Recombinant Human TGF-beta 1 Protein

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure (1‑7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1‑4). Each TGF-beta isoform has some non‑redundant functions; for TGF-beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature human TGF‑ beta 1 shares 100% aa identity with pig, dog and cow TGF‑ beta 1, and 99% aa identity with mouse, rat and horse TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta  RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

We have publications tested in 14 confirmed species: Human, Mouse, Rat, Bovine, Canine, Chicken, Equine, Feline, Fish, Mink, Porcine, Rabbit, Transgenic Mouse, Virus.

We have publications tested in 14 applications: Bioassay, Cell Culture, Differentiation, ELISA (Standard), ELISA Capture, ELISA Developmet, ELISA Standard, Flow Cytometry, IHC-P, In Vivo, Stimulation, Surface Plasmon Resonance (SPR, Tissue Culture, Western Blot.

Showing Publications 1 - 10 of 866. Show All 866 Publications. Collapse Publications.

Publications using 240-B	Applications	Species
Jaroszewski, A;Geysels, RC;Volpini, X;Pellizas, CG;Motran, CC;Stempin, CC;Nicola, JP;Cheng, SY;Fozzatti, L; Anaplastic thyroid cancer cell-secreted TGF?1 plays a key role in inducing macrophage polarization of human monocytes American journal of cancer research 2024-07-15 [PMID: 39113863] (Bioassay, Human)	Bioassay	Human
Lim, YJ;Park, SA;Wang, D;Jin, W;Ku, WL;Zhang, D;Xu, J;Patiño, LC;Liu, N;Chen, W;Kazmi, R;Zhao, K;Zhang, YE;Sun, L;Chen, W; MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells Cell reports 2024-07-30 [PMID: 39083380] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Fesneau, O;Thevin, V;Pinet, V;Goldsmith, C;Vieille, B;M'Homa Soudja, S;Lattanzio, R;Hahne, M;Dardalhon, V;Hernandez-Vargas, H;Benech, N;Marie, JC; An intestinal TH17 cell-derived subset can initiate cancer Nature immunology 2024-07-26 [PMID: 39060651] (Flow Cytometry, Mouse)	Flow Cytometry	Mouse
Weinberg, A;Johnson, M;Crotteau, M;Ghosh, D;Vu, T;Levin, MJ; Trained Immunity Generated by the Recombinant Zoster Vaccine Research square 2024-07-10 [PMID: 39041035] (Bioassay, Human)	Bioassay	Human
Patel, R;Cardona, CL;Angeles, E;Singh, G;Ashok, A;Teich, AF;Sproul, AA; Reduced SH3RF3 may protect against Alzheimer's disease by lowering microglial pro-inflammatory responses via modulation of JNK and NFkB signaling bioRxiv : the preprint server for biology 2024-06-28 [PMID: 38979369] (Bioassay, Human)	Bioassay	Human
Khanal, S;Liu, Y;Bamidele, AO;Wixom, AQ;Washington, AM;Jalan-Sakrikar, N;Cooper, SA;Vuckovic, I;Zhang, S;Zhong, J;Johnson, KL;Charlesworth, MC;Kim, I;Yeon, Y;Yoon, S;Noh, YK;Meroueh, C;Timbilla, AA;Yaqoob, U;Gao, J;Kim, Y;Lucien, F;Huebert, RC;Hay, N;Simons, M;Shah, VH;Kostallari, E; Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis Science advances 2024-06-28 [PMID: 38941469] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Nicholas, SE;Basu, SK;Mandal, N;Karamichos, D; Amelioration of Fibrosis via S1P Inhibition Is Regulated by Inactivation of TGF-? and SPL Pathways in the Human Cornea International journal of molecular sciences 2024-06-14 [PMID: 38928268] (Bioassay, Human)	Bioassay	Human
Shao, S;Zhang, N;Specht, GP;You, S;Song, L;Fu, Q;Huang, D;You, H;Shu, J;Domissy, A;Li, S;Nguyen-Tran, V;Joseph, SB;Chatterjee, AK;Chen, JJ;Schultz, PG;Bollong, MJ; Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair Proceedings of the National Academy of Sciences of the United States of America 2024-04-16 [PMID: 38598345] (Bioassay, Human)	Bioassay	Human
Min, K;Yenilmez, B;Kelly, M;Echeverria, D;Elleby, M;Lifshitz, LM;Raymond, N;Tsagkaraki, E;Harney, SM;DiMarzio, C;Wang, H;McHugh, N;Bramato, B;Morrison, B;Rothstein, JD;Khvorova, A;Czech, MP; Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis eLife 2024-04-02 [PMID: 38564479] (Bioassay, Human)	Bioassay	Human
Hao, J;Liu, C;Gu, Z;Yang, X;Lan, X;Guo, X; Dysregulation of Wnt/?-catenin signaling contributes to intestinal inflammation through regulation of group 3 innate lymphoid cells Nature communications 2024-04-01 [PMID: 38561332] (Mouse)		Mouse
Kim, M;Choi, K;Krizaj, D;Kim, J; Regulation of Corneal Stromal Cell Behavior by Modulating Curvature Using a Hydraulically Controlled Organ Chip Array Research square 2024-02-23 [PMID: 38464213] (Bioassay, Human)	Bioassay	Human
Korkaya, H;Koksalar Alkan, F;Caglayan, A;Alkan, H;Benson, E;Gunduz, Y;Sensoy, O;Durdagi, S;Zarbaliyev, E;Dyson, G;Assad, H;Shull, A;Chadli, A;Shi, H;Ozturk, G; Dual activity of Minnelide chemosensitize basal/triple negative breast cancer stem cells and reprograms immunosuppressive tumor microenvironment Research square 2024-02-22 [PMID: 38464167] (Bioassay, Human)	Bioassay	Human
Basurto-Cayuela, L;Guerrero-Martínez, JA;Gómez-Marín, E;Sánchez-Escabias, E;Escaño-Maestre, M;Ceballos-Chávez, M;Reyes, JC; SWI/SNF-dependent genes are defined by their chromatin landscape Cell reports 2024-02-29 [PMID: 38427563] (Mouse)		Mouse
Li, Y;Wang, W;Liu, C;Zeng, M;Xu, L;Du, R;Wang, C; Adiponectin C1q/Tumor Necrosis Factor-Related Protein 13 (CTRP13) Protects against Renal Inflammation and Fibrosis in Obstructive Nephropathy Biomedicines 2023-12-25 [PMID: 38255158] (Bioassay, Rat)	Bioassay	Rat
Rezi, CK;Aslanyan, MG;Diwan, GD;Cheng, T;Chamlali, M;Junger, K;Anvarian, Z;Lorentzen, E;Pauly, KB;Afshar-Bahadori, Y;Fernandes, EFA;Qian, F;Tosi, S;Christensen, ST;Pedersen, SF;Strømgaard, K;Russell, RB;Miner, JH;Mahjoub, MR;Boldt, K;Roepman, R;Pedersen, LB; DLG1 functions upstream of SDCCAG3 and IFT20 to control targeting of polycystin-2 to the primary cilium bioRxiv : the preprint server for biology 2023-11-10 [PMID: 37987012] (Bioassay, Mouse)	Bioassay	Mouse
Harmange, G;Hueros, RAR;Schaff, DL;Emert, B;Saint-Antoine, M;Kim, LC;Niu, Z;Nellore, S;Fane, ME;Alicea, GM;Weeraratna, AT;Simon, MC;Singh, A;Shaffer, SM; Disrupting cellular memory to overcome drug resistance Nature communications 2023-11-06 [PMID: 37932277] (Bioassay, Human)	Bioassay	Human
Gu, M;Jiang, H;Tan, M;Yu, L;Xu, N;Li, Y;Wu, H;Hou, Q;Dai, C; Palmitoyltransferase DHHC9 and acyl protein thioesterase APT1 modulate renal fibrosis through regulating ?-catenin palmitoylation Nature communications 2023-10-21 [PMID: 37865665] (Bioassay, Mouse)	Bioassay	Mouse
Do, NT;Lee, SY;Lee, YS;Shin, C;Kim, D;Lee, TG;Son, JG;Kim, SH; Time-sequential fibroblast-to-myofibroblast transition in elastin-variable 3D hydrogel environments by collagen networks Biomaterials research 2023-10-17 [PMID: 37848974] (Bioassay, Human)	Bioassay	Human
Lee, JH;Kim, KM;Jung, EH;Lee, HR;Yang, JH;Cho, SS;Ki, SH; Parkin-Mediated Mitophagy by TGF-? Is Connected with Hepatic Stellate Cell Activation International journal of molecular sciences 2023-10-02 [PMID: 37834275] (Bioassay, Human)	Bioassay	Human
Sandoval, S;Malany, K;Thongphanh, K;Martinez, CA;Goodson, ML;Souza, FDC;Lin, LW;Pennington, J;Lein, PJ;Kerkvliet, NI;Ehrlich, AK; Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2 responding CD4 + T cells bioRxiv : the preprint server for biology 2023-09-28 [PMID: 37808764] (Bioassay, Human)	Bioassay	Human
Ramesh, V;Gollavilli, PN;Pinna, L;Siddiqui, MA;Turtos, AM;Napoli, F;Antonelli, Y;Leal-Egaña, A;Havelund, JF;Jakobsen, ST;Boiteux, EL;Volante, M;Faergeman, NJ;Jensen, ON;Siersbaek, R;Somyajit, K;Ceppi, P; Propionate reinforces epithelial identity and reduces aggressiveness of lung carcinoma EMBO molecular medicine 2023-09-28 [PMID: 37766669] (Bioassay, Mouse)	Bioassay	Mouse
Dirand, Z;Tissot, M;Chatelain, B;Viennet, C;Rolin, G; Is Spheroid a Relevant Model to Address Fibrogenesis in Keloid Research? Biomedicines 2023-08-23 [PMID: 37760792] (Bioassay, Human)	Bioassay	Human
Barbayianni, I;Kanellopoulou, P;Fanidis, D;Nastos, D;Ntouskou, ED;Galaris, A;Harokopos, V;Hatzis, P;Tsitoura, E;Homer, R;Kaminski, N;Antoniou, KM;Crestani, B;Tzouvelekis, A;Aidinis, V; SRC and TKS5 mediated podosome formation in fibroblasts promotes extracellular matrix invasion and pulmonary fibrosis Nature communications 2023-09-21 [PMID: 37735172] (Cell Culture, Human, Mouse)	Cell Culture	Human, Mouse
Jalan-Sakrikar, N;Anwar, A;Yaqoob, U;Gan, C;Lagnado, AB;Wixom, AQ;Jurk, D;Huebert, RC; Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in Primary Sclerosing Cholangitis JCI insight 2023-09-14 [PMID: 37707950] (Bioassay, Human)	Bioassay	Human
Suzuki, M;Sakai, S;Ota, K;Bando, Y;Uchida, C;Niida, H;Kitagawa, M;Ohhata, T; CCIVR2 facilitates comprehensive identification of both overlapping and non-overlapping antisense transcripts within specified regions Scientific reports 2023-09-08 [PMID: 37684517] (Cell Culture, Human)	Cell Culture	Human
Vaikunthanathan, T;Landmann, E;Correa, DM;Romano, M;Trevelin, SC;Peng, Q;Crespo, E;Corrado, M;Lozano, JJ;Pearce, EL;Perpinan, E;Zoccarato, A;Siew, L;Edwards-Hicks, J;Khan, R;Luu, NT;Thursz, MR;Newsome, PN;Martinez-Llordella, M;Shah, N;Lechler, RI;Shah, AM;Sanchez-Fueyo, A;Lombardi, G;Safinia, N; Dysregulated anti-oxidant signalling and compromised mitochondrial integrity negatively influence regulatory T cell function and viability in liver disease EBioMedicine 2023-08-30 [PMID: 37657135] (Bioassay, Human)	Bioassay	Human
Fonseca, VC;Van, V;Ip, BC; Primary Human Cell-Derived Extracellular Matrix from Decellularized Fibroblast Microtissues with Tissue-Dependent Composition and Microstructure bioRxiv : the preprint server for biology 2023-08-17 [PMID: 37645710] (Bioassay, Human)	Bioassay	Human
Mercader-Barceló, J;Martín-Medina, A;Truyols-Vives, J;Escarrer-Garau, G;Elowsson, L;Montes-Worboys, A;Río-Bocos, C;Muncunill-Farreny, J;Velasco-Roca, J;Cederberg, A;Kadefors, M;Molina-Molina, M;Westergren-Thorsson, G;Sala-Llinàs, E; Mitochondrial Dysfunction in Lung Resident Mesenchymal Stem Cells from Idiopathic Pulmonary Fibrosis Patients Cells 2023-08-17 [PMID: 37626894] (Bioassay, Human)	Bioassay	Human
Zhou, L;Fang, L;Tamm, M;Stolz, D;Roth, M; Extracellular Heat Shock Protein 70 Increases the Glucocorticoid Receptor and Dual-Specificity Phosphatase 1 via Toll-like Receptor 4 and Attenuates Inflammation in Airway Epithelial Cells International journal of molecular sciences 2023-07-20 [PMID: 37511459] (Bioassay, Human)	Bioassay	Human
Hall, C;Law, JP;Reyat, JS;Cumberland, MJ;Hang, S;Vo, NTN;Raniga, K;Weston, CJ;O'Shea, C;Townend, JN;Gehmlich, K;Ferro, CJ;Denning, C;Pavlovic, D; Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype Scientific reports 2023-07-26 [PMID: 37495732] (Bioassay, Human)	Bioassay	Human
Koncina, E;Nurmik, M;Pozdeev, VI;Gilson, C;Tsenkova, M;Begaj, R;Stang, S;Gaigneaux, A;Weindorfer, C;Rodriguez, F;Schmoetten, M;Klein, E;Karta, J;Atanasova, VS;Grzyb, K;Ullmann, P;Halder, R;Hengstschläger, M;Graas, J;Augendre, V;Karapetyan, YE;Kerger, L;Zuegel, N;Skupin, A;Haan, S;Meiser, J;Dolznig, H;Letellier, E; IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer Nature communications 2023-07-17 [PMID: 37460545] (Differentiation, Mouse)	Differentiation	Mouse
Erdem, C;Gross, SM;Heiser, LM;Birtwistle, MR; MOBILE pipeline enables identification of context-specific networks and regulatory mechanisms Nature communications 2023-07-06 [PMID: 37414767] (Bioassay, Human)	Bioassay	Human
Wang, S;Qu, Y;Fang, X;Ding, Q;Zhao, H;Yu, X;Xu, T;Lu, R;Jing, S;Liu, C;Wu, H;Liu, Y; Decorin: a potential therapeutic candidate for ligamentum flavum hypertrophy by antagonizing TGF-beta 1 Experimental & molecular medicine 2023-07-03 [PMID: 37394592] (Bioassay, Human)	Bioassay	Human
Madsen, SF;Sand, JMB;Juhl, P;Karsdal, M;Thudium, CS;Siebuhr, AS;Bay-Jensen, AC; Fibroblasts are not just fibroblasts: clear differences between dermal and pulmonary fibroblasts' response to fibrotic growth factors Scientific reports 2023-06-09 [PMID: 37296166] (Bioassay, Human)	Bioassay	Human
Lu, ZZ;Sun, C;Zhang, X;Peng, Y;Wang, Y;Zeng, Y;Zhu, N;Yuan, Y;Zeng, MS; Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis Science advances 2023-05-24 [PMID: 37224259] (Bioassay, Human)	Bioassay	Human
Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR; Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung bioRxiv : the preprint server for biology 2023-05-05 [PMID: 37205521] (Bioassay, Human)	Bioassay	Human
Yoon, I;Song, JA;Suh, JH;Kim, S;Son, J;Kim, JH;Jang, SY;Hwang, KY;Kim, MH;Kim, S; EPRS1 Controls the TGF-? Signaling Pathway via Interaction with T?RI in Hepatic Stellate Cell Molecular and cellular biology 2023-05-08 [PMID: 37154023] (Bioassay, Human)	Bioassay	Human
M Krizanac, PB Mass Sanch, SK Schröder, R Weiskirche, A Asimakopou Lipid-Independent Regulation of PLIN5 via IL-6 through the JAK/STAT3 Axis in Hep3B Cells International Journal of Molecular Sciences, 2023-04-13;24(8):. 2023-04-13 [PMID: 37108378] (Bioassay, Human)	Bioassay	Human
O Anannya, W Huang, A August ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066370] (Bioassay, Mouse)	Bioassay	Mouse
P Matarrese, R Vona, B Ascione, C Cittadini, A Tocci, AM Mileo Tumor Microenvironmental Cytokines Drive NSCLC Cell Aggressiveness and Drug-Resistance via YAP-Mediated Autophagy Cells, 2023-03-30;12(7):. 2023-03-30 [PMID: 37048121] (Bioassay, Human)	Bioassay	Human
RL Azevedo-Pe, NC Manley, C Dong, Y Zhang, AG Lee, Y Zatulovska, V Gupta, J Vu, S Han, JE Berry, TM Bliss, GK Steinberg Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain Cell Reports, 2023-04-10;42(4):112353. 2023-04-10 [PMID: 37043353] (Bioassay, Human)	Bioassay	Human
N Fakatava, H Mitarai, A Yuda, A Haraguchi, H Wada, D Hasegawa, H Maeda, N Wada Actin alpha 2, smooth muscle, a transforming growth factor-beta1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway Journal of dental sciences, 2022-09-16;18(2):567-576. 2022-09-16 [PMID: 37021273] (Cell Culture, Human)	Cell Culture	Human
N Fakatava, H Mitarai, A Yuda, A Haraguchi, H Wada, D Hasegawa, H Maeda, N Wada Actin alpha 2, smooth muscle, a transforming growth factor-beta1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway Journal of dental sciences, 2023;18(2):567-576. 2023 [PMID: 37021273] (Cell Culture, Human)	Cell Culture	Human
J Sidhaye, P Trepte, N Sepke, M Novatchkov, M Schutzbier, G Dürnberger, K Mechtler, JA Knoblich Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids Elife, 2023-03-29;12(0):. 2023-03-29 [PMID: 36989136] (Bioassay, Human)	Bioassay	Human
AM Refaat, M Nakata, A Husain, H Kosako, T Honjo, NA Begum HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression Cell Reports, 2023-03-20;42(3):112284. 2023-03-20 [PMID: 36943867] (Bioassay, Mouse)	Bioassay	Mouse
Z Wang, J Lauko, AW Kijas, EP Gilbert, P Turunen, R Yegappan, D Zou, J Mata, AE Rowan Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation Nature Communications, 2023-02-23;14(1):1029. 2023-02-23 [PMID: 36823141] (Bioassay, Human)	Bioassay	Human
