klein, E;Karta, J;Atanasova, VS;Grzyb, K;Ullmann, P;Halder, R;Hengstschläger, M;Graas, J;Augendre, V;Karapetyan, YE;Kerger, L;Zuegel, N;Skupin, A;Haan, S;Meiser, J;Dolznig, H;Letellier, E; IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer Nature communications 2023-07-17 [PMID: 37460545] (Differentiation, Mouse) |
Differentiation |
Mouse |
| Erdem, C;Gross, SM;Heiser, LM;Birtwistle, MR; MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms Nature communications 2023-07-06 [PMID: 37414767] (Bioassay, Human) |
Bioassay |
Human |
| Wang, S;Qu, Y;Fang, X;Ding, Q;Zhao, H;Yu, X;Xu, T;Lu, R;Jing, S;Liu, C;Wu, H;Liu, Y; Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-beta 1 Experimental & molecular medicine 2023-07-03 [PMID: 37394592] (Bioassay, Human) |
Bioassay |
Human |
| Madsen, SF;Sand, JMB;Juhl, P;Karsdal, M;Thudium, CS;Siebuhr, AS;Bay-Jensen, AC; Fibroblasts are not just fibroblasts: clear differences between dermal and pulmonary fibroblasts' response to fibrotic growth factors Scientific reports 2023-06-09 [PMID: 37296166] (Bioassay, Human) |
Bioassay |
Human |
| Lu, ZZ;Sun, C;Zhang, X;Peng, Y;Wang, Y;Zeng, Y;Zhu, N;Yuan, Y;Zeng, MS; Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis Science advances 2023-05-24 [PMID: 37224259] (Bioassay, Human) |
Bioassay |
Human |
| Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR; Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung bioRxiv : the preprint server for biology 2023-05-05 [PMID: 37205521] (Bioassay, Human) |
Bioassay |
Human |
| Yoon, I;Song, JA;Suh, JH;Kim, S;Son, J;Kim, JH;Jang, SY;Hwang, KY;Kim, MH;Kim, S; EPRS1 Controls the TGF-? Signaling Pathway via Interaction with T?RI in Hepatic Stellate Cell Molecular and cellular biology 2023-05-08 [PMID: 37154023] (Bioassay, Human) |
Bioassay |
Human |
| M Krizanac, PB Mass Sanch, SK Schröder, R Weiskirche, A Asimakopou Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B Cells International Journal of Molecular Sciences, 2023-04-13;24(8):. 2023-04-13 [PMID: 37108378] (Bioassay, Human) |
Bioassay |
Human |
| O Anannya, W Huang, A August ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066370] (Bioassay, Mouse) |
Bioassay |
Mouse |
| P Matarrese, R Vona, B Ascione, C Cittadini, A Tocci, AM Mileo Tumor Microenvironmental Cytokines Drive NSCLC Cell Aggressiveness and Drug-Resistance via YAP-Mediated Autophagy Cells, 2023-03-30;12(7):. 2023-03-30 [PMID: 37048121] (Bioassay, Human) |
Bioassay |
Human |
| RL Azevedo-Pe, NC Manley, C Dong, Y Zhang, AG Lee, Y Zatulovska, V Gupta, J Vu, S Han, JE Berry, TM Bliss, GK Steinberg Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain Cell Reports, 2023-04-10;42(4):112353. 2023-04-10 [PMID: 37043353] (Bioassay, Human) |
Bioassay |
Human |
| N Fakatava, H Mitarai, A Yuda, A Haraguchi, H Wada, D Hasegawa, H Maeda, N Wada Actin alpha 2, smooth muscle, a transforming growth factor-beta1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway Journal of dental sciences, 2023;18(2):567-576. 2023 [PMID: 37021273] (Cell Culture, Human) |
Cell Culture |
Human |
| N Fakatava, H Mitarai, A Yuda, A Haraguchi, H Wada, D Hasegawa, H Maeda, N Wada Actin alpha 2, smooth muscle, a transforming growth factor-beta1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway Journal of dental sciences, 2022-09-16;18(2):567-576. 2022-09-16 [PMID: 37021273] (Cell Culture, Human) |
Cell Culture |
Human |
| J Sidhaye, P Trepte, N Sepke, M Novatchkov, M Schutzbier, G Dürnberger, K Mechtler, JA Knoblich Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids Elife, 2023-03-29;12(0):. 2023-03-29 [PMID: 36989136] (Bioassay, Human) |
Bioassay |
Human |
| AM Refaat, M Nakata, A Husain, H Kosako, T Honjo, NA Begum HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression Cell Reports, 2023-03-20;42(3):112284. 2023-03-20 [PMID: 36943867] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Z Wang, J Lauko, AW Kijas, EP Gilbert, P Turunen, R Yegappan, D Zou, J Mata, AE Rowan Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation Nature Communications, 2023-02-23;14(1):1029. 2023-02-23 [PMID: 36823141] (Bioassay, Human) |
Bioassay |
Human |
| S Matsuda, A Revandkar, TD Dubash, A Ravi, BS Wittner, M Lin, R Morris, R Burr, H Guo, K Seeger, A Szabolcs, D Che, L Nieman, GA Getz, DT Ting, MS Lawrence, J Gainor, DA Haber, S Maheswaran TGF-beta in the microenvironment induces a physiologically occurring immune-suppressive senescent state Cell Reports, 2023-02-22;42(3):112129. 2023-02-22 [PMID: 36821441] (Bioassay, Human) |
Bioassay |
Human |
| Y Horii, S Matsuda, C Toyota, T Morinaga, T Nakaya, S Tsuchiya, M Ohmuraya, T Hironaka, R Yoshiki, K Kasai, Y Yamauchi, N Takizawa, A Nagasaka, A Tanaka, H Kosako, M Nakaya VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation Nature Communications, 2023-02-08;14(1):550. 2023-02-08 [PMID: 36754961] (Bioassay, Rat) |
Bioassay |
Rat |
| S Kang, R Yasuhara, R Tokumasu, T Funatsu, K Mishima Adipose-derived mesenchymal stem cells promote salivary duct regeneration via a paracrine effect Journal of oral biosciences, 2023-02-01;0(0):. 2023-02-01 [PMID: 36736698] (Bioassay, Human) |
Bioassay |
Human |
| B Zadran, PD Sudhindar, D Wainwright, Y Bury, S Luli, R Howarth, MV McCain, R Watson, H Huet, F Palinkas, RB Palmini, J Casement, DA Mann, F Oakley, J Lunec, H Reeves, GJ Faulkner, R Shukla Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation British Journal of Cancer, 2023-01-27;0(0):. 2023-01-27 [PMID: 36707636] (Bioassay, Human) |
Bioassay |
Human |
| S Wenhua, T Tsunematsu, M Umeda, H Tawara, N Fujiwara, Y Mouri, R Arakaki, N Ishimaru, Y Kudo Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma Cancer Medicine, 2023-01-23;0(0):. 2023-01-23 [PMID: 36691359] (Bioassay, Human) |
Bioassay |
Human |
| T Hironaka, N Takizawa, Y Yamauchi, Y Horii, M Nakaya The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis The Journal of Biological Chemistry, 2023-01-20;0(0):102934. 2023-01-20 [PMID: 36690273] (Human) |
|
Human |
| SJ Coeyman, Y Zhang, CF Baicu, MR Zile, AD Bradshaw, WJ Richardson In vitro bioreactor for mechanical control and characterization of tissue constructs Journal of biomechanics, 2023-01-18;147(0):111458. 2023-01-18 [PMID: 36682211] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Z Itah, S Chaudhry, S Raju Ponny, O Aydemir, A Lee, J Cavanagh-K, C Tournier, WJ Muller, RJ Davis HER2-driven breast cancer suppression by the JNK signaling pathway Proceedings of the National Academy of Sciences of the United States of America, 2023-01-19;120(4):e2218373120. 2023-01-19 [PMID: 36656864] (Bioassay, Human) |
Bioassay |
Human |
| Y Wang, X Liu, Q Xu, W Xu, X Zhou, Z Lin CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development JCI Insight, 2023-01-10;8(1):. 2023-01-10 [PMID: 36625347] (Bioassay, Human) |
Bioassay |
Human |
| R Wang, AB Bhatt, BA Minden-Bir, OK Travis, S Tiwari, H Jia, W Rosikiewic, O Martinot, E Childs, R Loesch, G Tossou, S Jamieson, D Finkelstei, B Xu, M Labelle ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis Science Advances, 2023-01-06;9(1):eabq3951. 2023-01-06 [PMID: 36608120] (Bioassay, Human) |
Bioassay |
Human |
| R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie IL6 supports long-term expansion of hepatocytes in vitro Nature Communications, 2022-11-29;13(1):7345. 2022-11-29 [PMID: 36446858] (Bioassay, Mouse) |
Bioassay |
Mouse |
| R Varol, Z Karaveliog, S Omeroglu, G Aydemir, A Karadag, HE Meco, AA Demircali, A Yilmaz, GC Kocal, G Gencoglan, ME Oruc, GB Esmer, Y Basbinar, SK Ozdemir, H Uvet Acousto-holographic reconstruction of whole-cell stiffness maps Nature Communications, 2022-11-29;13(1):7351. 2022-11-29 [PMID: 36446776] (Bioassay, Human) |
Bioassay |
Human |
| SMT Rahman, M Aqdas, EW Martin, F Tomassoni, P Songkiatis, KS Oh, S Uderhardt, S Yun, QC Claybourne, RA McDevitt, V Greco, RN Germain, L Tessarollo, MH Sung Double knockin mice show NF-kappaB trajectories in immune signaling and aging Cell Reports, 2022-11-22;41(8):111682. 2022-11-22 [PMID: 36417863] (Bioassay, Transgenic Mouse) |
Bioassay |
Transgenic Mouse |
| Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang, Y Shen, H Gao, X Wu, I Noth, Y Huang, J Liu, X Fan PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis Nature Communications, 2022-11-19;13(1):7114. 2022-11-19 [PMID: 36402779] (Bioassay, Human) |
Bioassay |
Human |
| L Mlakar, SM Garrett, T Watanabe, M Sanderson, T Nishimoto, J Heywood, KL Helke, JM Pilewski, EL Herzog, C Feghali-Bo Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants Biomedicines, 2022-11-09;10(11):. 2022-11-09 [PMID: 36359382] (Cell Culture, Human) |
Cell Culture |
Human |
| S Xu, X Yang, Q Chen, Z Liu, Y Chen, X Yao, A Xiao, J Tian, L Xie, M Zhou, Z Hu, F Zhu, X Xu, F Hou, J Nie Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis EBioMedicine, 2022-11-04;86(0):104312. 2022-11-04 [PMID: 36335669] (Bioassay, Mouse, Rat) |
Bioassay |
Mouse, Rat |
| X Hu, Y Zou, DA Copland, LP Schewitz-B, Y Li, PJP Lait, M Stimpson, Z Zhang, S Guo, J Liang, T Chen, JJ Li, S Yuan, S Li, P Zhou, Y Liu, AD Dick, X Wen, RWJ Lee, L Wei Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2 EBioMedicine, 2022-11-03;86(0):104333. 2022-11-03 [PMID: 36335665] (Bioassay, Mouse, Transgenic Mouse) |
Bioassay |
Mouse, Transgenic Mouse |
| D Cai, SY Chen Nanoparticle endothelial delivery of PGC-1alpha attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling Redox Biology, 2022-10-28;58(0):102524. 2022-10-28 [PMID: 36334380] (Bioassay, Human) |
Bioassay |
Human |
| Q Ye, SJ Taleb, H Wang, NL Parinandi, DJ Kass, M Rojas, C Wang, Q Ma, J Zhao, Y Zhao Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis Biomolecules, 2022-10-21;12(10):. 2022-10-21 [PMID: 36291740] (Cell Culture, Human) |
Cell Culture |
Human |
| VR Herrera Mi, B Canciani, L Mangiavini, JFS Filipe, L Aidos, M Pallaoro, GM Peretti, P Pocar, SC Modina, A Di Giancam Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells Biomedicines, 2022-09-27;10(10):. 2022-09-27 [PMID: 36289678] (Bioassay, Porcine) |
Bioassay |
Porcine |
| SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Human) |
Bioassay |
Human |
| A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis Nature, 2022-10-05;0(0):. 2022-10-05 [PMID: 36198802] (Bioassay, Human) |
Bioassay |
Human |
| K Santerre, S Cortez Ghi, S Proulx TGF-beta-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells Investigative Ophthalmology & Visual Science, 2022-10-03;63(11):3. 2022-10-03 [PMID: 36194422] (Bioassay, Human) |
Bioassay |
Human |
| Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Bioassay, Human) |
Bioassay |
Human |
| Watanabe M, Buth J, Haney J, Vishlaghi N, Turcios F, Elahi L, Gu W, Pearson C, Kurdian A, Baliaouri N, Collier A, Miranda O, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark A, Plath K, Christofk H, Kornblum H, Gandal M, Novitch B TGFbeta superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports, 2022-09-29;17(10):2220-2238. 2022-09-29 [PMID: 36179695] (Bioassay, Human) |
Bioassay |
Human |
| X Li, W Li, Z Zhang, W Wang, H Huang SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease Frontiers in Pharmacology, 2022-09-12;13(0):1007168. 2022-09-12 [PMID: 36172184] (Bioassay, Human) |
Bioassay |
Human |
| WE Jiao, S Xu, YL Qiao, YG Kong, L Sun, YQ Deng, R Yang, ZZ Tao, QQ Hua, SM Chen Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response International immunopharmacology, 2022-09-22;112(0):109261. 2022-09-22 [PMID: 36155282] (Bioassay, Human) |
Bioassay |
Human |
| C Bengtson, N Silswal, N Baumlin, M Yoshida, J Dennis, S Yerrathota, M Kim, M Salathe The CFTR Amplifier Nesolicaftor Rescues TGF-beta1 Inhibition of Modulator-Corrected F508del CFTR Function International Journal of Molecular Sciences, 2022-09-19;23(18):. 2022-09-19 [PMID: 36142862] (Cell Culture, Human) |
Cell Culture |
Human |
| A Martisova, L Sommerova, A Krejci, I Selingerov, T Kolarova, F Zavadil Ko, M Holanek, J Podhorec, T Kazda, R Hrstka Identification of AGR2 Gene-Specific Expression Patterns Associated with Epithelial-Mesenchymal Transition International Journal of Molecular Sciences, 2022-09-16;23(18):. 2022-09-16 [PMID: 36142758] (Bioassay, Human) |
Bioassay |
Human |
| E Gómez-Marí, M Posavec-Ma, L Zarzuela, L Basurto-Ca, JA Guerrero-M, G Arribas, R Yerbes, M Ceballos-C, M Rodríguez-, M Tomé, RV Durán, M Buschbeck, JC Reyes The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFbeta and Hippo pathways Nucleic Acids Research, 2022-09-23;50(17):9838-9857. 2022-09-23 [PMID: 36124662] (Bioassay, Transgenic Mouse) |
Bioassay |
Transgenic Mouse |
| T Ohhata, M Suzuki, S Sakai, K Ota, H Yokota, C Uchida, H Niida, M Kitagawa CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles Scientific Reports, 2022-09-15;12(1):15525. 2022-09-15 [PMID: 36109624] (Cell Culture, Human) |
Cell Culture |
Human |
| HJ Lee Therapeutic Potential of the Combination of Pentoxifylline and Vitamin-E in Inflammatory Bowel Disease: Inhibition of Intestinal Fibrosis Journal of Clinical Medicine, 2022-08-12;11(16):. 2022-08-12 [PMID: 36012952] (Bioassay, Human) |
Bioassay |
Human |
| V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins International Journal of Molecular Sciences, 2022-08-17;23(16):. 2022-08-17 [PMID: 36012487] (Stimulation, Human) |
Stimulation |
Human |
| AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Cells, 2022-08-19;11(16):. 2022-08-19 [PMID: 36010663] (Stimulation, Human) |
Stimulation |
Human |
| K Kitsugi, H Noritake, M Matsumoto, T Hanaoka, M Umemura, M Yamashita, S Takatori, J Ito, K Ohta, T Chida, B Ulmasov, BA Neuschwand, T Suda, K Kawata Arg-Gly-Asp-binding integrins activate hepatic stellate cells via the hippo signaling pathway Cellular Signalling, 2022-08-12;99(0):110437. 2022-08-12 [PMID: 35970425] (Bioassay, Human) |
Bioassay |
Human |
| XQ Fang, M Lee, WJ Lim, S Lee, CH Lim, JH Lim PGC1alpha Cooperates with FOXA1 to Regulate Epithelial Mesenchymal Transition through the TCF4-TWIST1 International Journal of Molecular Sciences, 2022-07-26;23(15):. 2022-07-26 [PMID: 35897813] (Bioassay, Human) |
Bioassay |
Human |
| N Ju, H Hayashi, M Shimamura, S Baba, S Yoshida, R Morishita, H Rakugi, H Nakagami Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice Scientific Reports, 2022-07-21;12(1):12474. 2022-07-21 [PMID: 35864207] (Bioassay, Human) |
Bioassay |
Human |
| MC Mezger, C Conzelmann, T Weil, P von Maltit, DPJ Albers, J Münch, T Stamminger, EM Schilling Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression Viruses, 2022-06-15;14(6):. 2022-06-15 [PMID: 35746781] (Bioassay, Human) |
Bioassay |
Human |
| S Sawamura, K Makino, M Ide, S Shimada, I Kajihara, T Makino, M Jinnin, S Fukushima Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis International Journal of Molecular Sciences, 2022-06-18;23(12):. 2022-06-18 [PMID: 35743254] (Bioassay, Human) |
Bioassay |
Human |
| D Thumkeo, S Punyawatth, S Prasongtan, R Matsuura, K Arima, H Nie, R Yamamoto, N Aoyama, H Hamaguchi, S Sugahara, S Takeda, V Charoensaw, A Tanaka, S Sakaguchi, S Narumiya PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment Cell Reports, 2022-06-07;39(10):110914. 2022-06-07 [PMID: 35675777] (Bioassay, Mouse) |
Bioassay |
Mouse |
| DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells Cancers, 2022-05-19;14(10):. 2022-05-19 [PMID: 35626109] (Bioassay, Human) |
Bioassay |
Human |
| X Wang, H Ye, S Yang, X Sha, X Wang, T Zhang, R Chen, W Xiao, H Yang Disulfiram Exerts Antifibrotic and Anti-Inflammatory Therapeutic Effects on Perimysial Orbital Fibroblasts in Graves' Orbitopathy International Journal of Molecular Sciences, 2022-05-09;23(9):. 2022-05-09 [PMID: 35563653] (Bioassay, Human) |
Bioassay |
Human |
| GN Yin, DK Kim, JI Kang, Y Im, DS Lee, AR Han, J Ock, MJ Choi, MH Kwon, A Limanjaya, SB Jung, J Yang, KW Min, J Yun, Y Koh, JE Park, D Hwang, JK Suh, JK Ryu, HM Kim Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function Experimental & Molecular Medicine, 2022-05-13;0(0):. 2022-05-13 [PMID: 35562586] (Bioassay, Human) |
Bioassay |
Human |
| M Wang, S Lin, K Mequanint Electrospun Biodegradable alpha-Amino Acid-Substituted Poly(organophosphazene) Fiber Mats for Stem Cell Differentiation towards Vascular Smooth Muscle Cells Polymers, 2022-04-11;14(8):. 2022-04-11 [PMID: 35458303] (Cell Culture, Human) |
Cell Culture |
Human |
| P Arora, W Li, X Huang, W Yu, R Huang, Q Jiang, C Chen Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs International Journal of Molecular Sciences, 2022-04-06;23(7):. 2022-04-06 [PMID: 35409397] (Cell Culture, Human) |
Cell Culture |
Human |
| YC Chen, HJ Liao, YM Hsu, YS Shen, CH Chang Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model Polymers, 2022-04-05;14(7):. 2022-04-05 [PMID: 35406348] (Differentiation, Differentiation, Human) |
Differentiation, Differentiation |
Human |
| Y Liu, S Chen, L Yu, Y Deng, D Li, X Yu, D Chen, Y Lu, S Liu, R Chen Pemafibrate attenuates pulmonary fibrosis by inhibiting myofibroblast differentiation International immunopharmacology, 2022-04-06;108(0):108728. 2022-04-06 [PMID: 35397395] (Bioassay, Human) |
Bioassay |
Human |
| PM Van Hoose, L Yang, M Kraemer, M Ubele, AJ Morris, SS Smyth Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation Scientific Reports, 2022-04-05;12(1):5664. 2022-04-05 [PMID: 35383201] (Bioassay, Human) |
Bioassay |
Human |
| KE Ying, W Feng, WZ Ying, X Li, D Xing, Y Sun, Y Chen, PW Sanders Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4 Redox Biology, 2022-03-24;52(0):102296. 2022-03-24 [PMID: 35378363] (Cell Culture, Rat) |
Cell Culture |
Rat |
| KI Jeon, A Kumar, KT Wozniak, K Nehrke, KR Huxlin Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation Investigative Ophthalmology & Visual Science, 2022-04-01;63(4):2. 2022-04-01 [PMID: 35377925] (Bioassay, Feline) |
Bioassay |
Feline |
| D Chen, H Tang, H Jiang, L Sun, W Zhao, F Qian ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-beta-Smad2/3 Signaling-Mediated Lung Fibroblast Activation Frontiers in Pharmacology, 2022-03-09;13(0):835979. 2022-03-09 [PMID: 35355726] (Bioassay, Mouse) |
Bioassay |
Mouse |
| V Narayan, JS Barber-Rot, IY Jung, SF Lacey, AJ Rech, MM Davis, WT Hwang, P Lal, EL Carpenter, SL Maude, G Plesa, N Vapiwala, A Chew, M Moniak, RA Sebro, MD Farwell, A Marshall, J Gilmore, L Lledo, K Dengel, SE Church, TD Hether, J Xu, M Gohil, TH Buckingham, SS Yee, VE Gonzalez, I Kulikovska, F Chen, L Tian, K Tien, W Gladney, CL Nobles, HE Raymond, Prostate C, EO Hexner, DL Siegel, FD Bushman, CH June, JA Fraietta, NB Haas PSMA-targeting TGFbeta-insensitive armored CAR T?cells in metastatic castration-resistant prostate cancer: a phase 1 trial Nature Medicine, 2022-03-21;0(0):. 2022-03-21 [PMID: 35314843] (Stimulation, Human) |
Stimulation |
Human |
| S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against T�cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022-02-24;51(0):102274. 2022-02-24 [PMID: 35240537] (Bioassay, Human) |
Bioassay |
Human |
| CJ Brereton, L Yao, ER Davies, Y Zhou, M Vukmirovic, JA Bell, S Wang, RA Ridley, LSN Dean, OG Andriotis, F Conforti, L Brewitz, S Mohammed, T Wallis, A Tavassoli, RM Ewing, A Alzetani, BG Marshall, SV Fletcher, PJ Thurner, A Fabre, N Kaminski, L Richeldi, A Bhaskar, CJ Schofield, M Loxham, DE Davies, Y Wang, MG Jones Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 2022-02-21;11(0):. 2022-02-21 [PMID: 35188460] (Bioassay, Human) |
Bioassay |
Human |
| J Burk, A Sassmann, C Kasper, A Nimptsch, S Schubert Extracellular Matrix Synthesis and Remodeling by Mesenchymal Stromal Cells Is Context-Sensitive International Journal of Molecular Sciences, 2022-02-03;23(3):. 2022-02-03 [PMID: 35163683] (Stimulation, Human) |
Stimulation |
Human |
| M Archer, P Dasari, D Walsh, KL Britt, A Evdokiou, WV Ingman Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density Journal of Clinical Medicine, 2022-02-02;11(3):. 2022-02-02 [PMID: 35160252] (Bioassay, Human) |
Bioassay |
Human |
| Q Yuan, Q Ren, L Li, H Tan, M Lu, Y Tian, L Huang, B Zhao, H Fu, FF Hou, L Zhou, Y Liu A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling Nature Communications, 2022-01-21;13(1):438. 2022-01-21 [PMID: 35064106] (Bioassay, Rat) |
Bioassay |
Rat |
| YH Chen, RH Liu, YZ Cui, A Hettinghou, WY Fu, L Zhang, C Zhang, CJ Liu Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases Arthritis Research & Therapy, 2022-01-19;24(1):27. 2022-01-19 [PMID: 35045889] (Bioassay, Mouse) |
Bioassay |
Mouse |
| YJ Park, DM Kim, HB Choi, MH Jeong, SH Kwon, HR Kim, JH Kwak, KH Chung Dendropanoxide, a Triterpenoid from Dendropanax morbifera, Ameliorates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells through Autophagy Inhibition Nutrients, 2021-12-27;14(1):. 2021-12-27 [PMID: 35010975] (Bioassay, Human) |
Bioassay |
Human |
| Q Ding, Q Wei, G Sheng, S Wang, S Jing, T Ma, R Zhang, T Wang, W Li, X Tang, H Wu, C Liu The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy Frontiers in Pharmacology, 2021-12-16;12(0):774316. 2021-12-16 [PMID: 34975478] (Bioassay, Human) |
Bioassay |
Human |
| J Li, B Xu, M He, X Zong, T Cunningham, C Sha, Y Fan, R Cross, JH Hanna, Y Feng Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation Cell Reports, 2021-12-14;37(11):110124. 2021-12-14 [PMID: 34910919] (Bioassay, Mouse, Transgenic Mouse) |
Bioassay |
Mouse, Transgenic Mouse |
| W Cheng, HL Li, SY Xi, XF Zhang, Y Zhu, Le Xing, YX Mo, MM Li, FE Kong, WJ Zhu, XG Chen, HQ Cui, ZM Cao, YF Gong, YQ Tang, Y Zhang, XY Guan, NF Ma, M Liu Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma Nature Communications, 2021-12-08;12(1):7142. 2021-12-08 [PMID: 34880251] (Bioassay, Human) |
Bioassay |
Human |
| PM Munne, L Martikaine, I Räty, K Bertula, Nonappa, J Ruuska, H Ala-Hongis, A Peura, B Hollmann, L Euro, K Yavuz, L Patrikaine, M Salmela, J Pokki, M Kivento, J Väänänen, T Suomi, L Nevalaita, M Mutka, P Kovanen, M Leidenius, T Meretoja, K Hukkinen, O Monni, J Pouwels, B Sahu, J Mattson, H Joensuu, P Heikkilä, LL Elo, C Metcalfe, MR Junttila, O Ikkala, J Klefström Compressive stress-mediated p38 activation required for ERalpha?+?phenotype in breast cancer Nature Communications, 2021-11-29;12(1):6967. 2021-11-29 [PMID: 34845227] (Bioassay, Human) |
Bioassay |
Human |
| HM Shen, R Wuerffel, JF Cantillo, S Priyadarsh, X Lei, J Liang, YL Wu, AL Kenter Loop extrusion promotes an alternate pathway for isotype switching Cell Reports, 2021-11-23;37(8):110059. 2021-11-23 [PMID: 34818547] (Bioassay, Mouse) |
Bioassay |
Mouse |
| V Janbandhu, V Tallapraga, R Patrick, Y Li, D Abeygunawa, DT Humphreys, EMMA Martin, AO Ward, O Contreras, N Farbehi, E Yao, J Du, SL Dunwoodie, N Bursac, RP Harvey Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction Cell Stem Cell, 2021-11-10;0(0):. 2021-11-10 [PMID: 34762860] (Bioassay, Mouse) |
Bioassay |
Mouse |
| SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021-11-09;16(11):e0248034. 2021-11-09 [PMID: 34752458] (Bioassay, Human) |
Bioassay |
Human |
| P Prakhar, J Alvarez-De, H Keller, A Crossman, X Tai, YK Park, JH Park The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function JCI Insight, 2021-11-08;6(21):. 2021-11-08 [PMID: 34747370] (Bioassay, Mouse) |
Bioassay |
Mouse |
| MI Matias, CS Yong, A Foroushani, C Goldsmith, C Mongellaz, E Sezgin, KR Levental, A Talebi, J Perrault, A Rivière, J Dehairs, O Delos, J Bertand-Mi, JC Portais, M Wong, JC Marie, A Kelekar, S Kinet, VS Zimmermann, I Levental, L Yvan-Charv, JV Swinnen, SA Muljo, H Hernandez-, S Tardito, N Taylor, V Dardalhon Regulatory T�cell differentiation is controlled by alphaKG-induced alterations in mitochondrial metabolism and lipid homeostasis Cell Reports, 2021-11-02;37(5):109911. 2021-11-02 [PMID: 34731632] (Bioassay, Human) |
Bioassay |
Human |
| NM Wong, E Frias, FD Sigoillot, JH Letendre, M Hild, WW Wong Engineering digitizer circuits for chemical and genetic screens in human cells Nature Communications, 2021-10-22;12(1):6150. 2021-10-22 [PMID: 34686672] (Bioassay, Human) |
Bioassay |
Human |
| L Salvadori, S Chiappalup, I Arato, F Mancuso, M Calvitti, MC Marchetti, F Riuzzi, R Calafiore, G Luca, G Sorci Sertoli Cells Improve Myogenic Differentiation, Reduce Fibrogenic Markers, and Induce Utrophin Expression in Human DMD Myoblasts Biomolecules, 2021-10-12;11(10):. 2021-10-12 [PMID: 34680138] (Bioassay, Mouse) |
Bioassay |
Mouse |
| E Håland, IN Moen, E Veidal, H Hella, K Misund, TS Slørdahl, KK Starheim TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Oncotarget, 2021-10-12;12(21):2158-2168. 2021-10-12 [PMID: 34676048] (Cell Culture, Human) |
Cell Culture |
Human |
| M Bruschi, E La Porta, I Panfoli, G Candiano, A Petretto, E Vidal, X Kajana, M Bartolucci, S Granata, GM Ghiggeri, G Zaza, E Verrina Proteomic profile of mesothelial exosomes isolated from peritoneal dialysis effluent of children with focal segmental glomerulosclerosis Scientific Reports, 2021-10-21;11(1):20807. 2021-10-21 [PMID: 34675284] (Cell Culture, Human) |
Cell Culture |
Human |
| RE Carlisle, Z Mohammed-A, C Lu, T Yousof, V Tat, S Nademi, ME MacDonald, RC Austin, JG Dickhout TDAG51 induces renal interstitial fibrosis through modulation of TGF-beta receptor 1 in chronic kidney disease Cell Death & Disease, 2021-10-08;12(10):921. 2021-10-08 [PMID: 34625532] (Cell Culture, Human) |
Cell Culture |
Human |
| P Jiang, Y Zhang, B Ru, Y Yang, T Vu, R Paul, A Mirza, G Altan-Bonn, L Liu, E Ruppin, L Wakefield, KW Wucherpfen Systematic investigation of cytokine signaling activity at the tissue and single-cell levels Nature methods, 2021-09-30;18(10):1181-1191. 2021-09-30 [PMID: 34594031] (Bioassay, Human) |
Bioassay |
Human |
| MH Shihan, SG Novo, Y Wang, D Sheppard, A Atakilit, TD Arnold, NM Rossi, AP Faranda, MK Duncan alphaVbeta8 integrin targeting to prevent posterior capsular opacification (PCO) JCI Insight, 2021-11-08;0(0):. 2021-11-08 [PMID: 34554928] (In Vivo, Mouse) |
In Vivo |
Mouse |
| X Chi, W Jin, X Bai, X Zhao, J Shao, J Li, Q Sun, B Su, X Wang, XO Yang, C Dong RORalpha is critical for mTORC1 activity in T�cell-mediated colitis Cell Reports, 2021-09-14;36(11):109682. 2021-09-14 [PMID: 34525365] (Bioassay, Human) |
Bioassay |
Human |
| L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease Brain, Behavior, and Immunity, 2021-09-06;98(0):337-348. 2021-09-06 [PMID: 34500034] (Bioassay, Mouse) |
Bioassay |
Mouse |
| I Malenica, J Adam, S Corgnac, L Mezquita, E Auclin, I Damei, L Grynszpan, G Gros, V de Montpré, D Planchard, N Théret, B Besse, F Mami-Choua Integrin-alphaV-mediated activation of TGF-beta regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade Nature Communications, 2021-09-01;12(1):5209. 2021-09-01 [PMID: 34471106] (Cell Culture, Human) |
Cell Culture |
Human |
| T Bluhmki, S Traub, AK Müller, S Bitzer, E Schruf, MT Bammert, M Leist, F Gantner, JP Garnett, R Heilker Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96?Transwell air-liquid interface model Scientific Reports, 2021-08-23;11(1):17028. 2021-08-23 [PMID: 34426605] (Bioassay, Human) |
Bioassay |
Human |
| AG Kunihiro, JA Brickey, JB Frye, JN Cheng, PB Luis, C Schneider, JL Funk Curcumin Inhibition of TGFbeta signaling in bone metastatic breast cancer cells and the possible role of oxidative metabolites The Journal of nutritional biochemistry, 2021-08-15;0(0):108842. 2021-08-15 [PMID: 34407450] (Bioassay, Human) |
Bioassay |
Human |
| J Lee, JA Choi, HH Ju, JE Kim, SY Paik, PV Rao Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells Scientific Reports, 2021-07-22;11(1):14950. 2021-07-22 [PMID: 34294770] (Bioassay, Human) |
Bioassay |
Human |
| T Katsuyama, VR Moulton Splicing factor SRSF1 is indispensable for regulatory T�cell homeostasis and function Cell Reports, 2021-07-06;36(1):109339. 2021-07-06 [PMID: 34233194] (Bioassay, Mouse) |
Bioassay |
Mouse |
| A Kumar-Sing, MM Parniewska, N Giotopoulo, J Javadi, W Sun, T Szatmári, K Dobra, A Hjerpe, J Fuxe Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells Biology, 2021-06-11;10(6):. 2021-06-11 [PMID: 34208075] (Bioassay, Human) |
Bioassay |
Human |
| L Zhang, J Chen, L Yan, Q He, H Xie, M Chen Resveratrol Ameliorates Cardiac Remodeling in a Murine Model of Heart Failure With Preserved Ejection Fraction Frontiers in Pharmacology, 2021-06-10;12(0):646240. 2021-06-10 [PMID: 34177571] (Bioassay, Mouse) |
Bioassay |
Mouse |
| L Sun, X Zhao, X Liu, B Zhong, H Tang, W Jin, H Clevers, H Wang, X Wang, C Dong Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription Cell Reports, 2021-06-01;35(9):109188. 2021-06-01 [PMID: 34077723] (Bioassay, Mouse) |
Bioassay |
Mouse |
| S Naik, AR Wood, M Ongenaert, P Saidiyan, ED Elstak, HL Lanz, J Stallen, R Janssen, E Smythe, KS Erdmann A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy International Journal of Molecular Sciences, 2021-05-19;22(10):. 2021-05-19 [PMID: 34069732] (Bioassay, Human) |
Bioassay |
Human |
| HJ Kang, KJ Lee, J Woo, J Kim, YK Kim, CH Lee, CG Yoo, KH Lee Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase &alpha1 Experimental & Molecular Medicine, 2021-05-17;0(0):. 2021-05-17 [PMID: 34002012] (Bioassay, Human) |
Bioassay |
Human |
| V Zyulina, KK Yan, B Ju, E Schwarzenb, C Passegger, C Tam-Amersd, Q Pan, T Sconocchia, C Pollack, B Shaner, A Zebisch, J Easton, J Yu, JM Silva, H Strobl The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-&beta signaling Cell Reports, 2021-04-27;35(4):109049. 2021-04-27 [PMID: 33910004] (Bioassay, Human) |
Bioassay |
Human |
| X Zhu, Y Du, D Li, J Xu, Q Wu, W He, K Zhang, J Zhu, L Guo, M Qi, A Liu, J Qi, G Wang, J Meng, Z Yang, K Zhang, Y Lu Aberrant TGF-&beta1 signaling activation by MAF underlies pathological lens growth in high myopia Nature Communications, 2021-04-08;12(1):2102. 2021-04-08 [PMID: 33833231] (Cell Culture, Human) |
Cell Culture |
Human |
| A Tellegen, M Beukers, I Rudnik-Jan, N van Klaver, KL How, N Woike, G Mihov, J Thies, E Teske, L Creemers, M Tryfonidou, B Meij Intra-Articular Slow-Release Triamcinolone Acetonide from Polyesteramide Microspheres as a Treatment for Osteoarthritis Pharmaceutics, 2021-03-11;13(3):. 2021-03-11 [PMID: 33799665] (Canine) |
|
Canine |
| X Zhou, LJ Backman, P Danielson Activation of NF-&kapppaB signaling via cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA common deletion Scientific Reports, 2021-04-01;11(1):7360. 2021-04-01 [PMID: 33795727] (Bioassay, Human) |
Bioassay |
Human |
| Li Q, Ming Y, Jia H, Wang G Poricoic acid A suppresses TGF-beta1-induced renal fibrosis and proliferation via the PDGF-C, Smad3 and MAPK pathways. Exp Ther Med, 2021-01-27;21(4):289. 2021-01-27 [PMID: 33717232] (Bioassay, Rat) |
Bioassay |
Rat |
| J Calder, A Nagelberg, J Luu, D Lu, WW Lockwood Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4 Oncogenesis, 2021-03-12;10(3):27. 2021-03-12 [PMID: 33712563] (Bioassay, Human) |
Bioassay |
Human |
| MR Patel, AM Weaver Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-&beta signaling Cell Reports, 2021-03-09;34(10):108829. 2021-03-09 [PMID: 33691102] (Bioassay, Rat) |
Bioassay |
Rat |
| RB Bressan, B Southgate, KM Ferguson, C Blin, V Grant, N Alfazema, JC Wills, MA Marques-To, GM Morrison, J Ashmore, F Robertson, CAC Williams, L Bradley, A von Kriegs, RA Anderson, SR Tomlinson, SM Pollard Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants Cell Stem Cell, 2021-02-24;0(0):. 2021-02-24 [PMID: 33631116] (Bioassay, Human) |
Bioassay |
Human |
| D Wang, N Rabhi, SF Yet, SR Farmer, MD Layne Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A Scientific Reports, 2021-02-17;11(1):3948. 2021-02-17 [PMID: 33597582] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Y Jiang, Y Dong, Y Luo, S Jiang, FL Meng, M Tan, J Li, Y Zang AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ Cell Reports, 2021-02-16;34(7):108713. 2021-02-16 [PMID: 33596428] (Bioassay, Mouse) |
Bioassay |
Mouse |
| C Türlü, N Willumsen, D Marando, P Schjerling, E Biskup, J Hannibal, LN Jorgensen, MS Ågren A Human Cellular Model for Colorectal Anastomotic Repair: The Effect of Localization and Transforming Growth Factor-&beta1 Treatment on Collagen Deposition and Biomarkers International Journal of Molecular Sciences, 2021-02-05;22(4):. 2021-02-05 [PMID: 33562728] (Bioassay, Human) |
Bioassay |
Human |
| KJG Kenswil, P Pisterzi, G Sánchez-Du, C van Dijk, A Lolli, C Knuth, B Vanchin, AC Jaramillo, RM Hoogenboez, MA Sanders, J Feyen, T Cupedo, IG Costa, R Li, EMJ Bindels, K Lodder, B Blom, PK Bos, MJ Goumans, P Ten Dijke, E Farrell, G Krenning, MHGP Raaijmaker Endothelium-derived stromal cells contribute to hematopoietic bone marrow niche formation Cell Stem Cell, 2021-02-08;0(0):. 2021-02-08 [PMID: 33561425] (Bioassay, Human) |
Bioassay |
Human |
| S Jadhav, S Tripathi, A Chandrekar, SS Waikar, LL Hsiao A novel antibody for the detection of alternatively spliced secreted KLOTHO isoform in human plasma PLoS ONE, 2021-01-22;16(1):e0245614. 2021-01-22 [PMID: 33481901] (ELISA Capture, Human) |
ELISA Capture |
Human |
| J Behary, N Amorim, XT Jiang, A Raposo, L Gong, E McGovern, R Ibrahim, F Chu, C Stephens, H Jebeili, V Fragomeli, YC Koay, M Jackson, J O'Sullivan, M Weltman, G McCaughan, E El-Omar, A Zekry Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma Nature Communications, 2021-01-08;12(1):187. 2021-01-08 [PMID: 33420074] (Bioassay, Human) |
Bioassay |
Human |
| X Fan, Y Gao, X Zhang, HY Lughmani, DJ Kennedy, ST Haller, SV Pierre, JI Shapiro, J Tian A strategic expression method of miR-29b and its anti-fibrotic effect based on RNA-sequencing analysis PLoS ONE, 2020-12-17;15(12):e0244065. 2020-12-17 [PMID: 33332475] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| A Claveria-C, L Colyn, I Uriarte, MU Latasa, M Arechederr, JM Herranz, L Alvarez, JM Urman, ML Martinez-C, JM Banales, B Sangro, K Rombouts, J Oyarzabal, JJG Marin, C Berasain, MA Avila, MG Fernandez- Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis Cancers, 2020-12-13;12(12):. 2020-12-13 [PMID: 33322158] (Cell Culture, Human) |
Cell Culture |
Human |
| J Kim, W Kang, SH Kang, SH Park, JY Kim, S Yang, SY Ha, YH Paik Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis Scientific Reports, 2020-12-03;10(1):21018. 2020-12-03 [PMID: 33273492] (Cell Culture, Human, Mouse) |
Cell Culture |
Human, Mouse |
| JA Guerrero-M, M Ceballos-C, F Koehler, S Peiró, JC Reyes TGF&beta promotes widespread enhancer chromatin opening and operates on genomic regulatory domains Nature Communications, 2020-12-03;11(1):6196. 2020-12-03 [PMID: 33273453] (Cell Culture, Human) |
Cell Culture |
Human |
| T Li, X Weng, S Cheng, D Wang, G Cheng, H Gao, Y Li Wnt3a upregulation is involved in TGF&beta1-induced cardiac hypertrophy Cytokine, 2020-11-23;0(0):155376. 2020-11-23 [PMID: 33243628] (Cell Culture, Rat) |
Cell Culture |
Rat |
| Y Koike, M Yozaki, A Utani, H Murota Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process Sci Rep, 2020-10-29;10(1):18545. 2020-10-29 [PMID: 33122782] (Cell Culture, Human) |
Cell Culture |
Human |
| S Li, M Liu, MH Do, C Chou, EG Stamatiade, BG Nixon, W Shi, X Zhang, P Li, S Gao, KJ Capistrano, H Xu, NV Cheung, MO Li Cancer immunotherapy via targeted TGF-&beta signalling blockade in TH cells Nature, 2020-10-21;0(0):. 2020-10-21 [PMID: 33087933] (Mouse) |
|
Mouse |
| X Fu, L Hong, Z Yang, Y Tu, W Xin, M Zha, S Tu, G Sun, Y Li, W Xiao MicroRNA-148a-3p suppresses epithelial-to-mesenchymal transition and stemness properties via Wnt1-mediated Wnt/&beta-catenin pathway in pancreatic cancer J Cell Mol Med, 2020-10-07;0(0):. 2020-10-07 [PMID: 33026174] (Cell Culture, Human) |
Cell Culture |
Human |
| F Chen, Q Gao, A Wei, X Chen, Y Shi, H Wang, W Cao Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis Cell Death Differ, 2020-10-06;0(0):. 2020-10-06 [PMID: 33024274] (Bioassay, Human) |
Bioassay |
Human |
| SB Chia, JD Nolin, R Aboushoush, C Erikson, CG Irvin, ME Poynter, J van der Ve, DJ Taatjes, A van der Vl, V Anathy, YMW Janssen-He Glutaredoxin deficiency promotes activation of the transforming growth factor beta pathway in airway epithelial cells, in association with fibrotic airway remodeling Redox Biol, 2020-09-14;37(0):101720. 2020-09-14 [PMID: 32971362] (Bioassay, Mouse) |
Bioassay |
Mouse |
| S Khazaei, N De Jay, S Deshmukh, LD Hendrikse, W Jawhar, CCL Chen, LG Mikael, D Faury, DM Marchione, J Lanoix, É Bonneil, T Ishii, SU Jain, K Rossokhata, TS Sihota, R Eveleigh, V Lisi, AS Harutyunya, S Jung, J Karamchand, BC Dickson, R Turcotte, JS Wunder, P Thibault, PW Lewis, BA Garcia, SC Mack, MD Taylor, L Garzia, CL Kleinman, N Jabado H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Cancer Discovery, 2020-09-23;10(12):1968-1987. 2020-09-23 [PMID: 32967858] (Bioassay, Human) |
Bioassay |
Human |
| MV Guijarro, LS Danielson, M Cañamero, A Nawab, C Abrahan, E Hernando, GD Palmer Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells Cells, 2020-09-10;9(9):. 2020-09-10 [PMID: 32927859] (Bioassay, Human) |
Bioassay |
Human |
| W Wang, D Douglas, J Zhang, S Kumari, MS Enuameh, Y Dai, CT Wallace, SC Watkins, W Shu, J Xing Live-cell imaging and analysis reveal cell phenotypic transition dynamics inherently missing in snapshot data Science Advances, 2020-09-04;6(36):. 2020-09-04 [PMID: 32917609] (Bioassay, Human) |
Bioassay |
Human |
| F Ito, I Yanatori, Y Maeda, K Nimura, S Ito, T Hirayama, H Nagasawa, N Kohyama, Y Okazaki, S Akatsuka, S Toyokuni Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium Redox Biol, 2020-06-24;36(0):101616. 2020-06-24 [PMID: 32863225] (Bioassay, Human) |
Bioassay |
Human |
| T Bluhmki, S Bitzer, JA Gindele, E Schruf, T Kiechle, M Webster, J Schymeinsk, R Ries, F Gantner, D Bischoff, J Garnett, R Heilker Development of a miniaturized 96-Transwell air-liquid interface human small airway epithelial model Sci Rep, 2020-08-03;10(1):13022. 2020-08-03 [PMID: 32747751] (Bioassay, Human) |
Bioassay |
Human |
| J Fan, W Shen, SR Lee, AE Mathai, R Zhang, G Xu, MC Gillies Targeting the Notch and TGF-&beta signaling pathways to prevent retinal fibrosis in vitro and in vivo Theranostics, 2020-06-29;10(18):7956-7973. 2020-06-29 [PMID: 32724452] (Bioassay, Human) |
Bioassay |
Human |
| C Zogbi, NC Oliveira, D Levy, SP Bydlowski, V Bassaneze, EA Neri, JE Krieger Beneficial effects of IL-4 and IL-6 on rat neonatal target cardiac cells Sci Rep, 2020-07-23;10(1):12350. 2020-07-23 [PMID: 32704142] (Bioassay, Rat) |
Bioassay |
Rat |
| F Ma, H Hao, X Gao, Y Cai, J Zhou, P Liang, J Lv, Q He, C Shi, D Hu, B Chen, L Zhu, X Xiao, S Li Melatonin ameliorates necrotizing enterocolitis by preventing Th17/Treg imbalance through activation of the AMPK/SIRT1 pathway Theranostics, 2020-06-19;10(17):7730-7746. 2020-06-19 [PMID: 32685016] (Bioassay, Human) |
Bioassay |
Human |
| MND Svensson, M Zoccheddu, S Yang, G Nygaard, C Secchi, KM Doody, K Slowikowsk, F Mizoguchi, F Humby, R Hands, E Santelli, C Sacchetti, K Wakabayash, DJ Wu, C Barback, R Ai, W Wang, GP Sims, P Mydel, T Kasama, DL Boyle, F Galimi, D Vera, ML Tremblay, S Raychaudhu, MB Brenner, GS Firestein, C Pitzalis, AH Ekwall, SM Stanford, N Bottini Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal Sci Adv, 2020-06-26;6(26):eaba4353. 2020-06-26 [PMID: 32637608] (Bioassay, Mouse) |
Bioassay |
Mouse |
| A Fujiwara, S Funaki, E Fukui, K Kimura, T Kanou, N Ose, M Minami, Y Shintani Effects of pirfenidone targeting the tumor microenvironment and tumor-stroma interaction as a novel treatment for non-small cell lung cancer Sci Rep, 2020-07-02;10(1):10900. 2020-07-02 [PMID: 32616870] (Cell Culture, Human) |
Cell Culture |
Human |
| J Yan, SP Pandey, BJ Barnes, JR Turner, C Abraham T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Cell Rep, 2020-06-30;31(13):107820. 2020-06-30 [PMID: 32610123] (Bioassay, Human) |
Bioassay |
Human |
| H Chen, SX Guo, S Zhang, XD Li, H Wang, XW Li MiRNA-620 promotes TGF-beta1-induced proliferation of airway smooth muscle cell through controlling PTEN/AKT signaling pathway Kaohsiung J. Med. Sci., 2020-06-24;0(0):. 2020-06-24 [PMID: 32583575] (Bioassay, Human) |
Bioassay |
Human |
| C Yang, HL Wu, ZH Li, XC Chen, HY Su, XY Guo, N An, KP Jing, QJ Pan, HF Liu Autophagy Inhibition Sensitizes Renal Tubular Epithelial Cell to G1 Arrest Induced by Transforming Growth Factor beta (TGF-beta) Med. Sci. Monit., 2020-06-07;26(0):e922673. 2020-06-07 [PMID: 32555132] (Bioassay, Human) |
Bioassay |
Human |
| J Wu, D Song, Z Li, B Guo, Y Xiao, W Liu, L Liang, C Feng, T Gao, Y Chen, Y Li, Z Wang, J Wen, S Yang, P Liu, L Wang, Y Wang, L Peng, GN Stacey, Z Hu, G Feng, W Li, Y Huo, R Jin, N Shyh-Chang, Q Zhou, L Wang, B Hu, H Dai, J Hao Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis Cell Res., 2020-06-16;0(0):. 2020-06-16 [PMID: 32546764] (Bioassay, Human) |
Bioassay |
Human |
| TT Ross, C Crowley, KL Kelly, A Rinaldi, DA Beebe, MP Lech, RV Martinez, S Carvajal-G, M Boucher, D Hirenallur, J Morin, AC Opsahl, SR Vargas, KK Bence, JA Pfefferkor, WP Esler Acetyl-CoA Carboxylase inhibition improves multiple dimensions of NASH pathogenesis in model systems Cell Mol Gastroenterol Hepatol, 2020-06-09;0(0):. 2020-06-09 [PMID: 32526482] (Bioassay, Human) |
Bioassay |
Human |
| H Zhao, G Yan, L Zheng, Y Zhou, H Sheng, L Wu, Q Zhang, J Lei, J Zhang, R Xin, L Jiang, X Zhang, Y Chen, J Wang, Y Xu, D Li, Y Li STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma Theranostics, 2020-05-16;10(14):6483-6499. 2020-05-16 [PMID: 32483465] (Bioassay, Human) |
Bioassay |
Human |
| K Watanabe, Y Taketomi, Y Miki, K Kugiyama, M Murakami Group V secreted phospholipase A2 plays a protective role against aortic dissection J. Biol. Chem., 2020-06-01;295(30):10092-10111. 2020-06-01 [PMID: 32482892] (Cell Culture, Human) |
Cell Culture |
Human |
| DP Cook, BC Vanderhyde Context specificity of the EMT transcriptional response Nat Commun, 2020-05-01;11(1):2142. 2020-05-01 [PMID: 32358524] (Cell Culture, Human) |
Cell Culture |
Human |
| QM Nhu, L Hsieh, L Dohil, R Dohil, RO Newbury, R Kurten, FJ Moawad, SS Aceves Antifibrotic Effects of the Thiazolidinediones in Eosinophilic Esophagitis Pathologic Remodeling: A Preclinical Evaluation Clin Transl Gastroenterol, 2020-04-01;11(4):e00164. 2020-04-01 [PMID: 32352681] (Cell Culture, Human) |
Cell Culture |
Human |
| BR Maharjan, SV McLennan, SM Twigg, PF Williams The effect of TGFbeta1 on thermogenic markers is dependent on the degree of adipocyte differentiation Biosci. Rep., 2020-05-29;40(5):. 2020-05-29 [PMID: 32352511] (Bioassay, Mouse) |
Bioassay |
Mouse |
| IS Kang, JS Jang, C Kim Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation Sci Rep, 2020-04-27;10(1):7024. 2020-04-27 [PMID: 32341385] (Bioassay, Human) |
Bioassay |
Human |
| Á Torres, K Muñoz, Y Nahuelpán, AP R Saez, P Mendoza, C Jara, C Cappelli, R Suarez, C Oyarzún, C Quezada, R San Martín Intraglomerular Monocyte/Macrophage Infiltration and Macrophage-Myofibroblast Transition during Diabetic Nephropathy Is Regulated by the A2B Adenosine Receptor Cells, 2020-04-23;9(4):. 2020-04-23 [PMID: 32340145] (Bioassay, Human) |
Bioassay |
Human |
| W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice Sci Rep, 2020-04-24;10(1):7004. 2020-04-24 [PMID: 32332865] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| AM Steitz, A Steffes, F Finkernage, A Unger, L Sommerfeld, JM Jansen, U Wagner, J Graumann, R Müller, S Reinartz Tumor-associated macrophages promote ovarian cancer cell migration by secreting transforming growth factor beta induced (TGFBI) and tenascin C Cell Death Dis, 2020-04-20;11(4):249. 2020-04-20 [PMID: 32312959] (Bioassay, Human) |
Bioassay |
Human |
| X Xie, G Urabe, L Marcho, C Williams, LW Guo, KC Kent Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5' Untranslated Region J Am Heart Assoc, 2020-04-19;9(8):e015487. 2020-04-19 [PMID: 32306814] (Bioassay, Human) |
Bioassay |
Human |
| SS Beauford, A Kumari, C Garnett-Be Ionizing radiation modulates the phenotype and function of human CD4+ induced regulatory T cells BMC Immunol., 2020-04-16;21(1):18. 2020-04-16 [PMID: 32299365] (Differentiation, Differentiation, Human) |
Differentiation, Differentiation |
Human |
| YH Wang, FM Suk, CL Liu, TL Chen, YC Twu, MH Hsu, YJ Liao Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-&kappaB Signaling Pathway in Hepatic Stellate Cells Front Pharmacol, 2020-03-31;11(0):388. 2020-03-31 [PMID: 32296336] (Cell Culture, Human) |
Cell Culture |
Human |
| T Hurrell, V Kastrinou-, A Fardellas, DFG Hendriks, Å Nordling, I Johansson, A Baze, C Parmentier, L Richert, M Ingelman-S Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis Cells, 2020-04-14;9(4):. 2020-04-14 [PMID: 32295224] (Bioassay, Human) |
Bioassay |
Human |
| M Liu, Y Xiao, W Tang, J Li, L Hong, W Dai, W Zhang, Y Peng, X Wu, J Wang, Y Chen, Y Bai, J Lin, Q Yang, Y Wang, Z Lin, S Liu, J Xiong, J Wang, L Xiang HOXD9 promote epithelial-mesenchymal transition and metastasis in colorectal carcinoma Cancer Med, 2020-04-12;0(0):. 2020-04-12 [PMID: 32281284] (Human) |
|
Human |
| HY Seo, SH Lee, JH Lee, YN Kang, JS Hwang, KG Park, MK Kim, BK Jang Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connetive Tissue Growth Factor Cells, 2020-02-27;9(3):. 2020-02-27 [PMID: 32120837] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| M Riedl, C Witzmann, M Koch, S Lang, M Kerschbaum, F Baumann, W Krutsch, D Docheva, V Alt, C Pfeifer Attenuation of Hypertrophy in Human MSCs via Treatment with a Retinoic Acid Receptor Inverse Agonist Int J Mol Sci, 2020-02-20;21(4):. 2020-02-20 [PMID: 32093330] (Cell Culture, Human) |
Cell Culture |
Human |
| Y Lee, J Lee, SK Nam, Y Hoon Jun S-endoglin expression is induced in hyperoxia and contributes to altered pulmonary angiogenesis in bronchopulmonary dysplasia development Sci Rep, 2020-02-20;10(1):3043. 2020-02-20 [PMID: 32080296] (Bioassay, Human) |
Bioassay |
Human |
| H Yin, L Kalra, Z Lai, MC Guimaro, L Aber, BM Warner, D Michael, N Zhang, J Cabrera-Pe, A Karim, WD Swaim, S Afione, A Voigt, CQ Nguyen, PB Yu, DB Bloch, JA Chiorini Inhibition of bone morphogenetic protein 6 receptors ameliorates Sj�gren's syndrome in mice Sci Rep, 2020-02-19;10(1):2967. 2020-02-19 [PMID: 32076051] (Bioassay, Human) |
Bioassay |
Human |
| R Fonseca, LK Beura, CF Quarnstrom, HE Ghoneim, Y Fan, CC Zebley, MC Scott, NJ Fares-Fred, S Wijeyesing, EA Thompson, H Borges da, V Vezys, B Youngblood, D Masopust Developmental plasticity allows outside-in immune responses by resident memory T cells Nat. Immunol., 2020-02-17;0(0):. 2020-02-17 [PMID: 32066954] (Cell Culture, Human) |
Cell Culture |
Human |
| G Du, J Wang, T Zhang, Q Ding, X Jia, X Zhao, J Dong, X Yang, S Lu, C Zhang, Z Liu, Z Zeng, R Safadi, R Qi, X Zhao, Z Hong, Y Lu Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo Cell Death Dis, 2020-02-12;11(2):118. 2020-02-12 [PMID: 32051399] (Bioassay, Human, Mouse, Rat) |
Bioassay |
Human, Mouse, Rat |
| T Miyake, A Aziz, JC McDermott Maintenance of the Undifferentiated State in Myogenic Progenitor Cells by TGFbeta Signaling is Smad Independent and Requires MEK Activation Int J Mol Sci, 2020-02-05;21(3):. 2020-02-05 [PMID: 32033454] (Bioassay, Mouse) |
Bioassay |
Mouse |
| D Parate, ND Kadir, C Celik, EH Lee, JHP Hui, A Franco-Obr, Z Yang Pulsed electromagnetic fields potentiate the paracrine function of mesenchymal stem cells for cartilage regeneration Stem Cell Res Ther, 2020-02-03;11(1):46. 2020-02-03 [PMID: 32014064] (Cell Culture, Human) |
Cell Culture |
Human |
| LK Senavirath, C Huang, S Pushparaj, D Xu, L Liu Hypoxia and transforming growth factor &beta1 regulation of long non-coding RNA transcriptomes in human pulmonary fibroblasts Physiol Rep, 2020-01-01;8(1):e14343. 2020-01-01 [PMID: 31925944] (Bioassay, Human) |
Bioassay |
Human |
| R Xu, RK Shears, R Sharma, M Krishna, C Webb, R Ali, X Wei, A Kadioglu, Q Zhang IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue Mucosal Immunol, 2020-01-02;13(3):460-470. 2020-01-02 [PMID: 31896761] (Cell Culture, Human) |
Cell Culture |
Human |
| YZ Huang, CG Wu, HQ Xie, ZY Li, A Silini, O Parolini, Y Wu, L Deng, YC Huang Strontium Promotes the Proliferation and Osteogenic Differentiation of Human Placental Decidual Basalis- and Bone Marrow-Derived MSCs in a Dose-Dependent Manner Stem Cells Int, 2019-11-22;2019(0):4242178. 2019-11-22 [PMID: 31885606] (Bioassay, Human) |
Bioassay |
Human |
| L Andersen, AF Gülich, M Alteneder, T Preglej, MJ Orola, N Dhele, V Stolz, A Schebesta, P Hamminger, A Hladik, S Floess, T Krausgrube, T Faux, SBA Andrabi, J Huehn, S Knapp, T Sparwasser, C Bock, A Laiho, LL Elo, O Rasool, R Lahesmaa, S Sakaguchi, W Ellmeier The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells Cell Rep, 2019-12-24;29(13):4447-4459.e6. 2019-12-24 [PMID: 31875552] (Cell Culture, Human, Mouse) |
Cell Culture |
Human, Mouse |
| B Li, C Yan, J Wu, K Stephane, X Dong, YZ Zhang, Y Zhang, Q Yu, KY Zheng Clonorchis sinensis ESPs enhance the activation of hepatic stellate cells by a cross-talk of TLR4 and TGF-beta/Smads Signaling pathway Acta Trop., 2019-12-17;0(0):105307. 2019-12-17 [PMID: 31862462] (Bioassay, Human) |
Bioassay |
Human |
| M Tochimoto, Y Oguri, M Hashimura, R Konno, T Matsumoto, A Yokoi, Y Kodera, M Saegusa S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma Lab. Invest., 2019-12-19;0(0):. 2019-12-19 [PMID: 31857700] (Bioassay, Human) |
Bioassay |
Human |
| J Huang, S Chang, Y Lu, J Wang, Y Si, L Zhang, S Cheng, WG Jiang Enhanced osteopontin splicing regulated by RUNX2 is HDAC-dependent and induces invasive phenotypes in NSCLC cells Cancer Cell Int., 2019-11-21;19(0):306. 2019-11-21 [PMID: 31832019] (Bioassay, Human) |
Bioassay |
Human |
| P Stylianou, K Clark, B Gooptu, D Smallwood, CE Brightling, Y Amrani, KM Roach, P Bradding Tensin1 expression and function in chronic obstructive pulmonary disease Sci Rep, 2019-12-12;9(1):18942. 2019-12-12 [PMID: 31831813] (Stimulation, Human) |
Stimulation |
Human |
| E Foxall, A Staszowska, LM Hirvonen, M Georgouli, M Ciccioli, A Rimmer, L Williams, Y Calle, VS Moreno, S Cox, GE Jones, CM Wells PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells Cell Rep, 2019-12-10;29(11):3385-3393.e6. 2019-12-10 [PMID: 31825823] (Cell Culture, Human) |
Cell Culture |
Human |
| RW Scott, M Arostegui, R Schweitzer, FMV Rossi, TM Underhill Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration Cell Stem Cell, 2019-12-05;25(6):797-813.e9. 2019-12-05 [PMID: 31809738] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| JH Choi, SM Kim, GH Lee, SW Jin, HS Lee, YC Chung, HG Jeong Platyconic Acid A, Platycodi Radix-Derived Saponin, Suppresses TGF-1-induced Activation of Hepatic Stellate Cells via Blocking SMAD and Activating the PPAR Signaling Pathway Cells, 2019-11-29;8(12):. 2019-11-29 [PMID: 31795488] (Bioassay, Rat) |
Bioassay |
Rat |
| BS Ni, C Tzao, JH Huang Plug-and-Play In Vitro Metastasis System toward Recapitulating the Metastatic Cascade Sci Rep, 2019-12-02;9(1):18110. 2019-12-02 [PMID: 31792319] (Bioassay, Human) |
Bioassay |
Human |
| AW Horne, SF Ahmad, R Carter, I Simitsidel, E Greaves, C Hogg, NM Morton, PTK Saunders Repurposing dichloroacetate for the treatment of women with endometriosis Proc. Natl. Acad. Sci. U.S.A., 2019-12-02;116(51):25389-25391. 2019-12-02 [PMID: 31792175] (Cell Culture, Human) |
Cell Culture |
Human |
| N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation Sci Rep, 2019-11-26;9(1):17558. 2019-11-26 [PMID: 31772282] (IHC-P, Human) |
IHC-P |
Human |
| X Li, P Fang, Y Sun, Y Shao, WY Yang, X Jiang, H Wang, X Yang Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells Redox Biol, 2019-11-06;28(0):101373. 2019-11-06 [PMID: 31731100] (Bioassay, Human) |
Bioassay |
Human |
| M Krämer, P Markart, F Drakopanag, A Mamazhakyp, L Schaefer, M Didiasova, M Wygrecka Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system Cell. Signal., 2019-11-03;65(0):109432. 2019-11-03 [PMID: 31693876] (Cell Culture, Human) |
Cell Culture |
Human |
| H Basma, AN Johanson, K Dhar, D Anderson, F Qiu, S Rennard, BD Lowes TGF-beta induces a heart failure phenotype via fibroblasts exosome signaling Heliyon, 2019-10-21;5(10):e02633. 2019-10-21 [PMID: 31687497] (Cell Culture, Human) |
Cell Culture |
Human |
| D Pham, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun, BL Kee, RM Myers, CT Weaver, RD Hatton Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf Cell Rep, 2019-10-29;29(5):1203-1220.e7. 2019-10-29 [PMID: 31665634] (Bioassay, Mouse) |
Bioassay |
Mouse |
| V Welk, T Meul, C Lukas, IE Kammerl, SR Mulay, AC Schamberge, N Semren, IE Fernandez, HJ Anders, A Günther, J Behr, O Eickelberg, M Korfei, S Meiners Proteasome activator PA200 regulates myofibroblast differentiation Sci Rep, 2019-10-23;9(1):15224. 2019-10-23 [PMID: 31645612] (Cell Culture, Human) |
Cell Culture |
Human |
| N Ogasawara, JA Poposki, AI Klingler, BK Tan, KE Hulse, WW Stevens, AT Peters, LC Grammer, KC Welch, SS Smith, DB Conley, JR Raviv, P Soroosh, KI Takano, T Himi, RC Kern, RP Schleimer, A Kato Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps Mucosal Immunol, 2019-10-22;13(1):86-95. 2019-10-22 [PMID: 31641233] (Cell Culture, Human) |
Cell Culture |
Human |
| F Yao, X Wang, ZK Cui, H Lan, X Ai, Q Song, Z Chen, J Yang, B Wu, X Bai ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription Lab. Invest., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641227] (Cell Culture, Human) |
Cell Culture |
Human |
| D Bhatia, KP Chung, K Nakahira, E Patino, MC Rice, LK Torres, T Muthukumar, AM Choi, OM Akchurin, ME Choi Mitophagy dependent macrophage reprogramming protects against kidney fibrosis JCI Insight, 2019-12-05;0(0):. 2019-12-05 [PMID: 31639106] (Bioassay, Human) |
Bioassay |
Human |
| K Li, L Yang, J Li, C Guan, S Zhang, X Lao, D Ouyang, G Zheng, S Gao, D Wang, Y Liang, G Liao TGFbeta induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma EBioMedicine, 2019-10-16;0(0):. 2019-10-16 [PMID: 31629677] (Bioassay, Human) |
Bioassay |
Human |