S Matsuda, A Revandkar, TD Dubash, A Ravi, BS Wittner, M Lin, R Morris, R Burr, H Guo, K Seeger, A Szabolcs, D Che, L Nieman, GA Getz, DT Ting, MS Lawrence, J Gainor, DA Haber, S Maheswaran TGF-beta in the microenvironment induces a physiologically occurring immune-suppressive senescent state Cell Reports, 2023-02-22;42(3):112129. 2023-02-22 [PMID: 36821441] (Bioassay, Human)	Bioassay	Human
Y Horii, S Matsuda, C Toyota, T Morinaga, T Nakaya, S Tsuchiya, M Ohmuraya, T Hironaka, R Yoshiki, K Kasai, Y Yamauchi, N Takizawa, A Nagasaka, A Tanaka, H Kosako, M Nakaya VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation Nature Communications, 2023-02-08;14(1):550. 2023-02-08 [PMID: 36754961] (Bioassay, Rat)	Bioassay	Rat
S Kang, R Yasuhara, R Tokumasu, T Funatsu, K Mishima Adipose-derived mesenchymal stem cells promote salivary duct regeneration via a paracrine effect Journal of oral biosciences, 2023-02-01;0(0):. 2023-02-01 [PMID: 36736698] (Bioassay, Human)	Bioassay	Human
B Zadran, PD Sudhindar, D Wainwright, Y Bury, S Luli, R Howarth, MV McCain, R Watson, H Huet, F Palinkas, RB Palmini, J Casement, DA Mann, F Oakley, J Lunec, H Reeves, GJ Faulkner, R Shukla Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation British Journal of Cancer, 2023-01-27;0(0):. 2023-01-27 [PMID: 36707636] (Bioassay, Human)	Bioassay	Human
S Wenhua, T Tsunematsu, M Umeda, H Tawara, N Fujiwara, Y Mouri, R Arakaki, N Ishimaru, Y Kudo Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma Cancer Medicine, 2023-01-23;0(0):. 2023-01-23 [PMID: 36691359] (Bioassay, Human)	Bioassay	Human
T Hironaka, N Takizawa, Y Yamauchi, Y Horii, M Nakaya The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis The Journal of Biological Chemistry, 2023-01-20;0(0):102934. 2023-01-20 [PMID: 36690273] (Human)		Human
SJ Coeyman, Y Zhang, CF Baicu, MR Zile, AD Bradshaw, WJ Richardson In vitro bioreactor for mechanical control and characterization of tissue constructs Journal of biomechanics, 2023-01-18;147(0):111458. 2023-01-18 [PMID: 36682211] (Bioassay, Mouse)	Bioassay	Mouse
Z Itah, S Chaudhry, S Raju Ponny, O Aydemir, A Lee, J Cavanagh-K, C Tournier, WJ Muller, RJ Davis HER2-driven breast cancer suppression by the JNK signaling pathway Proceedings of the National Academy of Sciences of the United States of America, 2023-01-19;120(4):e2218373120. 2023-01-19 [PMID: 36656864] (Bioassay, Human)	Bioassay	Human
Y Wang, X Liu, Q Xu, W Xu, X Zhou, Z Lin CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development JCI Insight, 2023-01-10;8(1):. 2023-01-10 [PMID: 36625347] (Bioassay, Human)	Bioassay	Human
R Wang, AB Bhatt, BA Minden-Bir, OK Travis, S Tiwari, H Jia, W Rosikiewic, O Martinot, E Childs, R Loesch, G Tossou, S Jamieson, D Finkelstei, B Xu, M Labelle ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis Science Advances, 2023-01-06;9(1):eabq3951. 2023-01-06 [PMID: 36608120] (Bioassay, Human)	Bioassay	Human
R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie IL6 supports long-term expansion of hepatocytes in vitro Nature Communications, 2022-11-29;13(1):7345. 2022-11-29 [PMID: 36446858] (Bioassay, Mouse)	Bioassay	Mouse
R Varol, Z Karaveliog, S Omeroglu, G Aydemir, A Karadag, HE Meco, AA Demircali, A Yilmaz, GC Kocal, G Gencoglan, ME Oruc, GB Esmer, Y Basbinar, SK Ozdemir, H Uvet Acousto-holographic reconstruction of whole-cell stiffness maps Nature Communications, 2022-11-29;13(1):7351. 2022-11-29 [PMID: 36446776] (Bioassay, Human)	Bioassay	Human
SMT Rahman, M Aqdas, EW Martin, F Tomassoni, P Songkiatis, KS Oh, S Uderhardt, S Yun, QC Claybourne, RA McDevitt, V Greco, RN Germain, L Tessarollo, MH Sung Double knockin mice show NF-kappaB trajectories in immune signaling and aging Cell Reports, 2022-11-22;41(8):111682. 2022-11-22 [PMID: 36417863] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang, Y Shen, H Gao, X Wu, I Noth, Y Huang, J Liu, X Fan PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis Nature Communications, 2022-11-19;13(1):7114. 2022-11-19 [PMID: 36402779] (Bioassay, Human)	Bioassay	Human
L Mlakar, SM Garrett, T Watanabe, M Sanderson, T Nishimoto, J Heywood, KL Helke, JM Pilewski, EL Herzog, C Feghali-Bo Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants Biomedicines, 2022-11-09;10(11):. 2022-11-09 [PMID: 36359382] (Cell Culture, Human)	Cell Culture	Human
S Xu, X Yang, Q Chen, Z Liu, Y Chen, X Yao, A Xiao, J Tian, L Xie, M Zhou, Z Hu, F Zhu, X Xu, F Hou, J Nie Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis EBioMedicine, 2022-11-04;86(0):104312. 2022-11-04 [PMID: 36335669] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
X Hu, Y Zou, DA Copland, LP Schewitz-B, Y Li, PJP Lait, M Stimpson, Z Zhang, S Guo, J Liang, T Chen, JJ Li, S Yuan, S Li, P Zhou, Y Liu, AD Dick, X Wen, RWJ Lee, L Wei Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2 EBioMedicine, 2022-11-03;86(0):104333. 2022-11-03 [PMID: 36335665] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
D Cai, SY Chen Nanoparticle endothelial delivery of PGC-1alpha attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling Redox Biology, 2022-10-28;58(0):102524. 2022-10-28 [PMID: 36334380] (Bioassay, Human)	Bioassay	Human
Q Ye, SJ Taleb, H Wang, NL Parinandi, DJ Kass, M Rojas, C Wang, Q Ma, J Zhao, Y Zhao Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis Biomolecules, 2022-10-21;12(10):. 2022-10-21 [PMID: 36291740] (Cell Culture, Human)	Cell Culture	Human
VR Herrera Mi, B Canciani, L Mangiavini, JFS Filipe, L Aidos, M Pallaoro, GM Peretti, P Pocar, SC Modina, A Di Giancam Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells Biomedicines, 2022-09-27;10(10):. 2022-09-27 [PMID: 36289678] (Bioassay, Porcine)	Bioassay	Porcine
SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Human)	Bioassay	Human
A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis Nature, 2022-10-05;0(0):. 2022-10-05 [PMID: 36198802] (Bioassay, Human)	Bioassay	Human
K Santerre, S Cortez Ghi, S Proulx TGF-beta-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells Investigative Ophthalmology & Visual Science, 2022-10-03;63(11):3. 2022-10-03 [PMID: 36194422] (Bioassay, Human)	Bioassay	Human
Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Bioassay, Human)	Bioassay	Human
Watanabe M, Buth J, Haney J, Vishlaghi N, Turcios F, Elahi L, Gu W, Pearson C, Kurdian A, Baliaouri N, Collier A, Miranda O, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark A, Plath K, Christofk H, Kornblum H, Gandal M, Novitch B TGFbeta superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports, 2022-09-29;17(10):2220-2238. 2022-09-29 [PMID: 36179695] (Bioassay, Human)	Bioassay	Human
X Li, W Li, Z Zhang, W Wang, H Huang SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease Frontiers in Pharmacology, 2022-09-12;13(0):1007168. 2022-09-12 [PMID: 36172184] (Bioassay, Human)	Bioassay	Human
WE Jiao, S Xu, YL Qiao, YG Kong, L Sun, YQ Deng, R Yang, ZZ Tao, QQ Hua, SM Chen Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response International immunopharmacology, 2022-09-22;112(0):109261. 2022-09-22 [PMID: 36155282] (Bioassay, Human)	Bioassay	Human
C Bengtson, N Silswal, N Baumlin, M Yoshida, J Dennis, S Yerrathota, M Kim, M Salathe The CFTR Amplifier Nesolicaftor Rescues TGF-beta1 Inhibition of Modulator-Corrected F508del CFTR Function International Journal of Molecular Sciences, 2022-09-19;23(18):. 2022-09-19 [PMID: 36142862] (Cell Culture, Human)	Cell Culture	Human
A Martisova, L Sommerova, A Krejci, I Selingerov, T Kolarova, F Zavadil Ko, M Holanek, J Podhorec, T Kazda, R Hrstka Identification of AGR2 Gene-Specific Expression Patterns Associated with Epithelial-Mesenchymal Transition International Journal of Molecular Sciences, 2022-09-16;23(18):. 2022-09-16 [PMID: 36142758] (Bioassay, Human)	Bioassay	Human
E Gómez-Marí, M Posavec-Ma, L Zarzuela, L Basurto-Ca, JA Guerrero-M, G Arribas, R Yerbes, M Ceballos-C, M Rodríguez-, M Tomé, RV Durán, M Buschbeck, JC Reyes The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFbeta and Hippo pathways Nucleic Acids Research, 2022-09-23;50(17):9838-9857. 2022-09-23 [PMID: 36124662] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
T Ohhata, M Suzuki, S Sakai, K Ota, H Yokota, C Uchida, H Niida, M Kitagawa CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles Scientific Reports, 2022-09-15;12(1):15525. 2022-09-15 [PMID: 36109624] (Cell Culture, Human)	Cell Culture	Human
HJ Lee Therapeutic Potential of the Combination of Pentoxifylline and Vitamin-E in Inflammatory Bowel Disease: Inhibition of Intestinal Fibrosis Journal of Clinical Medicine, 2022-08-12;11(16):. 2022-08-12 [PMID: 36012952] (Bioassay, Human)	Bioassay	Human
V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins International Journal of Molecular Sciences, 2022-08-17;23(16):. 2022-08-17 [PMID: 36012487] (Stimulation, Human)	Stimulation	Human
AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Cells, 2022-08-19;11(16):. 2022-08-19 [PMID: 36010663] (Stimulation, Human)	Stimulation	Human
K Kitsugi, H Noritake, M Matsumoto, T Hanaoka, M Umemura, M Yamashita, S Takatori, J Ito, K Ohta, T Chida, B Ulmasov, BA Neuschwand, T Suda, K Kawata Arg-Gly-Asp-binding integrins activate hepatic stellate cells via the hippo signaling pathway Cellular Signalling, 2022-08-12;99(0):110437. 2022-08-12 [PMID: 35970425] (Bioassay, Human)	Bioassay	Human
XQ Fang, M Lee, WJ Lim, S Lee, CH Lim, JH Lim PGC1alpha Cooperates with FOXA1 to Regulate Epithelial Mesenchymal Transition through the TCF4-TWIST1 International Journal of Molecular Sciences, 2022-07-26;23(15):. 2022-07-26 [PMID: 35897813] (Bioassay, Human)	Bioassay	Human
N Ju, H Hayashi, M Shimamura, S Baba, S Yoshida, R Morishita, H Rakugi, H Nakagami Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice Scientific Reports, 2022-07-21;12(1):12474. 2022-07-21 [PMID: 35864207] (Bioassay, Human)	Bioassay	Human
MC Mezger, C Conzelmann, T Weil, P von Maltit, DPJ Albers, J Münch, T Stamminger, EM Schilling Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression Viruses, 2022-06-15;14(6):. 2022-06-15 [PMID: 35746781] (Bioassay, Human)	Bioassay	Human
S Sawamura, K Makino, M Ide, S Shimada, I Kajihara, T Makino, M Jinnin, S Fukushima Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis International Journal of Molecular Sciences, 2022-06-18;23(12):. 2022-06-18 [PMID: 35743254] (Bioassay, Human)	Bioassay	Human
D Thumkeo, S Punyawatth, S Prasongtan, R Matsuura, K Arima, H Nie, R Yamamoto, N Aoyama, H Hamaguchi, S Sugahara, S Takeda, V Charoensaw, A Tanaka, S Sakaguchi, S Narumiya PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment Cell Reports, 2022-06-07;39(10):110914. 2022-06-07 [PMID: 35675777] (Bioassay, Mouse)	Bioassay	Mouse
DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells Cancers, 2022-05-19;14(10):. 2022-05-19 [PMID: 35626109] (Bioassay, Human)	Bioassay	Human
X Wang, H Ye, S Yang, X Sha, X Wang, T Zhang, R Chen, W Xiao, H Yang Disulfiram Exerts Antifibrotic and Anti-Inflammatory Therapeutic Effects on Perimysial Orbital Fibroblasts in Graves' Orbitopathy International Journal of Molecular Sciences, 2022-05-09;23(9):. 2022-05-09 [PMID: 35563653] (Bioassay, Human)	Bioassay	Human
GN Yin, DK Kim, JI Kang, Y Im, DS Lee, AR Han, J Ock, MJ Choi, MH Kwon, A Limanjaya, SB Jung, J Yang, KW Min, J Yun, Y Koh, JE Park, D Hwang, JK Suh, JK Ryu, HM Kim Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function Experimental & Molecular Medicine, 2022-05-13;0(0):. 2022-05-13 [PMID: 35562586] (Bioassay, Human)	Bioassay	Human
M Wang, S Lin, K Mequanint Electrospun Biodegradable alpha-Amino Acid-Substituted Poly(organophosphazene) Fiber Mats for Stem Cell Differentiation towards Vascular Smooth Muscle Cells Polymers, 2022-04-11;14(8):. 2022-04-11 [PMID: 35458303] (Cell Culture, Human)	Cell Culture	Human
P Arora, W Li, X Huang, W Yu, R Huang, Q Jiang, C Chen Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs International Journal of Molecular Sciences, 2022-04-06;23(7):. 2022-04-06 [PMID: 35409397] (Cell Culture, Human)	Cell Culture	Human
YC Chen, HJ Liao, YM Hsu, YS Shen, CH Chang Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model Polymers, 2022-04-05;14(7):. 2022-04-05 [PMID: 35406348] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
Y Liu, S Chen, L Yu, Y Deng, D Li, X Yu, D Chen, Y Lu, S Liu, R Chen Pemafibrate attenuates pulmonary fibrosis by inhibiting myofibroblast differentiation International immunopharmacology, 2022-04-06;108(0):108728. 2022-04-06 [PMID: 35397395] (Bioassay, Human)	Bioassay	Human
PM Van Hoose, L Yang, M Kraemer, M Ubele, AJ Morris, SS Smyth Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation Scientific Reports, 2022-04-05;12(1):5664. 2022-04-05 [PMID: 35383201] (Bioassay, Human)	Bioassay	Human
KE Ying, W Feng, WZ Ying, X Li, D Xing, Y Sun, Y Chen, PW Sanders Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4 Redox Biology, 2022-03-24;52(0):102296. 2022-03-24 [PMID: 35378363] (Cell Culture, Rat)	Cell Culture	Rat
KI Jeon, A Kumar, KT Wozniak, K Nehrke, KR Huxlin Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation Investigative Ophthalmology & Visual Science, 2022-04-01;63(4):2. 2022-04-01 [PMID: 35377925] (Bioassay, Feline)	Bioassay	Feline
D Chen, H Tang, H Jiang, L Sun, W Zhao, F Qian ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-beta-Smad2/3 Signaling-Mediated Lung Fibroblast Activation Frontiers in Pharmacology, 2022-03-09;13(0):835979. 2022-03-09 [PMID: 35355726] (Bioassay, Mouse)	Bioassay	Mouse
V Narayan, JS Barber-Rot, IY Jung, SF Lacey, AJ Rech, MM Davis, WT Hwang, P Lal, EL Carpenter, SL Maude, G Plesa, N Vapiwala, A Chew, M Moniak, RA Sebro, MD Farwell, A Marshall, J Gilmore, L Lledo, K Dengel, SE Church, TD Hether, J Xu, M Gohil, TH Buckingham, SS Yee, VE Gonzalez, I Kulikovska, F Chen, L Tian, K Tien, W Gladney, CL Nobles, HE Raymond, Prostate C, EO Hexner, DL Siegel, FD Bushman, CH June, JA Fraietta, NB Haas PSMA-targeting TGFbeta-insensitive armored CAR T?cells in metastatic castration-resistant prostate cancer: a phase 1 trial Nature Medicine, 2022-03-21;0(0):. 2022-03-21 [PMID: 35314843] (Stimulation, Human)	Stimulation	Human
S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against T�cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse)	Cell Culture	Mouse
C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022-02-24;51(0):102274. 2022-02-24 [PMID: 35240537] (Bioassay, Human)	Bioassay	Human
CJ Brereton, L Yao, ER Davies, Y Zhou, M Vukmirovic, JA Bell, S Wang, RA Ridley, LSN Dean, OG Andriotis, F Conforti, L Brewitz, S Mohammed, T Wallis, A Tavassoli, RM Ewing, A Alzetani, BG Marshall, SV Fletcher, PJ Thurner, A Fabre, N Kaminski, L Richeldi, A Bhaskar, CJ Schofield, M Loxham, DE Davies, Y Wang, MG Jones Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 2022-02-21;11(0):. 2022-02-21 [PMID: 35188460] (Bioassay, Human)	Bioassay	Human