| R Sachdeva, M Wu, K Johnson, H Kim, A Celebre, U Shahzad, MS Graham, JA Kessler, JH Chuang, J Karamchand, M Bredel, R Verhaak, S Das BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma Sci Rep, 2019-10-10;9(1):14569. 2019-10-10 [PMID: 31602000] (Tissue Culture, Human) |
Tissue Culture |
Human |
| W Yoo, J Lee, KH Noh, S Lee, D Jung, MH Kabir, D Park, C Lee, KS Kwon, JS Kim, S Kim Progranulin attenuates liver fibrosis by downregulating the inflammatory response Cell Death Dis, 2019-10-07;10(10):758. 2019-10-07 [PMID: 31591383] (Bioassay, Human) |
Bioassay |
Human |
| A Acheva, S Haghdoost, A Sollazzo, V Launonen, M Kämäräinen Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiation Oxid Med Cell Longev, 2019-09-08;2019(0):4120379. 2019-09-08 [PMID: 31583039] (Bioassay, Human) |
Bioassay |
Human |
| T Kamitani, H Murota, N Arase, M Wataya-Kan, R Sato-Nishi, K Sekiguchi, D Okuzaki, D Motooka, I Katayama Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen's disease J. Dermatol. Sci., 2019-09-16;0(0):. 2019-09-16 [PMID: 31570272] (Bioassay, Human) |
Bioassay |
Human |
| LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity Cell Rep, 2019-09-24;28(13):3353-3366.e5. 2019-09-24 [PMID: 31553906] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| L Berning, L Scharf, E Aplak, D Stucki, C von Montfo, AS Reichert, W Stahl, P Brenneisen In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis PLoS ONE, 2019-09-25;14(9):e0222267. 2019-09-25 [PMID: 31553748] (Bioassay, Human) |
Bioassay |
Human |
| YJ Choi, JB Koo, HY Kim, JW Seo, EJ Lee, WR Kim, JY Cho, KB Hahm, SP Hong, DH Kim, JH Yoo Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A Stem Cell Res Ther, 2019-09-23;10(1):291. 2019-09-23 [PMID: 31547873] (Bioassay, Human) |
Bioassay |
Human |
| R Sreekumar, M Emaduddin, H Al-Saihati, K Moutasim, J Chan, M Spampinato, R Bhome, HM Yuen, C Mescoli, A Vitale, U Cillo, M Rugge, J Primrose, MA Hilal, S Thirdborou, E Tulchinsky, G Thomas, A Mirnezami, AE Sayan Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC Cell Death Dis, 2019-09-23;10(10):703. 2019-09-23 [PMID: 31543517] (Bioassay, Human) |
Bioassay |
Human |
| S Holvoet, M Perrot, N de Groot, G Prioult, T Mikogami, V Verhasselt, S Nutten Oral Tolerance Induction to Newly Introduced Allergen is Favored by a Transforming Growth Factor-beta-Enriched Formula Nutrients, 2019-09-13;11(9):. 2019-09-13 [PMID: 31540231] (Bioassay, Mink) |
Bioassay |
Mink |
| CL Hammond, E Roztocil, RP Phipps, SE Feldon, CF Woeller Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor PLoS ONE, 2019-09-19;14(9):e0222779. 2019-09-19 [PMID: 31536596] (Bioassay, Human) |
Bioassay |
Human |
| J Du, L Yan, R Torres, X Gong, H Bian, C Marugán, K Boehnke, C Baquero, YH Hui, SC Chapman, Y Yang, Y Zeng, SM Bogner, RT Foreman, A Capen, GP Donoho, RD Van Horn, DS Barnard, JA Dempsey, RP Beckmann, MS Marshall, LC Chio, Y Qian, YW Webster, A Aggarwal, S Chu, S Bhattachar, LF Stancato, MS Dowless, PW Iversen, JR Manro, JL Walgren, BW Halstead, MZ Dieter, R Martinez, SV Bhagwat, EL Kreklau, MJ Lallena, XS Ye, BKR Patel, C Reinhard, GD Plowman, DA Barda, JR Henry, SG Buchanan, RM Campbell Aurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy Mol. Cancer Ther., 2019-09-17;0(0):. 2019-09-17 [PMID: 31530649] (Bioassay, Human) |
Bioassay |
Human |
| T Zhou, K Kyritsi, N Wu, H Francis, Z Yang, L Chen, A O'Brien, L Kennedy, L Ceci, V Meadows, P Kusumanchi, C Wu, L Baiocchi, NJ Skill, R Saxena, A Sybenga, L Xie, S Liangpunsa, F Meng, G Alpini, S Glaser Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC) EBioMedicine, 2019-09-12;0(0):. 2019-09-12 [PMID: 31522982] (Bioassay, Human) |
Bioassay |
Human |
| M Bogdanova, A Zabirnyk, A Malashiche, KZ Enayati, TA Karlsen, ML Kaljusto, JE Kvitting, E Dissen, GJ Sullivan, A Kostareva, KO Stensløkke, A Rutkovskiy, J Vaage Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties Sci Rep, 2019-09-10;9(1):12934. 2019-09-10 [PMID: 31506459] (Cell Culture, Human) |
Cell Culture |
Human |
| TTD Luong, M Estepa, B Boehme, B Pieske, F Lang, KU Eckardt, J Voelkl, I Alesutan Inhibition of vascular smooth muscle cell calcification by vasorin through interference with TGF β1 signaling Cell. Signal., 2019-09-07;0(0):109414. 2019-09-07 [PMID: 31505229] (Bioassay, Human) |
Bioassay |
Human |
| M Lv, Z Li, J Liu, F Lin, Q Zhang, Z Li, Y Wang, K Wang, Y Xu MicroRNA?155 inhibits the proliferation of CD8+ T�cells via upregulating regulatory T cells in vitiligo Mol Med Rep, 2019-08-23;20(4):3617-3624. 2019-08-23 [PMID: 31485649] (Bioassay, Human) |
Bioassay |
Human |
| N Kaushansky, E Bakos, S Becker-Her, I Shachar, A Ben-Nun Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms J. Immunol., 2019-09-04;0(0):. 2019-09-04 [PMID: 31484731] (ELISA Standard, Mouse) |
ELISA Standard |
Mouse |
| K Krüger, S Schmid, F Paulsen, A Ignatius, P Klinger, T Hotfiel, B Swoboda, K Gelse Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair Int J Mol Sci, 2019-09-01;20(17):. 2019-09-01 [PMID: 31480518] (Bioassay, Human) |
Bioassay |
Human |
| YH Lee, DY Kim, SH Jeong, YJ Hwang Effect of exposure to Asian sand dust-Particulate matter on liver Tenascin-C expression in human cancer cell and mouse hepatic tissue J Toxicol Sci, 2019-01-01;44(9):633-641. 2019-01-01 [PMID: 31474744] (Bioassay, Human) |
Bioassay |
Human |
| DM Habiel, MS Hohmann, MS Espindola, AL Coelho, I Jones, H Jones, R Carnibella, I Pinar, F Werdiger, CM Hogaboam DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis BMC Pulm Med, 2019-08-29;19(1):165. 2019-08-29 [PMID: 31464599] (Bioassay, Human) |
Bioassay |
Human |
| YC Kim, KH Kim, S Lee, JW Jo, JY Park, MS Park, B Tsogbadrak, JP Lee, JW Lee, DK Kim, KH Oh, IJ Jang, YS Kim, RH Cha, SH Yang ST2 blockade mitigates peritoneal fibrosis induced by TGF-beta and high glucose J. Cell. Mol. Med., 2019-08-09;23(10):6872-6884. 2019-08-09 [PMID: 31397957] (Bioassay, Human) |
Bioassay |
Human |
| L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human) |
Bioassay |
Human |
| J Argemi, MU Latasa, SR Atkinson, IO Blokhin, V Massey, JP Gue, J Cabezas, JJ Lozano, D Van Booven, A Bell, S Cao, LA Vernetti, JP Arab, M Ventura-Co, LR Edmunds, C Fondevilla, P Stärkel, L Dubuquoy, A Louvet, G Odena, JL Gomez, T Aragon, J Altamirano, J Caballeria, MJ Jurczak, DL Taylor, C Berasain, C Wahlestedt, SP Monga, MY Morgan, P Sancho-Bru, P Mathurin, S Furuya, C Lackner, I Rusyn, VH Shah, MR Thursz, J Mann, MA Avila, R Bataller Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis Nat Commun, 2019-07-16;10(1):3126. 2019-07-16 [PMID: 31311938] (Bioassay, Human) |
Bioassay |
Human |
| M Aoki, H Aoki, P Mukhopadhy, T Tsuge, H Yamamoto, NM Matsumoto, E Toyohara, Y Okubo, R Ogawa, K Takabe Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation Int J Mol Sci, 2019-07-10;20(14):. 2019-07-10 [PMID: 31295813] (Bioassay, Mouse) |
Bioassay |
Mouse |
| S Saraswati, SMW Marrow, LA Watch, PP Young Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing Nat Commun, 2019-07-09;10(1):3027. 2019-07-09 [PMID: 31289275] (Cell Culture, Human) |
Cell Culture |
Human |
| M Pedroza, S To, J Smith, SK Agarwal Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride PLoS ONE, 2019-07-03;14(7):e0218971. 2019-07-03 [PMID: 31269038] (Bioassay, Mouse, Human) |
Bioassay |
Mouse, Human |
| J Duan, B Li, M Bhakta, S Xie, P Zhou, NV Munshi, GC Hon Rational Reprogramming of Cellular States by Combinatorial Perturbation Cell Rep, 2019-06-18;27(12):3486-3499.e6. 2019-06-18 [PMID: 31216470] (Bioassay, Mouse) |
Bioassay |
Mouse |
| J Jin, S Togo, K Kadoya, M Tulafu, Y Namba, M Iwai, J Watanabe, K Nagahama, T Okabe, M Hidayat, Y Kodama, H Kitamura, T Ogura, N Kitamura, K Ikeo, S Sasaki, S Tominaga, K Takahashi Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-?1 Respir. Res., 2019-06-11;20(1):119. 2019-06-11 [PMID: 31185973] (Cell Culture, Human) |
Cell Culture |
Human |
| J Castillo, E Wu, C Lowe, S Srinivasan, R McCord, MC Wagle, S Jayakar, M Gonzalez E, J Eastham-An, B Liu, KE Hutchinson, W Jones, MP Stokes, SS Tarighat, T Holcomb, A Glibicky, FA Romero, S Magnuson, SA Huang, V Plaks, JM Giltnane, MR Lackner, Z Mounir CBP/p300 drives the differentiation of Regulatory T cells through transcriptional and non-transcriptional mechanisms Cancer Res., 2019-06-10;0(0):. 2019-06-10 [PMID: 31182547] (Bioassay, Human) |
Bioassay |
Human |
| C Antognelli, S Moretti, R Frosini, E Puxeddu, A Sidoni, VN Talesa Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer Cells, 2019-06-06;8(6):. 2019-06-06 [PMID: 31174324] (Bioassay, Human) |
Bioassay |
Human |
| CJW Stock, C Michaeloud, P Leoni, AL Durham, S Mumby, AU Wells, KF Chung, IM Adcock, EA Renzoni, GE Lindahl Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation Biomed Res Int, 2019-04-18;2019(0):1484736. 2019-04-18 [PMID: 31119153] (Bioassay, Human) |
Bioassay |
Human |
| J Sakata, A Hirosue, R Yoshida, K Kawahara, Y Matsuoka, T Yamamoto, M Nakamoto, M Hirayama, N Takahashi, T Nakamura, H Arita, H Nakashima, M Nagata, A Hiraki, M Shinohara, H Nakayama HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma Int J Mol Sci, 2019-05-19;20(10):. 2019-05-19 [PMID: 31109142] (Bioassay, Human) |
Bioassay |
Human |
| R van Dalen, JS De La Cruz, M Rumpret, FF Fuchsberge, NH van Teijli, J Hanske, C Rademacher, TBH Geijtenbee, JAG van Strijp, C Weidenmaie, A Peschel, DH Kaplan, NM van Sorge Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses MBio, 2019-05-14;10(3):. 2019-05-14 [PMID: 31088921] (Bioassay, Human) |
Bioassay |
Human |
| DR Myers, E Norlin, Y Vercoulen, JP Roose Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells Cell Rep, 2019-05-07;27(6):1858-1874.e6. 2019-05-07 [PMID: 31067469] (Bioassay, Mouse) |
Bioassay |
Mouse |
| S Granados-A, K Hardy, S Franks, IB Sharum, SL Waite, MA Fenwick SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles Sci Rep, 2019-04-24;9(1):6513. 2019-04-24 [PMID: 31015579] (Bioassay, Mouse) |
Bioassay |
Mouse |
| HC Lien, YH Lee, YL Juang, YT Lu Fibrillin-1, a novel TGF-beta-induced factor, is preferentially expressed in metaplastic carcinoma with spindle sarcomatous metaplasia Pathology, 2019-04-19;0(0):. 2019-04-19 [PMID: 31010590] (Bioassay, Human) |
Bioassay |
Human |
| T Higuchi, K Takagi, A Tochimoto, Y Ichimura, T Norose, Y Katsumata, I Masuda, H Yamanaka, T Morohoshi, Y Kawaguchi Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment Arthritis Res. Ther., 2019-04-18;21(1):103. 2019-04-18 [PMID: 30999934] (Bioassay, Human) |
Bioassay |
Human |
| MR Hadjichara, BT Roux, E Csomor, CA Feghali-Bo, LA Murray, DL Clarke, MA Lindsay Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis Sci Rep, 2019-04-15;9(1):6020. 2019-04-15 [PMID: 30988425] (Bioassay, Human) |
Bioassay |
Human |
| Wei X, Zhang L, Zhou Z, Kwon O, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo M, Xu F, Creighton C, Ittmann M, Xin L Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell, 2019-04-11;24(5):753-768.e6. 2019-04-11 [PMID: 30982770] (Bioassay, Mouse) |
Bioassay |
Mouse |
| F Peng, H Li, S Li, Y Wang, W Liu, W Gong, B Yin, S Chen, Y Zhang, C Luo, W Zhou, Y Chen, P Li, Q Huang, Z Xu, H Long Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway Lab. Invest., 2019-04-11;0(0):. 2019-04-11 [PMID: 30976056] (Bioassay, Mouse) |
Bioassay |
Mouse |
| P Diao, H Ge, Y Song, Y Wu, J Li, Z Li, J Yang, Y Wang, J Cheng Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma J. Cell. Mol. Med., 2019-04-04;0(0):. 2019-04-04 [PMID: 30950191] (Bioassay, Human) |
Bioassay |
Human |
| DQ Chen, G Cao, H Chen, CP Argyopoulo, H Yu, W Su, L Chen, DC Samuels, S Zhuang, GP Bayliss, S Zhao, XY Yu, ND Vaziri, M Wang, D Liu, JR Mao, SX Ma, J Zhao, Y Zhang, YQ Shang, H Kang, F Ye, XH Cheng, XR Li, L Zhang, MX Meng, Y Guo, YY Zhao Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan Nat Commun, 2019-04-01;10(1):1476. 2019-04-01 [PMID: 30931940] (Bioassay, Human) |
Bioassay |
Human |
| K Wang, S Fang, Q Liu, J Gao, X Wang, H Zhu, Z Zhu, F Ji, J Wu, Y Ma, L Hu, X Shen, D Gao, J Zhu, P Liu, H Zhou TGF-?1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM EBioMedicine, 2019-03-27;0(0):. 2019-03-27 [PMID: 30926424] (Bioassay, Human) |
Bioassay |
Human |
| V Fleskens, CM Minutti, X Wu, P Wei, CEGM Pals, J McCrae, S Hemmers, V Groenewold, HJ Vos, A Rudensky, F Pan, H Li, DM Zaiss, PJ Coffer Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells Cell Rep, 2019-03-26;26(13):3600-3612.e6. 2019-03-26 [PMID: 30917315] (Human) |
|
Human |
| R Gramlich, E Aliahmadi, M Peiser In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists Int J Mol Sci, 2019-03-19;20(6):. 2019-03-19 [PMID: 30893757] (Bioassay, Human) |
Bioassay |
Human |
| T Hochdörfer, C Winkler, K Pardali, J Mjösberg Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-03-28;0(0):. 2019-03-28 [PMID: 30892687] (Bioassay, Human) |
Bioassay |
Human |
| JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma Nat Commun, 2019-03-08;10(1):1128. 2019-03-08 [PMID: 30850660] (Bioassay, Human) |
Bioassay |
Human |
| YB Kim, YH Ahn, JH Jung, YJ Lee, JH Lee, JL Kang Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis Cell. Mol. Immunol., 2019-03-06;0(0):. 2019-03-06 [PMID: 30842627] (Bioassay, Mouse) |
Bioassay |
Mouse |
| R Gao, N Zhang, J Yang, Y Zhu, Z Zhang, J Wang, X Xu, Z Li, X Liu, Z Li, J Li, C Kong, J Bi Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-?1 in bladder cancer cells J. Exp. Clin. Cancer Res., 2019-03-01;38(1):111. 2019-03-01 [PMID: 30823924] (Bioassay, Human) |
Bioassay |
Human |
| BW Liu, ZH Yu, AX Chen, JR Chi, J Ge, Y Yu, XC Cao Estrogen receptor-?-miR-1271-SNAI2 feedback loop regulates transforming growth factor-?-induced breast cancer progression J. Exp. Clin. Cancer Res., 2019-03-01;38(1):109. 2019-03-01 [PMID: 30823890] (Bioassay, Human) |
Bioassay |
Human |
| SS Kim, GE Nikoloudak, S Michelsons, K Creber, DW Hamilton Fibronectin synthesis, but not ?-smooth muscle expression, is regulated by periostin in gingival healing through FAK/JNK signaling Sci Rep, 2019-02-25;9(1):2708. 2019-02-25 [PMID: 30804350] (Bioassay, Human) |
Bioassay |
Human |
| Y Luo, Y Xue, J Wang, J Dang, Q Fang, G Huang, N Olsen, SG Zheng Negligible Effect of Sodium Chloride on the Development and Function of TGF-?-Induced CD4+ Foxp3+ Regulatory T Cells Cell Rep, 2019-02-12;26(7):1869-1879.e3. 2019-02-12 [PMID: 30759396] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| B Wang, X Xu, Z Yang, L Zhang, Y Liu, A Ma, G Xu, M Tang, T Jing, L Wu, Y Liu POH1 contributes to hyperactivation of TGF-? signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-? receptors and caveolin-1 EBioMedicine, 2019-02-07;0(0):. 2019-02-07 [PMID: 30745168] (Bioassay, Human) |
Bioassay |
Human |
| C Derada Tro, RD Fontijn, E Gowing, M Charabati, B van Het Ho, I Didouh, SMA van der Po, D Geerts, A Prat, J van Horsse, G Kooij, HE de Vries Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology Cell Death Dis, 2019-01-18;10(2):45. 2019-01-18 [PMID: 30718504] (Bioassay, Human) |
Bioassay |
Human |
| I Mannaerts, LFR Thoen, N Eysackers, FJ Cubero, S Batista Le, I Coldham, I Colle, C Trautwein, LA van Grunsv Unfolded protein response is an early, non-critical event during hepatic stellate cell activation Cell Death Dis, 2019-02-04;10(2):98. 2019-02-04 [PMID: 30718473] (Bioassay, Mouse) |
Bioassay |
Mouse |
| K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse) |
Bioassay |
Mouse |
| JN Pucella, M Cols, WF Yen, S Xu, J Chaudhuri The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses J. Immunol., 2019-01-25;0(0):. 2019-01-25 [PMID: 30683701] (Bioassay, Mouse) |
Bioassay |
Mouse |
| M Kijewska, C Viski, F Turrell, A Fitzpatric, A van Weverw, Q Gao, M Iravani, CM Isacke Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain Breast Cancer Res., 2019-01-14;21(1):4. 2019-01-14 [PMID: 30642388] (Bioassay, Mouse) |
Bioassay |
Mouse |
| RK Dutta, S Chinnapaiy, L Rasmussen, SV Raju, HJ Unwalla A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-?-Mediated CFTR Expression Mol. Ther., 2018-12-06;27(2):442-455. 2018-12-06 [PMID: 30595527] (Bioassay, Human) |
Bioassay |
Human |
| M Amir, S Chaudhari, R Wang, S Campbell, SA Mosure, LB Chopp, Q Lu, J Shang, OB Pelletier, Y He, C Doebelin, MD Cameron, DJ Kojetin, TM Kamenecka, LA Solt REV-ERB? Regulates TH17 Cell Development and Autoimmunity Cell Rep, 2018-12-26;25(13):3733-3749.e8. 2018-12-26 [PMID: 30590045] (Bioassay, Mouse) |
Bioassay |
Mouse |
| KB Kaylan, IC Berg, MJ Biehl, A Brougham-C, I Jain, SM Jamil, LH Sargeant, NJ Cornell, LT Raetzman, GH Underhill Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling Elife, 2018-12-27;7(0):. 2018-12-27 [PMID: 30589410] (Bioassay, Mouse) |
Bioassay |
Mouse |
| W Zheng, C Chen, S Chen, C Fan, H Ruan Integrated analysis of long non-coding RNAs and mRNAs associated with peritendinous fibrosis J Adv Res, 2018-08-30;15(0):49-58. 2018-08-30 [PMID: 30581612] (Bioassay, Mouse) |
Bioassay |
Mouse |
| J Zhang, CE Dunk, O Shynlova, I Caniggia, SJ Lye TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia EBioMedicine, 2018-12-19;39(0):531-539. 2018-12-19 [PMID: 30579870] (Bioassay, Human) |
Bioassay |
Human |
| J Wang, G Liu, M Liu, L Xiang, Y Xiao, H Zhu, X Wu, Y Peng, W Zhang, P Jiang, A Li, Q Nan, Y Chen, C Chen, T Cheng, S Liu, J Wang The FOXK1-CCDC43 Axis Promotes the Invasion and Metastasis of Colorectal Cancer Cells Cell. Physiol. Biochem., 2018-12-11;51(6):2547-2563. 2018-12-11 [PMID: 30562730] (Bioassay, Human) |
Bioassay |
Human |
| T Huang, X Huang, B Shi, F Wang, W Feng, M Yao Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs Vet. Res., 2018-12-12;49(1):121. 2018-12-12 [PMID: 30541630] (Bioassay, Porcine) |
Bioassay |
Porcine |
| R Martin-Mat, TM De Assunca, JP Arab, N Jalan-Sakr, U Yaqoob, T Greuter, VK Verma, AJ Mathison, S Cao, G Lomberk, P Mathurin, R Urrutia, RC Huebert, VH Shah Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-? Dependent Hepatic Stellate Cell Activation and Liver Fibrosis Cell Mol Gastroenterol Hepatol, 2018-09-15;7(1):197-209. 2018-09-15 [PMID: 30539787] (Bioassay, Human) |
Bioassay |
Human |
| Y Liu, YL Lightfoot, N Seto, C Carmona-Ri, E Moore, R Goel, L O'Neil, P Mistry, V Hoffmann, S Mondal, PN Premnath, K Gribbons, S Dell'Orso, K Jiang, PR Thompson, HW Sun, SA Coonrod, MJ Kaplan Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus JCI Insight, 2018-12-06;3(23):. 2018-12-06 [PMID: 30518690] (Bioassay, Mouse) |
Bioassay |
Mouse |
| CC Weng, PY Ding, YH Liu, JR Hawse, M Subramania, CC Wu, YC Lin, CY Chen, WC Hung, KH Cheng Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis Oncogene, 2018-11-22;0(0):. 2018-11-22 [PMID: 30467381] (Bioassay, Mouse) |
Bioassay |
Mouse |
| F Das, N Ghosh-Chou, DY Lee, Y Gorin, BS Kasinath, GG Choudhury Akt2 causes TGF?-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression PLoS ONE, 2018-11-16;13(11):e0207285. 2018-11-16 [PMID: 30444896] (Bioassay, Rat) |
Bioassay |
Rat |
| JS Park, M Kim, NJ Song, JH Kim, D Seo, JH Lee, SM Jung, JY Lee, J Lee, YS Lee, KW Park, SH Park A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells Stem Cells, 2018-12-07;0(0):. 2018-12-07 [PMID: 30444564] (Bioassay, Mouse) |
Bioassay |
Mouse |
| KH Kim, S Lee, H Lee, D Shin, D Min, M Kim, B Ryu, HW Kim, H Bae A standardized herbal extract PM014 ameliorates pulmonary fibrosis by suppressing the TGF-?1 pathway Sci Rep, 2018-11-15;8(1):16860. 2018-11-15 [PMID: 30443024] (Bioassay, Human) |
Bioassay |
Human |
| W Chen, MS Nyuydzefe, JM Weiss, J Zhang, SD Waksal, A Zanin-Zhor ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells Sci Rep, 2018-11-09;8(1):16636. 2018-11-09 [PMID: 30413785] (Bioassay, Human) |
Bioassay |
Human |
| J Park, JH Lee, BS Yoon, EK Jun, G Lee, IY Kim, S You Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells Stem Cell Res Ther, 2018-11-08;9(1):293. 2018-11-08 [PMID: 30409167] (Bioassay, Human) |
Bioassay |
Human |
| YT Tang, YY Huang, JH Li, SH Qin, Y Xu, TX An, CC Liu, Q Wang, L Zheng Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines BMC Genomics, 2018-11-06;19(1):802. 2018-11-06 [PMID: 30400814] (Bioassay, Human) |
Bioassay |
Human |
| AG Kunihiro, JA Brickey, JB Frye, PB Luis, C Schneider, JL Funk Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGF?-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues J. Nutr. Biochem., 2018-10-11;63(0):150-156. 2018-10-11 [PMID: 30393127] (Bioassay, Human) |
Bioassay |
Human |
| M Životi?, B Tampe, G Müller, C Müller, A Lipkovski, X Xu, G Nyamsuren, M Zeisberg, J Markovi?-L Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells PLoS ONE, 2018-11-01;13(11):e0206786. 2018-11-01 [PMID: 30383875] (Bioassay, Human) |
Bioassay |
Human |
| F Fang, N Xia, B Angulo, J Carey, Z Cady, J Durruthy-D, T Bennett, V Sebastiano, RA Reijo Pera A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells Nat Commun, 2018-10-22;9(1):4384. 2018-10-22 [PMID: 30349051] (Bioassay, Human) |
Bioassay |
Human |
| M Inoue, K Okamoto, A Terashima, T Nitta, R Muro, T Negishi-Ko, T Kitamura, T Nakashima, H Takayanagi Arginine methylation controls the strength of ?c-family cytokine signaling in T cell maintenance Nat. Immunol., 2018-10-15;19(11):1265-1276. 2018-10-15 [PMID: 30323341] (Bioassay, Mouse) |
Bioassay |
Mouse |
| L Guo, Y Hou, L Song, S Zhu, F Lin, Y Bai D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion Stem Cells Int, 2018-09-09;2018(0):7168231. 2018-09-09 [PMID: 30271438] (Bioassay, Human) |
Bioassay |
Human |
| T Yamashita, Y Asano, R Saigusa, T Taniguchi, K Nakamura, S Miura, T Toyama, T Takahashi, Y Ichimura, M Hirabayash, A Yoshizaki, T Miyagaki, M Sugaya, S Sato Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis J. Dermatol. Sci., 2018-09-21;93(1):24-32. 2018-09-21 [PMID: 30270117] (Bioassay, Human) |
Bioassay |
Human |
| BS Nepon-Sixt, MG Alexandrow TGF�1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-deficient Conditions Mol. Cancer Res., 2018-09-26;0(0):. 2018-09-26 [PMID: 30257992] (Bioassay, Mouse) |
Bioassay |
Mouse |
| X Zhang, L Liu, X Deng, D Li, H Cai, Y Ma, C Jia, B Wu, Y Fan, Z Lv MicroRNA 483-3p targets Pard3 to potentiate TGF-?1-induced cell migration, invasion, and epithelial-mesenchymal transition in anaplastic thyroid cancer cells Oncogene, 2018-08-31;0(0):. 2018-08-31 [PMID: 30171257] (Bioassay, Human) |
Bioassay |
Human |
| M Saxena, RKR Kalathur, M Neutzner, G Christofor PyMT-1099, a versatile murine cell model for EMT in breast cancer Sci Rep, 2018-08-14;8(1):12123. 2018-08-14 [PMID: 30108334] (Bioassay, Mouse) |
Bioassay |
Mouse |
| RJ Marsh, K Pfisterer, P Bennett, LM Hirvonen, M Gautel, GE Jones, S Cox Artifact-free high-density localization microscopy analysis Nat. Methods, 2018-07-30;0(0):. 2018-07-30 [PMID: 30061677] (Bioassay, Human) |
Bioassay |
Human |
| Martinez-Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, Ho H, Dosey A, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell, 2018-07-26;174(5):1158-1171.e19. 2018-07-26 [PMID: 30057110] (Surface Plasmon Resonance (SPR, Virus) |
Surface Plasmon Resonance (SPR |
Virus |
| D Dvornikov, MA Schneider, S Ohse, M Szczygie?, I Titkova, M Rosenblatt, T Muley, A Warth, FJ Herth, H Dienemann, M Thomas, J Timmer, M Schilling, H Busch, M Boerries, M Meister, U Klingmülle Expression ratio of the TGF?-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response Sci Rep, 2018-06-22;8(1):9517. 2018-06-22 [PMID: 29934580] (Bioassay, Human) |
Bioassay |
Human |
| MR Conith, Y Hu, AJ Conith, MA Maginnis, JF Webb, RC Albertson Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus Proc. Natl. Acad. Sci. U.S.A., 2018-06-18;0(0):. 2018-06-18 [PMID: 29915062] (In Vivo, Fish) |
In Vivo |
Fish |
| FC Bach, AR Tellegen, M Beukers, A Miranda-Be, M Teunissen, WAM de Jong, SAH de Vries, LB Creemers, K Benz, BP Meij, K Ito, MA Tryfonidou Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside Oncotarget, 2018-05-29;9(41):26507-26526. 2018-05-29 [PMID: 29899873] (Bioassay, Canine, Human) |
Bioassay |
Canine, Human |
| YW Liao, CC Yu, PL Hsieh, YC Chang miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2 J. Cell. Mol. Med., 2018-06-12;0(0):. 2018-06-12 [PMID: 29893466] (Bioassay, Human) |
Bioassay |
Human |
| A Kunita, S Morita, TU Irisa, A Goto, T Niki, D Takai, J Nakajima, M Fukayama MicroRNA-21 in cancer-associated fibroblasts supports�lung adenocarcinoma progression Sci Rep, 2018-06-11;8(1):8838. 2018-06-11 [PMID: 29892003] (Bioassay, Human) |
Bioassay |
Human |
| Z Qin, GJ Fisher, JJ Voorhees, T Quan Actin cytoskeleton assembly regulates collagen production via TGF-? type II receptor in human skin fibroblasts J. Cell. Mol. Med., 2018-06-11;0(0):. 2018-06-11 [PMID: 29888864] (Bioassay, Human) |
Bioassay |
Human |
| F Ghodrati, M Mehrabian, D Williams, O Halgas, MEC Bourkas, JC Watts, EF Pai, G Schmitt-Ul The prion protein is embedded in a molecular environment that modulates transforming growth factor ? and integrin signaling Sci Rep, 2018-06-05;8(1):8654. 2018-06-05 [PMID: 29872131] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Z Al Shareef, H Kardooni, V Murillo-Ga, G Domenici, E Stylianaki, JH Steel, M Rabano, I Gorroño-Et, I Zabalza, M dM Vivanco, J Waxman, RM Kypta Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1 Oncogene, 2018-06-01;0(0):. 2018-06-01 [PMID: 29858602] (Bioassay, Human) |
Bioassay |
Human |
| S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a Sci Rep, 2018-05-29;8(1):8267. 2018-05-29 [PMID: 29844613] (Bioassay, Human) |
Bioassay |
Human |
| X Feng, Z Li, J Wei, Z Feng, W Wu, Y Zhao Injectable cartilaginous template transformed BMSCs into vascularized bone Sci Rep, 2018-05-29;8(1):8244. 2018-05-29 [PMID: 29844536] (Bioassay, Rabbit) |
Bioassay |
Rabbit |
| CF Hung, CL Wilson, YH Chow, LM Schnapp Role of integrin alpha8 in murine model of lung fibrosis PLoS ONE, 2018-05-29;13(5):e0197937. 2018-05-29 [PMID: 29813125] (Bioassay, Mouse) |
Bioassay |
Mouse |
| CB Cummins, X Wang, O Nunez Lope, G Graham, HY Tie, J Zhou, RS Radhakrish Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway Int J Mol Sci, 2018-05-24;19(6):. 2018-05-24 [PMID: 29795016] (Bioassay, Human) |
Bioassay |
Human |
| YH Chung, YH Huang, TH Chu, CL Chen, PR Lin, SC Huang, DC Wu, CC Huang, TH Hu, YH Kao, MH Tai BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-?1 signaling Lab. Invest., 2018-05-22;0(0):. 2018-05-22 [PMID: 29789683] (Bioassay, Rat) |
Bioassay |
Rat |
| S Lively, D Lam, R Wong, LC Schlichter Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels Front Cell Neurosci, 2018-05-03;12(0):115. 2018-05-03 [PMID: 29780305] (Bioassay, Rat) |
Bioassay |
Rat |
| K Schlereth, D Weichenhan, T Bauer, T Heumann, E Giannakour, D Lipka, S Jaeger, M Schlesner, P Aloy, R Eils, C Plass, HG Augustin The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium Elife, 2018-05-11;7(0):. 2018-05-11 [PMID: 29749927] (Bioassay, Human) |
Bioassay |
Human |
| L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection Mol Med Rep, 2018-05-03;0(0):. 2018-05-03 [PMID: 29749506] (Bioassay, Human) |
Bioassay |
Human |
| S Ottaviani, J Stebbing, AE Frampton, S Zagorac, J Krell, A de Giorgio, SM Trabulo, VTM Nguyen, L Magnani, H Feng, E Giovannett, N Funel, TM Gress, LR Jiao, Y Lombardo, NR Lemoine, C Heeschen, L Castellano TGF-? induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression Nat Commun, 2018-05-10;9(1):1845. 2018-05-10 [PMID: 29748571] (Bioassay, Human) |
Bioassay |
Human |
| CC Tsai, SB Wu, HC Kau, YH Wei Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts Sci Rep, 2018-05-08;8(1):7276. 2018-05-08 [PMID: 29739987] (Bioassay, ELISA (Standard), Human) |
Bioassay, ELISA (Standard) |
Human |
| C Deng, YX Lin, XK Qi, GP He, Y Zhang, HJ Zhang, M Xu, QS Feng, JX Bei, YX Zeng, L Feng TNFRSF19 inhibits TGF? signaling through interaction with TGF? receptor type I to promote tumorigenesis Cancer Res., 2018-05-07;0(0):. 2018-05-07 [PMID: 29735548] (Bioassay, Human) |
Bioassay |
Human |
| LR Penke, JM Speth, VL Dommeti, ES White, IL Bergin, M Peters-Gol FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis J. Clin. Invest., 2018-05-07;0(0):. 2018-05-07 [PMID: 29733296] (Bioassay, Human) |
Bioassay |
Human |
| A Schmidt, F Marabita, NA Kiani, CC Gross, HJ Johansson, S Éliás, S Rautio, M Eriksson, SJ Fernandes, G Silberberg, U Ullah, U Bhatia, H Lähdesmäki, J Lehtiö, D Gomez-Cabr, H Wiendl, R Lahesmaa, J Tegnér Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3 BMC Biol., 2018-05-07;16(1):47. 2018-05-07 [PMID: 29730990] (Bioassay, Human) |
Bioassay |
Human |
| S Deshpande, M Abdollahi, M Wang, L Lanting, M Kato, R Natarajan Reduced Autophagy by a microRNA-mediated Signaling Cascade in Diabetes-induced Renal Glomerular Hypertrophy Sci Rep, 2018-05-03;8(1):6954. 2018-05-03 [PMID: 29725042] (Bioassay, Mouse) |
Bioassay |
Mouse |
| V Zaiatz-Bit, DK Finlay, CM Gardiner Canonical TGF-? Signaling Pathway Represses Human NK Cell Metabolism J. Immunol., 2018-05-02;0(0):. 2018-05-02 [PMID: 29720425] (Bioassay, Human) |
Bioassay |
Human |
| V Murillo-Ga, I Gorroño-Et, M Åkerfelt, MC Puustinen, L Sistonen, M Nees, J Carton, J Waxman, RM Kypta Frizzled-8 integrates Wnt-11 and transforming growth factor-? signaling in prostate cancer Nat Commun, 2018-05-01;9(1):1747. 2018-05-01 [PMID: 29717114] (Bioassay, Human) |
Bioassay |
Human |
| R Rekik, M Smiti Khan, T Larbi, I Zamali, A Beldi-Ferc, O Kammoun, S Marzouki, S Hamzaoui, S Mrad, MR Barbouche, MH Houman, M Ben Ahmed Impaired TGF-? signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22 Cytokine, 2018-04-21;108(0):182-189. 2018-04-21 [PMID: 29684755] (Bioassay, Human) |
Bioassay |
Human |
| F Liu, C Chu, Q Wei, J Shi, H Li, N Dong Metformin ameliorates TGF-β1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting β-catenin signaling Biochem. Biophys. Res. Commun., 2018-04-22;0(0):. 2018-04-22 [PMID: 29679571] (Bioassay, Human) |
Bioassay |
Human |
| M Wang, DQ Chen, L Chen, G Cao, H Zhao, D Liu, ND Vaziri, Y Guo, YY Zhao Novel inhibitors of the cellular RAS components, Poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis Br. J. Pharmacol., 2018-05-22;0(0):. 2018-05-22 [PMID: 29679507] (Cell Culture, Human) |
Cell Culture |
Human |
| L Knüppel, K Heinzelman, M Lindner, R Hatz, J Behr, O Eickelberg, CA Staab-Weij FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis Respir. Res., 2018-04-19;19(1):67. 2018-04-19 [PMID: 29673351] (Bioassay, Human) |
Bioassay |
Human |
| P Mallikarju, RT Sitaram, M Landström, B Ljungberg VHL status regulates transforming growth factor-? signaling pathways in renal cell carcinoma Oncotarget, 2018-03-27;9(23):16297-16310. 2018-03-27 [PMID: 29662646] (Bioassay, Human) |
Bioassay |
Human |
| L Corsuto, S Rother, L Koehler, E Bedini, S Moeller, M Schnabelra, V Hintze, C Schiraldi, D Scharnwebe Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response Carbohydr Polym, 2018-03-01;191(0):53-64. 2018-03-01 [PMID: 29661321] (ELISA Standard, Human) |
ELISA Standard |
Human |
| D Wu, P Lu, X Mi, J Miao Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis Mol. Hum. Reprod., 2018-07-01;0(0):. 2018-07-01 [PMID: 29660008] (Bioassay, Human) |
Bioassay |
Human |
| Y Nakayama, S Matsui, K Noda, M Yamazaki, Y Iwai, B Ganss, Y Ogata TGF?1-induced Amelotin gene expression is downregulated by Bax expression in mouse gingival epithelial cells J Oral Sci, 2018-04-16;0(0):. 2018-04-16 [PMID: 29657250] (Bioassay, Mouse) |
Bioassay |
Mouse |
| R Gupta, K Somyajit, T Narita, E Maskey, A Stanlie, M Kremer, D Typas, M Lammers, N Mailand, A Nussenzwei, J Lukas, C Choudhary DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity Cell, 2018-04-12;0(0):. 2018-04-12 [PMID: 29656893] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28 Nat Commun, 2018-04-12;9(1):1424. 2018-04-12 [PMID: 29651155] (Bioassay, Mouse) |
Bioassay |
Mouse |
| E Groppa, S Brkic, A Uccelli, G Wirth, P Korpisalo-, M Filippova, B Dasen, V Sacchi, MG Muraro, M Trani, S Reginato, R Gianni-Bar, S Ylä-Herttu, A Banfi EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF EMBO Rep., 2018-04-11;0(0):. 2018-04-11 [PMID: 29643120] (Bioassay, Human) |
Bioassay |
Human |
| S Park, KM Yang, Y Park, E Hong, CP Hong, J Park, K Pang, J Lee, B Park, S Lee, H An, MK Kwak, J Kim, JM Kang, P Kim, Y Xiao, G Nie, A Ooshima, SJ Kim Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation J Cancer Prev, 2018-03-30;23(1):1-9. 2018-03-30 [PMID: 29629343] (Bioassay, Human) |
Bioassay |
Human |
| PD Leiphrakpa, MG Brattain, JD Black, JJ Wang TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer�cells J. Biol. Chem., 2018-03-29;0(0):. 2018-03-29 [PMID: 29599290] (Bioassay, Human) |
Bioassay |
Human |
| DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells Biol. Reprod., 2018-09-01;0(0):. 2018-09-01 [PMID: 29596569] (Bioassay, Human) |
Bioassay |
Human |
| S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage Nat. Cell Biol., 2018-03-26;20(4):455-464. 2018-03-26 [PMID: 29581593] (Bioassay, Mouse) |
Bioassay |
Mouse |
| L Geng, X Tang, K Zhou, D Wang, S Wang, G Yao, W Chen, X Gao, W Chen, S Shi, N Shen, X Feng, L Sun MicroRNA-663 induces immune dysregulation by inhibiting TGF-?1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus Cell. Mol. Immunol., 2018-01-01;0(0):. 2018-01-01 [PMID: 29578533] (Bioassay, Human) |
Bioassay |
Human |
| R Thome, AP Bonfanti, J Rasouli, ER Mari, GX Zhang, A Rostami, L Verinaud Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity Eur. J. Immunol., 2018-04-17;0(0):. 2018-04-17 [PMID: 29572810] (Bioassay, Human) |
Bioassay |
Human |
| B Zhang, W Niu, HY Dong, ML Liu, Y Luo, ZC Li Hypoxia induces endothelial?mesenchymal transition in pulmonary vascular remodeling Int. J. Mol. Med., 2018-03-22;0(0):. 2018-03-22 [PMID: 29568878] (Bioassay, Rat) |
Bioassay |
Rat |
| H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209. 2018-01-31 [PMID: 29552576] (Bioassay, Human) |
Bioassay |
Human |
| X Hu, H Kan, A Boye, Y Jiang, C Wu, Y Yang Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells Oncol Lett, 2018-02-02;15(4):4867-4872. 2018-02-02 [PMID: 29552126] (Bioassay, Human) |
Bioassay |
Human |
| N Zila, A Bileck, B Muqaku, L Janker, OM Eichhoff, PF Cheng, R Dummer, MP Levesque, C Gerner, V Paulitschk Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases Clin Proteomics, 2018-03-09;15(0):13. 2018-03-09 [PMID: 29541007] (Bioassay, Human) |
Bioassay |
Human |
| V Beaulieu L, O Roy, K Santerre, S Proulx TGF-?1 promotes cell barrier function upon maturation of corneal endothelial cells Sci Rep, 2018-03-13;8(1):4438. 2018-03-13 [PMID: 29535350] (Bioassay, Human) |
Bioassay |
Human |
| S Liu, J Iaria, RJ Simpson, HJ Zhu Ras enhances TGF-? signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1 Cell Commun. Signal, 2018-03-13;16(1):10. 2018-03-13 [PMID: 29534718] (Bioassay, Canine) |
Bioassay |
Canine |
| R Yang, T Yu, D Liu, S Shi, Y Zhou Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway Stem Cell Res Ther, 2018-03-09;9(1):62. 2018-03-09 [PMID: 29523215] (Bioassay, Mouse) |
Bioassay |
Mouse |
| H Sugiura, A Matsushita, M Futaya, A Teraoka, KI Akiyama, N Usui, N Nagano, K Nitta, K Tsuchiya Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model PLoS ONE, 2018-03-08;13(3):e0191706. 2018-03-08 [PMID: 29518087] (Bioassay, Human) |
Bioassay |
Human |
| J Wang, A Faiz, Q Ge, CJ Vermeulen, J Van der Ve, KJ Snibson, R van de Vel, S Sawant, D Xenaki, B Oliver, W Timens, N Ten Hacken, M van den Be, A James, JG Elliot, L Dong, JK Burgess, AW Ashton Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling J. Cell. Mol. Med., 2018-03-07;0(0):. 2018-03-07 [PMID: 29516637] (Bioassay, Human) |
Bioassay |
Human |
| P Bozatzi, KS Dingwell, KZ Wu, F Cooper, TD Cummins, LD Hutchinson, J Vogt, NT Wood, TJ Macartney, J Varghese, R Gourlay, DG Campbell, JC Smith, GP Sapkota PAWS1 controls Wnt signalling through association with casein kinase 1? EMBO Rep., 2018-03-07;0(0):. 2018-03-07 [PMID: 29514862] (Bioassay, Human) |
Bioassay |
Human |
| A Merdrignac, G Angenard, C Allain, K Petitjean, D Bergeat, P Bellaud, A Fautrel, B Turlin, B Clément, S Dooley, L Sulpice, K Boudjema, C Coulouarn A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma Hepatol Commun, 2018-01-30;2(3):254-269. 2018-01-30 [PMID: 29507901] (Bioassay, Human) |
Bioassay |
Human |
| K Kobayashi, T Yoshioka, J Miyauchi, A Nakazawa, N Kiyokawa, T Maihara, I Usami Role of monocyte chemoattractant protein-1 in liver fibrosis with transient myeloproliferative disorder in down syndrome Hepatol Commun, 2018-02-01;2(3):230-236. 2018-02-01 [PMID: 29507898] (Cell Culture, Human) |
Cell Culture |
Human |
| MM Pleumeeker, L Nimeskern, JLM Koevoet, M Karperien, KS Stok, GJVM van Osch Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture PLoS ONE, 2018-02-28;13(2):e0190744. 2018-02-28 [PMID: 29489829] (Bioassay, Human) |
Bioassay |
Human |
| S Patalano, J Rodríguez-, C Colaneri, J Cotellessa, D Almanza, A Zhilin-Rot, T Riley, J Macoska CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation Sci Rep, 2018-02-22;8(1):3499. 2018-02-22 [PMID: 29472636] (Bioassay, Human) |
Bioassay |
Human |
| R Wang, T Fu, K You, S Li, N Zhao, J Yang, SM Zhuang Identification of a TGF-?-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells FASEB J., 2018-02-20;0(0):fj201701199R. 2018-02-20 [PMID: 29465312] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| JM Dave, T Mirabella, SD Weatherbee, DM Greif Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain Dev. Cell, 2018-02-15;0(0):. 2018-02-15 [PMID: 29456135] (Bioassay, Human) |
Bioassay |
Human |
| A Löfdahl, C Wenglén, K Rydell-Tör, G Westergren, AK Larsson-Ca Effects of 5-HT2receptor antagonists on bronchoconstriction and pulmonary remodeling processes Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454752] (Bioassay, Human) |
Bioassay |
Human |
| L Gagnon, M Leduc, JF Thibodeau, MZ Zhang, B Grouix, F Sarra-Bour, W Gagnon, K Hince, M Tremblay, L Geerts, CRJ Kennedy, RL Hébert, A Gutsol, CE Holterman, E Kamto, L Gervais, J Ouboudinar, J Richard, A Felton, A Laverdure, JC Simard, S Létourneau, MP Cloutier, FA Leblond, SD Abbott, C Penney, JS Duceppe, B Zacharie, J Dupuis, A Calderone, QT Nguyen, RC Harris, P Laurin A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84 Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454750] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy Int J Mol Sci, 2018-02-10;19(2):. 2018-02-10 [PMID: 29439436] (Bioassay, Equine) |
Bioassay |
Equine |
| M Losa, M Risolino, B Li, J Hart, L Quintana, I Grishina, H Yang, IF Choi, P Lewicki, S Khan, R Aho, J Feenstra, CT Vincent, AMC Brown, E Ferretti, T Williams, L Selleri Face morphogenesis is promoted by Pbx-dependent EMT via regulation ofduring frontonasal prominence fusion Development, 2018-03-01;0(0):. 2018-03-01 [PMID: 29437830] (Bioassay, Mouse) |
Bioassay |
Mouse |
| VNS Garikipati, SP Singh, Y Mohanram, AK Gupta, D Kapoor, S Nityanand Isolation and characterization of mesenchymal stem cells from human fetus heart PLoS ONE, 2018-02-08;13(2):e0192244. 2018-02-08 [PMID: 29420637] (Bioassay, Human) |
Bioassay |
Human |
| F Wang, V Zachar, CP Pennisi, T Fink, Y Maeda, J Emmersen Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype Int J Mol Sci, 2018-02-08;19(2):. 2018-02-08 [PMID: 29419805] (Bioassay, Human) |
Bioassay |
Human |
| M Imamura, JS Moon, KP Chung, K Nakahira, T Muthukumar, R Shingarev, SW Ryter, AM Choi, ME Choi RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415885] (Bioassay, Human) |
Bioassay |
Human |
| L Chen, J Li, Q Li, X Li, Y Gao, X Hua, B Zhou, J Li Overexpression of LncRNA AC067945.2 Down-Regulates Collagen Expression in Skin Fibroblasts and Possibly Correlates with the VEGF and Wnt Signalling Pathways Cell. Physiol. Biochem., 2018-02-01;45(2):761-771. 2018-02-01 [PMID: 29414824] (Bioassay, Human) |
Bioassay |
Human |
| H Tian, JJ Huang, C Golzio, X Gao, M Hector-Gre, N Katsanis, GC Blobe Endoglin interacts with VEGFR2 to promote angiogenesis FASEB J., 2018-01-11;0(0):fj201700867RR. 2018-01-11 [PMID: 29401587] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| T Rosengren, LJ Larsen, LB Pedersen, ST Christense, LB Møller TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms Cell. Mol. Life Sci., 2018-02-02;0(0):. 2018-02-02 [PMID: 29396625] (Bioassay, Mouse) |
Bioassay |
Mouse |
| R Zhang, Y Wu, F Xie, Y Zhong, Y Wang, M Xu, J Feng, J Charish, PP Monnier, X Qin RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke Cell Death Differ., 2018-02-02;0(0):. 2018-02-02 [PMID: 29396549] (Bioassay, Rat) |
Bioassay |
Rat |
| G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction EBioMedicine, 2018-01-13;28(0):287-302. 2018-01-13 [PMID: 29396297] (Bioassay, Human) |
Bioassay |
Human |
| O Kodet, B Dvo?ánková, B Bendlová, V Sýkorová, I Krajsová, J Štork, J Ku?era, P Szabo, H Strnad, M Kolá?, ? Vl?ek, K Smetana, L Lacina Microenvironment?driven resistance to B?Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts Int. J. Mol. Med., 2018-02-01;0(0):. 2018-02-01 [PMID: 29393387] (Bioassay, Human) |
Bioassay |
Human |
| L Jia, Y Tian, Y Chen, G Zhang The silencing of LncRNA-H19 decreases chemoresistance of human glioma cells to temozolomide by suppressing epithelial-mesenchymal transition via the Wnt/?-Catenin pathway Onco Targets Ther, 2018-01-11;11(0):313-321. 2018-01-11 [PMID: 29391808] (Bioassay, Human) |
Bioassay |
Human |
| J Nishida, K Miyazono, S Ehata Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms Oncogene, 2018-02-02;0(0):. 2018-02-02 [PMID: 29391598] (Bioassay, Human) |
Bioassay |
Human |
| PS Bellaye, C Shimbori, T Yanagihara, DA Carlson, P Hughes, C Upagupta, S Sato, N Wheildon, T Haystead, K Ask, M Kolb Synergistic role of HSP90? and HSP90? to promote myofibroblast persistence in lung fibrosis Eur. Respir. J., 2018-01-31;51(2):. 2018-01-31 [PMID: 29386344] (Bioassay, Human) |
Bioassay |
Human |
| F Zhang, G Liu, D Li, C Wei, J Hao DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway J. Immunol., 2018-01-29;0(0):. 2018-01-29 [PMID: 29378913] (Bioassay, Human) |
Bioassay |
Human |
| T Yamakawa, H Ohigashi, D Hashimoto, E Hayase, S Takahashi, M Miyazaki, K Minomi, M Onozawa, Y Niitsu, T Teshima Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease Blood, 2018-01-23;0(0):. 2018-01-23 [PMID: 29363541] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| JT Chen, CY Wang, MH Chen Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts J. Formos. Med. Assoc., 2018-01-17;0(0):. 2018-01-17 [PMID: 29339038] (Bioassay, Human) |
Bioassay |
Human |
| L Lin, M Li, L Lin, X Xu, G Jiang, L Wu FPPS mediates TGF-?1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway Biochem. Biophys. Res. Commun., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337059] (Bioassay, Human) |
Bioassay |
Human |
| SJ Han, JK Jung, SS Im, SR Lee, BC Jang, KM Park, JI Kim Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition Biochem. Biophys. Res. Commun., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337054] (Bioassay, Canine) |
Bioassay |
Canine |
| J Zhu, Z Zhang, Y Zhang, W Li, W Zheng, J Yu, B Wang, L Chen, Q Zhuo, L Chen, J Zhang, J Liu MicroRNA-212 activates hepatic stellate cells and promotes liver fibrosis via targeting SMAD7 Biochem. Biophys. Res. Commun., 2018-01-04;0(0):. 2018-01-04 [PMID: 29307832] (Bioassay, Human) |
Bioassay |
Human |
| J Choi, DR Pease, S Chen, B Zhang, H Phee P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells Immunology, 2018-02-02;0(0):. 2018-02-02 [PMID: 29297928] (Bioassay, Mouse) |
Bioassay |
Mouse |
| JC Cheng, Y Yi, HM Chang, PCK Leung TGF-?1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation Cell. Signal., 2017-12-18;43(0):55-61. 2017-12-18 [PMID: 29269046] (Bioassay, Human) |
Bioassay |
Human |
| EM Reyes-Reye, I Aispuro, MA Tavera-Gar, M Field, S Moore, I Ramos, KS Ramos LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells Oncotarget, 2017-10-23;8(61):103828-103842. 2017-10-23 [PMID: 29262603] (Bioassay, Human) |
Bioassay |
Human |
| SD Hardy, A Shinde, WH Wang, MK Wendt, RL Geahlen Regulation of epithelial-mesenchymal transition and metastasis by TGF-?, P-bodies, and autophagy Oncotarget, 2017-10-17;8(61):103302-103314. 2017-10-17 [PMID: 29262563] (Bioassay, Mouse) |
Bioassay |
Mouse |
| H Hanieh, K Masuda, H Metwally, JP Chalise, M Mohamed, KK Nyati, DM Standley, S Li, M Higa, MM Zaman, T Kishimoto Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-loop structure in its 3'UTR Eur. J. Immunol., 2018-02-05;0(0):. 2018-02-05 [PMID: 29244194] (Bioassay, Mouse) |
Bioassay |
Mouse |
| W Shin, Y Jeon, I Choi, YJ Kim V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80+ cells regulate oral antigen-specific responses in mouse Eur. J. Immunol., 2018-01-18;0(0):. 2018-01-18 [PMID: 29235119] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Shyam Kumar Gudey, Reshma Sundar, Carl-Henrik Heldin, Anders Bergh, Marene Landström Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF? stimulation in cancer. Oncotarget, 2017-08-09;0(0):1949-2553. 2017-08-09 [PMID: 29228645] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming Cell Stem Cell, 2017-11-22;0(0):. 2017-11-22 [PMID: 29174331] (Bioassay, Human) |
Bioassay |
Human |
| Chris J C Johnston, Danielle J Smyth, Ravindra B Kodali, Madeleine P J White, Yvonne Harcus, Kara J Filbey, James P Hewitson, Cynthia S Hinck, Alasdair Ivens, Andrea M Kemter, Anna O Kildemoes, Thierry Le Bihan, Dinesh C Soares, Stephen M Anderton, Thomas Brenn, Stephen J Wigmore, Hannah V Woodcock, Rachel C Chambers, Andrew P Hinck, Henry J McSorley, Rick M Maizels A structurally distinct TGF-? mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 2017-11-23;0(0):2041-1723. 2017-11-23 [PMID: 29170498] (Bioassay, Mouse) |
Bioassay |
Mouse |
| SK Sahu, N Tiwari, A Pataskar, Y Zhuang, M Borisova, M Diken, S Strand, P Beli, VK Tiwari FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development Nat Commun, 2017-11-15;8(1):1523. 2017-11-15 [PMID: 29142217] (Bioassay, Human) |
Bioassay |
Human |
| F Yu, B Chen, X Fan, G Li, P Dong, J Zheng Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2 Cell. Physiol. Biochem., 2017-10-27;43(6):2242-2252. 2017-10-27 [PMID: 29073595] (Bioassay, Human) |
Bioassay |
Human |
| A Shibata, M Kuno, R Adachi, Y Sato, H Hattori, A Matsuda, Y Okuzono, K Igaki, Y Tominari, T Takagi, M Yabuki, M Okaniwa Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy PLoS ONE, 2017-10-24;12(10):e0186587. 2017-10-24 [PMID: 29065190] (Bioassay, Human) |
Bioassay |
Human |
| S Saito, Y Zhuang, B Shan, S Danchuk, F Luo, M Korfei, A Guenther, JA Lasky Tubastatin ameliorates pulmonary fibrosis by targeting the TGF?-PI3K-Akt pathway PLoS ONE, 2017-10-18;12(10):e0186615. 2017-10-18 [PMID: 29045477] (Bioassay, Human) |
Bioassay |
Human |
| W Wang, P Li, W Li, J Jiang, Y Cui, S Li, Z Wang Osteopontin activates mesenchymal stem cells to repair skin wound PLoS ONE, 2017-09-28;12(9):e0185346. 2017-09-28 [PMID: 28957406] (Bioassay, Mouse) |
Bioassay |
Mouse |
| SZ Wu, SJ Yang, HM Chen, FF Peng, H Yu, JC Kreprinsky, BF Zhang Dual roles of parathyroid hormone-related protein in TGF-?1 signaling and fibronectin upregulation in mesangial cells Biosci. Rep., 2017-10-27;0(0):. 2017-10-27 [PMID: 28954822] (Bioassay, Rat) |
Bioassay |
Rat |
| M Sato-Matsu, T Matsubara, A Daikoku, Y Okina, L Longato, K Rombouts, LTT Thuy, J Adachi, T Tomonaga, K Ikeda, K Yoshizato, M Pinzani, N Kawada Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling J. Biol. Chem., 2017-09-15;0(0):. 2017-09-15 [PMID: 28916723] (Bioassay, Human) |
Bioassay |
Human |
| M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg CD73 promotes resistance to HER2/ErbB2 antibody therapy Cancer Res., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855210] (Bioassay, Human) |
Bioassay |
Human |
| Y Qi, N Wang, Y He, J Zhang, H Zou, W Zhang, W Gu, Y Huang, X Lian, J Hu, J Zhao, X Cui, L Pang, F Li Transforming growth factor-?1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells PLoS ONE, 2017-08-22;12(8):e0182680. 2017-08-22 [PMID: 28829837] (Bioassay, Human) |
Bioassay |
Human |
| Ying Chen, Dan-Dan Wang, Ye-Ping Wu, Dan Su, Tian-Yi Zhou, Ren-Hua Gai, Ying-Ying Fu, Lin Zheng, Qiao-Jun He, Hong Zhu, Bo Yang MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. British Journal of Cancer, 2017-08-17;0(0):1532-1827. 2017-08-17 [PMID: 28817834] (Bioassay, Human) |
Bioassay |
Human |
| VC Rodríguez-, P Martínez-R, F Català-Mol, J Rodríguez-, A Garcia-Gom, G Poorani-Su, L Ciudad, H Hernando, A Pérez-Garc, C Company, JM Urquiza, AR Ramiro, JM Di Noia, A Vaquero, E Ballestar Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites Sci Rep, 2017-08-08;7(1):7594. 2017-08-08 [PMID: 28790320] (Bioassay, Mouse) |
Bioassay |
Mouse |
| P Åström, K Juurikka, ES Hadler-Ols, G Svineng, NK Cervigne, RD Coletta, J Risteli, JH Kauppila, S Skarp, S Kuttner, A Oteiza, M Sutinen, T Salo The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma Br. J. Cancer, 2017-08-03;117(7):1007-1016. 2017-08-03 [PMID: 28772283] (Bioassay, Human) |
Bioassay |
Human |
| S Lee, D Kim, J Kang, E Kim, W Kim, H Youn, B Youn Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production Cell. Physiol. Biochem., 2017-07-25;42(4):1684-1700. 2017-07-25 [PMID: 28743125] (Bioassay, Human) |
Bioassay |
Human |
| M Renard, L Muiño-Mosq, EC Manalo, S Tufa, EJ Carlson, DR Keene, J De Backer, LY Sakai Sex, pregnancy and aortic disease in Marfan syndrome PLoS ONE, 2017-07-14;12(7):e0181166. 2017-07-14 [PMID: 28708846] (Bioassay, Human) |
Bioassay |
Human |
| H Kamata, Y Tsukasaki, T Sakai, R Ikebe, J Wang, A Jeffers, J Boren, S Owens, T Suzuki, M Higashihar, S Idell, TA Tucker, M Ikebe KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis Sci Rep, 2017-07-04;7(1):4556. 2017-07-04 [PMID: 28676645] (Bioassay, Human) |
Bioassay |
Human |
| JC Cheng, CP Tseng, MH Liao, CY Peng, JS Yu, PH Chuang, JT Huang, JJW Chen Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes Sci Rep, 2017-06-30;7(1):4448. 2017-06-30 [PMID: 28667290] (Bioassay, Human) |
Bioassay |
Human |
| C Caër, C Rouault, T Le Roy, C Poitou, J Aron-Wisne, A Torcivia, JC Bichet, K Clément, M Guerre-Mil, S André Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue Sci Rep, 2017-06-07;7(1):3000. 2017-06-07 [PMID: 28592801] (Bioassay, Human) |
Bioassay |
Human |
| JB Koo, MO Nam, Y Jung, J Yoo, DH Kim, G Kim, SJ Shin, KM Lee, KB Hahm, JW Kim, SP Hong, KJ Lee, JH Yoo Anti-fibrogenic effect of PPAR-? agonists in human intestinal myofibroblasts BMC Gastroenterol, 2017-06-07;17(1):73. 2017-06-07 [PMID: 28592228] (Bioassay, Human) |
Bioassay |
Human |
| TP Nguyen, SF Sieg TGF-? inhibits IL-7-induced proliferation in memory but not naive human CD4(+) T cells J. Leukoc. Biol., 2017-06-06;0(0):. 2017-06-06 [PMID: 28588029] (Bioassay, Human) |
Bioassay |
Human |
| L Bai, HM Chang, JC Cheng, C Klausen, G Chu, PCK Leung, G Yang SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells Cell. Signal., 2017-05-31;37(0):52-61. 2017-05-31 [PMID: 28578012] (Bioassay, Human) |
Bioassay |
Human |
| S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes Glia, 2017-06-01;0(0):. 2017-06-01 [PMID: 28568893] (Bioassay, Mouse) |
Bioassay |
Mouse |
| EJ Kim, SG Seo, HS Shin, DJ Lee, JH Kim, DY Lee Platelet-Derived Growth Factor Receptor-Positive Pericytic Cells of White Adipose Tissue from Critical Limb Ischemia Patients Display Mesenchymal Stem Cell-Like Properties Clin Orthop Surg, 2017-05-08;9(2):239-248. 2017-05-08 [PMID: 28567229] (Bioassay, Human) |
Bioassay |
Human |
| Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28539431] (Bioassay, Mouse) |
Bioassay |
Mouse |
| J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells Nat. Immunol., 2017-05-15;0(0):. 2017-05-15 [PMID: 28504697] (Bioassay, Human) |
Bioassay |
Human |
| N Salvarani, A Maguy, SA De Simone, M Miragoli, F Jousset, S Rohr TGF-?1 (Transforming Growth Factor-?1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity Circ Arrhythm Electrophysiol, 2017-05-01;10(5):e004567. 2017-05-01 [PMID: 28500173] (Bioassay, Rat) |
Bioassay |
Rat |
| J Ko, MK Chae, JH Lee, EJ Lee, JS Yoon Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy Invest. Ophthalmol. Vis. Sci., 2017-05-01;58(5):2544-2553. 2017-05-01 [PMID: 28492873] (Bioassay, Human) |
Bioassay |
Human |
| L Calvier, P Chouvarine, E Legchenko, N Hoffmann, J Geldner, P Borchert, D Jonigk, MM Mozes, G Hansmann PPAR? Links BMP2 and TGF?1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism Cell Metab., 2017-05-02;25(5):1118-1134.e7. 2017-05-02 [PMID: 28467929] (Bioassay, Human) |
Bioassay |
Human |
| R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells J. Immunol., 2017-04-28;0(0):. 2017-04-28 [PMID: 28455436] (Bioassay, Mouse) |
Bioassay |
Mouse |
| ZM Zhao, HL Liu, X Sun, T Guo, L Shen, YY Tao, CH Liu Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway Exp. Biol. Med. (Maywood), 2017-03-22;242(9):974-985. 2017-03-22 [PMID: 28440736] (Bioassay, Human) |
Bioassay |
Human |
| Y Zhang Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling Biochem. Biophys. Res. Commun., 2017-04-17;0(0):. 2017-04-17 [PMID: 28427938] (Bioassay, Human) |
Bioassay |
Human |
| A Shiokawa, R Kotaki, T Takano, H Nakajima-A, S Hachimura Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cells highly induce regulatory T cells Immunology, 2017-06-01;0(0):. 2017-06-01 [PMID: 28423181] (Bioassay, Mouse) |
Bioassay |
Mouse |
| JJ Kathiriya, N Nakra, J Nixon, PS Patel, V Vaghasiya, A Alhassani, Z Tian, D Allen-Gips, V Davé Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis Cell Death Discov, 2017-04-10;3(0):17010. 2017-04-10 [PMID: 28417017] (Bioassay, Human) |
Bioassay |
Human |
| KA Whelan, PM Chandramou, K Tanaka, M Natsuizaka, M Guha, S Srinivasan, DS Darling, Y Kita, S Natsugoe, JD Winkler, AJ Klein-Szan, RK Amaravadi, NG Avadhani, AK Rustgi, H Nakagawa Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance Oncogene, 2017-04-17;0(0):. 2017-04-17 [PMID: 28414310] (Bioassay, Human) |