J Burk, A Sassmann, C Kasper, A Nimptsch, S Schubert Extracellular Matrix Synthesis and Remodeling by Mesenchymal Stromal Cells Is Context-Sensitive International Journal of Molecular Sciences, 2022-02-03;23(3):. 2022-02-03 [PMID: 35163683] (Stimulation, Human)	Stimulation	Human
M Archer, P Dasari, D Walsh, KL Britt, A Evdokiou, WV Ingman Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density Journal of Clinical Medicine, 2022-02-02;11(3):. 2022-02-02 [PMID: 35160252] (Bioassay, Human)	Bioassay	Human
Q Yuan, Q Ren, L Li, H Tan, M Lu, Y Tian, L Huang, B Zhao, H Fu, FF Hou, L Zhou, Y Liu A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling Nature Communications, 2022-01-21;13(1):438. 2022-01-21 [PMID: 35064106] (Bioassay, Rat)	Bioassay	Rat
YH Chen, RH Liu, YZ Cui, A Hettinghou, WY Fu, L Zhang, C Zhang, CJ Liu Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases Arthritis Research & Therapy, 2022-01-19;24(1):27. 2022-01-19 [PMID: 35045889] (Bioassay, Mouse)	Bioassay	Mouse
YJ Park, DM Kim, HB Choi, MH Jeong, SH Kwon, HR Kim, JH Kwak, KH Chung Dendropanoxide, a Triterpenoid from Dendropanax morbifera, Ameliorates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells through Autophagy Inhibition Nutrients, 2021-12-27;14(1):. 2021-12-27 [PMID: 35010975] (Bioassay, Human)	Bioassay	Human
Q Ding, Q Wei, G Sheng, S Wang, S Jing, T Ma, R Zhang, T Wang, W Li, X Tang, H Wu, C Liu The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy Frontiers in Pharmacology, 2021-12-16;12(0):774316. 2021-12-16 [PMID: 34975478] (Bioassay, Human)	Bioassay	Human
J Li, B Xu, M He, X Zong, T Cunningham, C Sha, Y Fan, R Cross, JH Hanna, Y Feng Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation Cell Reports, 2021-12-14;37(11):110124. 2021-12-14 [PMID: 34910919] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
W Cheng, HL Li, SY Xi, XF Zhang, Y Zhu, Le Xing, YX Mo, MM Li, FE Kong, WJ Zhu, XG Chen, HQ Cui, ZM Cao, YF Gong, YQ Tang, Y Zhang, XY Guan, NF Ma, M Liu Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma Nature Communications, 2021-12-08;12(1):7142. 2021-12-08 [PMID: 34880251] (Bioassay, Human)	Bioassay	Human
PM Munne, L Martikaine, I Räty, K Bertula, Nonappa, J Ruuska, H Ala-Hongis, A Peura, B Hollmann, L Euro, K Yavuz, L Patrikaine, M Salmela, J Pokki, M Kivento, J Väänänen, T Suomi, L Nevalaita, M Mutka, P Kovanen, M Leidenius, T Meretoja, K Hukkinen, O Monni, J Pouwels, B Sahu, J Mattson, H Joensuu, P Heikkilä, LL Elo, C Metcalfe, MR Junttila, O Ikkala, J Klefström Compressive stress-mediated p38 activation required for ERalpha?+?phenotype in breast cancer Nature Communications, 2021-11-29;12(1):6967. 2021-11-29 [PMID: 34845227] (Bioassay, Human)	Bioassay	Human
HM Shen, R Wuerffel, JF Cantillo, S Priyadarsh, X Lei, J Liang, YL Wu, AL Kenter Loop extrusion promotes an alternate pathway for isotype switching Cell Reports, 2021-11-23;37(8):110059. 2021-11-23 [PMID: 34818547] (Bioassay, Mouse)	Bioassay	Mouse
V Janbandhu, V Tallapraga, R Patrick, Y Li, D Abeygunawa, DT Humphreys, EMMA Martin, AO Ward, O Contreras, N Farbehi, E Yao, J Du, SL Dunwoodie, N Bursac, RP Harvey Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction Cell Stem Cell, 2021-11-10;0(0):. 2021-11-10 [PMID: 34762860] (Bioassay, Mouse)	Bioassay	Mouse
SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021-11-09;16(11):e0248034. 2021-11-09 [PMID: 34752458] (Bioassay, Human)	Bioassay	Human
P Prakhar, J Alvarez-De, H Keller, A Crossman, X Tai, YK Park, JH Park The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function JCI Insight, 2021-11-08;6(21):. 2021-11-08 [PMID: 34747370] (Bioassay, Mouse)	Bioassay	Mouse
MI Matias, CS Yong, A Foroushani, C Goldsmith, C Mongellaz, E Sezgin, KR Levental, A Talebi, J Perrault, A Rivière, J Dehairs, O Delos, J Bertand-Mi, JC Portais, M Wong, JC Marie, A Kelekar, S Kinet, VS Zimmermann, I Levental, L Yvan-Charv, JV Swinnen, SA Muljo, H Hernandez-, S Tardito, N Taylor, V Dardalhon Regulatory T�cell differentiation is controlled by alphaKG-induced alterations in mitochondrial metabolism and lipid homeostasis Cell Reports, 2021-11-02;37(5):109911. 2021-11-02 [PMID: 34731632] (Bioassay, Human)	Bioassay	Human
NM Wong, E Frias, FD Sigoillot, JH Letendre, M Hild, WW Wong Engineering digitizer circuits for chemical and genetic screens in human cells Nature Communications, 2021-10-22;12(1):6150. 2021-10-22 [PMID: 34686672] (Bioassay, Human)	Bioassay	Human
L Salvadori, S Chiappalup, I Arato, F Mancuso, M Calvitti, MC Marchetti, F Riuzzi, R Calafiore, G Luca, G Sorci Sertoli Cells Improve Myogenic Differentiation, Reduce Fibrogenic Markers, and Induce Utrophin Expression in Human DMD Myoblasts Biomolecules, 2021-10-12;11(10):. 2021-10-12 [PMID: 34680138] (Bioassay, Mouse)	Bioassay	Mouse
E Håland, IN Moen, E Veidal, H Hella, K Misund, TS Slørdahl, KK Starheim TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Oncotarget, 2021-10-12;12(21):2158-2168. 2021-10-12 [PMID: 34676048] (Cell Culture, Human)	Cell Culture	Human
M Bruschi, E La Porta, I Panfoli, G Candiano, A Petretto, E Vidal, X Kajana, M Bartolucci, S Granata, GM Ghiggeri, G Zaza, E Verrina Proteomic profile of mesothelial exosomes isolated from peritoneal dialysis effluent of children with focal segmental glomerulosclerosis Scientific Reports, 2021-10-21;11(1):20807. 2021-10-21 [PMID: 34675284] (Cell Culture, Human)	Cell Culture	Human
RE Carlisle, Z Mohammed-A, C Lu, T Yousof, V Tat, S Nademi, ME MacDonald, RC Austin, JG Dickhout TDAG51 induces renal interstitial fibrosis through modulation of TGF-beta receptor 1 in chronic kidney disease Cell Death & Disease, 2021-10-08;12(10):921. 2021-10-08 [PMID: 34625532] (Cell Culture, Human)	Cell Culture	Human
P Jiang, Y Zhang, B Ru, Y Yang, T Vu, R Paul, A Mirza, G Altan-Bonn, L Liu, E Ruppin, L Wakefield, KW Wucherpfen Systematic investigation of cytokine signaling activity at the tissue and single-cell levels Nature methods, 2021-09-30;18(10):1181-1191. 2021-09-30 [PMID: 34594031] (Bioassay, Human)	Bioassay	Human
MH Shihan, SG Novo, Y Wang, D Sheppard, A Atakilit, TD Arnold, NM Rossi, AP Faranda, MK Duncan alphaVbeta8 integrin targeting to prevent posterior capsular opacification (PCO) JCI Insight, 2021-11-08;0(0):. 2021-11-08 [PMID: 34554928] (In Vivo, Mouse)	In Vivo	Mouse
X Chi, W Jin, X Bai, X Zhao, J Shao, J Li, Q Sun, B Su, X Wang, XO Yang, C Dong RORalpha is critical for mTORC1 activity in T�cell-mediated colitis Cell Reports, 2021-09-14;36(11):109682. 2021-09-14 [PMID: 34525365] (Bioassay, Human)	Bioassay	Human
L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease Brain, Behavior, and Immunity, 2021-09-06;98(0):337-348. 2021-09-06 [PMID: 34500034] (Bioassay, Mouse)	Bioassay	Mouse
I Malenica, J Adam, S Corgnac, L Mezquita, E Auclin, I Damei, L Grynszpan, G Gros, V de Montpré, D Planchard, N Théret, B Besse, F Mami-Choua Integrin-alphaV-mediated activation of TGF-beta regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade Nature Communications, 2021-09-01;12(1):5209. 2021-09-01 [PMID: 34471106] (Cell Culture, Human)	Cell Culture	Human
T Bluhmki, S Traub, AK Müller, S Bitzer, E Schruf, MT Bammert, M Leist, F Gantner, JP Garnett, R Heilker Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96?Transwell air-liquid interface model Scientific Reports, 2021-08-23;11(1):17028. 2021-08-23 [PMID: 34426605] (Bioassay, Human)	Bioassay	Human
AG Kunihiro, JA Brickey, JB Frye, JN Cheng, PB Luis, C Schneider, JL Funk Curcumin Inhibition of TGFbeta signaling in bone metastatic breast cancer cells and the possible role of oxidative metabolites The Journal of nutritional biochemistry, 2021-08-15;0(0):108842. 2021-08-15 [PMID: 34407450] (Bioassay, Human)	Bioassay	Human
J Lee, JA Choi, HH Ju, JE Kim, SY Paik, PV Rao Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells Scientific Reports, 2021-07-22;11(1):14950. 2021-07-22 [PMID: 34294770] (Bioassay, Human)	Bioassay	Human
T Katsuyama, VR Moulton Splicing factor SRSF1 is indispensable for regulatory T�cell homeostasis and function Cell Reports, 2021-07-06;36(1):109339. 2021-07-06 [PMID: 34233194] (Bioassay, Mouse)	Bioassay	Mouse
A Kumar-Sing, MM Parniewska, N Giotopoulo, J Javadi, W Sun, T Szatmári, K Dobra, A Hjerpe, J Fuxe Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells Biology, 2021-06-11;10(6):. 2021-06-11 [PMID: 34208075] (Bioassay, Human)	Bioassay	Human
L Zhang, J Chen, L Yan, Q He, H Xie, M Chen Resveratrol Ameliorates Cardiac Remodeling in a Murine Model of Heart Failure With Preserved Ejection Fraction Frontiers in Pharmacology, 2021-06-10;12(0):646240. 2021-06-10 [PMID: 34177571] (Bioassay, Mouse)	Bioassay	Mouse
L Sun, X Zhao, X Liu, B Zhong, H Tang, W Jin, H Clevers, H Wang, X Wang, C Dong Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription Cell Reports, 2021-06-01;35(9):109188. 2021-06-01 [PMID: 34077723] (Bioassay, Mouse)	Bioassay	Mouse
S Naik, AR Wood, M Ongenaert, P Saidiyan, ED Elstak, HL Lanz, J Stallen, R Janssen, E Smythe, KS Erdmann A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy International Journal of Molecular Sciences, 2021-05-19;22(10):. 2021-05-19 [PMID: 34069732] (Bioassay, Human)	Bioassay	Human
HJ Kang, KJ Lee, J Woo, J Kim, YK Kim, CH Lee, CG Yoo, KH Lee Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase &alpha1 Experimental & Molecular Medicine, 2021-05-17;0(0):. 2021-05-17 [PMID: 34002012] (Bioassay, Human)	Bioassay	Human
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N Uyama, H Tsutsui, S Wu, K Yasuda, E Hatano, XY Qin, S Kojima, J Fujimoto Anti-interleukin-6 receptor antibody treatment ameliorates postoperative adhesion formation Sci Rep, 2019-11-26;9(1):17558. 2019-11-26 [PMID: 31772282] (IHC-P, Human)	IHC-P	Human
X Li, P Fang, Y Sun, Y Shao, WY Yang, X Jiang, H Wang, X Yang Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells Redox Biol, 2019-11-06;28(0):101373. 2019-11-06 [PMID: 31731100] (Bioassay, Human)	Bioassay	Human
M Krämer, P Markart, F Drakopanag, A Mamazhakyp, L Schaefer, M Didiasova, M Wygrecka Pirfenidone inhibits motility of NSCLC cells by interfering with the urokinase system Cell. Signal., 2019-11-03;65(0):109432. 2019-11-03 [PMID: 31693876] (Cell Culture, Human)	Cell Culture	Human
H Basma, AN Johanson, K Dhar, D Anderson, F Qiu, S Rennard, BD Lowes TGF-beta induces a heart failure phenotype via fibroblasts exosome signaling Heliyon, 2019-10-21;5(10):e02633. 2019-10-21 [PMID: 31687497] (Cell Culture, Human)	Cell Culture	Human
D Pham, CE Moseley, M Gao, D Savic, CJ Winstead, M Sun, BL Kee, RM Myers, CT Weaver, RD Hatton Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of Ctcf Cell Rep, 2019-10-29;29(5):1203-1220.e7. 2019-10-29 [PMID: 31665634] (Bioassay, Mouse)	Bioassay	Mouse
V Welk, T Meul, C Lukas, IE Kammerl, SR Mulay, AC Schamberge, N Semren, IE Fernandez, HJ Anders, A Günther, J Behr, O Eickelberg, M Korfei, S Meiners Proteasome activator PA200 regulates myofibroblast differentiation Sci Rep, 2019-10-23;9(1):15224. 2019-10-23 [PMID: 31645612] (Cell Culture, Human)	Cell Culture	Human
N Ogasawara, JA Poposki, AI Klingler, BK Tan, KE Hulse, WW Stevens, AT Peters, LC Grammer, KC Welch, SS Smith, DB Conley, JR Raviv, P Soroosh, KI Takano, T Himi, RC Kern, RP Schleimer, A Kato Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps Mucosal Immunol, 2019-10-22;13(1):86-95. 2019-10-22 [PMID: 31641233] (Cell Culture, Human)	Cell Culture	Human
F Yao, X Wang, ZK Cui, H Lan, X Ai, Q Song, Z Chen, J Yang, B Wu, X Bai ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription Lab. Invest., 2019-10-22;0(0):. 2019-10-22 [PMID: 31641227] (Cell Culture, Human)	Cell Culture	Human
D Bhatia, KP Chung, K Nakahira, E Patino, MC Rice, LK Torres, T Muthukumar, AM Choi, OM Akchurin, ME Choi Mitophagy dependent macrophage reprogramming protects against kidney fibrosis JCI Insight, 2019-12-05;0(0):. 2019-12-05 [PMID: 31639106] (Bioassay, Human)	Bioassay	Human
K Li, L Yang, J Li, C Guan, S Zhang, X Lao, D Ouyang, G Zheng, S Gao, D Wang, Y Liang, G Liao TGFbeta induces stemness through non-canonical AKT-FOXO3a axis in oral squamous cell carcinoma EBioMedicine, 2019-10-16;0(0):. 2019-10-16 [PMID: 31629677] (Bioassay, Human)	Bioassay	Human
R Sachdeva, M Wu, K Johnson, H Kim, A Celebre, U Shahzad, MS Graham, JA Kessler, JH Chuang, J Karamchand, M Bredel, R Verhaak, S Das BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma Sci Rep, 2019-10-10;9(1):14569. 2019-10-10 [PMID: 31602000] (Tissue Culture, Human)	Tissue Culture	Human
W Yoo, J Lee, KH Noh, S Lee, D Jung, MH Kabir, D Park, C Lee, KS Kwon, JS Kim, S Kim Progranulin attenuates liver fibrosis by downregulating the inflammatory response Cell Death Dis, 2019-10-07;10(10):758. 2019-10-07 [PMID: 31591383] (Bioassay, Human)	Bioassay	Human
A Acheva, S Haghdoost, A Sollazzo, V Launonen, M Kämäräinen Presence of Stromal Cells Enhances Epithelial-to-Mesenchymal Transition (EMT) Induction in Lung Bronchial Epithelium after Protracted Exposure to Oxidative Stress of Gamma Radiation Oxid Med Cell Longev, 2019-09-08;2019(0):4120379. 2019-09-08 [PMID: 31583039] (Bioassay, Human)	Bioassay	Human
T Kamitani, H Murota, N Arase, M Wataya-Kan, R Sato-Nishi, K Sekiguchi, D Okuzaki, D Motooka, I Katayama Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen's disease J. Dermatol. Sci., 2019-09-16;0(0):. 2019-09-16 [PMID: 31570272] (Bioassay, Human)	Bioassay	Human
LP Garo, AK Ajay, M Fujiwara, V Beynon, C Kuhn, G Gabriely, S Sadhukan, R Raheja, S Rubino, HL Weiner, G Murugaiyan Smad7 Controls Immunoregulatory PDL2/1-PD1 Signaling in Intestinal Inflammation and Autoimmunity Cell Rep, 2019-09-24;28(13):3353-3366.e5. 2019-09-24 [PMID: 31553906] (Cell Culture, Mouse)	Cell Culture	Mouse
L Berning, L Scharf, E Aplak, D Stucki, C von Montfo, AS Reichert, W Stahl, P Brenneisen In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis PLoS ONE, 2019-09-25;14(9):e0222267. 2019-09-25 [PMID: 31553748] (Bioassay, Human)	Bioassay	Human
YJ Choi, JB Koo, HY Kim, JW Seo, EJ Lee, WR Kim, JY Cho, KB Hahm, SP Hong, DH Kim, JH Yoo Umbilical cord/placenta-derived mesenchymal stem cells inhibit fibrogenic activation in human intestinal myofibroblasts via inhibition of myocardin-related transcription factor A Stem Cell Res Ther, 2019-09-23;10(1):291. 2019-09-23 [PMID: 31547873] (Bioassay, Human)	Bioassay	Human
R Sreekumar, M Emaduddin, H Al-Saihati, K Moutasim, J Chan, M Spampinato, R Bhome, HM Yuen, C Mescoli, A Vitale, U Cillo, M Rugge, J Primrose, MA Hilal, S Thirdborou, E Tulchinsky, G Thomas, A Mirnezami, AE Sayan Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC Cell Death Dis, 2019-09-23;10(10):703. 2019-09-23 [PMID: 31543517] (Bioassay, Human)	Bioassay	Human
S Holvoet, M Perrot, N de Groot, G Prioult, T Mikogami, V Verhasselt, S Nutten Oral Tolerance Induction to Newly Introduced Allergen is Favored by a Transforming Growth Factor-beta-Enriched Formula Nutrients, 2019-09-13;11(9):. 2019-09-13 [PMID: 31540231] (Bioassay, Mink)	Bioassay	Mink