Bioassay |
Human |
| D Zhou, L Zhang, W Sun, W Guan, Q Lin, W Ren, J Zhang, G Xu Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer Cell. Signal., 2017-04-14;0(0):. 2017-04-14 [PMID: 28414100] (Bioassay, Human) |
Bioassay |
Human |
| Y Dimitrova, AJ Gruber, N Mittal, S Ghosh, B Dimitriade, D Mathow, WA Grandy, G Christofor, M Zavolan TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition Biol. Direct, 2017-04-17;12(1):8. 2017-04-17 [PMID: 28412966] (Bioassay, Mouse) |
Bioassay |
Mouse |
| S Ghatak, VC Hascall, RR Markwald, C Feghali-Bo, CM Artlett, M Gooz, GS Bogatkevic, I Atanelishv, RM Silver, J Wood, VJ Thannickal, S Misra TGF beta-1 induced CD44v6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis J. Biol. Chem., 2017-04-07;0(0):. 2017-04-07 [PMID: 28389561] (Bioassay, Human) |
Bioassay |
Human |
| F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis Scand. J. Immunol., 2017-06-01;0(0):. 2017-06-01 [PMID: 28376277] (Bioassay, Human) |
Bioassay |
Human |
| KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Human) |
Bioassay |
Human |
| K Desai, R Aiyappa, JS Prabhu, MG Nair, PV Lawrence, A Korlimarla, A Ce, A Alexander, RS Kaluve, S Manjunath, M Correa, BS Srinath, S Patil, A Kalamdani, M Prasad, TS Sridhar HR+HER2- breast cancers with growth factor receptor-mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells Tumour Biol, 2017-03-01;39(3):1010428317695. 2017-03-01 [PMID: 28349782] (Bioassay, Human) |
Bioassay |
Human |
| C Pagiatakis, D Sun, SW Tobin, T Miyake, JC McDermott TGF?-TAZ/SRF Signaling regulates vascular smooth muscle cell differentiation FEBS J, 2017-04-20;0(0):. 2017-04-20 [PMID: 28342289] (Bioassay, Mouse) |
Bioassay |
Mouse |
| A Siddiqui, ME Vazakidou, A Schwab, F Napoli, C Fernandez-, I Rapa, MP Stemmler, M Volante, T Brabletz, P Ceppi Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells J. Pathol, 2017-06-01;0(0):. 2017-06-01 [PMID: 28337746] (Bioassay, Human) |
Bioassay |
Human |
| V Ruiz-Carpi, P Sandoval, A Aguilera, P Albar-Vizc, ML Perez-Loza, GT González-M, A Acuña-Ruiz, J García-Can, P Botías, MA Bajo, R Selgas, JA Sánchez-To, J Passlick-D, D Piecha, J Büchel, S Steppan, M López-Cabr Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients Sci Rep, 2017-03-22;7(0):44941. 2017-03-22 [PMID: 28327551] (Bioassay, Human) |
Bioassay |
Human |
| K Kamio, A Azuma, J Usuki, K Matsuda, M Inomata, N Nishijima, S Itakura, H Hayashi, T Kashiwada, N Kokuho, K Atsumi, T Yamaguchi, K Fujita, Y Saito, S Abe, K Kubota, A Gemma XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts Pulm Pharmacol Ther, 2017-03-14;0(0):. 2017-03-14 [PMID: 28315487] (Bioassay, Human) |
Bioassay |
Human |
| D Iizuka, M Sasatani, MH Barcellos-, K Kamiya Hydrogen Peroxide Enhances TGF?-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells Anticancer Res, 2017-03-01;37(3):987-995. 2017-03-01 [PMID: 28314256] (Bioassay, Human) |
Bioassay |
Human |
| Y Tachida, N Izumi, T Sakurai, H Kobayashi Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells Biol Open, 2017-03-15;6(3):370-380. 2017-03-15 [PMID: 28298363] (Bioassay, Human) |
Bioassay |
Human |
| F Loayza-Puc, K Rooijers, J Zijlstra, B Moumbeini, EA Zaal, JF Oude Vriel, R Lopes, A Pineiro Ug, CR Berkers, R Agami TGF?1-induced leucine limitation uncovered by differential ribosome codon reading EMBO Rep, 2017-03-08;0(0):. 2017-03-08 [PMID: 28274951] (Bioassay, Human) |
Bioassay |
Human |
| DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-04-01;0(0):. 2017-04-01 [PMID: 28270449] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| KH Bae, JB Seo, YA Jung, HY Seo, SH Kang, HJ Jeon, JM Lee, S Lee, JG Kim, IK Lee, GS Jung, KG Park Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor ? Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice Endocrinol Metab (Seoul), 2017-02-28;0(0):. 2017-02-28 [PMID: 28256116] (Bioassay, Rat) |
Bioassay |
Rat |
| W Zhao, J Yan, L Gao, J Zhao, C Zhao, C Gao, X Luo, X Zhu Cdk5 is required for the neuroprotective effect of transforming growth factor-?1 against cerebral ischemia-reperfusion Biochem. Biophys. Res. Commun, 2017-02-27;0(0):. 2017-02-27 [PMID: 28254431] (Bioassay, Rat) |
Bioassay |
Rat |
| D Pap, E Sziksz, Z Kiss, R Rokonay, A Veres-Szék, R Lippai, IM Takács, É Kis, A Fekete, G Reusz, A Vannay, AJ Szabó Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling Kidney Blood Press. Res, 2017-02-28;42(1):16-32. 2017-02-28 [PMID: 28253513] (Bioassay, Human) |
Bioassay |
Human |
| A Rynne-Vida, CL Au-Yeung, JA Jiménez-He, ML Pérez-Loza, L Cremades-J, C Bárcena, I Cristóbal-, C Fernández-, TL Yeung, SC Mok, P Sandoval, M López-Cabr Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer J. Pathol, 2017-04-03;0(0):. 2017-04-03 [PMID: 28247413] (Bioassay, Human) |
Bioassay |
Human |
| G Mondanelli, R Bianchi, MT Pallotta, C Orabona, E Albini, A Iacono, ML Belladonna, C Vacca, F Fallarino, A Macchiarul, S Ugel, V Bronte, F Gevi, L Zolla, A Verhaar, M Peppelenbo, EM Mazza, S Bicciato, Y Laouar, L Santambrog, P Puccetti, C Volpi, U Grohmann A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells Immunity, 2017-02-14;46(2):233-244. 2017-02-14 [PMID: 28214225] (Bioassay, Mouse) |
Bioassay |
Mouse |
| BA Boswell, A Korol, JA West-Mays, LS Musil Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract Mol. Biol. Cell, 2017-02-16;0(0):. 2017-02-16 [PMID: 28209733] (Bioassay, Chicken) |
Bioassay |
Chicken |
| A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells Oncotarget, 2017-04-11;8(15):24869-24881. 2017-04-11 [PMID: 28206960] (Bioassay, Human) |
Bioassay |
Human |
| Y Hu, L Lao, J Mao, W Jin, H Luo, T Charpentie, S Qi, J Peng, B Hu, MM Marcinkiew, A Lamarre, J Wu Armc5 deletion causes developmental defects and compromises T-cell immune responses Nat Commun, 2017-02-07;8(0):13834. 2017-02-07 [PMID: 28169274] (Bioassay, Mouse) |
Bioassay |
Mouse |
| K Sakaguchi, W Katagiri, M Osugi, T Kawai, Y Sugimura-W, H Hibi Periodontal tissue regeneration using the cytokine cocktail mimicking secretomes in the conditioned media from human mesenchymal stem cells Biochem. Biophys. Res. Commun, 2017-01-16;484(1):100-106. 2017-01-16 [PMID: 28104393] (Bioassay, Canine) |
Bioassay |
Canine |
| S Gopal, L Veracini, D Grall, C Butori, S Schaub, S Audebert, L Camoin, E Baudelet, A Radwanska, S Beghelli-d, SM Violette, PH Weinreb, S Rekima, M Ilie, A Sudaka, P Hofman, E Van Obberg Fibronectin-guided migration of carcinoma collectives Nat Commun, 2017-01-19;8(0):14105. 2017-01-19 [PMID: 28102238] (Bioassay, Human) |
Bioassay |
Human |
| D Brethour, M Mehrabian, D Williams, X Wang, F Ghodrati, S Ehsani, EA Rubie, JR Woodgett, J Sevalle, Z Xi, E Rogaeva, G Schmitt-Ul A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition Sci Rep, 2017-01-18;7(0):40313. 2017-01-18 [PMID: 28098160] (Bioassay, Human) |
Bioassay |
Human |
| MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis Proc. Natl. Acad. Sci. U.S.A, 2017-01-09;114(4):E524-E533. 2017-01-09 [PMID: 28069965] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Claire Yu Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem/stromal cell expansion Biomaterials, 2016-12-23;120(0):66-80. 2016-12-23 [PMID: 28038353] (Bioassay, Human) |
Bioassay |
Human |
| Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases Cell Death Dis, 2016-12-29;7(12):e2565. 2016-12-29 [PMID: 28032864] (Bioassay, Human) |
Bioassay |
Human |
| Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas PLoS ONE, 2016-12-28;11(12):e0167200. 2016-12-28 [PMID: 28030558] (Bioassay, Mouse) |
Bioassay |
Mouse |
| IL-10 production in murine IgM(+) CD138(hi) cells is driven by Blimp1 and downregulated in class-switched cells Eur. J. Immunol, 2017-01-10;0(0):. 2017-01-10 [PMID: 28012163] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Bharat Vaidyanath The aryl hydrocarbon receptor controls cell-fate decisions in B cells J. Exp. Med, 2016-12-23;0(0):. 2016-12-23 [PMID: 28011866] (Bioassay, Human) |
Bioassay |
Human |
| Nisha Bte Mohd Rafiq Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO J. Cell Biol, 2016-12-22;216(1):181-197. 2016-12-22 [PMID: 28007915] (Bioassay, Human) |
Bioassay |
Human |
| H Kusumoto, Y Shintani, R Kanzaki, T Kawamura, S Funaki, M Minami, I Nagatomo, E Morii, M Okumura Podocalyxin influences malignant potential by controlling epithelial-mesenchymal transition in lung adenocarcinoma Cancer Sci., 2017-03-01;108(3):528-535. 2017-03-01 [PMID: 28004467] (Bioassay, Human) |
Bioassay |
Human |
| Tsugumi Horikiri Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia Respir Med, 2016-11-24;122(0):43-50. 2016-11-24 [PMID: 27993290] (Bioassay, Human) |
Bioassay |
Human |
| Hoeke A Baarsma Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD J. Exp. Med, 2016-12-15;0(0):. 2016-12-15 [PMID: 27979969] (Bioassay, Human) |
Bioassay |
Human |
| Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-? Small Molecule Inhibitor Neoplasia, 2016-12-01;18(12):795-805. 2016-12-01 [PMID: 27978994] (Bioassay, Human) |
Bioassay |
Human |
| M F Griffin Chemical group-dependent plasma polymerisation preferentially directs adipose stem cell differentiation towards osteogenic or chondrogenic lineages Acta Biomater, 2016-12-09;0(0):. 2016-12-09 [PMID: 27956359] (Bioassay, Human) |
Bioassay |
Human |
| Dong-Chuan Guo Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease Am. J. Hum. Genet, 2016-12-08;0(0):. 2016-12-08 [PMID: 27939641] (Bioassay, Human) |
Bioassay |
Human |
| YL Li, JT Chang, LY Lee, KH Fan, YC Lu, YC Li, CH Chiang, GR You, HY Chen, AJ Cheng GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway Oncotarget, 2017-01-03;8(1):1508-1528. 2017-01-03 [PMID: 27903972] (Bioassay, Human) |
Bioassay |
Human |
| Xiuyun Zeng TAR DNA-binding protein 43 inhibits inflammatory response and protects chondrocyte function by modulating RACK1 expression in osteoarthritis Biomed. Pharmacother., 2016-11-24;0(0):. 2016-11-24 [PMID: 27890430] (Bioassay, Human) |
Bioassay |
Human |
| Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis Sci Rep, 2016-11-21;6(0):37445. 2016-11-21 [PMID: 27869174] (Bioassay, Human) |
Bioassay |
Human |
| CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT Nat Commun, 2016-11-21;7(0):13362. 2016-11-21 [PMID: 27869122] (Bioassay, Human) |
Bioassay |
Human |
| Saverio Bellusci Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis Cell Stem Cell, 2016-11-17;0(0):. 2016-11-17 [PMID: 27867035] (Bioassay, Human) |
Bioassay |
Human |
| Menq-Jer Lee TGF-?/ SMAD3 Pathway Stimulates Sphingosine-1-phosphate Receptor 3 Expression: Implication of Sphingosine-1-Phosphate Receptor 3 in Lung Adenocarcinoma Progression J. Biol. Chem., 2016-11-17;0(0):. 2016-11-17 [PMID: 27856637] (Bioassay, Human) |
Bioassay |
Human |
| Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching Sci Rep, 2016-11-17;6(0):37215. 2016-11-17 [PMID: 27853268] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Takeshi Suzuki MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines J. Biol. Chem., 2016-11-16;0(0):. 2016-11-16 [PMID: 27852821] (Bioassay, Human) |
Bioassay |
Human |
| Interleukin-22 ameliorates liver fibrosis through miR-200a/beta-catenin Sci Rep, 2016-11-07;6(0):36436. 2016-11-07 [PMID: 27819314] (Bioassay, Rat) |
Bioassay |
Rat |
| Karthikeyan Mythreye Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling J. Biol. Chem., 2016-10-26;291(49):25716-25728. 2016-10-26 [PMID: 27784788] (Bioassay, Human) |
Bioassay |
Human |
| M Gamboa Cas, SE Leggett, IY Wong Clustering and jamming in epithelial-mesenchymal co-cultures Soft Matter, 2016-10-12;12(40):8327-8337. 2016-10-12 [PMID: 27722738] (Bioassay, Human) |
Bioassay |
Human |
| Transient RUNX1 Expression during Early Mesendodermal Differentiation of�hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling Stem Cell Reports, 2016-10-06;7(5):884-896. 2016-10-06 [PMID: 27720906] (Bioassay, Human) |
Bioassay |
Human |
| Context-Specific Function of S6K2 in Th Cell Differentiation J Immunol, 2016-09-09;0(0):. 2016-09-09 [PMID: 27613697] (Bioassay, Mouse) |
Bioassay |
Mouse |
| EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis Physiol Rep, 2016-09-01;4(17):. 2016-09-01 [PMID: 27582065] (Bioassay, Human) |
Bioassay |
Human |
| 24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats PLoS ONE, 2016-08-30;11(8):e0161782. 2016-08-30 [PMID: 27575371] (Bioassay, Rat) |
Bioassay |
Rat |
| Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-?1 in Airway Epithelium PLoS ONE, 2016-08-29;11(8):e0162058. 2016-08-29 [PMID: 27571418] (Bioassay, Human) |
Bioassay |
Human |
| Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes Stem Cell Reports, 2016-08-25;0(0):. 2016-08-25 [PMID: 27569062] (ELISA (Standard), Human) |
ELISA (Standard) |
Human |
| Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation Nat Commun, 2016-08-22;7(0):12603. 2016-08-22 [PMID: 27545838] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves EBioMedicine, 2016-07-01;10(0):282-90. 2016-07-01 [PMID: 27394642] (Bioassay, Human) |
Bioassay |
Human |
| Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci Nat Commun, 2016-07-08;7(0):12092. 2016-07-08 [PMID: 27386823] (Bioassay, Human) |
Bioassay |
Human |
| Mohadeseh Mehrabian Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue PLoS ONE, 2016-06-21;11(6):e0156779. 2016-06-21 [PMID: 27327609] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Martine Schrøder CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits PLoS ONE, 2016-06-16;11(6):e0157387. 2016-06-16 [PMID: 27311059] (Bioassay, Human) |
Bioassay |
Human |
| Qisheng Li Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition Proc Natl Acad Sci USA, 2016-06-13;0(0):. 2016-06-13 [PMID: 27298373] (Bioassay, Human) |
Bioassay |
Human |
| Brian G Oliver A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro Thorax, 2016-06-10;71(11):1039-1049. 2016-06-10 [PMID: 27287090] (Bioassay, Human) |
Bioassay |
Human |
| Shoko Ohno Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure Sci Rep, 2016-06-07;6(0):27192. 2016-06-07 [PMID: 27273361] (Bioassay, Human) |
Bioassay |
Human |
| Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells Cancer Res, 2016-05-24;0(0):. 2016-05-24 [PMID: 27221703] (Bioassay, Human) |
Bioassay |
Human |
| Cell-cell contact and matrix adhesion promote ?SMA expression during TGF?1-induced epithelial-myofibroblast transition via Notch and MRTF-A Sci Rep, 2016-05-19;6(0):26226. 2016-05-19 [PMID: 27194451] (Bioassay, Mouse) |
Bioassay |
Mouse |
| MAP3K19 Is a Novel Regulator of TGF-? Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis PLoS ONE, 2016-05-04;11(5):e0154874. 2016-05-04 [PMID: 27144281] (Bioassay, Human) |
Bioassay |
Human |
| Transforming Growth Factor-? Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors Clin Cancer Res, 2016-04-28;0(0):. 2016-04-28 [PMID: 27126993] (Bioassay, Human) |
Bioassay |
Human |
| Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Biol, 2016-05-10;94(8):747-62. 2016-05-10 [PMID: 27075967] (Bioassay, Human) |
Bioassay |
Human |
| R Flynn, K Paz, J Du, DK Reichenbac, PA Taylor, A Panoskalts, A Vulic, L Luznik, KK MacDonald, GR Hill, MS Nyuydzefe, JM Weiss, W Chen, A Trzeciak, JS Serody, EG Aguilar, WJ Murphy, I Maillard, D Munn, J Koreth, CS Cutler, JH Antin, J Ritz, SD Waksal, A Zanin-Zhor, BR Blazar Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism Blood, 2016-03-16;127(17):2144-54. 2016-03-16 [PMID: 26983850] (Bioassay, Human) |
Bioassay |
Human |
| Isabela Pedroza-Pa, Divya Shah, Anna Domogala, Martha Luevano, Michael Blundell, Nicola Jackson, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation. Scientific Reports, 2016-02-26;0(0):2045-2322. 2016-02-26 [PMID: 26915707] (Bioassay, Human) |
Bioassay |
Human |
| Schmidt A, Eriksson M, Shang M, Weyd H, Tegner J Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. PLoS ONE, 2016-02-17;11(2):e0148474. 2016-02-17 [PMID: 26886923] (Bioassay, Human) |
Bioassay |
Human |
| Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc Natl Acad Sci U S A, 2016-01-19;113(5):1256-60. 2016-01-19 [PMID: 26787905] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Masani S, Han L, Meek K, Yu K Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A, 2016-01-19;113(5):1261-6. 2016-01-19 [PMID: 26787901] (Bioassay, Mouse) |
Bioassay |
Mouse |
| A Miyashita, S Fukushima, S Nakahara, Y Kubo, A Tokuzumi, J Yamashita, J Aoi, M Haruta, S Senju, Y Nishimura, M Jinnin, H Ihn Immunotherapy against Metastatic Melanoma with Human iPS Cell-Derived Myeloid Cell Lines Producing Type I Interferons Cancer Immunol Res, 2015-12-29;4(3):248-58. 2015-12-29 [PMID: 26714554] (Bioassay, Human) |
Bioassay |
Human |
| MH Fan, Q Zhu, HH Li, HJ Ra, S Majumdar, DL Gulick, JA Jerome, DH Madsen, M Christofid, DW Speicher, WW Bachovchin, C Feghali-Bo, E Puré Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice J. Biol. Chem., 2015-12-09;291(15):8070-89. 2015-12-09 [PMID: 26663085] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol, 2015-11-19;46(1):212-22. 2015-11-19 [PMID: 26514620] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol, 2015-08-31;16(10):1077-84. 2015-08-31 [PMID: 26322481] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Mehrabian M, Brethour D, Wang H, Xi Z, Rogaeva E, Schmitt-Ulms G The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis. PLoS ONE, 2015-08-19;10(8):e0133741. 2015-08-19 [PMID: 26288071] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Roach K, Feghali-Bostwick C, Amrani Y, Bradding P Lipoxin A4 Attenuates Constitutive and TGF-beta1-Dependent Profibrotic Activity in Human Lung Myofibroblasts. J Immunol, 2015-08-14;195(6):2852-60. 2015-08-14 [PMID: 26276873] (Bioassay, Human) |
Bioassay |
Human |
| Lian M, Luo W, Sui Y, Li Z, Hua J Dietary n-3 PUFA Protects Mice from Con A Induced Liver Injury by Modulating Regulatory T Cells and PPAR-gamma Expression. PLoS ONE, 2015-07-15;10(7):e0132741. 2015-07-15 [PMID: 26177196] (Bioassay, Human) |
Bioassay |
Human |
| Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M, Tiwari V JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J, 2015-07-08;34(16):2162-81. 2015-07-08 [PMID: 26157010] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells. PLoS ONE, 2015-06-25;10(6):e0130808. 2015-06-25 [PMID: 26110809] (Bioassay, Human) |
Bioassay |
Human |
| Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Kruger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G High mobility group protein-mediated transcription requires DNA damage marker gamma-H2AX. Cell Res, 2015-06-05;25(7):837-50. 2015-06-05 [PMID: 26045162] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis. Oncogene, 2015-05-11;35(6):748-60. 2015-05-11 [PMID: 25961925] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Harris T, McGargill M Drak2 Does Not Regulate TGF-beta Signaling in T Cells. PLoS ONE, 2015-05-07;10(5):e0123650. 2015-05-07 [PMID: 25951457] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Kuk H, Hutchenreuther J, Murphy-Marshman H, Carter D, Leask A 5Z-7-Oxozeanol Inhibits the Effects of TGFbeta1 on Human Gingival Fibroblasts. PLoS ONE, 2015-04-30;10(4):e0123689. 2015-04-30 [PMID: 25927238] (Bioassay, Human) |
Bioassay |
Human |
| Rojas-Fernandez A, Herhaus L, Macartney T, Lachaud C, Hay R, Sapkota G Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9. Sci Rep, 2015-04-29;5(0):9811. 2015-04-29 [PMID: 25922883] (Bioassay, Human) |
Bioassay |
Human |
| Sun , Yue, Deng , Wei, Geng , Linyu, Zhang , Lu, Liu , Rui, Chen , Weiwei, Yao , Genhong, Zhang , Huayong, Feng , Xuebing, Gao , Xiang, Sun , Lingyun Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells. J Immunol Res, 2015-03-31;2015(0):284215. 2015-03-31 [PMID: 25918734] (Bioassay, Human) |
Bioassay |
Human |
| Kaushansky N, Eisenstein M, Boura-Halfon S, Hansen B, Nielsen C, Milo R, Zeilig G, Lassmann H, Altmann D, Ben-Nun A Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease. J Biol Chem, 2015-04-24;290(24):15260-78. 2015-04-24 [PMID: 25911099] (ELISA (Standard), Mouse) |
ELISA (Standard) |
Mouse |
| Young K, Tweedie E, Conley B, Ames J, FitzSimons M, Brooks P, Liaw L, Vary C BMP9 Crosstalk with the Hippo Pathway Regulates Endothelial Cell Matricellular and Chemokine Responses. PLoS ONE, 2015-04-24;10(4):e0122892. 2015-04-24 [PMID: 25909848] (Bioassay, Human) |
Bioassay |
Human |
| Ilkow C, Marguerie M, Batenchuk C, Mayer J, Ben Neriah D, Cousineau S, Falls T, Jennings V, Boileau M, Bellamy D, Bastin D, de Souza C, Alkayyal A, Zhang J, Le Boeuf F, Arulanandam R, Stubbert L, Sampath P, Thorne S, Paramanthan P, Chatterjee A, Strieter R, Burdick M, Addison C, Stojdl D, Atkins H, Auer R, Diallo J, Lichty B, Bell J Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity. Nat Med, 2015-04-20;21(5):530-6. 2015-04-20 [PMID: 25894825] (Bioassay, Human) |
Bioassay |
Human |
| Giraldo C, Alvarez M, Carmona J Effects of sodium citrate and acid citrate dextrose solutions on cell counts and growth factor release from equine pure-platelet rich plasma and pure-platelet rich gel. BMC Vet Res, 2015-03-14;11(0):60. 2015-03-14 [PMID: 25889052] (Equine) |
|
Equine |
| Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M CXCL13 antibody for the treatment of autoimmune disorders. BMC Immunol, 2015-02-12;16(0):6. 2015-02-12 [PMID: 25879435] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Cruet-Hennequart S, Drougard C, Shaw G, Legendre F, Demoor M, Barry F, Lefaix J, Galera P Radiation-induced alterations of osteogenic and chondrogenic differentiation of human mesenchymal stem cells. PLoS ONE, 2015-04-02;10(3):e0119334. 2015-04-02 [PMID: 25837977] (Bioassay, Human) |
Bioassay |
Human |
| Yu D, Zhang C, Zhao S, Zhang S, Zhang H, Cai S, Shao R, He H The anti-fibrotic effects of epigallocatechin-3-gallate in bile duct-ligated cholestatic rats and human hepatic stellate LX-2 cells are mediated by the PI3K/Akt/Smad pathway. Acta Pharmacol Sin, 2015-03-16;36(4):473-82. 2015-03-16 [PMID: 25832428] (Bioassay, Human) |
Bioassay |
Human |
| Cho W, Kim Y, Kim J, Park S, Park D, Kim B, Jeoung D, Kim Y, Choe J Suppressor of cytokine signaling 1 is a positive regulator of TGF-beta-induced prostaglandin production in human follicular dendritic cell-like cells. J Immunol, 2015-03-30;194(9):4287-97. 2015-03-30 [PMID: 25825445] (Bioassay, Human) |
Bioassay |
Human |
| Jia D, Duan F, Peng P, Sun L, Ruan Y, Gu J Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice. PLoS ONE, 2015-03-30;10(3):e0121939. 2015-03-30 [PMID: 25822822] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Schmitt-Ney M, Camussi G The PAX3-FOXO1 fusion protein present in rhabdomyosarcoma interferes with normal FOXO activity and the TGF-beta pathway. PLoS ONE, 2015-03-25;10(3):e0121474. 2015-03-25 [PMID: 25806826] (Bioassay, Human) |
Bioassay |
Human |
| Woltje K, Jabs M, Fischer A Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE, 2015-03-23;10(3):e0120547. 2015-03-23 [PMID: 25799559] (Bioassay, Human) |
Bioassay |
Human |
| Mu Y, Zang G, Engstrom U, Busch C, Landstrom M TGFbeta-induced phosphorylation of Par6 promotes migration and invasion in prostate cancer cells. Br J Cancer, 2015-03-31;112(7):1223-31. 2015-03-31 [PMID: 25756394] (Bioassay, Human) |
Bioassay |
Human |
| Narcisi R, Cleary M, Brama P, Hoogduijn M, Tuysuz N, ten Berge D, van Osch G Long-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation. Stem Cell Reports, 2015-02-26;4(3):459-72. 2015-02-26 [PMID: 25733021] (Bioassay, Human) |
Bioassay |
Human |
| James B Canavan Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease Gut, 2015-02-24;65(4):584-94. 2015-02-24 [PMID: 25715355] (Bioassay, Human) |
Bioassay |
Human |
| Kinugasa H, Whelan K, Tanaka K, Natsuizaka M, Long A, Guo A, Chang S, Kagawa S, Srinivasan S, Guha M, Yamamoto K, St Clair D, Avadhani N, Diehl J, Nakagawa H Mitochondrial SOD2 regulates epithelial-mesenchymal transition and cell populations defined by differential CD44 expression. Oncogene, 2015-02-09;34(41):5229-39. 2015-02-09 [PMID: 25659582] (Bioassay, Human) |
Bioassay |
Human |
| Czysz , Katherin, Minger , Stephen, Thomas , Nick DMSO efficiently down regulates pluripotency genes in human embryonic stem cells during definitive endoderm derivation and increases the proficiency of hepatic differentiation. PLoS ONE, 2015-02-06;10(2):e0117689. 2015-02-06 [PMID: 25659159] (Bioassay, Human) |
Bioassay |
Human |
| Herova M, Schmid M, Gemperle C, Hersberger M ChemR23, the receptor for chemerin and resolvin E1, is expressed and functional on M1 but not on M2 macrophages. J Immunol, 2015-01-30;194(5):2330-7. 2015-01-30 [PMID: 25637017] (Bioassay, Human) |
Bioassay |
Human |
| Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu-Kaoud N, Halabi N, Guerrouahen B, Rafii S, Rafii A Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. J Transl Med, 2015-01-27;13(0):27. 2015-01-27 [PMID: 25623554] (Bioassay, Human) |
Bioassay |
Human |
| Sugita S, Kamao H, Iwasaki Y, Okamoto S, Hashiguchi T, Iseki K, Hayashi N, Mandai M, Takahashi M Inhibition of T-cell activation by retinal pigment epithelial cells derived from induced pluripotent stem cells. Invest Ophthalmol Vis Sci, 2015-01-20;56(2):1051-62. 2015-01-20 [PMID: 25604685] (Bioassay, Human) |
Bioassay |
Human |
| Haffner-Luntzer , Melanie, Heilmann , Aline, Rapp , Anna Eli, Beie , Simon, Schinke , Thorsten, Amling , Michael, Ignatius , Anita, Liedert , Astrid Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. PLoS ONE, 2014-12-31;9(12):e116282. 2014-12-31 [PMID: 25551381] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Waight J, Takai S, Marelli B, Qin G, Hance K, Zhang D, Tighe R, Lan Y, Lo K, Sabzevari H, Hofmeister R, Wilson N Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans. J Immunol, 2014-12-29;194(3):878-82. 2014-12-29 [PMID: 25548231] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Woeller C, O'Loughlin C, Roztocil E, Feldon S, Phipps R Salinomycin and other polyether ionophores are a new class of antiscarring agent. J Biol Chem, 2014-12-23;290(6):3563-75. 2014-12-23 [PMID: 25538236] (Bioassay, Human) |
Bioassay |
Human |
| Nguyen L, Pan J, Dinh T, Hadeiba H, O'Hara E, Ebtikar A, Hertweck A, Gokmen M, Lord G, Jenner R, Butcher E, Habtezion A Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol, 2014-12-22;16(2):207-13. 2014-12-22 [PMID: 25531831] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Galvagni F, Lentucci C, Neri F, Dettori D, De Clemente C, Orlandini M, Anselmi F, Rapelli S, Grillo M, Borghi S, Oliviero S Snai1 promotes ESC exit from the pluripotency by direct repression of self-renewal genes. Stem Cells, 2015-03-01;33(3):742-50. 2015-03-01 [PMID: 25504116] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Gordian E, Li J, Pevzner Y, Mediavilla-Varela M, Luddy K, Ohaegbulam K, Daniel K, Haura E, Munoz-Antonia T Transforming growth factor beta signaling overcomes dasatinib resistance in lung cancer. PLoS ONE, 2014-12-11;9(12):e114131. 2014-12-11 [PMID: 25501935] (Bioassay, Human) |