CL Hammond, E Roztocil, RP Phipps, SE Feldon, CF Woeller Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor PLoS ONE, 2019-09-19;14(9):e0222779. 2019-09-19 [PMID: 31536596] (Bioassay, Human)	Bioassay	Human
J Du, L Yan, R Torres, X Gong, H Bian, C Marugán, K Boehnke, C Baquero, YH Hui, SC Chapman, Y Yang, Y Zeng, SM Bogner, RT Foreman, A Capen, GP Donoho, RD Van Horn, DS Barnard, JA Dempsey, RP Beckmann, MS Marshall, LC Chio, Y Qian, YW Webster, A Aggarwal, S Chu, S Bhattachar, LF Stancato, MS Dowless, PW Iversen, JR Manro, JL Walgren, BW Halstead, MZ Dieter, R Martinez, SV Bhagwat, EL Kreklau, MJ Lallena, XS Ye, BKR Patel, C Reinhard, GD Plowman, DA Barda, JR Henry, SG Buchanan, RM Campbell Aurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy Mol. Cancer Ther., 2019-09-17;0(0):. 2019-09-17 [PMID: 31530649] (Bioassay, Human)	Bioassay	Human
T Zhou, K Kyritsi, N Wu, H Francis, Z Yang, L Chen, A O'Brien, L Kennedy, L Ceci, V Meadows, P Kusumanchi, C Wu, L Baiocchi, NJ Skill, R Saxena, A Sybenga, L Xie, S Liangpunsa, F Meng, G Alpini, S Glaser Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2-/- mouse model of primary sclerosing cholangitis (PSC) EBioMedicine, 2019-09-12;0(0):. 2019-09-12 [PMID: 31522982] (Bioassay, Human)	Bioassay	Human
M Bogdanova, A Zabirnyk, A Malashiche, KZ Enayati, TA Karlsen, ML Kaljusto, JE Kvitting, E Dissen, GJ Sullivan, A Kostareva, KO Stensløkke, A Rutkovskiy, J Vaage Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties Sci Rep, 2019-09-10;9(1):12934. 2019-09-10 [PMID: 31506459] (Cell Culture, Human)	Cell Culture	Human
TTD Luong, M Estepa, B Boehme, B Pieske, F Lang, KU Eckardt, J Voelkl, I Alesutan Inhibition of vascular smooth muscle cell calcification by vasorin through interference with TGF β1 signaling Cell. Signal., 2019-09-07;0(0):109414. 2019-09-07 [PMID: 31505229] (Bioassay, Human)	Bioassay	Human
M Lv, Z Li, J Liu, F Lin, Q Zhang, Z Li, Y Wang, K Wang, Y Xu MicroRNA?155 inhibits the proliferation of CD8+ T�cells via upregulating regulatory T cells in vitiligo Mol Med Rep, 2019-08-23;20(4):3617-3624. 2019-08-23 [PMID: 31485649] (Bioassay, Human)	Bioassay	Human
N Kaushansky, E Bakos, S Becker-Her, I Shachar, A Ben-Nun Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms J. Immunol., 2019-09-04;0(0):. 2019-09-04 [PMID: 31484731] (ELISA Standard, Mouse)	ELISA Standard	Mouse
K Krüger, S Schmid, F Paulsen, A Ignatius, P Klinger, T Hotfiel, B Swoboda, K Gelse Trefoil Factor 3 (TFF3) Is Involved in Cell Migration for Skeletal Repair Int J Mol Sci, 2019-09-01;20(17):. 2019-09-01 [PMID: 31480518] (Bioassay, Human)	Bioassay	Human
YH Lee, DY Kim, SH Jeong, YJ Hwang Effect of exposure to Asian sand dust-Particulate matter on liver Tenascin-C expression in human cancer cell and mouse hepatic tissue J Toxicol Sci, 2019-01-01;44(9):633-641. 2019-01-01 [PMID: 31474744] (Bioassay, Human)	Bioassay	Human
DM Habiel, MS Hohmann, MS Espindola, AL Coelho, I Jones, H Jones, R Carnibella, I Pinar, F Werdiger, CM Hogaboam DNA-PKcs modulates progenitor cell proliferation and fibroblast senescence in idiopathic pulmonary fibrosis BMC Pulm Med, 2019-08-29;19(1):165. 2019-08-29 [PMID: 31464599] (Bioassay, Human)	Bioassay	Human
YC Kim, KH Kim, S Lee, JW Jo, JY Park, MS Park, B Tsogbadrak, JP Lee, JW Lee, DK Kim, KH Oh, IJ Jang, YS Kim, RH Cha, SH Yang ST2 blockade mitigates peritoneal fibrosis induced by TGF-beta and high glucose J. Cell. Mol. Med., 2019-08-09;23(10):6872-6884. 2019-08-09 [PMID: 31397957] (Bioassay, Human)	Bioassay	Human
L Messerschm, S Fischer, P Wiedemann, A Bringmann, M Hollborn Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation Mol. Vis., 2019-06-30;25(0):329-344. 2019-06-30 [PMID: 31341381] (Bioassay, Human)	Bioassay	Human
J Argemi, MU Latasa, SR Atkinson, IO Blokhin, V Massey, JP Gue, J Cabezas, JJ Lozano, D Van Booven, A Bell, S Cao, LA Vernetti, JP Arab, M Ventura-Co, LR Edmunds, C Fondevilla, P Stärkel, L Dubuquoy, A Louvet, G Odena, JL Gomez, T Aragon, J Altamirano, J Caballeria, MJ Jurczak, DL Taylor, C Berasain, C Wahlestedt, SP Monga, MY Morgan, P Sancho-Bru, P Mathurin, S Furuya, C Lackner, I Rusyn, VH Shah, MR Thursz, J Mann, MA Avila, R Bataller Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis Nat Commun, 2019-07-16;10(1):3126. 2019-07-16 [PMID: 31311938] (Bioassay, Human)	Bioassay	Human
M Aoki, H Aoki, P Mukhopadhy, T Tsuge, H Yamamoto, NM Matsumoto, E Toyohara, Y Okubo, R Ogawa, K Takabe Sphingosine-1-Phosphate Facilitates Skin Wound Healing by Increasing Angiogenesis and Inflammatory Cell Recruitment with Less Scar Formation Int J Mol Sci, 2019-07-10;20(14):. 2019-07-10 [PMID: 31295813] (Bioassay, Mouse)	Bioassay	Mouse
S Saraswati, SMW Marrow, LA Watch, PP Young Identification of a pro-angiogenic functional role for FSP1-positive fibroblast subtype in wound healing Nat Commun, 2019-07-09;10(1):3027. 2019-07-09 [PMID: 31289275] (Cell Culture, Human)	Cell Culture	Human
M Pedroza, S To, J Smith, SK Agarwal Cadherin-11 contributes to liver fibrosis induced by carbon tetrachloride PLoS ONE, 2019-07-03;14(7):e0218971. 2019-07-03 [PMID: 31269038] (Bioassay, Mouse, Human)	Bioassay	Mouse, Human
J Duan, B Li, M Bhakta, S Xie, P Zhou, NV Munshi, GC Hon Rational Reprogramming of Cellular States by Combinatorial Perturbation Cell Rep, 2019-06-18;27(12):3486-3499.e6. 2019-06-18 [PMID: 31216470] (Bioassay, Mouse)	Bioassay	Mouse
J Jin, S Togo, K Kadoya, M Tulafu, Y Namba, M Iwai, J Watanabe, K Nagahama, T Okabe, M Hidayat, Y Kodama, H Kitamura, T Ogura, N Kitamura, K Ikeo, S Sasaki, S Tominaga, K Takahashi Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-?1 Respir. Res., 2019-06-11;20(1):119. 2019-06-11 [PMID: 31185973] (Cell Culture, Human)	Cell Culture	Human
J Castillo, E Wu, C Lowe, S Srinivasan, R McCord, MC Wagle, S Jayakar, M Gonzalez E, J Eastham-An, B Liu, KE Hutchinson, W Jones, MP Stokes, SS Tarighat, T Holcomb, A Glibicky, FA Romero, S Magnuson, SA Huang, V Plaks, JM Giltnane, MR Lackner, Z Mounir CBP/p300 drives the differentiation of Regulatory T cells through transcriptional and non-transcriptional mechanisms Cancer Res., 2019-06-10;0(0):. 2019-06-10 [PMID: 31182547] (Bioassay, Human)	Bioassay	Human
C Antognelli, S Moretti, R Frosini, E Puxeddu, A Sidoni, VN Talesa Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer Cells, 2019-06-06;8(6):. 2019-06-06 [PMID: 31174324] (Bioassay, Human)	Bioassay	Human
CJW Stock, C Michaeloud, P Leoni, AL Durham, S Mumby, AU Wells, KF Chung, IM Adcock, EA Renzoni, GE Lindahl Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation Biomed Res Int, 2019-04-18;2019(0):1484736. 2019-04-18 [PMID: 31119153] (Bioassay, Human)	Bioassay	Human
J Sakata, A Hirosue, R Yoshida, K Kawahara, Y Matsuoka, T Yamamoto, M Nakamoto, M Hirayama, N Takahashi, T Nakamura, H Arita, H Nakashima, M Nagata, A Hiraki, M Shinohara, H Nakayama HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma Int J Mol Sci, 2019-05-19;20(10):. 2019-05-19 [PMID: 31109142] (Bioassay, Human)	Bioassay	Human
R van Dalen, JS De La Cruz, M Rumpret, FF Fuchsberge, NH van Teijli, J Hanske, C Rademacher, TBH Geijtenbee, JAG van Strijp, C Weidenmaie, A Peschel, DH Kaplan, NM van Sorge Langerhans Cells Sense Staphylococcus aureus Wall Teichoic Acid through Langerin To Induce Inflammatory Responses MBio, 2019-05-14;10(3):. 2019-05-14 [PMID: 31088921] (Bioassay, Human)	Bioassay	Human
DR Myers, E Norlin, Y Vercoulen, JP Roose Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells Cell Rep, 2019-05-07;27(6):1858-1874.e6. 2019-05-07 [PMID: 31067469] (Bioassay, Mouse)	Bioassay	Mouse
S Granados-A, K Hardy, S Franks, IB Sharum, SL Waite, MA Fenwick SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles Sci Rep, 2019-04-24;9(1):6513. 2019-04-24 [PMID: 31015579] (Bioassay, Mouse)	Bioassay	Mouse
HC Lien, YH Lee, YL Juang, YT Lu Fibrillin-1, a novel TGF-beta-induced factor, is preferentially expressed in metaplastic carcinoma with spindle sarcomatous metaplasia Pathology, 2019-04-19;0(0):. 2019-04-19 [PMID: 31010590] (Bioassay, Human)	Bioassay	Human
T Higuchi, K Takagi, A Tochimoto, Y Ichimura, T Norose, Y Katsumata, I Masuda, H Yamanaka, T Morohoshi, Y Kawaguchi Antifibrotic effects of 2-carba cyclic phosphatidic acid (2ccPA) in systemic sclerosis: contribution to the novel treatment Arthritis Res. Ther., 2019-04-18;21(1):103. 2019-04-18 [PMID: 30999934] (Bioassay, Human)	Bioassay	Human
MR Hadjichara, BT Roux, E Csomor, CA Feghali-Bo, LA Murray, DL Clarke, MA Lindsay Long intergenic non-coding RNAs regulate human lung fibroblast function: Implications for idiopathic pulmonary fibrosis Sci Rep, 2019-04-15;9(1):6020. 2019-04-15 [PMID: 30988425] (Bioassay, Human)	Bioassay	Human
Wei X, Zhang L, Zhou Z, Kwon O, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo M, Xu F, Creighton C, Ittmann M, Xin L Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms. Cell Stem Cell, 2019-04-11;24(5):753-768.e6. 2019-04-11 [PMID: 30982770] (Bioassay, Mouse)	Bioassay	Mouse
F Peng, H Li, S Li, Y Wang, W Liu, W Gong, B Yin, S Chen, Y Zhang, C Luo, W Zhou, Y Chen, P Li, Q Huang, Z Xu, H Long Micheliolide ameliorates renal fibrosis by suppressing the Mtdh/BMP/MAPK pathway Lab. Invest., 2019-04-11;0(0):. 2019-04-11 [PMID: 30976056] (Bioassay, Mouse)	Bioassay	Mouse
P Diao, H Ge, Y Song, Y Wu, J Li, Z Li, J Yang, Y Wang, J Cheng Overexpression of ZEB2-AS1 promotes epithelial-to-mesenchymal transition and metastasis by stabilizing ZEB2 mRNA in head neck squamous cell carcinoma J. Cell. Mol. Med., 2019-04-04;0(0):. 2019-04-04 [PMID: 30950191] (Bioassay, Human)	Bioassay	Human
DQ Chen, G Cao, H Chen, CP Argyopoulo, H Yu, W Su, L Chen, DC Samuels, S Zhuang, GP Bayliss, S Zhao, XY Yu, ND Vaziri, M Wang, D Liu, JR Mao, SX Ma, J Zhao, Y Zhang, YQ Shang, H Kang, F Ye, XH Cheng, XR Li, L Zhang, MX Meng, Y Guo, YY Zhao Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan Nat Commun, 2019-04-01;10(1):1476. 2019-04-01 [PMID: 30931940] (Bioassay, Human)	Bioassay	Human
K Wang, S Fang, Q Liu, J Gao, X Wang, H Zhu, Z Zhu, F Ji, J Wu, Y Ma, L Hu, X Shen, D Gao, J Zhu, P Liu, H Zhou TGF-?1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM EBioMedicine, 2019-03-27;0(0):. 2019-03-27 [PMID: 30926424] (Bioassay, Human)	Bioassay	Human
V Fleskens, CM Minutti, X Wu, P Wei, CEGM Pals, J McCrae, S Hemmers, V Groenewold, HJ Vos, A Rudensky, F Pan, H Li, DM Zaiss, PJ Coffer Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells Cell Rep, 2019-03-26;26(13):3600-3612.e6. 2019-03-26 [PMID: 30917315] (Human)		Human
R Gramlich, E Aliahmadi, M Peiser In Vitro Induction of T Helper 17 Cells by Synergistic Activation of Human Monocyte-Derived Langerhans Cell-Like Cells with Bacterial Agonists Int J Mol Sci, 2019-03-19;20(6):. 2019-03-19 [PMID: 30893757] (Bioassay, Human)	Bioassay	Human
T Hochdörfer, C Winkler, K Pardali, J Mjösberg Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Eur. J. Immunol., 2019-03-28;0(0):. 2019-03-28 [PMID: 30892687] (Bioassay, Human)	Bioassay	Human
JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma Nat Commun, 2019-03-08;10(1):1128. 2019-03-08 [PMID: 30850660] (Bioassay, Human)	Bioassay	Human
YB Kim, YH Ahn, JH Jung, YJ Lee, JH Lee, JL Kang Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis Cell. Mol. Immunol., 2019-03-06;0(0):. 2019-03-06 [PMID: 30842627] (Bioassay, Mouse)	Bioassay	Mouse
R Gao, N Zhang, J Yang, Y Zhu, Z Zhang, J Wang, X Xu, Z Li, X Liu, Z Li, J Li, C Kong, J Bi Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-?1 in bladder cancer cells J. Exp. Clin. Cancer Res., 2019-03-01;38(1):111. 2019-03-01 [PMID: 30823924] (Bioassay, Human)	Bioassay	Human
BW Liu, ZH Yu, AX Chen, JR Chi, J Ge, Y Yu, XC Cao Estrogen receptor-?-miR-1271-SNAI2 feedback loop regulates transforming growth factor-?-induced breast cancer progression J. Exp. Clin. Cancer Res., 2019-03-01;38(1):109. 2019-03-01 [PMID: 30823890] (Bioassay, Human)	Bioassay	Human
SS Kim, GE Nikoloudak, S Michelsons, K Creber, DW Hamilton Fibronectin synthesis, but not ?-smooth muscle expression, is regulated by periostin in gingival healing through FAK/JNK signaling Sci Rep, 2019-02-25;9(1):2708. 2019-02-25 [PMID: 30804350] (Bioassay, Human)	Bioassay	Human
Y Luo, Y Xue, J Wang, J Dang, Q Fang, G Huang, N Olsen, SG Zheng Negligible Effect of Sodium Chloride on the Development and Function of TGF-?-Induced CD4+ Foxp3+ Regulatory T Cells Cell Rep, 2019-02-12;26(7):1869-1879.e3. 2019-02-12 [PMID: 30759396] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
B Wang, X Xu, Z Yang, L Zhang, Y Liu, A Ma, G Xu, M Tang, T Jing, L Wu, Y Liu POH1 contributes to hyperactivation of TGF-? signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-? receptors and caveolin-1 EBioMedicine, 2019-02-07;0(0):. 2019-02-07 [PMID: 30745168] (Bioassay, Human)	Bioassay	Human
C Derada Tro, RD Fontijn, E Gowing, M Charabati, B van Het Ho, I Didouh, SMA van der Po, D Geerts, A Prat, J van Horsse, G Kooij, HE de Vries Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology Cell Death Dis, 2019-01-18;10(2):45. 2019-01-18 [PMID: 30718504] (Bioassay, Human)	Bioassay	Human
I Mannaerts, LFR Thoen, N Eysackers, FJ Cubero, S Batista Le, I Coldham, I Colle, C Trautwein, LA van Grunsv Unfolded protein response is an early, non-critical event during hepatic stellate cell activation Cell Death Dis, 2019-02-04;10(2):98. 2019-02-04 [PMID: 30718473] (Bioassay, Mouse)	Bioassay	Mouse
K Yasuda, Y Kitagawa, R Kawakami, Y Isaka, H Watanabe, G Kondoh, T Kohwi-Shig, S Sakaguchi, K Hirota Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation Nat Commun, 2019-02-01;10(1):549. 2019-02-01 [PMID: 30710091] (Bioassay, Mouse)	Bioassay	Mouse
JN Pucella, M Cols, WF Yen, S Xu, J Chaudhuri The B Cell Activation-Induced miR-183 Cluster Plays a Minimal Role in Canonical Primary Humoral Responses J. Immunol., 2019-01-25;0(0):. 2019-01-25 [PMID: 30683701] (Bioassay, Mouse)	Bioassay	Mouse
M Kijewska, C Viski, F Turrell, A Fitzpatric, A van Weverw, Q Gao, M Iravani, CM Isacke Using an in-vivo syngeneic spontaneous metastasis model identifies ID2 as a promoter of breast cancer colonisation in the brain Breast Cancer Res., 2019-01-14;21(1):4. 2019-01-14 [PMID: 30642388] (Bioassay, Mouse)	Bioassay	Mouse
RK Dutta, S Chinnapaiy, L Rasmussen, SV Raju, HJ Unwalla A Neutralizing Aptamer to TGFBR2 and miR-145 Antagonism Rescue Cigarette Smoke- and TGF-?-Mediated CFTR Expression Mol. Ther., 2018-12-06;27(2):442-455. 2018-12-06 [PMID: 30595527] (Bioassay, Human)	Bioassay	Human
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KB Kaylan, IC Berg, MJ Biehl, A Brougham-C, I Jain, SM Jamil, LH Sargeant, NJ Cornell, LT Raetzman, GH Underhill Spatial patterning of liver progenitor cell differentiation mediated by cellular contractility and Notch signaling Elife, 2018-12-27;7(0):. 2018-12-27 [PMID: 30589410] (Bioassay, Mouse)	Bioassay	Mouse