Bioassay |
Human |
| Wang J, Cao Z, Zhang X, Nakamura M, Sun M, Hartman J, Harris R, Sun Y, Cao Y Novel mechanism of macrophage-mediated metastasis revealed in a zebrafish model of tumor development. Cancer Res, 2014-12-09;75(2):306-15. 2014-12-09 [PMID: 25492861] (Bioassay, Human) |
Bioassay |
Human |
| Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, Lesch J, Lu R, Newton K, Huang O, Cochran A, Vasser M, Fauber B, DeVoss J, Webster J, Diehl L, Modrusan Z, Kirkpatrick D, Lill J, Ouyang W, Dixit V Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature, 2014-12-03;518(7539):417-21. 2014-12-03 [PMID: 25470037] (Bioassay, Mouse) |
Bioassay |
Mouse |
| MiR-133 modulates TGF-β1-induced bladder smooth muscle cell hypertrophic and fibrotic response: implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction. Cell Signal, 2014-11-11;27(2):215-27. 2014-11-11 [PMID: 25451078] (Bioassay, Human, Rat) |
Bioassay |
Human, Rat |
| Presnell S, Al-Attar A, Cichocki F, Miller J, Lutz C Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs. Genes Immun, 2014-11-20;16(1):89-98. 2014-11-20 [PMID: 25410655] (Bioassay, Human) |
Bioassay |
Human |
| Eun S, Lee S, Xu Y, Croft M 4-1BB ligand signaling to T cells limits T cell activation. J Immunol, 2014-11-17;194(1):134-41. 2014-11-17 [PMID: 25404362] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Li J, Ballim D, Rodriguez M, Cui R, Goding C, Teng H, Prince S The anti-proliferative function of the TGF-beta1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3. J Biol Chem, 2014-11-04;289(51):35633-43. 2014-11-04 [PMID: 25371204] (Bioassay, Human) |
Bioassay |
Human |
| Bohnsack R, Warejcka D, Wang L, Gillespie S, Bernstein A, Twining S, Dahms N Expression of insulin-like growth factor 2 receptor in corneal keratocytes during differentiation and in response to wound healing. Invest Ophthalmol Vis Sci, 2014-10-30;55(12):7697-708. 2014-10-30 [PMID: 25358730] (Bioassay, Human) |
Bioassay |
Human |
| Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation. J Biol Chem, 2014-10-22;289(51):35246-63. 2014-10-22 [PMID: 25339175] (Bioassay, Human) |
Bioassay |
Human |
| Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. J Clin Invest, 2014-09-17;124(10):4657-67. 2014-09-17 [PMID: 25244097] (Bioassay, Human) |
Bioassay |
Human |
| Xiao , Guan-Yu, Liu , I-Hsuan, Cheng , Chun-Chu, Chang , Chia-Chu, Lee , Yen-Hua, Cheng , Winston, Wu , Shinn-Ch Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy. PLoS ONE, 2014-09-08;9(9):e106538. 2014-09-08 [PMID: 25198549] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Chen K, Hsu H, Lee C, Yen T, Ko Y, Yang C, Hung C The AMPK agonist AICAR inhibits TGF-beta1 induced activation of kidney myofibroblasts. PLoS ONE, 2014-09-04;9(9):e106554. 2014-09-04 [PMID: 25188319] (Bioassay, Rat) |
Bioassay |
Rat |
| Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion. PLoS ONE, 2014-09-03;9(9):e106673. 2014-09-03 [PMID: 25184791] (Bioassay, Human) |
Bioassay |
Human |
| Tobar N, Toyos M, Urra C, Mendez N, Arancibia R, Smith P, Martinez J c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. BMC Cancer, 2014-08-30;14(0):640. 2014-08-30 [PMID: 25175743] (Bioassay, Human) |
Bioassay |
Human |
| Cheng T, Hu C, Yang H, Cao L, An J Transforming growth factor-beta-induced miR143 expression in regulation of non-small cell lung cancer cell viability and invasion capacity in vitro and in vivo. Int J Oncol, 2014-08-27;45(5):1977-88. 2014-08-27 [PMID: 25175415] (Bioassay, Human) |
Bioassay |
Human |
| Pessina P, Cabrera D, Morales M, Riquelme C, Gutierrez J, Serrano A, Brandan E, Munoz-Canoves P Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy. Skelet Muscle, 2014-08-25;4(0):7. 2014-08-25 [PMID: 25157321] (In Vivo, Mouse) |
In Vivo |
Mouse |
| Zhou Y, Xiong M, Niu J, Sun Q, Su W, Zen K, Dai C, Yang J Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney. J Cell Sci, 2014-08-08;127(0):4494-506. 2014-08-08 [PMID: 25107369] (Bioassay, Rat) |
Bioassay |
Rat |
| Scherz-Shouval R, Santagata S, Mendillo M, Sholl L, Ben-Aharon I, Beck A, Dias-Santagata D, Koeva M, Stemmer S, Whitesell L, Lindquist S The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell, 2014-07-31;158(3):564-78. 2014-07-31 [PMID: 25083868] (Bioassay, Human) |
Bioassay |
Human |
| Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 2014-07-29;211(9):1807-19. 2014-07-29 [PMID: 25073792] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Speck S, Lim J, Shelake S, Matka M, Stoddard J, Farr A, Kuchroo V, Laouar Y TGF-beta signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation. PLoS ONE, 2014-07-29;9(7):e102390. 2014-07-29 [PMID: 25072375] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells. J Biol Chem, 2014-07-28;289(37):25546-55. 2014-07-28 [PMID: 25070893] (Bioassay, Human) |
Bioassay |
Human |
| Pan C, Kumar S, Shah N, Hoyt D, Hawinkels L, Mythreye K, Lee N Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis. J Biol Chem, 2014-07-28;289(37):25486-96. 2014-07-28 [PMID: 25070888] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Okada Y, Shirai K, Reinach P, Kitano-Izutani A, Miyajima M, Flanders K, Jester J, Tominaga M, Saika S TRPA1 is required for TGF-beta signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma. Lab Invest, 2014-07-28;94(9):1030-41. 2014-07-28 [PMID: 25068659] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Chen L, Munoz-Antonia T, Cress W Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines. PLoS ONE, 2014-07-01;9(7):e101040. 2014-07-01 [PMID: 24983967] (Bioassay, Human) |
Bioassay |
Human |
| Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors. J Immunol, 2014-06-23;193(3):1047-54. 2014-06-23 [PMID: 24958901] (Bioassay, Human) |
Bioassay |
Human |
| Hardin H, Guo Z, Shan W, Montemayor-Garcia C, Asioli S, Yu X, Harrison A, Chen H, Lloyd R The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression. Am J Pathol, 2014-06-17;184(8):2342-54. 2014-06-17 [PMID: 24946010] (Bioassay, Human) |
Bioassay |
Human |
| Lim M, Ahn J, Yi J, Kim M, Son A, Lee S, Lim D, Kim S, Kang M, Han Y, Song J Induction of galectin-1 by TGF-beta1 accelerates fibrosis through enhancing nuclear retention of Smad2. Exp Cell Res, 2014-06-11;326(1):125-35. 2014-06-11 [PMID: 24928277] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| Arts M, Baron M, Chokr N, Fritzler M, Servant M Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor. PLoS ONE, 2014-06-13;9(6):e100035. 2014-06-13 [PMID: 24927197] (Bioassay, Human) |
Bioassay |
Human |
| Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol, 2014-06-11;193(2):879-88. 2014-06-11 [PMID: 24920846] (Bioassay, Human) |
Bioassay |
Human |
| Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling. FEBS Open Bio, 2014-04-01;4(0):353-61. 2014-04-01 [PMID: 24918049] (Bioassay, Human) |
Bioassay |
Human |
| Liu Y, Kimura K, Orita T, Teranishi S, Suzuki K, Sonoda K Inhibition by all-trans-retinoic acid of transforming growth factor-beta-induced collagen gel contraction mediated by human tenon fibroblasts. Invest Ophthalmol Vis Sci, 2014-06-03;55(7):4199-205. 2014-06-03 [PMID: 24894398] (Bioassay, Human) |
Bioassay |
Human |
| Okabe H, Delgado E, Lee J, Yang J, Kinoshita H, Hayashi H, Tsung A, Behari J, Beppu T, Baba H, Monga S Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PLoS ONE, 2014-06-03;9(6):e98817. 2014-06-03 [PMID: 24892551] (Bioassay, Human) |
Bioassay |
Human |
| Zafar A, Wu F, Hardy K, Li J, Tu W, McCuaig R, Harris J, Khanna K, Attema J, Gregory P, Goodall G, Harrington K, Dahlstrom J, Boulding T, Madden R, Tan A, Milburn P, Rao S Chromatinized protein kinase C-theta directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells. Mol Cell Biol, 2014-06-02;34(16):2961-80. 2014-06-02 [PMID: 24891615] (Bioassay, Human) |
Bioassay |
Human |
| Togashi , Yosuke, Sakamoto , Hiroki, Hayashi , Hidetosh, Terashima , Masato, de Velasco , Marco A, Fujita , Yoshihik, Kodera , Yasuo, Sakai , Kazuko, Tomida , Shuta, Kitano , Masayuki, Ito , Akihiko, Kudo , Masatosh, Nishio , Kazuto Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer. Mol Cancer, 2014-05-27;13(0):126. 2014-05-27 [PMID: 24886203] (Bioassay, Human) |
Bioassay |
Human |
| Salvo E, Garasa S, Dotor J, Morales X, Pelaez R, Altevogt P, Rouzaut A Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer. Mol Cancer, 2014-05-19;13(0):112. 2014-05-19 [PMID: 24884715] (Bioassay, Human) |
Bioassay |
Human |
| Matthews A, Husain S, Chaudhuri J Binding of AID to DNA does not correlate with mutator activity. J Immunol, 2014-05-30;193(1):252-7. 2014-05-30 [PMID: 24879790] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Choi S, Kim B, Robinson J, Fink S, Yan M, Sporn M, Markowitz S, Letterio J Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J Clin Invest, 2014-05-16;124(6):2472-82. 2014-05-16 [PMID: 24837432] (Bioassay, Human) |
Bioassay |
Human |
| Desai L, Zhou Y, Estrada A, Ding Q, Cheng G, Collawn J, Thannickal V Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein. J Biol Chem, 2014-05-15;289(26):18270-8. 2014-05-15 [PMID: 24831009] (Bioassay, Human) |
Bioassay |
Human |
| Fehrholz M, Speer C, Kunzmann S Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells. PLoS ONE, 2014-05-14;9(5):e97357. 2014-05-14 [PMID: 24828686] (Bioassay, Human) |
Bioassay |
Human |
| Solomon J, Heitzer M, Liu T, Beumer J, Parise R, Normolle D, Leach D, Buchanan G, DeFranco D VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells. Mol Cancer Res, 2014-05-13;12(8):1166-80. 2014-05-13 [PMID: 24825850] (Bioassay, Human) |
Bioassay |
Human |
| Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines. Int J Oncol, 2014-05-09;45(1):393-400. 2014-05-09 [PMID: 24819550] (Bioassay, Human) |
Bioassay |
Human |
| Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE, 2014-05-09;9(5):e96615. 2014-05-09 [PMID: 24816923] (Bioassay, Human) |
Bioassay |
Human |
| Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest, 2014-05-08;124(6):2513-22. 2014-05-08 [PMID: 24812667] (Human) |
|
Human |
| Gobel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth S Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol, 2014-06-05;44(8):2295-305. 2014-06-05 [PMID: 24811005] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE, 2014-05-02;9(5):e96695. 2014-05-02 [PMID: 24792400] (Bioassay, Human) |
Bioassay |
Human |
| Kasabova M, Joulin-Giet A, Lecaille F, Gilmore B, Marchand-Adam S, Saidi A, Lalmanach G Regulation of TGF-beta1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. J Biol Chem, 2014-04-30;289(23):16239-51. 2014-04-30 [PMID: 24790080] (Bioassay, Human) |
Bioassay |
Human |
| Luo F, Zhuang Y, Sides M, Sanchez C, Shan B, White E, Lasky J Arsenic trioxide inhibits transforming growth factor-beta1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo. Respir Res, 2014-04-24;15(0):51. 2014-04-24 [PMID: 24762191] (Bioassay, Human) |
Bioassay |
Human |
| Li H, Fitchett C, Kozdon K, Jayaram H, Rose G, Bailly M, Ezra D Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments. PLoS ONE, 2014-04-21;9(4):e95586. 2014-04-21 [PMID: 24751986] (Bioassay, Human) |
Bioassay |
Human |
| Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin. PLoS ONE, 2014-04-11;9(4):e94801. 2014-04-11 [PMID: 24728340] (Bioassay, Human) |
Bioassay |
Human |
| Tulley S, Chen W Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-beta signaling. J Biol Chem, 2014-04-13;289(22):15280-96. 2014-04-13 [PMID: 24727589] (Bioassay, Human) |
Bioassay |
Human |
| Villegas V, Rahman M, Fernandez-Barrena M, Diao Y, Liapi E, Sonkoly E, Stahle M, Pivarcsi A, Annaratone L, Sapino A, Ramirez Clavijo S, Burglin T, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico M, Zaphiropoulos P Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1. Mol Oncol, 2014-03-22;8(5):912-26. 2014-03-22 [PMID: 24726458] (Bioassay, Human) |
Bioassay |
Human |
| Wei D, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry J, Stepan G, Stray K, Tsai A, Yu H, Spindler J, Kearney M, Spina C, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog, 2014-04-10;10(4):e1004071. 2014-04-10 [PMID: 24722454] (Bioassay, Human) |
Bioassay |
Human |
| Shi X, DiRenzo D, Guo L, Franco S, Wang B, Seedial S, Kent K TGF-beta/Smad3 stimulates stem cell/developmental gene expression and vascular smooth muscle cell de-differentiation. 2014-04-09;9(0):. 2014-04-09 [PMID: 24718260] (Bioassay, Rat) |
Bioassay |
Rat |
| Echeverria C, Montorfano I, Hermosilla T, Armisen R, Velasquez L, Cabello-Verrugio C, Varela D, Simon F Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS ONE, 2014-04-07;9(4):e94146. 2014-04-07 [PMID: 24710004] (Bioassay, Human) |
Bioassay |
Human |
| Yu Y, Yiang G, Chou P, Tseng H, Wu T, Hung Y, Lin P, Lin S, Liu H, Chang W, Wei C Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation. Mol Med Rep, 2014-03-28;9(6):2077-84. 2014-03-28 [PMID: 24682227] (Bioassay, Rat) |
Bioassay |
Rat |
| Miller C, Haas U, Diaz R, Leeper N, Kundu R, Patlolla B, Assimes T, Kaiser F, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genet, 2014-03-27;10(3):e1004263. 2014-03-27 [PMID: 24676100] (Bioassay, Human) |
Bioassay |
Human |
| Kim S, Lee S, Wang Z, Ding Y, Haque N, Zhang J, Zhou J, Choi M TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation. J Am Soc Nephrol, 2014-03-20;25(9):1966-78. 2014-03-20 [PMID: 24652804] (Bioassay, Human) |
Bioassay |
Human |
| Gurunathan S, Winkles J, Ghosh S, Hayden M Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem, 2014-03-20;289(19):12976-88. 2014-03-20 [PMID: 24652288] |
|
|
| Aschner Y, Khalifah A, Briones N, Yamashita C, Dolgonos L, Young S, Campbell M, Riches D, Redente E, Janssen W, Henson P, Sap J, Vacaresse N, Kapus A, McCulloch C, Zemans R, Downey G Protein tyrosine phosphatase alpha mediates profibrotic signaling in lung fibroblasts through TGF-beta responsiveness. Am J Pathol, 2014-03-17;184(5):1489-502. 2014-03-17 [PMID: 24650563] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Jeon K, Kulkarni A, Woeller C, Phipps R, Sime P, Hindman H, Huxlin K Inhibitory effects of PPARgamma ligands on TGF-beta1-induced corneal myofibroblast transformation. Am J Pathol, 2014-03-17;184(5):1429-45. 2014-03-17 [PMID: 24650561] (Bioassay, Feline) |
Bioassay |
Feline |
| Xu S, Zhu J, Wu Z Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-beta and induce Tregs development via TGF-beta. PLoS ONE, 2014-03-17;9(3):e91709. 2014-03-17 [PMID: 24638085] (Bioassay, Human) |
Bioassay |
Human |
| Olderoy M, Lilledahl M, Beckwith M, Melvik J, Reinholt F, Sikorski P, Brinchmann J Biochemical and structural characterization of neocartilage formed by mesenchymal stem cells in alginate hydrogels. PLoS ONE, 2014-03-13;9(3):e91662. 2014-03-13 [PMID: 24626259] (Bioassay, Human) |
Bioassay |
Human |
| Overstreet J, Samarakoon R, Meldrum K, Higgins P Redox control of p53 in the transcriptional regulation of TGF-beta1 target genes through SMAD cooperativity. Cell Signal, 2014-03-05;26(7):1427-36. 2014-03-05 [PMID: 24613410] (Bioassay, Human) |
Bioassay |
Human |
| Kudo-Saito C, Yura M, Yamamoto R, Kawakami Y Induction of immunoregulatory CD271+ cells by metastatic tumor cells that express human endogenous retrovirus H. Cancer Res, 2014-03-01;74(5):1361-70. 2014-03-01 [PMID: 24590808] (Bioassay, Human) |
Bioassay |
Human |
| Gao X, Cao Y, Staloch D, Gonzales M, Aronson J, Chao C, Hellmich M, Ko T Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS ONE, 2014-02-21;9(2):e89114. 2014-02-21 [PMID: 24586530] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Mael-Ainin M, Abed A, Conway S, Dussaule J, Chatziantoniou C Inhibition of periostin expression protects against the development of renal inflammation and fibrosis. J Am Soc Nephrol, 2014-02-27;25(8):1724-36. 2014-02-27 [PMID: 24578131] (Bioassay, Human) |
Bioassay |
Human |
| Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells. Int J Oncol, 2014-02-21;44(5):1643-51. 2014-02-21 [PMID: 24573038] (Bioassay, Human) |
Bioassay |
Human |
| Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer, 2014-02-20;14(0):113. 2014-02-20 [PMID: 24555435] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Diepenbruck , Maren, Waldmeier , Lorenz, Ivanek , Robert, Berninger , Philipp, Arnold , Phil, van Nimwegen , Erik, Christofori , Gerhard Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. J Cell Sci, 2014-02-19;127(0):1523-36. 2014-02-19 [PMID: 24554433] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Bioassay, Human) |
Bioassay |
Human |
| Italiani , Paola, Mazza , Emilia M, Lucchesi , Davide, Cifola , Ingrid, Gemelli , Claudia, Grande , Alexis, Battaglia , Cristina, Bicciato , Silvio, Boraschi , Diana Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro. PLoS ONE, 2014-02-03;9(2):e87680. 2014-02-03 [PMID: 24498352] (Bioassay, Human) |
Bioassay |
Human |
| Mirkina I, Hadzijusufovic E, Krepler C, Mikula M, Mechtcheriakova D, Strommer S, Stella A, Jensen-Jarolim E, Holler C, Wacheck V, Pehamberger H, Valent P Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R. PLoS ONE, 2014-01-29;9(1):e84417. 2014-01-29 [PMID: 24489649] (Bioassay, Human) |
Bioassay |
Human |
| Oliveira W, Ribeiro L, Schrieffer A, Machado P, Carvalho E, Bacellar O The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine, 2014-01-30;66(2):127-32. 2014-01-30 [PMID: 24485388] (Bioassay, Human) |
Bioassay |
Human |
| Du , Lili, Yu , Yanqiu, Ma , Haiying, Lu , Xiaomei, Ma , Ling, Jin , Yunan, Zhang , Haipeng Hypoxia enhances protective effect of placental-derived mesenchymal stem cells on damaged intestinal epithelial cells by promoting secretion of insulin-like growth factor-1. Int J Mol Sci, 2014-01-27;15(2):1983-2002. 2014-01-27 [PMID: 24473145] (Bioassay, Human) |
Bioassay |
Human |
| Ratnayake M, Ploger F, Santibanez-Koref M, Loughlin J Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLoS ONE, 2014-01-21;9(1):e86590. 2014-01-21 [PMID: 24466161] (Bioassay, Human) |
Bioassay |
Human |
| Wang X, Gui L, Zhang Y, Zhang J, Shi J, Xu G Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-beta signaling pathway. Int J Oncol, 2014-01-21;44(4):1099-106. 2014-01-21 [PMID: 24452274] (Bioassay, Human) |
Bioassay |
Human |
| Miller M, Petty C, Tompkins M, Fogle J CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism. Virol J, 2014-01-18;11(0):7. 2014-01-18 [PMID: 24438223] (Bioassay, Feline) |
Bioassay |
Feline |
| Chen X, Yang Y, Zhou Q, Weiss J, Howard O, McPherson J, Wakefield L, Oppenheim J Effective chemoimmunotherapy with anti-TGFbeta antibody and cyclophosphamide in a mouse model of breast cancer. PLoS ONE, 2014-01-09;9(1):e85398. 2014-01-09 [PMID: 24416401] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Rozycki M, Lodyga M, Lam J, Miranda M, Fatyol K, Speight P, Kapus A The fate of the primary cilium during myofibroblast transition. Mol Biol Cell, 2014-01-08;25(5):643-57. 2014-01-08 [PMID: 24403605] (Bioassay, Human) |
Bioassay |
Human |
| Chen C, Akiyama K, Yamaza T, You Y, Xu X, Li B, Zhao Y, Shi S Telomerase governs immunomodulatory properties of mesenchymal stem cells by regulating FAS ligand expression. EMBO Mol Med, 2014-01-08;6(3):322-34. 2014-01-08 [PMID: 24401839] (Bioassay, Human) |
Bioassay |
Human |
| Kim D, Lee M, Yoo K, Lee T, Kim H, Jang I, Chun Y, Kim H, Park S, Lee S, Son M, Jung H, Sung K, Koo H Gene expression profiles of human adipose tissue-derived mesenchymal stem cells are modified by cell culture density. PLoS ONE, 2014-01-06;9(1):e83363. 2014-01-06 [PMID: 24400072] (Cell Culture, Human) |
Cell Culture |
Human |
| Hou S, Landego I, Jayachandran N, Miller A, Gibson I, Ambrose C, Marshall A Follicular dendritic cell secreted protein FDC-SP controls IgA production. Mucosal Immunol, 2014-01-08;7(4):948-57. 2014-01-08 [PMID: 24399151] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Park S, Deering R, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert B, Hacohen N, Leslie C, Daley G, Lengner C, Kharas M Musashi-2 controls cell fate, lineage bias, and TGF-beta signaling in HSCs. J Exp Med, 2014-01-06;211(1):71-87. 2014-01-06 [PMID: 24395885] (Bioassay, Human) |
Bioassay |
Human |
| Axpe E, Lopez-Euba T, Castellanos-Rubio A, Merida D, Garcia J, Plaza-Izurieta L, Fernandez-Jimenez N, Plazaola F, Bilbao J Detection of atomic scale changes in the free volume void size of three-dimensional colorectal cancer cell culture using positron annihilation lifetime spectroscopy. PLoS ONE, 2014-01-02;9(1):e83838. 2014-01-02 [PMID: 24392097] (Bioassay, Human) |
Bioassay |
Human |
| Roach K, Duffy S, Coward W, Feghali-Bostwick C, Wulff H, Bradding P The K+ channel KCa3.1 as a novel target for idiopathic pulmonary fibrosis. PLoS ONE, 2013-12-31;8(12):e85244. 2013-12-31 [PMID: 24392001] (Bioassay, Human) |
Bioassay |
Human |
| Leung L, Radulovich N, Zhu C, Wang D, To C, Ibrahimov E, Tsao M Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis. PLoS ONE, 2013-12-27;8(12):e84366. 2013-12-27 [PMID: 24386371] (Bioassay, Human) |
Bioassay |
Human |
| Gong J, Cho I, Shin D, Han S, Park S, Kang Y Inhibition of airway epithelial-to-mesenchymal transition and fibrosis by kaempferol in endotoxin-induced epithelial cells and ovalbumin-sensitized mice. Lab Invest, 2013-12-30;94(3):297-308. 2013-12-30 [PMID: 24378645] (Stimulation, Human) |
Stimulation |
Human |
| Komatsu N, Okamoto K, Sawa S, Nakashima T, Oh-hora M, Kodama T, Tanaka S, Bluestone J, Takayanagi H Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis. Nat Med, 2013-12-22;20(1):62-8. 2013-12-22 [PMID: 24362934] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Tammaro A, Stroo I, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing M Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy. PLoS ONE, 2013-12-16;8(12):e82498. 2013-12-16 [PMID: 24358193] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Serrano , Isabel, McDonald , Paul C, Lock , Frances, Muller , William, Dedhar , Shoukat Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase. Nat Commun, 2013-01-01;4(0):2976. 2013-01-01 [PMID: 24356468] (Bioassay, Human) |
Bioassay |
Human |
| Gallo E, Loch D, Habashi J, Calderon J, Chen Y, Bedja D, van Erp C, Gerber E, Parker S, Sauls K, Judge D, Cooke S, Lindsay M, Rouf R, Myers L, ap Rhys C, Kent K, Norris R, Huso D, Dietz H Angiotensin II-dependent TGF-beta signaling contributes to Loeys-Dietz syndrome vascular pathogenesis. J Clin Invest, 2013-12-20;124(1):448-60. 2013-12-20 [PMID: 24355923] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| Schwartze J, Becker S, Sakkas E, Wujak L, Niess G, Usemann J, Reichenberger F, Herold S, Vadasz I, Mayer K, Seeger W, Morty R Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts. J Biol Chem, 2013-12-17;289(6):3262-75. 2013-12-17 [PMID: 24347165] (Bioassay, Human) |
Bioassay |
Human |
| O'Connor J, Gomez E Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling. PLoS ONE, 2013-12-10;8(12):e83188. 2013-12-10 [PMID: 24340092] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Matsuhashi S, Hamajima H, Xia J, Zhang H, Mizuta T, Anzai K, Ozaki I Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells. Cell Signal, 2013-12-12;26(3):603-10. 2013-12-12 [PMID: 24334270] (Bioassay, Human) |
Bioassay |
Human |
| Liu Y, Holdbrooks A, De Sarno P, Rowse A, Yanagisawa L, McFarland B, Harrington L, Raman C, Sabbaj S, Benveniste E, Qin H Therapeutic efficacy of suppressing the Jak/STAT pathway in multiple models of experimental autoimmune encephalomyelitis. J Immunol, 2013-12-09;192(1):59-72. 2013-12-09 [PMID: 24323580] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Karki S, Surolia R, Hock T, Guroji P, Zolak J, Duggal R, Ye T, Thannickal V, Antony V Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis. FASEB J, 2013-11-21;28(3):1122-31. 2013-11-21 [PMID: 24265486] (Bioassay, Human) |
Bioassay |
Human |
| Rojo J, Ojeda G, Acosta Y, Montes-Casado M, Criado G, Portoles P Characteristics of TCR/CD3 complex CD3{varepsilon} chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo. J Leukoc Biol, 2013-11-08;95(3):441-50. 2013-11-08 [PMID: 24212096] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Baldwin A, Cain S, Lennon R, Godwin A, Merry C, Kielty C Epithelial-mesenchymal status influences how cells deposit fibrillin microfibrils. J Cell Sci, 2013-11-04;127(0):158-71. 2013-11-04 [PMID: 24190885] (Bioassay, Human) |
Bioassay |
Human |
| Yasmin N, Bauer T, Modak M, Wagner K, Schuster C, Koffel R, Seyerl M, Stockl J, Elbe-Burger A, Graf D, Strobl H Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation. J Exp Med, 2013-11-04;210(12):2597-610. 2013-11-04 [PMID: 24190429] (Bioassay, Human) |
Bioassay |
Human |
| Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev, 2013-12-04;23(5):541-54. 2013-12-04 [PMID: 24172175] (Bioassay, Human) |
Bioassay |
Human |
| Long , Jianyin, Badal , Shawn S, Wang , Yin, Chang , Benny H, Rodriguez , Antony, Danesh , Farhad R MicroRNA-22 is a master regulator of bone morphogenetic protein-7/6 homeostasis in the kidney. J Biol Chem, 2013-10-25;288(51):36202-14. 2013-10-25 [PMID: 24163368] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Acuna M, Pessina P, Olguin H, Cabrera D, Vio C, Bader M, Munoz-Canoves P, Santos R, Cabello-Verrugio C, Brandan E Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-beta signalling. Hum Mol Genet, 2013-10-24;23(5):1237-49. 2013-10-24 [PMID: 24163134] (Bioassay, In Vivo, Mouse) |
Bioassay, In Vivo |
Mouse |
| Yao G, Liang M, Liang N, Yin M, Lu M, Lian J, Wang Y, Sun F MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3. Mol Cell Endocrinol, 2013-10-18;382(1):244-53. 2013-10-18 [PMID: 24145127] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol, 2013-10-18;191(11):5420-9. 2013-10-18 [PMID: 24140642] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Sun H, Sun C, Xiao W Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine, 2013-10-15;65(1):33-41. 2013-10-15 [PMID: 24139237] (Bioassay, Human) |
Bioassay |
Human |
| Zheng J, Wu C, Lin Z, Guo Y, Shi L, Dong P, Lu Z, Gao S, Liao Y, Chen B, Yu F Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis. FEBS J, 2013-11-05;281(1):88-103. 2013-11-05 [PMID: 24138392] (Bioassay, Rat) |
Bioassay |
Rat |
| Midgley A, Bowen T, Phillips A, Steadman R MicroRNA-7 inhibition rescues age-associated loss of epidermal growth factor receptor and hyaluronan-dependent differentiation in fibroblasts. Aging Cell, 2013-11-12;13(2):235-44. 2013-11-12 [PMID: 24134702] (Bioassay, Human) |
Bioassay |
Human |
| Keune W, Sims A, Jones D, Bultsma Y, Lynch J, Jirstrom K, Landberg G, Divecha N Low PIP4K2B expression in human breast tumors correlates with reduced patient survival: A role for PIP4K2B in the regulation of E-cadherin expression. Cancer Res, 2013-10-14;73(23):6913-25. 2013-10-14 [PMID: 24127122] (Bioassay, Human) |
Bioassay |
Human |
| Nasarre P, Gemmill R, Potiron V, Roche J, Lu X, Baron A, Korch C, Garrett-Mayer E, Lagana A, Howe P, Drabkin H Neuropilin-2 Is upregulated in lung cancer cells during TGF-beta1-induced epithelial-mesenchymal transition. Cancer Res, 2013-10-11;73(23):7111-21. 2013-10-11 [PMID: 24121493] (Bioassay, Human) |
Bioassay |
Human |
| Cheng J, Chang H, Leung P Transforming growth factor-beta1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein. J Biol Chem, 2013-10-08;288(46):33181-92. 2013-10-08 [PMID: 24106276] (Bioassay, Human) |
Bioassay |
Human |
| Hung C, Rohani M, Lee S, Chen P, Schnapp L Role of IGF-1 pathway in lung fibroblast activation. Respir Res, 2013-10-08;14(0):102. 2013-10-08 [PMID: 24103846] (Cell Culture, Mouse) |
Cell Culture |
Mouse |
| Ramdas V, McBride M, Denby L, Baker A Canonical transforming growth factor-beta signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Am J Pathol, 2013-10-06;183(6):1885-96. 2013-10-06 [PMID: 24103556] (Bioassay, Rat) |
Bioassay |
Rat |
| Lin Y, Zhang B, Liang H, Lu Y, Ai X, Zhang B, Chen X JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner. Mol Med Rep, 2013-10-02;8(6):1623-9. 2013-10-02 [PMID: 24100678] (Bioassay, Human) |
Bioassay |
Human |
| Xu Z, Zhang Q, Li H Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-beta1 and platelet-derived growth factor BB. Mol Med Rep, 2013-09-27;8(6):1715-21. 2013-09-27 [PMID: 24084832] (Bioassay, Human) |
Bioassay |
Human |
| Zhou Q, Hu Y, Howard O, Oppenheim J, Chen X In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo. Cytokine, 2013-09-27;65(1):56-64. 2013-09-27 [PMID: 24080164] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ueda J, Matsuda Y, Yamahatsu K, Uchida E, Naito Z, Korc M, Ishiwata T Epithelial splicing regulatory protein 1 is a favorable prognostic factor in pancreatic cancer that attenuates pancreatic metastases. Oncogene, 2013-09-30;33(36):4485-95. 2013-09-30 [PMID: 24077287] (Bioassay, Human) |
Bioassay |
Human |
| Kinashi H, Ito Y, Mizuno M, Suzuki Y, Terabayashi T, Nagura F, Hattori R, Matsukawa Y, Mizuno T, Noda Y, Nishimura H, Nishio R, Maruyama S, Imai E, Matsuo S, Takei Y TGF-beta1 promotes lymphangiogenesis during peritoneal fibrosis. J Am Soc Nephrol, 2013-08-29;24(10):1627-42. 2013-08-29 [PMID: 23990681] (Bioassay, Human) |
Bioassay |
Human |
| Wu Y, Chang T, Huang Y, Huang H, Chou C COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer. Oncogene, 2013-08-12;33(26):3432-40. 2013-08-12 [PMID: 23934190] (Bioassay, Human) |
Bioassay |
Human |
| Qu X, Shen L, Zheng Y, Cui Y, Feng Z, Liu F, Liu J A signal transduction pathway from TGF-beta1 to SKP2 via Akt1 and c-Myc and its correlation with progression in human melanoma. J Invest Dermatol, 2013-06-21;134(1):159-67. 2013-06-21 [PMID: 23792459] (Bioassay, Human) |
Bioassay |
Human |
| Park J, Kato M, Yuan H, Castro N, Lanting L, Wang M, Natarajan R FOG2 protein down-regulation by transforming growth factor-beta1-induced microRNA-200b/c leads to Akt kinase activation and glomerular mesangial hypertrophy related to diabetic nephropathy. J Biol Chem, 2013-06-20;288(31):22469-80. 2013-06-20 [PMID: 23788640] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Hanieh H, Alzahrani A MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration. Eur J Immunol, 2013-10-01;43(10):2771-82. 2013-10-01 [PMID: 23780851] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Loureiro J, Sandoval P, del Peso G, Gonzalez-Mateo G, Fernandez-Millara V, Santamaria B, Bajo M, Sanchez-Tomero J, Guerra-Azcona G, Selgas R, Lopez-Cabrera M, Aguilera A Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis. PLoS ONE, 2013-04-23;8(4):e61165. 2013-04-23 [PMID: 23637793] (Bioassay, Human) |
Bioassay |
Human |
| Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder T, Sato S Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. J Leukoc Biol, 2013-04-29;94(4):563-73. 2013-04-29 [PMID: 23630391] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ammann J, Cooke A, Trowsdale J Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol, 2013-04-15;190(10):5030-6. 2013-04-15 [PMID: 23589618] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Stephens G, Wang Q, Swerdlow B, Bhat G, Kolbeck R, Fung M Kynurenine 3-monooxygenase mediates inhibition of Th17 differentiation via catabolism of endogenous aryl hydrocarbon receptor ligands. Eur J Immunol, 2013-05-08;43(7):1727-34. 2013-05-08 [PMID: 23568529] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Liu M, Wang H, Wang Z, Zhang Y, Chen Y, Zhu F, Zhang Y, Ma J, Li Z TGF-beta1 regulation of estrogen production in mature rat Leydig cells. PLoS ONE, 2013-03-29;8(3):e60197. 2013-03-29 [PMID: 23555924] (Bioassay, Rat) |
Bioassay |
Rat |
| Gotz A, Jessberger R Dendritic cell podosome dynamics does not depend on the F-actin regulator SWAP-70. PLoS ONE, 2013-03-27;8(3):e60642. 2013-03-27 [PMID: 23544157] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Geng L, Chaudhuri A, Talmon G, Wisecarver J, Wang J TGF-Beta suppresses VEGFA-mediated angiogenesis in colon cancer metastasis. PLoS ONE, 2013-03-25;8(3):e59918. 2013-03-25 [PMID: 23536895] (Bioassay, Human) |
Bioassay |
Human |
| Wang C, Yi T, Qin L, Maldonado R, von Andrian U, Kulkarni S, Tellides G, Pober J Rapamycin-treated human endothelial cells preferentially activate allogeneic regulatory T cells. J Clin Invest, 2013-03-08;123(4):1677-93. 2013-03-08 [PMID: 23478407] (Bioassay, Human) |
Bioassay |
Human |
| Romero D, Kawano Y, Bengoa N, Walker M, Maltry N, Niehrs C, Waxman J, Kypta R Downregulation of Dickkopf-3 disrupts prostate acinar morphogenesis through TGF-beta/Smad signalling. J Cell Sci, 2013-02-26;126(0):1858-67. 2013-02-26 [PMID: 23444370] (Bioassay, Human) |
Bioassay |
Human |
| Gu L, Johno H, Nakajima S, Kato H, Takahashi S, Katoh R, Kitamura M Blockade of Smad signaling by 3'-deoxyadenosine: a mechanism for its anti-fibrotic potential. Lab Invest, 2013-02-25;93(4):450-61. 2013-02-25 [PMID: 23439432] (Bioassay, Rat) |
Bioassay |
Rat |
| Tannetta D, Dragovic R, Gardiner C, Redman C, Sargent I Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre-eclampsia: expression of Flt-1 and endoglin. PLoS ONE, 2013-02-20;8(2):e56754. 2013-02-20 [PMID: 23437230] (Bioassay, Human) |
Bioassay |
Human |
| Hojo , Hironori, Ohba , Shinsuke, Taniguchi , Kiyomi, Shirai , Masataka, Yano , Fumiko, Saito , Taku, Ikeda , Toshiyuk, Nakajima , Keiji, Komiyama , Yuske, Nakagata , Naomi, Suzuki , Kentaro, Mishina , Yuji, Yamada , Masahisa, Konno , Tomohiro, Takato , Tsuyoshi, Kawaguchi , Hiroshi, Kambara , Hideki, Chung , Ung-il Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem, 2013-02-19;288(14):9924-32. 2013-02-19 [PMID: 23423383] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Nguyen H, Zhuang Y, Sun L, Kantrow S, Kolls J, You Z, Zhuo Y, Shan B Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture. Cancer Cell Int, 2013-02-14;13(1):16. 2013-02-14 [PMID: 23409704] (Bioassay, Human) |
Bioassay |
Human |
| Masani , Shahnaz, Han , Li, Yu , Kefei Apurinic/apyrimidinic endonuclease 1 is the essential nuclease during immunoglobulin class switch recombination. Mol Cell Biol, 2013-02-04;33(7):1468-73. 2013-02-04 [PMID: 23382073] (Bioassay, Mouse) |
Bioassay |
Mouse |
| van der Kraan A, Chai R, Singh P, Lang B, Xu J, Gillespie M, Price J, Quinn J HSP90 inhibitors enhance differentiation and MITF (microphthalmia transcription factor) activity in osteoclast progenitors. Biochem J, 2013-04-15;451(2):235-44. 2013-04-15 [PMID: 23379601] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini F, Andreeff M, Kuratsu J, Lang F TGF-beta mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells. Cancer Res, 2013-01-30;73(7):2333-44. 2013-01-30 [PMID: 23365134] (Bioassay, Human) |
Bioassay |
Human |
| Mae , Shin-Ich, Shono , Akemi, Shiota , Fumihiko, Yasuno , Tetsuhik, Kajiwara , Masatosh, Gotoda-Nishimura , Nanaka, Arai , Sayaka, Sato-Otubo , Aiko, Toyoda , Taro, Takahashi , Kazutosh, Nakayama , Naoki, Cowan , Chad A, Aoi , Takashi, Ogawa , Seishi, McMahon , Andrew P, Yamanaka , Shinya, Osafune , Kenji Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nat Commun, 2013-01-01;4(0):1367. 2013-01-01 [PMID: 23340407] (Bioassay, Human) |
Bioassay |
Human |
| Truchetet M, Brembilla N, Montanari E, Lonati P, Raschi E, Zeni S, Fontao L, Meroni P, Chizzolini C Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement. Arthritis Rheum, 2013-05-01;65(5):1347-56. 2013-05-01 [PMID: 23335253] (Bioassay, Human) |
Bioassay |
Human |
| Balli D, Ustiyan V, Zhang Y, Wang I, Masino A, Ren X, Whitsett J, Kalinichenko V, Kalin T Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition. EMBO J, 2013-01-04;32(2):231-44. 2013-01-04 [PMID: 23288041] (Bioassay, Human) |
Bioassay |
Human |
| Chen , Jiekai, Liu , He, Liu , Jing, Qi , Jing, Wei , Bei, Yang , Jiaqi, Liang , Hanquan, Chen , You, Chen , Jing, Wu , Yaran, Guo , Lin, Zhu , Jieying, Zhao , Xiangjie, Peng , Tianran, Zhang , Yixin, Chen , Shen, Li , Xuejia, Li , Dongwei, Wang , Tao, Pei , Duanqing H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nat Genet, 2012-12-02;45(1):34-42. 2012-12-02 [PMID: 23202127] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis. Am J Pathol, 2012-11-09;182(1):118-31. 2012-11-09 [PMID: 23142380] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Sohni A, Mulas F, Ferrazzi F, Luttun A, Bellazzi R, Huylebroeck D, Ekker S, Verfaillie C TGF beta1-Induced Baf60c Regulates both Smooth Muscle Cell Commitment and Quiescence. PLoS ONE, 2012-10-26;7(10):e47629. 2012-10-26 [PMID: 23110084] (Bioassay, Rat) |
Bioassay |
Rat |
| Abushahba W, Olabisi O, Jeong B, Boregowda R, Wen Y, Liu F, Goydos J, Lasfar A, Cohen-Solal K Non-Canonical Smads Phosphorylation Induced by the Glutamate Release Inhibitor, Riluzole, through GSK3 Activation in Melanoma. PLoS ONE, 2012-10-12;7(10):e47312. 2012-10-12 [PMID: 23077590] (Bioassay, Human) |
Bioassay |
Human |
| Identification of Axl as a downstream effector of TGF-beta1 during Langerhans cell differentiation and epidermal homeostasis. J. Exp. Med., 2012-10-15;209(11):2033-47. 2012-10-15 [PMID: 23071254] (Bioassay, Human) |
Bioassay |
Human |
| Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, Hoppe E, Barre B, Audran M, Bouvard B, Saint-Andre J, Jeannin P IL-26 Is Overexpressed in Rheumatoid Arthritis and Induces Proinflammatory Cytokine Production and Th17 Cell Generation. PLoS Biol, 2012-09-25;10(9):e1001395. 2012-09-25 [PMID: 23055831] (Bioassay, Human) |
Bioassay |
Human |
| Huse K, Bakkebo M, Walchli S, Oksvold M, Hilden V, Forfang L, Bredahl M, Liestol K, Alizadeh A, Smeland E, Myklebust J Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE, 2012-10-01;7(10):e46117. 2012-10-01 [PMID: 23049692] (Bioassay, Human) |
Bioassay |
Human |
| Krishnan A, Li X, Kao W, Viker K, Butters K, Masuoka H, Knudsen B, Gores G, Charlton M Lumican, an extracellular matrix proteoglycan, is a novel requisite for hepatic fibrosis. Lab Invest, 2012-09-24;92(12):1712-25. 2012-09-24 [PMID: 23007134] (Bioassay, Human) |
Bioassay |
Human |
| Kudo , Yasusei, Iizuka , Shinji, Yoshida , Maki, Tsunematsu , Takaaki, Kondo , Tomoyuki, Subarnbhesaj , Ajiravud, Deraz , Elsayed, Siriwardena , Samadara, Tahara , Hidetosh, Ishimaru , Naozumi, Ogawa , Ikuko, Takata , Takashi Matrix metalloproteinase-13 (MMP-13) directly and indirectly promotes tumor angiogenesis. J Biol Chem, 2012-09-19;287(46):38716-28. 2012-09-19 [PMID: 22992737] (Bioassay, Human) |
Bioassay |
Human |
| Cerchia , Laura, Esposito , Carla L, Camorani , Simona, Rienzo , Anna, Stasio , Loredana, Insabato , Luigi, Affuso , Andrea, de Franciscis , Vittorio Targeting Axl with an high-affinity inhibitory aptamer. Mol Ther, 2012-08-21;20(12):2291-303. 2012-08-21 [PMID: 22910292] (Bioassay, Human) |
Bioassay |
Human |
| Li J, Mo H, Xiong G, Zhang L, He J, Huang Z, Liu Z, Chen Q, Du Z, Zheng L, Qian C, Zeng Y Tumor Microenvironment Macrophage Inhibitory Factor Directs the Accumulation of Interleukin-17-producing Tumor-infiltrating Lymphocytes and Predicts Favorable Survival in Nasopharyngeal Carcinoma Patients. J Biol Chem, 2012-08-14;287(42):35484-95. 2012-08-14 [PMID: 22893706] (Bioassay, Human) |
Bioassay |
Human |
| Flanagan K, Fitzgerald K, Baker J Laminin-411 Is a Vascular Ligand for MCAM and Facilitates TH17 Cell Entry into the CNS. PLoS ONE, 2012-07-06;7(7):e40443. 2012-07-06 [PMID: 22792325] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| Bruce D, Macartney T, Yong W, Shou W, Sapkota G Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway. Cell Signal, 2012-07-07;24(11):1999-2006. 2012-07-07 [PMID: 22781750] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat. Med., 2012-07-08;1248(0):18. 2012-07-08 [PMID: 22772464] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Nam D, Mau E, Wang Y, Wright D, Silkstone D, Whetstone H, Whyne C, Alman B T-Lymphocytes Enable Osteoblast Maturation via IL-17F during the Early Phase of Fracture Repair. PLoS ONE, 2012-06-29;7(6):e40044. 2012-06-29 [PMID: 22768215] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 2012-07-26;487(7408):505-9. 2012-07-26 [PMID: 22763448] (Bioassay, Human) |
Bioassay |
Human |
| Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors. Clin. Cancer Res., 2012-06-06;18(15):4122-35. 2012-06-06 [PMID: 22675171] (Bioassay, Human) |
Bioassay |
Human |
| Grubisha MJ, Cifuentes ME, Hammes SR, Defranco DB A Local Paracrine and Endocrine Network Involving TGF beta, Cox-2, ROS, and Estrogen Receptor beta Influences Reactive Stromal Cell Regulation of Prostate Cancer Cell Motility. Mol. Endocrinol., 2012-05-16;26(6):940-54. 2012-05-16 [PMID: 22593181] (Bioassay, Human) |
Bioassay |
Human |
| Pignatelli J, Tumbarello DA, Schmidt RP, Turner CE Hic-5 promotes invadopodia formation and invasion during TGF-beta-induced epithelial-mesenchymal transition. J. Cell Biol., 2012-04-23;197(3):421-37. 2012-04-23 [PMID: 22529104] (Bioassay, Human) |
Bioassay |
Human |
| Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J. Immunol., 2012-04-13;188(10):4866-75. 2012-04-13 [PMID: 22504644] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Liu Y, Yin J, Abou-Kheir W, Hynes P, Casey O, Fang L, Yi M, Stephens R, Seng V, Sheppard-Tillman H, Martin P, Kelly K MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms. Oncogene, 2012-02-27;32(3):296-306. 2012-02-27 [PMID: 22370643] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Dupuy S, Lambert M, Zucman D, Choukem SP, Tognarelli S, Pages C, Lebbe C, Caillat-Zucman S Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma. PLoS Pathog., 2012-01-12;8(1):e1002486. 2012-01-12 [PMID: 22253598] (Bioassay, Human) |
Bioassay |
Human |
| Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential. J. Immunol., 2012-01-16;188(4):2001-13. 2012-01-16 [PMID: 22250092] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Jin W, Qi S, Luo H The effect of conditional EFNB1 deletion in the T cell compartment on T cell development and function. BMC Immunol., 2011-12-19;12(0):68. 2011-12-19 [PMID: 22182253] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell, 2011-11-23;147(5):1146-58. 2011-11-23 [PMID: 22118468] (In Vivo, Mouse) |
In Vivo |
Mouse |
| Duchez S, Pascal V, Cogne N, Jayat-Vignoles C, Julien R, Cogne M Glycotranscriptome study reveals an enzymatic switch modulating glycosaminoglycan synthesis during B-cell development and activation. Eur. J. Immunol., 2011-11-10;41(12):3632-44. 2011-11-10 [PMID: 22076801] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Nakasone Y, Fujimoto M, Matsushita T, Hamaguchi Y, Huu DL, Yanaba M, Sato S, Takehara K, Hasegawa M Host-derived MCP-1 and MIP-1alpha regulate protective anti-tumor immunity to localized and metastatic B16 melanoma. Am. J. Pathol., 2011-10-26;180(1):365-74. 2011-10-26 [PMID: 22037251] (In Vivo, Mouse) |
In Vivo |
Mouse |
| Mottershead D, Ritter L, Gilchrist R Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15. Mol Hum Reprod, 2011-09-12;18(3):121-8. 2011-09-12 [PMID: 21911477] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Yilmaz M, Maass D, Tiwari N, Waldmeier L, Schmidt P, Lehembre F, Christofori G Transcription factor Dlx2 protects from TGFbeta-induced cell-cycle arrest and apoptosis. EMBO J., 2011-09-06;30(21):4489-99. 2011-09-06 [PMID: 21897365] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Nakahama T, Kimura A, Nguyen NT, Chinen I, Hanieh H, Nohara K, Fujii-Kuriyama Y, Kishimoto T Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. Proc. Natl. Acad. Sci. U.S.A., 2011-08-08;108(34):14222-7. 2011-08-08 [PMID: 21825138] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes. Diabetologia, 2011-07-09;54(10):2713-23. 2011-07-09 [PMID: 21744073] (ELISA (Standard)) |
ELISA (Standard) |
|
| Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B, Strobl H Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-beta1-dependent human epidermal Langerhans cells. J. Invest. Dermatol., 2011-06-16;131(10):2049-57. 2011-06-16 [PMID: 21677668] (Bioassay, Human) |
Bioassay |
Human |
| Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A Down-regulation of Kruppel-like Factor-4 (KLF4) by MicroRNA-143/145 Is Critical for Modulation of Vascular Smooth Muscle Cell Phenotype by Transforming Growth Factor-{beta} and Bone Morphogenetic Protein 4. J. Biol. Chem., 2011-06-13;286(32):28097-110. 2011-06-13 [PMID: 21673106] (Bioassay, Human) |
Bioassay |
Human |
| Hoffman AM, Paxson JA, Mazan MR, Davis AM, Tyagi S, Murthy S, Ingenito EP Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung. Stem Cells Dev., 2011-07-06;20(10):1779-92. 2011-07-06 [PMID: 21585237] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Zheng L, Foley K, Huang L, Leubner A, Mo G, Olino K, Edil BH, Mizuma M, Sharma R, Le DT, Anders RA, Illei PB, Van Eyk JE, Maitra A, Laheru D, Jaffee EM Tyrosine 23 phosphorylation-dependent cell-surface localization of annexin A2 is required for invasion and metastases of pancreatic cancer. PLoS ONE, 2011-04-29;6(4):e19390. 2011-04-29 [PMID: 21572519] (Bioassay, Human) |
Bioassay |
Human |
| El-Behi M, Ciric B, Dai H The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol., 2011-04-24;12(6):568-75. 2011-04-24 [PMID: 21516111] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Kashiwada M, Cassel SL, Colgan JD NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J., 2011-04-15;30(10):2071-82. 2011-04-15 [PMID: 21499227] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S Induction of latency-associated peptide (transforming growth factor-beta(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-alpha production in a transforming growth factor-beta-dependent manner. Immunology, 2011-03-23;133(3):278-87. 2011-03-23 [PMID: 21426338] (Bioassay, Human) |
Bioassay |
Human |
| Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Mol. Biol. Cell, 2011-03-16;22(10):1686-98. 2011-03-16 [PMID: 21411626] (Bioassay, Canine) |
Bioassay |
Canine |
| Sierra-Filardi E, Puig-Kroger A, Blanco FJ, Nieto C, Bragado R, Palomero MI, Bernabeu C, Vega MA, Corbi AL Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers. Blood, 2011-03-09;117(19):5092-101. 2011-03-09 [PMID: 21389328] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ma Y, Aymeric L, Locher C, Mattarollo SR, Delahaye NF, Pereira P, Boucontet L, Apetoh L, Ghiringhelli F, Casares N, Lasarte JJ, Matsuzaki G, Ikuta K, Ryffel B, Benlagha K, Tesniere A, Ibrahim N, Dechanet-Merville J, Chaput N, Smyth MJ, Kroemer G, Zitvogel L Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy. J. Exp. Med., 2011-03-07;208(3):491-503. 2011-03-07 [PMID: 21383056] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Henriksson ML, Edin S, Dahlin AM, Oldenborg PA, Oberg Ã…, Van Guelpen B, Rutegard J, Stenling R, Palmqvist R Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion. Am. J. Pathol., 2011-03-01;178(3):1387-94. 2011-03-01 [PMID: 21356388] (Bioassay, Human) |
Bioassay |
Human |
| DePaolo RW, Abadie V, Tang F Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature, 2011-02-09;471(7337):220-4. 2011-02-09 [PMID: 21307853] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Kato N, Kosugi T, Sato W, Ishimoto T, Kojima H, Sato Y, Sakamoto K, Maruyama S, Yuzawa Y, Matsuo S, Kadomatsu K Basigin/CD147 promotes renal fibrosis after unilateral ureteral obstruction. Am. J. Pathol., 2011-02-01;178(2):572-9. 2011-02-01 [PMID: 21281789] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Elkabets M, Gifford AM, Scheel C, Nilsson B, Reinhardt F, Bray MA, Carpenter AE, Jirstrom K, Magnusson K, Ebert BL, Ponten F, Weinberg RA, McAllister SS Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J. Clin. Invest., 2011-01-25;121(2):784-99. 2011-01-25 [PMID: 21266779] (Bioassay, Human) |
Bioassay |
Human |
| Bohr W, Kupper M, Hoffmann K, Weiskirchen R Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein. PLoS ONE, 2010-12-30;5(12):e16000. 2010-12-30 [PMID: 21209863] (Bioassay, Human) |
Bioassay |
Human |
| Krueger C, Hoffmann FM Identification of retinoic acid in a high content screen for agents that overcome the anti-myogenic effect of TGF-beta-1. PLoS ONE, 2010-11-30;5(11):e15511. 2010-11-30 [PMID: 21152098] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ley C, Svala E, Nilton A, Lindahl A, Eloranta ML, Ekman S, Skioldebrand E Effects of high mobility group box protein-1, interleukin-1beta, and interleukin-6 on cartilage matrix metabolism in three-dimensional equine chondrocyte cultures. Connect. Tissue Res., 2010-11-30;52(4):290-300. 2010-11-30 [PMID: 21117899] (Bioassay, Equine) |
Bioassay |
Equine |
| Bourne GL, Grainger DJ Development and characterisation of an assay for furin activity. J. Immunol. Methods, 2010-11-25;364(1):101-8. 2010-11-25 [PMID: 21112328] (Bioassay, Human) |
Bioassay |
Human |
| Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, Delaporte M, Xu K, Aubertin AM, Moog C HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies. J. Virol., 2010-11-17;85(2):1077-85. 2010-11-17 [PMID: 21084491] (Bioassay, Human) |
Bioassay |
Human |
| Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-activated receptor-gamma sumoylation, and HIF-1alpha. J. Biol. Chem., 2010-11-08;286(2):961-75. 2010-11-08 [PMID: 21059659] (Bioassay, Human) |
Bioassay |
Human |
| Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site. J. Immunol., 2010-10-22;185(11):6795-801. 2010-10-22 [PMID: 20971929] (Bioassay, Human) |
Bioassay |
Human |
| Boenisch O, D'Addio F, Watanabe T, Elyaman W, Magee CN, Yeung MY, Padera RF, Rodig SJ, Murayama T, Tanaka K, Yuan X, Ueno T, Jurisch A, Mfarrej B, Akiba H, Yagita H, Najafian N TIM-3: a novel regulatory molecule of alloimmune activation. J. Immunol., 2010-10-18;185(10):5806-19. 2010-10-18 [PMID: 20956339] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Maupin KA, Sinha A, Eugster E, Miller J, Ross J, Paulino V, Keshamouni VG, Tran N, Berens M, Webb C, Haab BB Glycogene expression alterations associated with pancreatic cancer epithelial-mesenchymal transition in complementary model systems. PLoS ONE, 2010-09-27;5(9):e13002. 2010-09-27 [PMID: 20885998] (Bioassay, Human) |
Bioassay |
Human |
| Jones GW, Stumhofer JS, Foster T, Twohig JP, Hertzog P, Topley N, Williams AS, Hunter CA, Jenkins BJ, Wang EC, Jones SA Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. FASEB J., 2010-09-08;25(1):409-19. 2010-09-08 [PMID: 20826539] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Suzuki K, Maruya M, Kawamoto S The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut. Immunity, 2010-07-23;33(1):71-83. 2010-07-23 [PMID: 20643338] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Chen G, Hardy K, Bunting K Regulation of the IL-21 gene by the NF-kappaB transcription factor c-Rel. J. Immunol., 2010-07-16;185(4):2350-9. 2010-07-16 [PMID: 20639489] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Yoshizaki A, Yanaba K, Iwata Y Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. J. Immunol., 2010-07-12;185(4):2502-15. 2010-07-12 [PMID: 20624949] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Chang HC, Sehra S, Goswami R, Yao W, Yu Q, Stritesky GL, Jabeen R, McKinley C, Ahyi AN, Han L, Nguyen ET, Robertson MJ, Perumal NB, Tepper RS, Nutt SL, Kaplan MH The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol., 2010-05-02;11(6):527-34. 2010-05-02 [PMID: 20431622] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Rai D, Kim SW, McKeller MR Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc. Natl. Acad. Sci. U.S.A., 2010-02-01;107(7):3111-6. 2010-02-01 [PMID: 20133617] (Bioassay, Human) |
Bioassay |
Human |
| Morizane S, Yamasaki K, Kabigting FD, Gallo RL Kallikrein expression and cathelicidin processing are independently controlled in keratinocytes by calcium, vitamin D(3), and retinoic acid. J. Invest. Dermatol., 2010-01-21;130(5):1297-306. 2010-01-21 [PMID: 20090765] (Bioassay, Human) |
Bioassay |
Human |
| Jones GW, McLoughlin RM, Hammond VJ, Parker CR, Williams JD, Malhotra R, Scheller J, Williams AS, Rose-John S, Topley N, Jones SA Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J. Immunol., 2010-01-18;184(4):2130-9. 2010-01-18 [PMID: 20083667] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat. Med., 2010-01-10;16(2):191-7. 2010-01-10 [PMID: 20062065] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Roux J, Carles M, Koh H, Goolaerts A, Ganter MT, Chesebro BB, Howard M, Houseman BT, Finkbeiner W, Shokat KM, Paquet AC, Matthay MA, Pittet JF Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism. J. Biol. Chem., 2009-12-08;285(7):4278-90. 2009-12-08 [PMID: 19996317] (Bioassay, Rat) |
Bioassay |
Rat |
| Miyake T, Alli NS, McDermott JC Nuclear function of Smad7 promotes myogenesis. Mol. Cell. Biol., 2009-12-07;30(3):722-35. 2009-12-07 [PMID: 19995910] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Lee WW, Kang SW, Choi J Regulating human Th17 cells via differential expression of IL-1 receptor. Blood, 2009-11-12;115(3):530-40. 2009-11-12 [PMID: 19965648] (Bioassay, Human) |
Bioassay |
Human |
| Jindra C Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. Eur J Immunol, 2010-02-01;40(2):321-9. 2010-02-01 [PMID: 19950173] (Bioassay, Human) |
Bioassay |
Human |
| Moransard M, Sawitzky M, Fontana A, Suter T Expression of the HGF receptor c-met by macrophages in experimental autoimmune encephalomyelitis. Glia, 2010-04-01;58(5):559-71. 2010-04-01 [PMID: 19941340] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Stockis J, Colau D, Coulie PG, Lucas S Membrane protein GARP is a receptor for latent TGF-beta on the surface of activated human Treg. Eur. J. Immunol., 2009-12-01;39(12):3315-22. 2009-12-01 [PMID: 19750484] (Bioassay, Human) |
Bioassay |
Human |
| Duraisingham SS, Hornig J, Gotch F, Patterson S TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses. J. Immunol., 2009-07-22;183(4):2242-51. 2009-07-22 [PMID: 19625644] (Bioassay, Human) |
Bioassay |
Human |
| Veraldi KL, Gibson BT, Yasuoka H, Myerburg MM, Kelly EA, Balzar S, Jarjour NN, Pilewski JM, Wenzel SE, Feghali-Bostwick CA Role of insulin-like growth factor binding protein-3 in allergic airway remodeling. Am. J. Respir. Crit. Care Med., 2009-07-16;180(7):611-7. 2009-07-16 [PMID: 19608721] (Bioassay, Human) |