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J Zhang, CE Dunk, O Shynlova, I Caniggia, SJ Lye TGFb1 suppresses the activation of distinct dNK subpopulations in preeclampsia EBioMedicine, 2018-12-19;39(0):531-539. 2018-12-19 [PMID: 30579870] (Bioassay, Human)	Bioassay	Human
J Wang, G Liu, M Liu, L Xiang, Y Xiao, H Zhu, X Wu, Y Peng, W Zhang, P Jiang, A Li, Q Nan, Y Chen, C Chen, T Cheng, S Liu, J Wang The FOXK1-CCDC43 Axis Promotes the Invasion and Metastasis of Colorectal Cancer Cells Cell. Physiol. Biochem., 2018-12-11;51(6):2547-2563. 2018-12-11 [PMID: 30562730] (Bioassay, Human)	Bioassay	Human
T Huang, X Huang, B Shi, F Wang, W Feng, M Yao Regulators of Salmonella-host interaction identified by peripheral blood transcriptome profiling: roles of TGFB1 and TRP53 in intracellular Salmonella replication in pigs Vet. Res., 2018-12-12;49(1):121. 2018-12-12 [PMID: 30541630] (Bioassay, Porcine)	Bioassay	Porcine
R Martin-Mat, TM De Assunca, JP Arab, N Jalan-Sakr, U Yaqoob, T Greuter, VK Verma, AJ Mathison, S Cao, G Lomberk, P Mathurin, R Urrutia, RC Huebert, VH Shah Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-? Dependent Hepatic Stellate Cell Activation and Liver Fibrosis Cell Mol Gastroenterol Hepatol, 2018-09-15;7(1):197-209. 2018-09-15 [PMID: 30539787] (Bioassay, Human)	Bioassay	Human
Y Liu, YL Lightfoot, N Seto, C Carmona-Ri, E Moore, R Goel, L O'Neil, P Mistry, V Hoffmann, S Mondal, PN Premnath, K Gribbons, S Dell'Orso, K Jiang, PR Thompson, HW Sun, SA Coonrod, MJ Kaplan Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus JCI Insight, 2018-12-06;3(23):. 2018-12-06 [PMID: 30518690] (Bioassay, Mouse)	Bioassay	Mouse
CC Weng, PY Ding, YH Liu, JR Hawse, M Subramania, CC Wu, YC Lin, CY Chen, WC Hung, KH Cheng Mutant Kras-induced upregulation of CD24 enhances prostate cancer stemness and bone metastasis Oncogene, 2018-11-22;0(0):. 2018-11-22 [PMID: 30467381] (Bioassay, Mouse)	Bioassay	Mouse
F Das, N Ghosh-Chou, DY Lee, Y Gorin, BS Kasinath, GG Choudhury Akt2 causes TGF?-induced deptor downregulation facilitating mTOR to drive podocyte hypertrophy and matrix protein expression PLoS ONE, 2018-11-16;13(11):e0207285. 2018-11-16 [PMID: 30444896] (Bioassay, Rat)	Bioassay	Rat
JS Park, M Kim, NJ Song, JH Kim, D Seo, JH Lee, SM Jung, JY Lee, J Lee, YS Lee, KW Park, SH Park A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells Stem Cells, 2018-12-07;0(0):. 2018-12-07 [PMID: 30444564] (Bioassay, Mouse)	Bioassay	Mouse
KH Kim, S Lee, H Lee, D Shin, D Min, M Kim, B Ryu, HW Kim, H Bae A standardized herbal extract PM014 ameliorates pulmonary fibrosis by suppressing the TGF-?1 pathway Sci Rep, 2018-11-15;8(1):16860. 2018-11-15 [PMID: 30443024] (Bioassay, Human)	Bioassay	Human
W Chen, MS Nyuydzefe, JM Weiss, J Zhang, SD Waksal, A Zanin-Zhor ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells Sci Rep, 2018-11-09;8(1):16636. 2018-11-09 [PMID: 30413785] (Bioassay, Human)	Bioassay	Human
J Park, JH Lee, BS Yoon, EK Jun, G Lee, IY Kim, S You Additive effect of bFGF and selenium on expansion and paracrine action of human amniotic fluid-derived mesenchymal stem cells Stem Cell Res Ther, 2018-11-08;9(1):293. 2018-11-08 [PMID: 30409167] (Bioassay, Human)	Bioassay	Human
YT Tang, YY Huang, JH Li, SH Qin, Y Xu, TX An, CC Liu, Q Wang, L Zheng Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines BMC Genomics, 2018-11-06;19(1):802. 2018-11-06 [PMID: 30400814] (Bioassay, Human)	Bioassay	Human
AG Kunihiro, JA Brickey, JB Frye, PB Luis, C Schneider, JL Funk Curcumin, but not curcumin-glucuronide, inhibits Smad signaling in TGF?-dependent bone metastatic breast cancer cells and is enriched in bone compared to other tissues J. Nutr. Biochem., 2018-10-11;63(0):150-156. 2018-10-11 [PMID: 30393127] (Bioassay, Human)	Bioassay	Human
M Životi?, B Tampe, G Müller, C Müller, A Lipkovski, X Xu, G Nyamsuren, M Zeisberg, J Markovi?-L Modulation of NCAM/FGFR1 signaling suppresses EMT program in human proximal tubular epithelial cells PLoS ONE, 2018-11-01;13(11):e0206786. 2018-11-01 [PMID: 30383875] (Bioassay, Human)	Bioassay	Human
F Fang, N Xia, B Angulo, J Carey, Z Cady, J Durruthy-D, T Bennett, V Sebastiano, RA Reijo Pera A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells Nat Commun, 2018-10-22;9(1):4384. 2018-10-22 [PMID: 30349051] (Bioassay, Human)	Bioassay	Human
M Inoue, K Okamoto, A Terashima, T Nitta, R Muro, T Negishi-Ko, T Kitamura, T Nakashima, H Takayanagi Arginine methylation controls the strength of ?c-family cytokine signaling in T cell maintenance Nat. Immunol., 2018-10-15;19(11):1265-1276. 2018-10-15 [PMID: 30323341] (Bioassay, Mouse)	Bioassay	Mouse
L Guo, Y Hou, L Song, S Zhu, F Lin, Y Bai D-Mannose Enhanced Immunomodulation of Periodontal Ligament Stem Cells via Inhibiting IL-6 Secretion Stem Cells Int, 2018-09-09;2018(0):7168231. 2018-09-09 [PMID: 30271438] (Bioassay, Human)	Bioassay	Human
T Yamashita, Y Asano, R Saigusa, T Taniguchi, K Nakamura, S Miura, T Toyama, T Takahashi, Y Ichimura, M Hirabayash, A Yoshizaki, T Miyagaki, M Sugaya, S Sato Increased expression of aquaporin-1 in dermal fibroblasts and dermal microvascular endothelial cells possibly contributes to skin fibrosis and edema in patients with systemic sclerosis J. Dermatol. Sci., 2018-09-21;93(1):24-32. 2018-09-21 [PMID: 30270117] (Bioassay, Human)	Bioassay	Human
BS Nepon-Sixt, MG Alexandrow TGF�1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-deficient Conditions Mol. Cancer Res., 2018-09-26;0(0):. 2018-09-26 [PMID: 30257992] (Bioassay, Mouse)	Bioassay	Mouse
X Zhang, L Liu, X Deng, D Li, H Cai, Y Ma, C Jia, B Wu, Y Fan, Z Lv MicroRNA 483-3p targets Pard3 to potentiate TGF-?1-induced cell migration, invasion, and epithelial-mesenchymal transition in anaplastic thyroid cancer cells Oncogene, 2018-08-31;0(0):. 2018-08-31 [PMID: 30171257] (Bioassay, Human)	Bioassay	Human
M Saxena, RKR Kalathur, M Neutzner, G Christofor PyMT-1099, a versatile murine cell model for EMT in breast cancer Sci Rep, 2018-08-14;8(1):12123. 2018-08-14 [PMID: 30108334] (Bioassay, Mouse)	Bioassay	Mouse
RJ Marsh, K Pfisterer, P Bennett, LM Hirvonen, M Gautel, GE Jones, S Cox Artifact-free high-density localization microscopy analysis Nat. Methods, 2018-07-30;0(0):. 2018-07-30 [PMID: 30061677] (Bioassay, Human)	Bioassay	Human
Martinez-Martin N, Marcandalli J, Huang C, Arthur C, Perotti M, Foglierini M, Ho H, Dosey A, Shriver S, Payandeh J, Leitner A, Lanzavecchia A, Perez L, Ciferri C An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor. Cell, 2018-07-26;174(5):1158-1171.e19. 2018-07-26 [PMID: 30057110] (Surface Plasmon Resonance (SPR, Virus)	Surface Plasmon Resonance (SPR	Virus
D Dvornikov, MA Schneider, S Ohse, M Szczygie?, I Titkova, M Rosenblatt, T Muley, A Warth, FJ Herth, H Dienemann, M Thomas, J Timmer, M Schilling, H Busch, M Boerries, M Meister, U Klingmülle Expression ratio of the TGF?-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response Sci Rep, 2018-06-22;8(1):9517. 2018-06-22 [PMID: 29934580] (Bioassay, Human)	Bioassay	Human
MR Conith, Y Hu, AJ Conith, MA Maginnis, JF Webb, RC Albertson Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus Proc. Natl. Acad. Sci. U.S.A., 2018-06-18;0(0):. 2018-06-18 [PMID: 29915062] (In Vivo, Fish)	In Vivo	Fish
FC Bach, AR Tellegen, M Beukers, A Miranda-Be, M Teunissen, WAM de Jong, SAH de Vries, LB Creemers, K Benz, BP Meij, K Ito, MA Tryfonidou Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside Oncotarget, 2018-05-29;9(41):26507-26526. 2018-05-29 [PMID: 29899873] (Bioassay, Canine, Human)	Bioassay	Canine, Human
YW Liao, CC Yu, PL Hsieh, YC Chang miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2 J. Cell. Mol. Med., 2018-06-12;0(0):. 2018-06-12 [PMID: 29893466] (Bioassay, Human)	Bioassay	Human
A Kunita, S Morita, TU Irisa, A Goto, T Niki, D Takai, J Nakajima, M Fukayama MicroRNA-21 in cancer-associated fibroblasts supports�lung adenocarcinoma progression Sci Rep, 2018-06-11;8(1):8838. 2018-06-11 [PMID: 29892003] (Bioassay, Human)	Bioassay	Human
Z Qin, GJ Fisher, JJ Voorhees, T Quan Actin cytoskeleton assembly regulates collagen production via TGF-? type II receptor in human skin fibroblasts J. Cell. Mol. Med., 2018-06-11;0(0):. 2018-06-11 [PMID: 29888864] (Bioassay, Human)	Bioassay	Human
F Ghodrati, M Mehrabian, D Williams, O Halgas, MEC Bourkas, JC Watts, EF Pai, G Schmitt-Ul The prion protein is embedded in a molecular environment that modulates transforming growth factor ? and integrin signaling Sci Rep, 2018-06-05;8(1):8654. 2018-06-05 [PMID: 29872131] (Bioassay, Mouse)	Bioassay	Mouse
Z Al Shareef, H Kardooni, V Murillo-Ga, G Domenici, E Stylianaki, JH Steel, M Rabano, I Gorroño-Et, I Zabalza, M dM Vivanco, J Waxman, RM Kypta Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1 Oncogene, 2018-06-01;0(0):. 2018-06-01 [PMID: 29858602] (Bioassay, Human)	Bioassay	Human
S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a Sci Rep, 2018-05-29;8(1):8267. 2018-05-29 [PMID: 29844613] (Bioassay, Human)	Bioassay	Human
X Feng, Z Li, J Wei, Z Feng, W Wu, Y Zhao Injectable cartilaginous template transformed BMSCs into vascularized bone Sci Rep, 2018-05-29;8(1):8244. 2018-05-29 [PMID: 29844536] (Bioassay, Rabbit)	Bioassay	Rabbit
CF Hung, CL Wilson, YH Chow, LM Schnapp Role of integrin alpha8 in murine model of lung fibrosis PLoS ONE, 2018-05-29;13(5):e0197937. 2018-05-29 [PMID: 29813125] (Bioassay, Mouse)	Bioassay	Mouse
CB Cummins, X Wang, O Nunez Lope, G Graham, HY Tie, J Zhou, RS Radhakrish Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway Int J Mol Sci, 2018-05-24;19(6):. 2018-05-24 [PMID: 29795016] (Bioassay, Human)	Bioassay	Human
YH Chung, YH Huang, TH Chu, CL Chen, PR Lin, SC Huang, DC Wu, CC Huang, TH Hu, YH Kao, MH Tai BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-?1 signaling Lab. Invest., 2018-05-22;0(0):. 2018-05-22 [PMID: 29789683] (Bioassay, Rat)	Bioassay	Rat
S Lively, D Lam, R Wong, LC Schlichter Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels Front Cell Neurosci, 2018-05-03;12(0):115. 2018-05-03 [PMID: 29780305] (Bioassay, Rat)	Bioassay	Rat
K Schlereth, D Weichenhan, T Bauer, T Heumann, E Giannakour, D Lipka, S Jaeger, M Schlesner, P Aloy, R Eils, C Plass, HG Augustin The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium Elife, 2018-05-11;7(0):. 2018-05-11 [PMID: 29749927] (Bioassay, Human)	Bioassay	Human
L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection Mol Med Rep, 2018-05-03;0(0):. 2018-05-03 [PMID: 29749506] (Bioassay, Human)	Bioassay	Human
S Ottaviani, J Stebbing, AE Frampton, S Zagorac, J Krell, A de Giorgio, SM Trabulo, VTM Nguyen, L Magnani, H Feng, E Giovannett, N Funel, TM Gress, LR Jiao, Y Lombardo, NR Lemoine, C Heeschen, L Castellano TGF-? induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression Nat Commun, 2018-05-10;9(1):1845. 2018-05-10 [PMID: 29748571] (Bioassay, Human)	Bioassay	Human
CC Tsai, SB Wu, HC Kau, YH Wei Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts Sci Rep, 2018-05-08;8(1):7276. 2018-05-08 [PMID: 29739987] (Bioassay, ELISA (Standard), Human)	Bioassay, ELISA (Standard)	Human
C Deng, YX Lin, XK Qi, GP He, Y Zhang, HJ Zhang, M Xu, QS Feng, JX Bei, YX Zeng, L Feng TNFRSF19 inhibits TGF? signaling through interaction with TGF? receptor type I to promote tumorigenesis Cancer Res., 2018-05-07;0(0):. 2018-05-07 [PMID: 29735548] (Bioassay, Human)	Bioassay	Human
LR Penke, JM Speth, VL Dommeti, ES White, IL Bergin, M Peters-Gol FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis J. Clin. Invest., 2018-05-07;0(0):. 2018-05-07 [PMID: 29733296] (Bioassay, Human)	Bioassay	Human
A Schmidt, F Marabita, NA Kiani, CC Gross, HJ Johansson, S Éliás, S Rautio, M Eriksson, SJ Fernandes, G Silberberg, U Ullah, U Bhatia, H Lähdesmäki, J Lehtiö, D Gomez-Cabr, H Wiendl, R Lahesmaa, J Tegnér Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3 BMC Biol., 2018-05-07;16(1):47. 2018-05-07 [PMID: 29730990] (Bioassay, Human)	Bioassay	Human
S Deshpande, M Abdollahi, M Wang, L Lanting, M Kato, R Natarajan Reduced Autophagy by a microRNA-mediated Signaling Cascade in Diabetes-induced Renal Glomerular Hypertrophy Sci Rep, 2018-05-03;8(1):6954. 2018-05-03 [PMID: 29725042] (Bioassay, Mouse)	Bioassay	Mouse
V Zaiatz-Bit, DK Finlay, CM Gardiner Canonical TGF-? Signaling Pathway Represses Human NK Cell Metabolism J. Immunol., 2018-05-02;0(0):. 2018-05-02 [PMID: 29720425] (Bioassay, Human)	Bioassay	Human
V Murillo-Ga, I Gorroño-Et, M Åkerfelt, MC Puustinen, L Sistonen, M Nees, J Carton, J Waxman, RM Kypta Frizzled-8 integrates Wnt-11 and transforming growth factor-? signaling in prostate cancer Nat Commun, 2018-05-01;9(1):1747. 2018-05-01 [PMID: 29717114] (Bioassay, Human)	Bioassay	Human
R Rekik, M Smiti Khan, T Larbi, I Zamali, A Beldi-Ferc, O Kammoun, S Marzouki, S Hamzaoui, S Mrad, MR Barbouche, MH Houman, M Ben Ahmed Impaired TGF-? signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22 Cytokine, 2018-04-21;108(0):182-189. 2018-04-21 [PMID: 29684755] (Bioassay, Human)	Bioassay	Human
F Liu, C Chu, Q Wei, J Shi, H Li, N Dong Metformin ameliorates TGF-β1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting β-catenin signaling Biochem. Biophys. Res. Commun., 2018-04-22;0(0):. 2018-04-22 [PMID: 29679571] (Bioassay, Human)	Bioassay	Human
M Wang, DQ Chen, L Chen, G Cao, H Zhao, D Liu, ND Vaziri, Y Guo, YY Zhao Novel inhibitors of the cellular RAS components, Poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis Br. J. Pharmacol., 2018-05-22;0(0):. 2018-05-22 [PMID: 29679507] (Cell Culture, Human)	Cell Culture	Human
L Knüppel, K Heinzelman, M Lindner, R Hatz, J Behr, O Eickelberg, CA Staab-Weij FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis Respir. Res., 2018-04-19;19(1):67. 2018-04-19 [PMID: 29673351] (Bioassay, Human)	Bioassay	Human
P Mallikarju, RT Sitaram, M Landström, B Ljungberg VHL status regulates transforming growth factor-? signaling pathways in renal cell carcinoma Oncotarget, 2018-03-27;9(23):16297-16310. 2018-03-27 [PMID: 29662646] (Bioassay, Human)	Bioassay	Human
L Corsuto, S Rother, L Koehler, E Bedini, S Moeller, M Schnabelra, V Hintze, C Schiraldi, D Scharnwebe Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response Carbohydr Polym, 2018-03-01;191(0):53-64. 2018-03-01 [PMID: 29661321] (ELISA Standard, Human)	ELISA Standard	Human
D Wu, P Lu, X Mi, J Miao Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis Mol. Hum. Reprod., 2018-07-01;0(0):. 2018-07-01 [PMID: 29660008] (Bioassay, Human)	Bioassay	Human
Y Nakayama, S Matsui, K Noda, M Yamazaki, Y Iwai, B Ganss, Y Ogata TGF?1-induced Amelotin gene expression is downregulated by Bax expression in mouse gingival epithelial cells J Oral Sci, 2018-04-16;0(0):. 2018-04-16 [PMID: 29657250] (Bioassay, Mouse)	Bioassay	Mouse
R Gupta, K Somyajit, T Narita, E Maskey, A Stanlie, M Kremer, D Typas, M Lammers, N Mailand, A Nussenzwei, J Lukas, C Choudhary DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity Cell, 2018-04-12;0(0):. 2018-04-12 [PMID: 29656893] (Bioassay, Mouse)	Bioassay	Mouse
Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28 Nat Commun, 2018-04-12;9(1):1424. 2018-04-12 [PMID: 29651155] (Bioassay, Mouse)	Bioassay	Mouse
E Groppa, S Brkic, A Uccelli, G Wirth, P Korpisalo-, M Filippova, B Dasen, V Sacchi, MG Muraro, M Trani, S Reginato, R Gianni-Bar, S Ylä-Herttu, A Banfi EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF EMBO Rep., 2018-04-11;0(0):. 2018-04-11 [PMID: 29643120] (Bioassay, Human)	Bioassay	Human
S Park, KM Yang, Y Park, E Hong, CP Hong, J Park, K Pang, J Lee, B Park, S Lee, H An, MK Kwak, J Kim, JM Kang, P Kim, Y Xiao, G Nie, A Ooshima, SJ Kim Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation J Cancer Prev, 2018-03-30;23(1):1-9. 2018-03-30 [PMID: 29629343] (Bioassay, Human)	Bioassay	Human
PD Leiphrakpa, MG Brattain, JD Black, JJ Wang TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancer�cells J. Biol. Chem., 2018-03-29;0(0):. 2018-03-29 [PMID: 29599290] (Bioassay, Human)	Bioassay	Human
DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells Biol. Reprod., 2018-09-01;0(0):. 2018-09-01 [PMID: 29596569] (Bioassay, Human)	Bioassay	Human
S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage Nat. Cell Biol., 2018-03-26;20(4):455-464. 2018-03-26 [PMID: 29581593] (Bioassay, Mouse)	Bioassay	Mouse
L Geng, X Tang, K Zhou, D Wang, S Wang, G Yao, W Chen, X Gao, W Chen, S Shi, N Shen, X Feng, L Sun MicroRNA-663 induces immune dysregulation by inhibiting TGF-?1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus Cell. Mol. Immunol., 2018-01-01;0(0):. 2018-01-01 [PMID: 29578533] (Bioassay, Human)	Bioassay	Human
R Thome, AP Bonfanti, J Rasouli, ER Mari, GX Zhang, A Rostami, L Verinaud Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity Eur. J. Immunol., 2018-04-17;0(0):. 2018-04-17 [PMID: 29572810] (Bioassay, Human)	Bioassay	Human
B Zhang, W Niu, HY Dong, ML Liu, Y Luo, ZC Li Hypoxia induces endothelial?mesenchymal transition in pulmonary vascular remodeling Int. J. Mol. Med., 2018-03-22;0(0):. 2018-03-22 [PMID: 29568878] (Bioassay, Rat)	Bioassay	Rat
H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209. 2018-01-31 [PMID: 29552576] (Bioassay, Human)	Bioassay	Human
X Hu, H Kan, A Boye, Y Jiang, C Wu, Y Yang Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells Oncol Lett, 2018-02-02;15(4):4867-4872. 2018-02-02 [PMID: 29552126] (Bioassay, Human)	Bioassay	Human
N Zila, A Bileck, B Muqaku, L Janker, OM Eichhoff, PF Cheng, R Dummer, MP Levesque, C Gerner, V Paulitschk Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases Clin Proteomics, 2018-03-09;15(0):13. 2018-03-09 [PMID: 29541007] (Bioassay, Human)	Bioassay	Human
V Beaulieu L, O Roy, K Santerre, S Proulx TGF-?1 promotes cell barrier function upon maturation of corneal endothelial cells Sci Rep, 2018-03-13;8(1):4438. 2018-03-13 [PMID: 29535350] (Bioassay, Human)	Bioassay	Human
S Liu, J Iaria, RJ Simpson, HJ Zhu Ras enhances TGF-? signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1 Cell Commun. Signal, 2018-03-13;16(1):10. 2018-03-13 [PMID: 29534718] (Bioassay, Canine)	Bioassay	Canine
R Yang, T Yu, D Liu, S Shi, Y Zhou Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway Stem Cell Res Ther, 2018-03-09;9(1):62. 2018-03-09 [PMID: 29523215] (Bioassay, Mouse)	Bioassay	Mouse
H Sugiura, A Matsushita, M Futaya, A Teraoka, KI Akiyama, N Usui, N Nagano, K Nitta, K Tsuchiya Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model PLoS ONE, 2018-03-08;13(3):e0191706. 2018-03-08 [PMID: 29518087] (Bioassay, Human)	Bioassay	Human
J Wang, A Faiz, Q Ge, CJ Vermeulen, J Van der Ve, KJ Snibson, R van de Vel, S Sawant, D Xenaki, B Oliver, W Timens, N Ten Hacken, M van den Be, A James, JG Elliot, L Dong, JK Burgess, AW Ashton Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling J. Cell. Mol. Med., 2018-03-07;0(0):. 2018-03-07 [PMID: 29516637] (Bioassay, Human)	Bioassay	Human
P Bozatzi, KS Dingwell, KZ Wu, F Cooper, TD Cummins, LD Hutchinson, J Vogt, NT Wood, TJ Macartney, J Varghese, R Gourlay, DG Campbell, JC Smith, GP Sapkota PAWS1 controls Wnt signalling through association with casein kinase 1? EMBO Rep., 2018-03-07;0(0):. 2018-03-07 [PMID: 29514862] (Bioassay, Human)	Bioassay	Human
A Merdrignac, G Angenard, C Allain, K Petitjean, D Bergeat, P Bellaud, A Fautrel, B Turlin, B Clément, S Dooley, L Sulpice, K Boudjema, C Coulouarn A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma Hepatol Commun, 2018-01-30;2(3):254-269. 2018-01-30 [PMID: 29507901] (Bioassay, Human)	Bioassay	Human
K Kobayashi, T Yoshioka, J Miyauchi, A Nakazawa, N Kiyokawa, T Maihara, I Usami Role of monocyte chemoattractant protein-1 in liver fibrosis with transient myeloproliferative disorder in down syndrome Hepatol Commun, 2018-02-01;2(3):230-236. 2018-02-01 [PMID: 29507898] (Cell Culture, Human)	Cell Culture	Human
MM Pleumeeker, L Nimeskern, JLM Koevoet, M Karperien, KS Stok, GJVM van Osch Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture PLoS ONE, 2018-02-28;13(2):e0190744. 2018-02-28 [PMID: 29489829] (Bioassay, Human)	Bioassay	Human
S Patalano, J Rodríguez-, C Colaneri, J Cotellessa, D Almanza, A Zhilin-Rot, T Riley, J Macoska CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation Sci Rep, 2018-02-22;8(1):3499. 2018-02-22 [PMID: 29472636] (Bioassay, Human)	Bioassay	Human
R Wang, T Fu, K You, S Li, N Zhao, J Yang, SM Zhuang Identification of a TGF-?-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells FASEB J., 2018-02-20;0(0):fj201701199R. 2018-02-20 [PMID: 29465312] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
JM Dave, T Mirabella, SD Weatherbee, DM Greif Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain Dev. Cell, 2018-02-15;0(0):. 2018-02-15 [PMID: 29456135] (Bioassay, Human)	Bioassay	Human
A Löfdahl, C Wenglén, K Rydell-Tör, G Westergren, AK Larsson-Ca Effects of 5-HT2receptor antagonists on bronchoconstriction and pulmonary remodeling processes Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454752] (Bioassay, Human)	Bioassay	Human
L Gagnon, M Leduc, JF Thibodeau, MZ Zhang, B Grouix, F Sarra-Bour, W Gagnon, K Hince, M Tremblay, L Geerts, CRJ Kennedy, RL Hébert, A Gutsol, CE Holterman, E Kamto, L Gervais, J Ouboudinar, J Richard, A Felton, A Laverdure, JC Simard, S Létourneau, MP Cloutier, FA Leblond, SD Abbott, C Penney, JS Duceppe, B Zacharie, J Dupuis, A Calderone, QT Nguyen, RC Harris, P Laurin A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84 Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454750] (Cell Culture, Mouse)	Cell Culture	Mouse
M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy Int J Mol Sci, 2018-02-10;19(2):. 2018-02-10 [PMID: 29439436] (Bioassay, Equine)	Bioassay	Equine
M Losa, M Risolino, B Li, J Hart, L Quintana, I Grishina, H Yang, IF Choi, P Lewicki, S Khan, R Aho, J Feenstra, CT Vincent, AMC Brown, E Ferretti, T Williams, L Selleri Face morphogenesis is promoted by Pbx-dependent EMT via regulation ofduring frontonasal prominence fusion Development, 2018-03-01;0(0):. 2018-03-01 [PMID: 29437830] (Bioassay, Mouse)	Bioassay	Mouse
VNS Garikipati, SP Singh, Y Mohanram, AK Gupta, D Kapoor, S Nityanand Isolation and characterization of mesenchymal stem cells from human fetus heart PLoS ONE, 2018-02-08;13(2):e0192244. 2018-02-08 [PMID: 29420637] (Bioassay, Human)	Bioassay	Human
F Wang, V Zachar, CP Pennisi, T Fink, Y Maeda, J Emmersen Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype Int J Mol Sci, 2018-02-08;19(2):. 2018-02-08 [PMID: 29419805] (Bioassay, Human)	Bioassay	Human
M Imamura, JS Moon, KP Chung, K Nakahira, T Muthukumar, R Shingarev, SW Ryter, AM Choi, ME Choi RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415885] (Bioassay, Human)	Bioassay	Human
L Chen, J Li, Q Li, X Li, Y Gao, X Hua, B Zhou, J Li Overexpression of LncRNA AC067945.2 Down-Regulates Collagen Expression in Skin Fibroblasts and Possibly Correlates with the VEGF and Wnt Signalling Pathways Cell. Physiol. Biochem., 2018-02-01;45(2):761-771. 2018-02-01 [PMID: 29414824] (Bioassay, Human)	Bioassay	Human
H Tian, JJ Huang, C Golzio, X Gao, M Hector-Gre, N Katsanis, GC Blobe Endoglin interacts with VEGFR2 to promote angiogenesis FASEB J., 2018-01-11;0(0):fj201700867RR. 2018-01-11 [PMID: 29401587] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
T Rosengren, LJ Larsen, LB Pedersen, ST Christense, LB Møller TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms Cell. Mol. Life Sci., 2018-02-02;0(0):. 2018-02-02 [PMID: 29396625] (Bioassay, Mouse)	Bioassay	Mouse
R Zhang, Y Wu, F Xie, Y Zhong, Y Wang, M Xu, J Feng, J Charish, PP Monnier, X Qin RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke Cell Death Differ., 2018-02-02;0(0):. 2018-02-02 [PMID: 29396549] (Bioassay, Rat)	Bioassay	Rat
G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction EBioMedicine, 2018-01-13;28(0):287-302. 2018-01-13 [PMID: 29396297] (Bioassay, Human)	Bioassay	Human
O Kodet, B Dvo?ánková, B Bendlová, V Sýkorová, I Krajsová, J Štork, J Ku?era, P Szabo, H Strnad, M Kolá?, ? Vl?ek, K Smetana, L Lacina Microenvironment?driven resistance to B?Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts Int. J. Mol. Med., 2018-02-01;0(0):. 2018-02-01 [PMID: 29393387] (Bioassay, Human)	Bioassay	Human
L Jia, Y Tian, Y Chen, G Zhang The silencing of LncRNA-H19 decreases chemoresistance of human glioma cells to temozolomide by suppressing epithelial-mesenchymal transition via the Wnt/?-Catenin pathway Onco Targets Ther, 2018-01-11;11(0):313-321. 2018-01-11 [PMID: 29391808] (Bioassay, Human)	Bioassay	Human
J Nishida, K Miyazono, S Ehata Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms Oncogene, 2018-02-02;0(0):. 2018-02-02 [PMID: 29391598] (Bioassay, Human)	Bioassay	Human
PS Bellaye, C Shimbori, T Yanagihara, DA Carlson, P Hughes, C Upagupta, S Sato, N Wheildon, T Haystead, K Ask, M Kolb Synergistic role of HSP90? and HSP90? to promote myofibroblast persistence in lung fibrosis Eur. Respir. J., 2018-01-31;51(2):. 2018-01-31 [PMID: 29386344] (Bioassay, Human)	Bioassay	Human
F Zhang, G Liu, D Li, C Wei, J Hao DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway J. Immunol., 2018-01-29;0(0):. 2018-01-29 [PMID: 29378913] (Bioassay, Human)	Bioassay	Human
T Yamakawa, H Ohigashi, D Hashimoto, E Hayase, S Takahashi, M Miyazaki, K Minomi, M Onozawa, Y Niitsu, T Teshima Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease Blood, 2018-01-23;0(0):. 2018-01-23 [PMID: 29363541] (Cell Culture, Mouse)	Cell Culture	Mouse
JT Chen, CY Wang, MH Chen Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts J. Formos. Med. Assoc., 2018-01-17;0(0):. 2018-01-17 [PMID: 29339038] (Bioassay, Human)	Bioassay	Human
L Lin, M Li, L Lin, X Xu, G Jiang, L Wu FPPS mediates TGF-?1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway Biochem. Biophys. Res. Commun., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337059] (Bioassay, Human)	Bioassay	Human
SJ Han, JK Jung, SS Im, SR Lee, BC Jang, KM Park, JI Kim Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition Biochem. Biophys. Res. Commun., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337054] (Bioassay, Canine)	Bioassay	Canine
J Zhu, Z Zhang, Y Zhang, W Li, W Zheng, J Yu, B Wang, L Chen, Q Zhuo, L Chen, J Zhang, J Liu MicroRNA-212 activates hepatic stellate cells and promotes liver fibrosis via targeting SMAD7 Biochem. Biophys. Res. Commun., 2018-01-04;0(0):. 2018-01-04 [PMID: 29307832] (Bioassay, Human)	Bioassay	Human
J Choi, DR Pease, S Chen, B Zhang, H Phee P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells Immunology, 2018-02-02;0(0):. 2018-02-02 [PMID: 29297928] (Bioassay, Mouse)	Bioassay	Mouse
JC Cheng, Y Yi, HM Chang, PCK Leung TGF-?1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation Cell. Signal., 2017-12-18;43(0):55-61. 2017-12-18 [PMID: 29269046] (Bioassay, Human)	Bioassay	Human
EM Reyes-Reye, I Aispuro, MA Tavera-Gar, M Field, S Moore, I Ramos, KS Ramos LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells Oncotarget, 2017-10-23;8(61):103828-103842. 2017-10-23 [PMID: 29262603] (Bioassay, Human)	Bioassay	Human
SD Hardy, A Shinde, WH Wang, MK Wendt, RL Geahlen Regulation of epithelial-mesenchymal transition and metastasis by TGF-?, P-bodies, and autophagy Oncotarget, 2017-10-17;8(61):103302-103314. 2017-10-17 [PMID: 29262563] (Bioassay, Mouse)	Bioassay	Mouse
H Hanieh, K Masuda, H Metwally, JP Chalise, M Mohamed, KK Nyati, DM Standley, S Li, M Higa, MM Zaman, T Kishimoto Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-loop structure in its 3'UTR Eur. J. Immunol., 2018-02-05;0(0):. 2018-02-05 [PMID: 29244194] (Bioassay, Mouse)	Bioassay	Mouse
W Shin, Y Jeon, I Choi, YJ Kim V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80+ cells regulate oral antigen-specific responses in mouse Eur. J. Immunol., 2018-01-18;0(0):. 2018-01-18 [PMID: 29235119] (Bioassay, Mouse)	Bioassay	Mouse
Shyam Kumar Gudey, Reshma Sundar, Carl-Henrik Heldin, Anders Bergh, Marene Landström Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF? stimulation in cancer. Oncotarget, 2017-08-09;0(0):1949-2553. 2017-08-09 [PMID: 29228645] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming Cell Stem Cell, 2017-11-22;0(0):. 2017-11-22 [PMID: 29174331] (Bioassay, Human)	Bioassay	Human
Chris J C Johnston, Danielle J Smyth, Ravindra B Kodali, Madeleine P J White, Yvonne Harcus, Kara J Filbey, James P Hewitson, Cynthia S Hinck, Alasdair Ivens, Andrea M Kemter, Anna O Kildemoes, Thierry Le Bihan, Dinesh C Soares, Stephen M Anderton, Thomas Brenn, Stephen J Wigmore, Hannah V Woodcock, Rachel C Chambers, Andrew P Hinck, Henry J McSorley, Rick M Maizels A structurally distinct TGF-? mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 2017-11-23;0(0):2041-1723. 2017-11-23 [PMID: 29170498] (Bioassay, Mouse)	Bioassay	Mouse
SK Sahu, N Tiwari, A Pataskar, Y Zhuang, M Borisova, M Diken, S Strand, P Beli, VK Tiwari FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development Nat Commun, 2017-11-15;8(1):1523. 2017-11-15 [PMID: 29142217] (Bioassay, Human)	Bioassay	Human
F Yu, B Chen, X Fan, G Li, P Dong, J Zheng Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2 Cell. Physiol. Biochem., 2017-10-27;43(6):2242-2252. 2017-10-27 [PMID: 29073595] (Bioassay, Human)	Bioassay	Human
A Shibata, M Kuno, R Adachi, Y Sato, H Hattori, A Matsuda, Y Okuzono, K Igaki, Y Tominari, T Takagi, M Yabuki, M Okaniwa Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy PLoS ONE, 2017-10-24;12(10):e0186587. 2017-10-24 [PMID: 29065190] (Bioassay, Human)	Bioassay	Human
S Saito, Y Zhuang, B Shan, S Danchuk, F Luo, M Korfei, A Guenther, JA Lasky Tubastatin ameliorates pulmonary fibrosis by targeting the TGF?-PI3K-Akt pathway PLoS ONE, 2017-10-18;12(10):e0186615. 2017-10-18 [PMID: 29045477] (Bioassay, Human)	Bioassay	Human
W Wang, P Li, W Li, J Jiang, Y Cui, S Li, Z Wang Osteopontin activates mesenchymal stem cells to repair skin wound PLoS ONE, 2017-09-28;12(9):e0185346. 2017-09-28 [PMID: 28957406] (Bioassay, Mouse)	Bioassay	Mouse
SZ Wu, SJ Yang, HM Chen, FF Peng, H Yu, JC Kreprinsky, BF Zhang Dual roles of parathyroid hormone-related protein in TGF-?1 signaling and fibronectin upregulation in mesangial cells Biosci. Rep., 2017-10-27;0(0):. 2017-10-27 [PMID: 28954822] (Bioassay, Rat)	Bioassay	Rat
M Sato-Matsu, T Matsubara, A Daikoku, Y Okina, L Longato, K Rombouts, LTT Thuy, J Adachi, T Tomonaga, K Ikeda, K Yoshizato, M Pinzani, N Kawada Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling J. Biol. Chem., 2017-09-15;0(0):. 2017-09-15 [PMID: 28916723] (Bioassay, Human)	Bioassay	Human
M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg CD73 promotes resistance to HER2/ErbB2 antibody therapy Cancer Res., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855210] (Bioassay, Human)	Bioassay	Human
Y Qi, N Wang, Y He, J Zhang, H Zou, W Zhang, W Gu, Y Huang, X Lian, J Hu, J Zhao, X Cui, L Pang, F Li Transforming growth factor-?1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells PLoS ONE, 2017-08-22;12(8):e0182680. 2017-08-22 [PMID: 28829837] (Bioassay, Human)	Bioassay	Human
Ying Chen, Dan-Dan Wang, Ye-Ping Wu, Dan Su, Tian-Yi Zhou, Ren-Hua Gai, Ying-Ying Fu, Lin Zheng, Qiao-Jun He, Hong Zhu, Bo Yang MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. British Journal of Cancer, 2017-08-17;0(0):1532-1827. 2017-08-17 [PMID: 28817834] (Bioassay, Human)	Bioassay	Human
VC Rodríguez-, P Martínez-R, F Català-Mol, J Rodríguez-, A Garcia-Gom, G Poorani-Su, L Ciudad, H Hernando, A Pérez-Garc, C Company, JM Urquiza, AR Ramiro, JM Di Noia, A Vaquero, E Ballestar Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites Sci Rep, 2017-08-08;7(1):7594. 2017-08-08 [PMID: 28790320] (Bioassay, Mouse)	Bioassay	Mouse
P Åström, K Juurikka, ES Hadler-Ols, G Svineng, NK Cervigne, RD Coletta, J Risteli, JH Kauppila, S Skarp, S Kuttner, A Oteiza, M Sutinen, T Salo The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma Br. J. Cancer, 2017-08-03;117(7):1007-1016. 2017-08-03 [PMID: 28772283] (Bioassay, Human)	Bioassay	Human
S Lee, D Kim, J Kang, E Kim, W Kim, H Youn, B Youn Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production Cell. Physiol. Biochem., 2017-07-25;42(4):1684-1700. 2017-07-25 [PMID: 28743125] (Bioassay, Human)	Bioassay	Human
M Renard, L Muiño-Mosq, EC Manalo, S Tufa, EJ Carlson, DR Keene, J De Backer, LY Sakai Sex, pregnancy and aortic disease in Marfan syndrome PLoS ONE, 2017-07-14;12(7):e0181166. 2017-07-14 [PMID: 28708846] (Bioassay, Human)	Bioassay	Human
H Kamata, Y Tsukasaki, T Sakai, R Ikebe, J Wang, A Jeffers, J Boren, S Owens, T Suzuki, M Higashihar, S Idell, TA Tucker, M Ikebe KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis Sci Rep, 2017-07-04;7(1):4556. 2017-07-04 [PMID: 28676645] (Bioassay, Human)	Bioassay	Human
JC Cheng, CP Tseng, MH Liao, CY Peng, JS Yu, PH Chuang, JT Huang, JJW Chen Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes Sci Rep, 2017-06-30;7(1):4448. 2017-06-30 [PMID: 28667290] (Bioassay, Human)	Bioassay	Human
C Caër, C Rouault, T Le Roy, C Poitou, J Aron-Wisne, A Torcivia, JC Bichet, K Clément, M Guerre-Mil, S André Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue Sci Rep, 2017-06-07;7(1):3000. 2017-06-07 [PMID: 28592801] (Bioassay, Human)	Bioassay	Human
JB Koo, MO Nam, Y Jung, J Yoo, DH Kim, G Kim, SJ Shin, KM Lee, KB Hahm, JW Kim, SP Hong, KJ Lee, JH Yoo Anti-fibrogenic effect of PPAR-? agonists in human intestinal myofibroblasts BMC Gastroenterol, 2017-06-07;17(1):73. 2017-06-07 [PMID: 28592228] (Bioassay, Human)	Bioassay	Human
TP Nguyen, SF Sieg TGF-? inhibits IL-7-induced proliferation in memory but not naive human CD4(+) T cells J. Leukoc. Biol., 2017-06-06;0(0):. 2017-06-06 [PMID: 28588029] (Bioassay, Human)	Bioassay	Human
L Bai, HM Chang, JC Cheng, C Klausen, G Chu, PCK Leung, G Yang SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells Cell. Signal., 2017-05-31;37(0):52-61. 2017-05-31 [PMID: 28578012] (Bioassay, Human)	Bioassay	Human
S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes Glia, 2017-06-01;0(0):. 2017-06-01 [PMID: 28568893] (Bioassay, Mouse)	Bioassay	Mouse
EJ Kim, SG Seo, HS Shin, DJ Lee, JH Kim, DY Lee Platelet-Derived Growth Factor Receptor-Positive Pericytic Cells of White Adipose Tissue from Critical Limb Ischemia Patients Display Mesenchymal Stem Cell-Like Properties Clin Orthop Surg, 2017-05-08;9(2):239-248. 2017-05-08 [PMID: 28567229] (Bioassay, Human)	Bioassay	Human
Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28539431] (Bioassay, Mouse)	Bioassay	Mouse
J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells Nat. Immunol., 2017-05-15;0(0):. 2017-05-15 [PMID: 28504697] (Bioassay, Human)	Bioassay	Human
N Salvarani, A Maguy, SA De Simone, M Miragoli, F Jousset, S Rohr TGF-?1 (Transforming Growth Factor-?1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity Circ Arrhythm Electrophysiol, 2017-05-01;10(5):e004567. 2017-05-01 [PMID: 28500173] (Bioassay, Rat)	Bioassay	Rat
J Ko, MK Chae, JH Lee, EJ Lee, JS Yoon Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy Invest. Ophthalmol. Vis. Sci., 2017-05-01;58(5):2544-2553. 2017-05-01 [PMID: 28492873] (Bioassay, Human)	Bioassay	Human
L Calvier, P Chouvarine, E Legchenko, N Hoffmann, J Geldner, P Borchert, D Jonigk, MM Mozes, G Hansmann PPAR? Links BMP2 and TGF?1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism Cell Metab., 2017-05-02;25(5):1118-1134.e7. 2017-05-02 [PMID: 28467929] (Bioassay, Human)	Bioassay	Human
R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells J. Immunol., 2017-04-28;0(0):. 2017-04-28 [PMID: 28455436] (Bioassay, Mouse)	Bioassay	Mouse
ZM Zhao, HL Liu, X Sun, T Guo, L Shen, YY Tao, CH Liu Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway Exp. Biol. Med. (Maywood), 2017-03-22;242(9):974-985. 2017-03-22 [PMID: 28440736] (Bioassay, Human)	Bioassay	Human
Y Zhang Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling Biochem. Biophys. Res. Commun., 2017-04-17;0(0):. 2017-04-17 [PMID: 28427938] (Bioassay, Human)	Bioassay	Human
A Shiokawa, R Kotaki, T Takano, H Nakajima-A, S Hachimura Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cells highly induce regulatory T cells Immunology, 2017-06-01;0(0):. 2017-06-01 [PMID: 28423181] (Bioassay, Mouse)	Bioassay	Mouse
JJ Kathiriya, N Nakra, J Nixon, PS Patel, V Vaghasiya, A Alhassani, Z Tian, D Allen-Gips, V Davé Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis Cell Death Discov, 2017-04-10;3(0):17010. 2017-04-10 [PMID: 28417017] (Bioassay, Human)	Bioassay	Human
KA Whelan, PM Chandramou, K Tanaka, M Natsuizaka, M Guha, S Srinivasan, DS Darling, Y Kita, S Natsugoe, JD Winkler, AJ Klein-Szan, RK Amaravadi, NG Avadhani, AK Rustgi, H Nakagawa Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance Oncogene, 2017-04-17;0(0):. 2017-04-17 [PMID: 28414310] (Bioassay, Human)	Bioassay	Human
D Zhou, L Zhang, W Sun, W Guan, Q Lin, W Ren, J Zhang, G Xu Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer Cell. Signal., 2017-04-14;0(0):. 2017-04-14 [PMID: 28414100] (Bioassay, Human)	Bioassay	Human
Y Dimitrova, AJ Gruber, N Mittal, S Ghosh, B Dimitriade, D Mathow, WA Grandy, G Christofor, M Zavolan TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition Biol. Direct, 2017-04-17;12(1):8. 2017-04-17 [PMID: 28412966] (Bioassay, Mouse)	Bioassay	Mouse
S Ghatak, VC Hascall, RR Markwald, C Feghali-Bo, CM Artlett, M Gooz, GS Bogatkevic, I Atanelishv, RM Silver, J Wood, VJ Thannickal, S Misra TGF beta-1 induced CD44v6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis J. Biol. Chem., 2017-04-07;0(0):. 2017-04-07 [PMID: 28389561] (Bioassay, Human)	Bioassay	Human
F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis Scand. J. Immunol., 2017-06-01;0(0):. 2017-06-01 [PMID: 28376277] (Bioassay, Human)	Bioassay	Human
KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Human)	Bioassay	Human
K Desai, R Aiyappa, JS Prabhu, MG Nair, PV Lawrence, A Korlimarla, A Ce, A Alexander, RS Kaluve, S Manjunath, M Correa, BS Srinath, S Patil, A Kalamdani, M Prasad, TS Sridhar HR+HER2- breast cancers with growth factor receptor-mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells Tumour Biol, 2017-03-01;39(3):1010428317695. 2017-03-01 [PMID: 28349782] (Bioassay, Human)	Bioassay	Human
C Pagiatakis, D Sun, SW Tobin, T Miyake, JC McDermott TGF?-TAZ/SRF Signaling regulates vascular smooth muscle cell differentiation FEBS J, 2017-04-20;0(0):. 2017-04-20 [PMID: 28342289] (Bioassay, Mouse)	Bioassay	Mouse
A Siddiqui, ME Vazakidou, A Schwab, F Napoli, C Fernandez-, I Rapa, MP Stemmler, M Volante, T Brabletz, P Ceppi Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells J. Pathol, 2017-06-01;0(0):. 2017-06-01 [PMID: 28337746] (Bioassay, Human)	Bioassay	Human
V Ruiz-Carpi, P Sandoval, A Aguilera, P Albar-Vizc, ML Perez-Loza, GT González-M, A Acuña-Ruiz, J García-Can, P Botías, MA Bajo, R Selgas, JA Sánchez-To, J Passlick-D, D Piecha, J Büchel, S Steppan, M López-Cabr Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients Sci Rep, 2017-03-22;7(0):44941. 2017-03-22 [PMID: 28327551] (Bioassay, Human)	Bioassay	Human
K Kamio, A Azuma, J Usuki, K Matsuda, M Inomata, N Nishijima, S Itakura, H Hayashi, T Kashiwada, N Kokuho, K Atsumi, T Yamaguchi, K Fujita, Y Saito, S Abe, K Kubota, A Gemma XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts Pulm Pharmacol Ther, 2017-03-14;0(0):. 2017-03-14 [PMID: 28315487] (Bioassay, Human)	Bioassay	Human
D Iizuka, M Sasatani, MH Barcellos-, K Kamiya Hydrogen Peroxide Enhances TGF?-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells Anticancer Res, 2017-03-01;37(3):987-995. 2017-03-01 [PMID: 28314256] (Bioassay, Human)	Bioassay	Human
Y Tachida, N Izumi, T Sakurai, H Kobayashi Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells Biol Open, 2017-03-15;6(3):370-380. 2017-03-15 [PMID: 28298363] (Bioassay, Human)	Bioassay	Human
F Loayza-Puc, K Rooijers, J Zijlstra, B Moumbeini, EA Zaal, JF Oude Vriel, R Lopes, A Pineiro Ug, CR Berkers, R Agami TGF?1-induced leucine limitation uncovered by differential ribosome codon reading EMBO Rep, 2017-03-08;0(0):. 2017-03-08 [PMID: 28274951] (Bioassay, Human)	Bioassay	Human
DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-04-01;0(0):. 2017-04-01 [PMID: 28270449] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
KH Bae, JB Seo, YA Jung, HY Seo, SH Kang, HJ Jeon, JM Lee, S Lee, JG Kim, IK Lee, GS Jung, KG Park Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor ? Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice Endocrinol Metab (Seoul), 2017-02-28;0(0):. 2017-02-28 [PMID: 28256116] (Bioassay, Rat)	Bioassay	Rat
W Zhao, J Yan, L Gao, J Zhao, C Zhao, C Gao, X Luo, X Zhu Cdk5 is required for the neuroprotective effect of transforming growth factor-?1 against cerebral ischemia-reperfusion Biochem. Biophys. Res. Commun, 2017-02-27;0(0):. 2017-02-27 [PMID: 28254431] (Bioassay, Rat)	Bioassay	Rat
D Pap, E Sziksz, Z Kiss, R Rokonay, A Veres-Szék, R Lippai, IM Takács, É Kis, A Fekete, G Reusz, A Vannay, AJ Szabó Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling Kidney Blood Press. Res, 2017-02-28;42(1):16-32. 2017-02-28 [PMID: 28253513] (Bioassay, Human)	Bioassay	Human
A Rynne-Vida, CL Au-Yeung, JA Jiménez-He, ML Pérez-Loza, L Cremades-J, C Bárcena, I Cristóbal-, C Fernández-, TL Yeung, SC Mok, P Sandoval, M López-Cabr Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer J. Pathol, 2017-04-03;0(0):. 2017-04-03 [PMID: 28247413] (Bioassay, Human)	Bioassay	Human
G Mondanelli, R Bianchi, MT Pallotta, C Orabona, E Albini, A Iacono, ML Belladonna, C Vacca, F Fallarino, A Macchiarul, S Ugel, V Bronte, F Gevi, L Zolla, A Verhaar, M Peppelenbo, EM Mazza, S Bicciato, Y Laouar, L Santambrog, P Puccetti, C Volpi, U Grohmann A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells Immunity, 2017-02-14;46(2):233-244. 2017-02-14 [PMID: 28214225] (Bioassay, Mouse)	Bioassay	Mouse
BA Boswell, A Korol, JA West-Mays, LS Musil Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract Mol. Biol. Cell, 2017-02-16;0(0):. 2017-02-16 [PMID: 28209733] (Bioassay, Chicken)	Bioassay	Chicken
A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells Oncotarget, 2017-04-11;8(15):24869-24881. 2017-04-11 [PMID: 28206960] (Bioassay, Human)	Bioassay	Human
Y Hu, L Lao, J Mao, W Jin, H Luo, T Charpentie, S Qi, J Peng, B Hu, MM Marcinkiew, A Lamarre, J Wu Armc5 deletion causes developmental defects and compromises T-cell immune responses Nat Commun, 2017-02-07;8(0):13834. 2017-02-07 [PMID: 28169274] (Bioassay, Mouse)	Bioassay	Mouse
K Sakaguchi, W Katagiri, M Osugi, T Kawai, Y Sugimura-W, H Hibi Periodontal tissue regeneration using the cytokine cocktail mimicking secretomes in the conditioned media from human mesenchymal stem cells Biochem. Biophys. Res. Commun, 2017-01-16;484(1):100-106. 2017-01-16 [PMID: 28104393] (Bioassay, Canine)	Bioassay	Canine
S Gopal, L Veracini, D Grall, C Butori, S Schaub, S Audebert, L Camoin, E Baudelet, A Radwanska, S Beghelli-d, SM Violette, PH Weinreb, S Rekima, M Ilie, A Sudaka, P Hofman, E Van Obberg Fibronectin-guided migration of carcinoma collectives Nat Commun, 2017-01-19;8(0):14105. 2017-01-19 [PMID: 28102238] (Bioassay, Human)	Bioassay	Human
D Brethour, M Mehrabian, D Williams, X Wang, F Ghodrati, S Ehsani, EA Rubie, JR Woodgett, J Sevalle, Z Xi, E Rogaeva, G Schmitt-Ul A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition Sci Rep, 2017-01-18;7(0):40313. 2017-01-18 [PMID: 28098160] (Bioassay, Human)	Bioassay	Human
MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis Proc. Natl. Acad. Sci. U.S.A, 2017-01-09;114(4):E524-E533. 2017-01-09 [PMID: 28069965] (Bioassay, Mouse)	Bioassay	Mouse
Claire Yu Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem/stromal cell expansion Biomaterials, 2016-12-23;120(0):66-80. 2016-12-23 [PMID: 28038353] (Bioassay, Human)	Bioassay	Human
Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases Cell Death Dis, 2016-12-29;7(12):e2565. 2016-12-29 [PMID: 28032864] (Bioassay, Human)	Bioassay	Human
Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas PLoS ONE, 2016-12-28;11(12):e0167200. 2016-12-28 [PMID: 28030558] (Bioassay, Mouse)	Bioassay	Mouse
IL-10 production in murine IgM(+) CD138(hi) cells is driven by Blimp1 and downregulated in class-switched cells Eur. J. Immunol, 2017-01-10;0(0):. 2017-01-10 [PMID: 28012163] (Bioassay, Mouse)	Bioassay	Mouse
Bharat Vaidyanath The aryl hydrocarbon receptor controls cell-fate decisions in B cells J. Exp. Med, 2016-12-23;0(0):. 2016-12-23 [PMID: 28011866] (Bioassay, Human)	Bioassay	Human
Nisha Bte Mohd Rafiq Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO J. Cell Biol, 2016-12-22;216(1):181-197. 2016-12-22 [PMID: 28007915] (Bioassay, Human)	Bioassay	Human