Bioassay |
Human |
| Margulis A, Nocka KH, Brennan AM, Deng B, Fleming M, Goldman SJ, Kasaian MT Mast cell-dependent contraction of human airway smooth muscle cell-containing collagen gels: influence of cytokines, matrix metalloproteases, and serine proteases. J. Immunol., 2009-07-10;183(3):1739-50. 2009-07-10 [PMID: 19592653] (Bioassay, Human) |
Bioassay |
Human |
| Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat. Immunol., 2009-07-05;10(8):857-63. 2009-07-05 [PMID: 19578369] (Bioassay, Human) |
Bioassay |
Human |
| Pedroja BS, Kang LE, Imas AO, Carmeliet P, Bernstein AM Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling. J. Biol. Chem., 2009-06-01;284(0):20708. 2009-06-01 [PMID: 19487690] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Vitsky A, Waire J, Pawliuk R, Bond A, Matthews D, Lacasse E, Hawes ML, Nelson C, Richards S, Piepenhagen PA, Garman RD, Andrews L, Thurberg BL, Lonning S, Ledbetter S, Ruzek MC Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues. Am. J. Pathol., 2009-04-30;174(6):2137-49. 2009-04-30 [PMID: 19406991] (Western Blot) |
Western Blot |
|
| Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int. J. Cancer, 2009-07-15;125(2):367-73. 2009-07-15 [PMID: 19378341] (Bioassay, Human) |
Bioassay |
Human |
| Aliahmadi E, Gramlich R, Grutzkau A, Hitzler M, Kruger M, Baumgrass R, Schreiner M, Wittig B, Wanner R, Peiser M TLR2-activated human langerhans cells promote Th17 polarization via IL-1beta, TGF-beta and IL-23. Eur. J. Immunol., 2009-05-01;39(5):1221-30. 2009-05-01 [PMID: 19350551] (Bioassay, Human) |
Bioassay |
Human |
| Shafer SL, Towler DA Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element. J. Mol. Cell. Cardiol., 2009-01-21;46(5):621-35. 2009-01-21 [PMID: 19344627] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Dai Z, Turtle CJ, Booth GC, Riddell SR, Gooley TA, Stevens AM, Spies T, Groh V Normally occurring NKG2D+CD4+ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus. J. Exp. Med., 2009-03-16;206(4):793-805. 2009-03-16 [PMID: 19289577] (Bioassay, Human) |
Bioassay |
Human |
| Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J. Exp. Med., 2009-03-09;206(3):535-48. 2009-03-09 [PMID: 19273625] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Amiable N, Tat SK, Lajeunesse D, Duval N, Pelletier JP, Martel-Pelletier J, Boileau C Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts. Bone, 2009-03-02;44(6):1143-50. 2009-03-02 [PMID: 19264156] (Bioassay, Human) |
Bioassay |
Human |
| Eid RE, Rao DA, Zhou J, Lo SF, Ranjbaran H, Gallo A, Sokol SI, Pfau S, Pober JS, Tellides G Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cells. Circulation, 2009-03-02;119(10):1424-32. 2009-03-02 [PMID: 19255340] (Bioassay, Human) |
Bioassay |
Human |
| van Steensel L, Paridaens D, Schrijver B, Dingjan GM, van Daele PL, van Hagen PM, van den Bosch WA, Drexhage HA, Hooijkaas H, Dik WA Imatinib mesylate and AMN107 inhibit PDGF-signaling in orbital fibroblasts: a potential treatment for Graves' ophthalmopathy. Invest. Ophthalmol. Vis. Sci., 2009-02-21;50(7):3091-8. 2009-02-21 [PMID: 19234339] (Bioassay, Human) |
Bioassay |
Human |
| Sehrawat S, Suryawanshi A, Hirashima M, Rouse BT Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J. Immunol., 2009-03-01;182(5):3191-201. 2009-03-01 [PMID: 19234217] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Bhowmick S, Mazumdar T, Ali N Vaccination route that induces transforming growth factor beta production fails to elicit protective immunity against Leishmania donovani infection. Infect. Immun., 2009-01-21;77(4):1514-23. 2009-01-21 [PMID: 19168736] (In Vivo, Mouse) |
In Vivo |
Mouse |
| Shi S, Mercer S, Eckert GJ, Trippel SB Growth factor regulation of growth factors in articular chondrocytes. J. Biol. Chem., 2009-01-09;284(11):6697-704. 2009-01-09 [PMID: 19136669] (Bioassay, Human) |
Bioassay |
Human |
| Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernandez-Zapico ME, Hanahan D GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev., 2009-01-01;23(1):24-36. 2009-01-01 [PMID: 19136624] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Albanesi C, Scarponi C, Pallotta S, Daniele R, Bosisio D, Madonna S, Fortugno P, Gonzalvo-Feo S, Franssen JD, Parmentier M, De Pita O, Girolomoni G, Sozzani S Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. J. Exp. Med., 2008-12-29;206(1):249-58. 2008-12-29 [PMID: 19114666] (Bioassay, Human) |
Bioassay |
Human |
| Han Y, Guo Q, Zhang M, Chen Z, Cao X CD69+ CD4+ CD25- T cells, a new subset of regulatory T cells, suppress T cell proliferation through membrane-bound TGF-beta 1. J. Immunol., 2009-01-01;182(1):111-20. 2009-01-01 [PMID: 19109141] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Lamba S, Ravichandran V, Major EO Glial cell type-specific subcellular localization of 14-3-3 zeta: an implication for JCV tropism. Glia, 2009-07-01;57(9):971-7. 2009-07-01 [PMID: 19062179] (Bioassay, Human) |
Bioassay |
Human |
| Kinoshita H, Takai T, Le TA, Kamijo S, Wang XL, Ushio H, Hara M, Kawasaki J, Vu AT, Ogawa T, Gunawan H, Ikeda S, Okumura K, Ogawa H Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. J. Allergy Clin. Immunol., 2008-12-03;123(1):179-86. 2008-12-03 [PMID: 19056108] (Bioassay, Human) |
Bioassay |
Human |
| Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M Activation of Toll-like receptor 3 augments myofibroblast differentiation. Am. J. Respir. Cell Mol. Biol., 2008-11-06;40(6):654-62. 2008-11-06 [PMID: 18988918] (Bioassay, Human) |
Bioassay |
Human |
| Ohba T, Haro H, Ando T, Koyama K, Hatsushika K, Suenaga F, Ohnuma Y, Nakamura Y, Katoh R, Ogawa H, Hamada Y, Nakao A A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: implications for herniated discs. Arthritis Rheum., 2008-11-01;58(11):3510-9. 2008-11-01 [PMID: 18975342] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Herman S, Muller RB, Kronke G, Zwerina J, Redlich K, Hueber AJ, Gelse H, Neumann E, Muller-Ladner U, Schett G Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis. Arthritis Rheum., 2008-10-01;58(10):3041-50. 2008-10-01 [PMID: 18821671] (Bioassay, Human) |
Bioassay |
Human |
| Tsoporis JN, Izhar S, Parker TG Expression of S100A6 in cardiac myocytes limits apoptosis induced by tumor necrosis factor-alpha. J. Biol. Chem., 2008-08-27;283(44):30174-83. 2008-08-27 [PMID: 18753141] (Bioassay, Rat) |
Bioassay |
Rat |
| Pen A, Moreno MJ, Durocher Y, Deb-Rinker P, Stanimirovic DB Glioblastoma-secreted factors induce IGFBP7 and angiogenesis by modulating Smad-2-dependent TGF-beta signaling. Oncogene, 2008-08-18;27(54):6834-44. 2008-08-18 [PMID: 18711401] (Bioassay, Human) |
Bioassay |
Human |
| Aoudjehane L, Pissaia A, Scatton O, Podevin P, Massault PP, Chouzenoux S, Soubrane O, Calmus Y, Conti F Interleukin-4 induces the activation and collagen production of cultured human intrahepatic fibroblasts via the STAT-6 pathway. Lab. Invest., 2008-07-14;88(9):973-85. 2008-07-14 [PMID: 18626468] (Bioassay, Human) |
Bioassay |
Human |
| Shinohara ML, Kim JH, Garcia VA, Cantor H Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. Immunity, 2008-07-18;29(1):68-78. 2008-07-18 [PMID: 18619869] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Barbaroux JB, Beleut M, Brisken C, Mueller CG, Groves RW Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation. J. Immunol., 2008-07-15;181(2):1103-8. 2008-07-15 [PMID: 18606662] (Bioassay, Human) |
Bioassay |
Human |
| Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL. J. Immunol., 2008-07-15;181(2):976-90. 2008-07-15 [PMID: 18606649] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Walsh MF, Ampasala DR, Hatfield J, Vander Heide R, Suer S, Rishi AK, Basson MD Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via smad- and p38-dependent mechanisms. Am. J. Pathol., 2008-06-26;173(2):385-99. 2008-06-26 [PMID: 18583311] (Bioassay, Rat) |
Bioassay |
Rat |
| Carlson ME, Hsu M, Conboy IM Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature, 2008-06-15;454(7203):528-32. 2008-06-15 [PMID: 18552838] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol., 2008-06-01;180(11):7414-22. 2008-06-01 [PMID: 18490741] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ke Y, Jiang G, Sun D, Kaplan HJ, Shao H Ocular regulatory T cells distinguish monophasic from recurrent autoimmune uveitis. Invest. Ophthalmol. Vis. Sci., 2008-05-16;49(9):3999-4007. 2008-05-16 [PMID: 18487362] (Bioassay, Rat) |
Bioassay |
Rat |
| Fineschi S, Bongiovanni M, Donati Y, Djaafar S, Naso F, Goffin L, Argiroffo CB, Pache JC, Dayer JM, Ferrari-Lacraz S, Chizzolini C In vivo investigations on anti-fibrotic potential of proteasome inhibition in lung and skin fibrosis. Am. J. Respir. Cell Mol. Biol., 2008-05-05;39(4):458-65. 2008-05-05 [PMID: 18458239] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res., 2008-05-01;68(9):3295-303. 2008-05-01 [PMID: 18451156] (Bioassay, Human) |
Bioassay |
Human |
| Kuchtey J, Kallberg ME, Gelatt KN, Rinkoski T, Komaromy AM, Kuchtey RW Angiopoietin-like 7 secretion is induced by glaucoma stimuli and its concentration is elevated in glaucomatous aqueous humor. Invest. Ophthalmol. Vis. Sci., 2008-04-17;49(8):3438-48. 2008-04-17 [PMID: 18421092] (Bioassay, Human) |
Bioassay |
Human |
| Kato A, Peters A, Suh L, Carter R, Harris KE, Chandra R, Conley D, Grammer LC, Kern R, Schleimer RP Evidence of a role for B cell-activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J. Allergy Clin. Immunol., 2008-04-14;121(6):1385-92, 1392. 2008-04-14 [PMID: 18410958] (Bioassay, Human) |
Bioassay |
Human |
| Haydont V, Riser BL, Aigueperse J, Vozenin-Brotons MC Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1. Am. J. Physiol., Cell Physiol., 2008-04-09;294(6):C1332-41. 2008-04-09 [PMID: 18400984] (Bioassay, Human) |
Bioassay |
Human |
| Guo B, Chang EY, Cheng G The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J. Clin. Invest., 2008-05-01;118(5):1680-90. 2008-05-01 [PMID: 18382764] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Sheng MH, Wergedal JE, Mohan S, Lau KH Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity. FEBS Lett., 2008-03-31;582(10):1451-8. 2008-03-31 [PMID: 18381073] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Muranski P, Boni A, Antony PA, Cassard L, Irvine KR, Kaiser A, Paulos CM, Palmer DC, Touloukian CE, Ptak K, Gattinoni L, Wrzesinski C, Hinrichs CS, Kerstann KW, Feigenbaum L, Chan CC, Restifo NP Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood, 2008-03-19;112(2):362-73. 2008-03-19 [PMID: 18354038] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Pittet P, Lee K, Kulik AJ, Meister JJ, Hinz B Fibrogenic fibroblasts increase intercellular adhesion strength by reinforcing individual OB-cadherin bonds. J. Cell. Sci., 2008-02-26;121(0):877-86. 2008-02-26 [PMID: 18303045] (Bioassay, Rat) |
Bioassay |
Rat |
| Van Aarsen LA, Leone DR, Ho S, Dolinski BM, McCoon PE, LePage DJ, Kelly R, Heaney G, Rayhorn P, Reid C, Simon KJ, Horan GS, Tao N, Gardner HA, Skelly MM, Gown AM, Thomas GJ, Weinreb PH, Fawell SE, Violette SM Antibody-mediated blockade of integrin alpha v beta 6 inhibits tumor progression in vivo by a transforming growth factor-beta-regulated mechanism. Cancer Res., 2008-01-15;68(2):561-70. 2008-01-15 [PMID: 18199553] (Bioassay, Human) |
Bioassay |
Human |
| Oh JY, Kim MK, Shin MS, Lee HJ, Ko JH, Wee WR, Lee JH The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells, 2008;26(4):1047-55. 2008 [PMID: 18192235] (ELISA Developmet, Rat) |
ELISA Developmet |
Rat |
| Anderson BC, Christiansen SP, McLoon LK Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus. Invest. Ophthalmol. Vis. Sci., 2008-01-01;49(1):221-9. 2008-01-01 [PMID: 18172096] (In Vivo, Rabbit) |
In Vivo |
Rabbit |
| Link DP, van den Dolder J, van den Beucken JJ, Wolke JG, Mikos AG, Jansen JA Bone response and mechanical strength of rabbit femoral defects filled with injectable CaP cements containing TGF-beta 1 loaded gelatin microparticles. Biomaterials, 2007-11-08;29(6):675-82. 2007-11-08 [PMID: 17996293] (In Vivo, Rabbit) |
In Vivo |
Rabbit |
| McGeachy MJ, Bak-Jensen KS, Chen Y, Tato CM, Blumenschein W, McClanahan T, Cua DJ TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol., 2007-11-11;8(12):1390-7. 2007-11-11 [PMID: 17994024] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Korff T, Aufgebauer K, Hecker M Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-beta1 response. Circulation, 2007-10-29;116(20):2288-97. 2007-10-29 [PMID: 17967972] (Bioassay, Human) |
Bioassay |
Human |
| Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G, Wang XF, Frangogiannis NG Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation, 2007-10-22;116(19):2127-38. 2007-10-22 [PMID: 17967775] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Reed SA, Johnson SE Equine umbilical cord blood contains a population of stem cells that express Oct4 and differentiate into mesodermal and endodermal cell types. J. Cell. Physiol., 2008-05-01;215(2):329-36. 2008-05-01 [PMID: 17929245] (Bioassay, Equine) |
Bioassay |
Equine |
| Baker K, Raut P, Jass JR Microsatellite unstable colorectal cancer cell lines with truncating TGFbetaRII mutations remain sensitive to endogenous TGFbeta. J. Pathol., 2007-11-01;213(3):257-65. 2007-11-01 [PMID: 17893910] (Bioassay, Human) |
Bioassay |
Human |
| Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, Kim CH Vitamin A metabolites induce gut-homing FoxP3+ regulatory T cells. J. Immunol., 2007-09-15;179(6):3724-33. 2007-09-15 [PMID: 17785809] (Bioassay, Human, Mouse) |
Bioassay |
Human, Mouse |
| Lamar JM, Iyer V, DiPersio CM Integrin alpha3beta1 potentiates TGFbeta-mediated induction of MMP-9 in immortalized keratinocytes. J. Invest. Dermatol., 2007-08-30;128(3):575-86. 2007-08-30 [PMID: 17762853] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med., 2007-08-26;13(9):1096-101. 2007-08-26 [PMID: 17721544] (Western Blot) |
Western Blot |
|
| Shintani Y, Maeda M, Chaika N, Johnson KR, Wheelock MJ Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-beta signaling. Am. J. Respir. Cell Mol. Biol., 2007-08-02;38(1):95-104. 2007-08-02 [PMID: 17673689] (Bioassay, Human) |
Bioassay |
Human |
| Kato A, Favoreto S, Avila PC, Schleimer RP TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J. Immunol., 2007-07-15;179(2):1080-7. 2007-07-15 [PMID: 17617600] (Bioassay, Human) |
Bioassay |
Human |
| Bogatkevich GS, Ludwicka-Bradley A, Highland KB, Hant F, Nietert PJ, Singleton CB, Feghali-Bostwick CA, Silver RM Impairment of the antifibrotic effect of hepatocyte growth factor in lung fibroblasts from African Americans: possible role in systemic sclerosis. Arthritis Rheum., 2007-07-01;56(7):2432-42. 2007-07-01 [PMID: 17599773] (Bioassay, Human) |
Bioassay |
Human |
| Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG, Rabinovich GA Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat. Immunol., 2007-06-24;8(8):825-34. 2007-06-24 [PMID: 17589510] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Zeisberg M, Yang C, Martino M, Duncan MB, Rieder F, Tanjore H, Kalluri R Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J. Biol. Chem., 2007-06-11;282(32):23337-47. 2007-06-11 [PMID: 17562716] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Scaldaferri F, Sans M, Vetrano S, Graziani C, De Cristofaro R, Gerlitz B, Repici A, Arena V, Malesci A, Panes J, Grinnell BW, Danese S Crucial role of the protein C pathway in governing microvascular inflammation in inflammatory bowel disease. J. Clin. Invest., 2007-07-01;117(7):1951-60. 2007-07-01 [PMID: 17557119] (Bioassay, Human) |
Bioassay |
Human |
| Hong KM, Belperio JA, Keane MP, Burdick MD, Strieter RM Differentiation of human circulating fibrocytes as mediated by transforming growth factor-beta and peroxisome proliferator-activated receptor gamma. J. Biol. Chem., 2007-06-07;282(31):22910-20. 2007-06-07 [PMID: 17556364] (Bioassay, Human) |
Bioassay |
Human |
| McLennan SV, Kelly DJ, Schache M, Waltham M, Dy V, Langham RG, Yue DK, Gilbert RE Advanced glycation end products decrease mesangial cell MMP-7: a role in matrix accumulation in diabetic nephropathy? Kidney Int., 2007-06-06;72(4):481-8. 2007-06-06 [PMID: 17554258] (Bioassay, Human) |
Bioassay |
Human |
| Liu SJ, Tsai JP, Shen CR, Sher YP, Hsieh CL, Yeh YC, Chou AH, Chang SR, Hsiao KN, Yu FW, Chen HW Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6. J. Leukoc. Biol., 2007-05-15;82(2):354-60. 2007-05-15 [PMID: 17505023] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ao M, Franco OE, Park D, Raman D, Williams K, Hayward SW Cross-talk between paracrine-acting cytokine and chemokine pathways promotes malignancy in benign human prostatic epithelium. Cancer Res., 2007-05-01;67(9):4244-53. 2007-05-01 [PMID: 17483336] (Bioassay, Human) |
Bioassay |
Human |
| Ball SG, Shuttleworth CA, Kielty CM Vascular endothelial growth factor can signal through platelet-derived growth factor receptors. J. Cell Biol., 2007-04-30;177(3):489-500. 2007-04-30 [PMID: 17470632] (Bioassay, Human) |
Bioassay |
Human |
| Tacke F, Gabele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C, Brenner DA, Scholmerich J, Schnabl B Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Dig. Dis. Sci., 2007-04-06;52(12):3404-15. 2007-04-06 [PMID: 17415633] (Bioassay, Human) |
Bioassay |
Human |
| Zakrzewicz A, Kouri FM, Nejman B, Kwapiszewska G, Hecker M, Sandu R, Dony E, Seeger W, Schermuly RT, Eickelberg O, Morty RE The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension. Eur. Respir. J., 2007-03-28;29(6):1094-104. 2007-03-28 [PMID: 17392319] (Bioassay, Rat) |
Bioassay |
Rat |
| Brechter AB, Lerner UH Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression. Arthritis Rheum., 2007-03-01;56(3):910-23. 2007-03-01 [PMID: 17328065] (Bioassay, Human) |
Bioassay |
Human |
| Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard)) |
ELISA (Standard) |
|
| Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 2007-02-15;178(4):2018-27. 2007-02-15 [PMID: 17277105] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ungefroren H, Schniewind B, Groth S, Chen WB, Muerkoster SS, Kalthoff H, Fandrich F Antitumor activity of ALK1 in pancreatic carcinoma cells. Int. J. Cancer, 2007-04-15;120(8):1641-51. 2007-04-15 [PMID: 17230504] (Bioassay, Human) |
Bioassay |
Human |
| Ogawa K, Funaba M, Chen Y, Tsujimoto M Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol., 2006-11-15;177(10):6787-94. 2006-11-15 [PMID: 17082592] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood, 2006-11-02;109(5):2234-42. 2006-11-02 [PMID: 17082320] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo. Cancer Res., 2006-10-15;66(20):9878-85. 2006-10-15 [PMID: 17047049] (Bioassay, Human) |
Bioassay |
Human |
| Rose DM, Sydlaske AD, Agha-Babakhani A, Johnson K, Terkeltaub R Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils. Arthritis Rheum., 2006-10-01;54(10):3363-71. 2006-10-01 [PMID: 17009310] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Mukhopadhyay A, Chan SY, Lim IJ, Phillips DJ, Phan TT The role of the activin system in keloid pathogenesis. Am. J. Physiol., Cell Physiol., 2006-09-13;292(4):C1331-8. 2006-09-13 [PMID: 16971493] (Bioassay, Human) |
Bioassay |
Human |
| Rosendahl AH, Forsberg G IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells. Kidney Int., 2006-09-13;70(9):1584-90. 2006-09-13 [PMID: 16969385] (Bioassay, Human) |
Bioassay |
Human |
| Letterio J, Rudikoff E, Voong N, Bauer SR Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors. Stem Cells, 2006-08-31;24(12):2611-7. 2006-08-31 [PMID: 16945999] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine) |
Bioassay |
Porcine |
| Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am. J. Pathol., 2006-06-01;168(6):1879-88. 2006-06-01 [PMID: 16723703] (Bioassay, Human) |
Bioassay |
Human |
| Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006-05-11;126(9):2096-105. 2006-05-11 [PMID: 16691197] (Bioassay, Human) |
Bioassay |
Human |
| Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 2006-04-30;441(7090):235-8. 2006-04-30 [PMID: 16648838] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat) |
Bioassay |
Rat |
| Rhodes KE, Raivich G, Fawcett JW The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience, 2006-04-21;140(1):87-100. 2006-04-21 [PMID: 16631314] (In Vivo, Rat) |
In Vivo |
Rat |
| Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol., 2006-05-01;36(5):1309-23. 2006-05-01 [PMID: 16619290] (Bioassay, Human) |
Bioassay |
Human |
| Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp. Cell Res., 2006-04-04;312(10):1909-23. 2006-04-04 [PMID: 16600214] (Bioassay, Human) |
Bioassay |
Human |
| Neurohr C, Nishimura SL, Sheppard D Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9. 2006-03-30 [PMID: 16574941] (Bioassay, Human) |
Bioassay |
Human |
| Létuvé S, Lajoie-Kadoch S, Audusseau S, Rothenberg ME, Fiset PO, Ludwig MS, Hamid Q IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J. Allergy Clin. Immunol., 2006-02-08;117(3):590-6. 2006-02-08 [PMID: 16522458] (Bioassay, Human) |
Bioassay |
Human |
| Yue Z, Jiang TX, Widelitz RB, Chuong CM Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia. Proc. Natl. Acad. Sci. U.S.A., 2006-01-17;103(0):951-5. 2006-01-17 [PMID: 16418297] (In Vivo, Chicken) |
In Vivo |
Chicken |
| Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J. Allergy Clin. Immunol., 2005-12-02;117(1):103-10. 2005-12-02 [PMID: 16387592] (Bioassay, Human) |
Bioassay |
Human |
| Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone, 2005-12-05;38(4):497-508. 2005-12-05 [PMID: 16337237] (Bioassay, Human) |
Bioassay |
Human |
| Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum., 2005-03-01;52(3):770-8. 2005-03-01 [PMID: 15751070] (Bioassay, Human) |
Bioassay |
Human |
| Pound JD, Batth BK, Johannessen I, Wood K Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma. J. Immunol., 2005-03-01;174(5):3015-23. 2005-03-01 [PMID: 15728515] (Bioassay, Human) |
Bioassay |
Human |
| Mesples B, Fontaine RH, Lelievre V, Launay JM, Gressens P Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice. Neurobiol. Dis., 2005-02-01;18(1):193-205. 2005-02-01 [PMID: 15649710] (In Vivo, Mouse) |
In Vivo |
Mouse |
| Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human) |
Bioassay |
Human |
| Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum., 2004-08-01;50(8):2521-30. 2004-08-01 [PMID: 15334466] (Bioassay, Human) |
Bioassay |
Human |
| Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R IL-22 increases the innate immunity of tissues. Immunity, 2004-08-01;21(2):241-54. 2004-08-01 [PMID: 15308104] (Bioassay, Human) |
Bioassay |
Human |
| Brenner N, Huning M, Stange R Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif. Tissue Int., 2004-04-01;74(4):388-97. 2004-04-01 [PMID: 15255077] (In Vivo, Rat) |
In Vivo |
Rat |
| Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254] |
|
|
| Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats. Bone, 2004-05-01;34(5):862-8. 2004-05-01 [PMID: 15121018] (In Vivo, Rat) |
In Vivo |
Rat |
| Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am. J. Respir. Crit. Care Med., 2004-04-22;170(2):188-94. 2004-04-22 [PMID: 15105163] (Bioassay, Mink) |
Bioassay |
Mink |
| Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J. Immunol., 2004-05-01;172(9):5753-64. 2004-05-01 [PMID: 15100322] (Western Blot) |
Western Blot |
|
| Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol., 2004-05-01;172(9):5213-21. 2004-05-01 [PMID: 15100259] (Bioassay, Human) |
Bioassay |
Human |
| Studer RK, Bergman R, Stubbs T, Decker K Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther., 2003-11-07;6(1):R56-R64. 2003-11-07 [PMID: 14979938] (Bioassay, Rabbit) |
Bioassay |
Rabbit |
| Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev. Biol., 2004-02-15;266(2):223-37. 2004-02-15 [PMID: 14738873] (Bioassay, Human) |
Bioassay |
Human |
| Chen , WanJun, Jin , Wenwen, Hardegen , Neil, Lei , Ke-Jian, Li , Li, Marinos , Nancy, McGrady , George, Wahl , Sharon M Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med, 2003-12-15;198(12):1875-86. 2003-12-15 [PMID: 14676299] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Ashcroft GS, Mills SJ, Lei K, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J. Clin. Invest., 2003-05-01;111(9):1309-18. 2003-05-01 [PMID: 12727922] (In Vivo, Mouse) |
In Vivo |
Mouse |
| Khattri , Roli, Cox , Tom, Yasayko , Sue-Ann, Ramsdell , Fred An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol, 2003-03-03;4(4):337-42. 2003-03-03 [PMID: 12612581] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Mouse) |
|
Mouse |
| Scharstuhl A, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Ann. Rheum. Dis., 2002-12-01;61(12):1095-8. 2002-12-01 [PMID: 12429542] (In Vivo, Mouse) |
In Vivo |
Mouse |
| Huaux F, 107322, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms, 2002-09-01;169(5):2653-61. 2002-09-01 [PMID: 12193738] (Bioassay, Mouse) |
Bioassay |
Mouse |
| Zhao W, Kobayashi M, Ding W, Yuan L, Seth P, Cornain S, Wang J, Okada F, Hosokawa M Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II. Cancer Immunol. Immunother., 2002-06-25;51(7):381-8. 2002-06-25 [PMID: 12192538] (Bioassay, Rat) |
Bioassay |
Rat |
| Rosado E, 2019, Schwartz Z, Sylvia VL, Dean DD, Boyan BD Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. 91, 2002-06-12;1590(1):1-15. 2002-06-12 [PMID: 12063164] (Bioassay, Rat) |
Bioassay |
Rat |
| Schmidt A, 2019, Gopfert C, Vlodavsky I, Volker W, Buddecke E Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta. 101211, 2002-03-01;81(3):138-44. 2002-03-01 [PMID: 11998865] (Bioassay, Bovine) |
Bioassay |
Bovine |
| Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56. 2002-05-01 [PMID: 11943670] (ELISA (Standard)) |
ELISA (Standard) |
|
| Cashman J, Clark-Lewis I, Eaves A, Eaves C Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood, 2002-02-01;99(3):792-9. 2002-02-01 [PMID: 11806978] (Bioassay, Human) |
Bioassay |
Human |
| Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J. Immunol., 2000-05-15;164(10):5337-43. 2000-05-15 [PMID: 10799896] (ELISA (Standard)) |
ELISA (Standard) |
|
| Desfaits AC, 48971, Raymond J, Muizelaar JP Growth factors stimulate neointimal cells in vitro and increase the thickness of the neointima formed at the neck of porcine aneurysms treated by embolization. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions, 2000-02-01;31(0):498-507. 2000-02-01 [PMID: 10657429] (Bioassay, In Vivo, Canine, Porcine) |
Bioassay, In Vivo |
Canine, Porcine |
| Mozes MM, Hodics T, Kopp JB Isoform specificity of commercially-available anti-TGF-beta antibodies. J. Immunol. Methods, 1999-05-27;225(1):87-93. 1999-05-27 [PMID: 10365785] (Western Blot) |
Western Blot |
|
| Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-09-01;58(17):4008-14. 1998-09-01 [PMID: 9731515] (Bioassay, Human) |
Bioassay |
Human |
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Show All 854 Publications.
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