H Kusumoto, Y Shintani, R Kanzaki, T Kawamura, S Funaki, M Minami, I Nagatomo, E Morii, M Okumura Podocalyxin influences malignant potential by controlling epithelial-mesenchymal transition in lung adenocarcinoma Cancer Sci., 2017-03-01;108(3):528-535. 2017-03-01 [PMID: 28004467] (Bioassay, Human)	Bioassay	Human
Tsugumi Horikiri Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia Respir Med, 2016-11-24;122(0):43-50. 2016-11-24 [PMID: 27993290] (Bioassay, Human)	Bioassay	Human
Hoeke A Baarsma Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD J. Exp. Med, 2016-12-15;0(0):. 2016-12-15 [PMID: 27979969] (Bioassay, Human)	Bioassay	Human
Patient-Specific Screening Using High-Grade Glioma Explants to Determine Potential Radiosensitization by a TGF-? Small Molecule Inhibitor Neoplasia, 2016-12-01;18(12):795-805. 2016-12-01 [PMID: 27978994] (Bioassay, Human)	Bioassay	Human
M F Griffin Chemical group-dependent plasma polymerisation preferentially directs adipose stem cell differentiation towards osteogenic or chondrogenic lineages Acta Biomater, 2016-12-09;0(0):. 2016-12-09 [PMID: 27956359] (Bioassay, Human)	Bioassay	Human
Dong-Chuan Guo Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease Am. J. Hum. Genet, 2016-12-08;0(0):. 2016-12-08 [PMID: 27939641] (Bioassay, Human)	Bioassay	Human
YL Li, JT Chang, LY Lee, KH Fan, YC Lu, YC Li, CH Chiang, GR You, HY Chen, AJ Cheng GDF15 contributes to radioresistance and cancer stemness of head and neck cancer by regulating cellular reactive oxygen species via a SMAD-associated signaling pathway Oncotarget, 2017-01-03;8(1):1508-1528. 2017-01-03 [PMID: 27903972] (Bioassay, Human)	Bioassay	Human
Xiuyun Zeng TAR DNA-binding protein 43 inhibits inflammatory response and protects chondrocyte function by modulating RACK1 expression in osteoarthritis Biomed. Pharmacother., 2016-11-24;0(0):. 2016-11-24 [PMID: 27890430] (Bioassay, Human)	Bioassay	Human
Developmental Reprogramming in Mesenchymal Stromal Cells of Human Subjects with Idiopathic Pulmonary Fibrosis Sci Rep, 2016-11-21;6(0):37445. 2016-11-21 [PMID: 27869174] (Bioassay, Human)	Bioassay	Human
CELF1 is a central node in post-transcriptional regulatory programmes underlying EMT Nat Commun, 2016-11-21;7(0):13362. 2016-11-21 [PMID: 27869122] (Bioassay, Human)	Bioassay	Human
Saverio Bellusci Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis Cell Stem Cell, 2016-11-17;0(0):. 2016-11-17 [PMID: 27867035] (Bioassay, Human)	Bioassay	Human
Menq-Jer Lee TGF-?/ SMAD3 Pathway Stimulates Sphingosine-1-phosphate Receptor 3 Expression: Implication of Sphingosine-1-Phosphate Receptor 3 in Lung Adenocarcinoma Progression J. Biol. Chem., 2016-11-17;0(0):. 2016-11-17 [PMID: 27856637] (Bioassay, Human)	Bioassay	Human
Kin17 facilitates multiple double-strand break repair pathways that govern B cell class switching Sci Rep, 2016-11-17;6(0):37215. 2016-11-17 [PMID: 27853268] (Bioassay, Mouse)	Bioassay	Mouse
Takeshi Suzuki MEG3 long noncoding RNA contributes to the epigenetic regulation of epithelial-mesenchymal transition in lung cancer cell lines J. Biol. Chem., 2016-11-16;0(0):. 2016-11-16 [PMID: 27852821] (Bioassay, Human)	Bioassay	Human
Interleukin-22 ameliorates liver fibrosis through miR-200a/beta-catenin Sci Rep, 2016-11-07;6(0):36436. 2016-11-07 [PMID: 27819314] (Bioassay, Rat)	Bioassay	Rat
Karthikeyan Mythreye Altering the Proteoglycan State of Transforming Growth Factor ? Type III Receptor (T?RIII)/Betaglycan Modulates Canonical Wnt/?-Catenin Signaling J. Biol. Chem., 2016-10-26;291(49):25716-25728. 2016-10-26 [PMID: 27784788] (Bioassay, Human)	Bioassay	Human
M Gamboa Cas, SE Leggett, IY Wong Clustering and jamming in epithelial-mesenchymal co-cultures Soft Matter, 2016-10-12;12(40):8327-8337. 2016-10-12 [PMID: 27722738] (Bioassay, Human)	Bioassay	Human
Transient RUNX1 Expression during Early Mesendodermal Differentiation of�hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling Stem Cell Reports, 2016-10-06;7(5):884-896. 2016-10-06 [PMID: 27720906] (Bioassay, Human)	Bioassay	Human
Context-Specific Function of S6K2 in Th Cell Differentiation J Immunol, 2016-09-09;0(0):. 2016-09-09 [PMID: 27613697] (Bioassay, Mouse)	Bioassay	Mouse
EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis Physiol Rep, 2016-09-01;4(17):. 2016-09-01 [PMID: 27582065] (Bioassay, Human)	Bioassay	Human
24R,25-Dihydroxyvitamin D3 Protects against Articular Cartilage Damage following Anterior Cruciate Ligament Transection in Male Rats PLoS ONE, 2016-08-30;11(8):e0161782. 2016-08-30 [PMID: 27575371] (Bioassay, Rat)	Bioassay	Rat
Trichostatin A Inhibits Epithelial Mesenchymal Transition Induced by TGF-?1 in Airway Epithelium PLoS ONE, 2016-08-29;11(8):e0162058. 2016-08-29 [PMID: 27571418] (Bioassay, Human)	Bioassay	Human
Autonomous and Non-autonomous Defects Underlie Hypertrophic Cardiomyopathy in BRAF-Mutant hiPSC-Derived Cardiomyocytes Stem Cell Reports, 2016-08-25;0(0):. 2016-08-25 [PMID: 27569062] (ELISA (Standard), Human)	ELISA (Standard)	Human
Fscn1 is required for the trafficking of TGF-? family type I receptors during endoderm formation Nat Commun, 2016-08-22;7(0):12603. 2016-08-22 [PMID: 27545838] (Bioassay, Mouse)	Bioassay	Mouse
Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves EBioMedicine, 2016-07-01;10(0):282-90. 2016-07-01 [PMID: 27394642] (Bioassay, Human)	Bioassay	Human
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci Nat Commun, 2016-07-08;7(0):12092. 2016-07-08 [PMID: 27386823] (Bioassay, Human)	Bioassay	Human
Mohadeseh Mehrabian Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue PLoS ONE, 2016-06-21;11(6):e0156779. 2016-06-21 [PMID: 27327609] (Bioassay, Mouse)	Bioassay	Mouse
Martine Schrøder CD1c-Expression by Monocytes - Implications for the Use of Commercial CD1c+ Dendritic Cell Isolation Kits PLoS ONE, 2016-06-16;11(6):e0157387. 2016-06-16 [PMID: 27311059] (Bioassay, Human)	Bioassay	Human
Qisheng Li Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition Proc Natl Acad Sci USA, 2016-06-13;0(0):. 2016-06-13 [PMID: 27298373] (Bioassay, Human)	Bioassay	Human
Brian G Oliver A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro Thorax, 2016-06-10;71(11):1039-1049. 2016-06-10 [PMID: 27287090] (Bioassay, Human)	Bioassay	Human
Shoko Ohno Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure Sci Rep, 2016-06-07;6(0):27192. 2016-06-07 [PMID: 27273361] (Bioassay, Human)	Bioassay	Human
Tissue factor induced by epithelial-mesenchymal transition triggers a pro-coagulant state that drives metastasis of circulating tumor cells Cancer Res, 2016-05-24;0(0):. 2016-05-24 [PMID: 27221703] (Bioassay, Human)	Bioassay	Human
Cell-cell contact and matrix adhesion promote ?SMA expression during TGF?1-induced epithelial-myofibroblast transition via Notch and MRTF-A Sci Rep, 2016-05-19;6(0):26226. 2016-05-19 [PMID: 27194451] (Bioassay, Mouse)	Bioassay	Mouse
MAP3K19 Is a Novel Regulator of TGF-? Signaling That Impacts Bleomycin-Induced Lung Injury and Pulmonary Fibrosis PLoS ONE, 2016-05-04;11(5):e0154874. 2016-05-04 [PMID: 27144281] (Bioassay, Human)	Bioassay	Human
Transforming Growth Factor-? Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors Clin Cancer Res, 2016-04-28;0(0):. 2016-04-28 [PMID: 27126993] (Bioassay, Human)	Bioassay	Human
Schmidt A, Zhang X, Joshi R, Iqbal S, Wahlund C, Gabrielsson S, Harris R, Tegner J Human macrophages induce CD4(+)Foxp3(+) regulatory T cells via binding and re-release of TGF-beta. Immunol Cell Biol, 2016-05-10;94(8):747-62. 2016-05-10 [PMID: 27075967] (Bioassay, Human)	Bioassay	Human
R Flynn, K Paz, J Du, DK Reichenbac, PA Taylor, A Panoskalts, A Vulic, L Luznik, KK MacDonald, GR Hill, MS Nyuydzefe, JM Weiss, W Chen, A Trzeciak, JS Serody, EG Aguilar, WJ Murphy, I Maillard, D Munn, J Koreth, CS Cutler, JH Antin, J Ritz, SD Waksal, A Zanin-Zhor, BR Blazar Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism Blood, 2016-03-16;127(17):2144-54. 2016-03-16 [PMID: 26983850] (Bioassay, Human)	Bioassay	Human
Isabela Pedroza-Pa, Divya Shah, Anna Domogala, Martha Luevano, Michael Blundell, Nicola Jackson, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation. Scientific Reports, 2016-02-26;0(0):2045-2322. 2016-02-26 [PMID: 26915707] (Bioassay, Human)	Bioassay	Human
Schmidt A, Eriksson M, Shang M, Weyd H, Tegner J Comparative Analysis of Protocols to Induce Human CD4+Foxp3+ Regulatory T Cells by Combinations of IL-2, TGF-beta, Retinoic Acid, Rapamycin and Butyrate. PLoS ONE, 2016-02-17;11(2):e0148474. 2016-02-17 [PMID: 26886923] (Bioassay, Human)	Bioassay	Human
Lu G, Duan J, Shu S, Wang X, Gao L, Guo J, Zhang Y Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining. Proc Natl Acad Sci U S A, 2016-01-19;113(5):1256-60. 2016-01-19 [PMID: 26787905] (Bioassay, Mouse)	Bioassay	Mouse
Masani S, Han L, Meek K, Yu K Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination. Proc Natl Acad Sci U S A, 2016-01-19;113(5):1261-6. 2016-01-19 [PMID: 26787901] (Bioassay, Mouse)	Bioassay	Mouse
A Miyashita, S Fukushima, S Nakahara, Y Kubo, A Tokuzumi, J Yamashita, J Aoi, M Haruta, S Senju, Y Nishimura, M Jinnin, H Ihn Immunotherapy against Metastatic Melanoma with Human iPS Cell-Derived Myeloid Cell Lines Producing Type I Interferons Cancer Immunol Res, 2015-12-29;4(3):248-58. 2015-12-29 [PMID: 26714554] (Bioassay, Human)	Bioassay	Human
MH Fan, Q Zhu, HH Li, HJ Ra, S Majumdar, DL Gulick, JA Jerome, DH Madsen, M Christofid, DW Speicher, WW Bachovchin, C Feghali-Bo, E Puré Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice J. Biol. Chem., 2015-12-09;291(15):8070-89. 2015-12-09 [PMID: 26663085] (Bioassay, Mouse)	Bioassay	Mouse
Sasaki C, Chen G, Munk R, Eitan E, Martindale J, Longo D, Ghosh P p(70S6K1) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol, 2015-11-19;46(1):212-22. 2015-11-19 [PMID: 26514620] (Bioassay, Mouse)	Bioassay	Mouse
Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol, 2015-08-31;16(10):1077-84. 2015-08-31 [PMID: 26322481] (Bioassay, Mouse)	Bioassay	Mouse
Mehrabian M, Brethour D, Wang H, Xi Z, Rogaeva E, Schmitt-Ulms G The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 during Cellular Morphogenesis. PLoS ONE, 2015-08-19;10(8):e0133741. 2015-08-19 [PMID: 26288071] (Bioassay, Mouse)	Bioassay	Mouse
Roach K, Feghali-Bostwick C, Amrani Y, Bradding P Lipoxin A4 Attenuates Constitutive and TGF-beta1-Dependent Profibrotic Activity in Human Lung Myofibroblasts. J Immunol, 2015-08-14;195(6):2852-60. 2015-08-14 [PMID: 26276873] (Bioassay, Human)	Bioassay	Human
Lian M, Luo W, Sui Y, Li Z, Hua J Dietary n-3 PUFA Protects Mice from Con A Induced Liver Injury by Modulating Regulatory T Cells and PPAR-gamma Expression. PLoS ONE, 2015-07-15;10(7):e0132741. 2015-07-15 [PMID: 26177196] (Bioassay, Human)	Bioassay	Human
Sahu S, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M, Tiwari V JNK-dependent gene regulatory circuitry governs mesenchymal fate. EMBO J, 2015-07-08;34(16):2162-81. 2015-07-08 [PMID: 26157010] (Bioassay, Mouse)	Bioassay	Mouse
Fujita T, Chiwaki F, Takahashi R, Aoyagi K, Yanagihara K, Nishimura T, Tamaoki M, Komatsu M, Komatsuzaki R, Matsusaki K, Ichikawa H, Sakamoto H, Yamada Y, Fukagawa T, Katai H, Konno H, Ochiya T, Yoshida T, Sasaki H Identification and Characterization of CXCR4-Positive Gastric Cancer Stem Cells. PLoS ONE, 2015-06-25;10(6):e0130808. 2015-06-25 [PMID: 26110809] (Bioassay, Human)	Bioassay	Human
Singh I, Ozturk N, Cordero J, Mehta A, Hasan D, Cosentino C, Sebastian C, Kruger M, Looso M, Carraro G, Bellusci S, Seeger W, Braun T, Mostoslavsky R, Barreto G High mobility group protein-mediated transcription requires DNA damage marker gamma-H2AX. Cell Res, 2015-06-05;25(7):837-50. 2015-06-05 [PMID: 26045162] (Bioassay, Mouse)	Bioassay	Mouse
Pang M, Georgoudaki A, Lambut L, Johansson J, Tabor V, Hagikura K, Jin Y, Jansson M, Alexander J, Nelson C, Jakobsson L, Betsholtz C, Sund M, Karlsson M, Fuxe J TGF-beta1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis. Oncogene, 2015-05-11;35(6):748-60. 2015-05-11 [PMID: 25961925] (Bioassay, Mouse)	Bioassay	Mouse
Harris T, McGargill M Drak2 Does Not Regulate TGF-beta Signaling in T Cells. PLoS ONE, 2015-05-07;10(5):e0123650. 2015-05-07 [PMID: 25951457] (Bioassay, Mouse)	Bioassay	Mouse
Kuk H, Hutchenreuther J, Murphy-Marshman H, Carter D, Leask A 5Z-7-Oxozeanol Inhibits the Effects of TGFbeta1 on Human Gingival Fibroblasts. PLoS ONE, 2015-04-30;10(4):e0123689. 2015-04-30 [PMID: 25927238] (Bioassay, Human)	Bioassay	Human
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MiR-133 modulates TGF-β1-induced bladder smooth muscle cell hypertrophic and fibrotic response: implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction. Cell Signal, 2014-11-11;27(2):215-27. 2014-11-11 [PMID: 25451078] (Bioassay, Human, Rat)	Bioassay	Human, Rat
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Chen L, Munoz-Antonia T, Cress W Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines. PLoS ONE, 2014-07-01;9(7):e101040. 2014-07-01 [PMID: 24983967] (Bioassay, Human)	Bioassay	Human
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Matthews A, Husain S, Chaudhuri J Binding of AID to DNA does not correlate with mutator activity. J Immunol, 2014-05-30;193(1):252-7. 2014-05-30 [PMID: 24879790] (Bioassay, Mouse)	Bioassay	Mouse
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Yu Y, Yiang G, Chou P, Tseng H, Wu T, Hung Y, Lin P, Lin S, Liu H, Chang W, Wei C Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation. Mol Med Rep, 2014-03-28;9(6):2077-84. 2014-03-28 [PMID: 24682227] (Bioassay, Rat)	Bioassay	Rat
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Gurunathan S, Winkles J, Ghosh S, Hayden M Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem, 2014-03-20;289(19):12976-88. 2014-03-20 [PMID: 24652288]
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Xu S, Zhu J, Wu Z Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-beta and induce Tregs development via TGF-beta. PLoS ONE, 2014-03-17;9(3):e91709. 2014-03-17 [PMID: 24638085] (Bioassay, Human)	Bioassay	Human
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Overstreet J, Samarakoon R, Meldrum K, Higgins P Redox control of p53 in the transcriptional regulation of TGF-beta1 target genes through SMAD cooperativity. Cell Signal, 2014-03-05;26(7):1427-36. 2014-03-05 [PMID: 24613410] (Bioassay, Human)	Bioassay	Human
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Gao X, Cao Y, Staloch D, Gonzales M, Aronson J, Chao C, Hellmich M, Ko T Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS ONE, 2014-02-21;9(2):e89114. 2014-02-21 [PMID: 24586530] (Bioassay, Mouse)	Bioassay	Mouse
Mael-Ainin M, Abed A, Conway S, Dussaule J, Chatziantoniou C Inhibition of periostin expression protects against the development of renal inflammation and fibrosis. J Am Soc Nephrol, 2014-02-27;25(8):1724-36. 2014-02-27 [PMID: 24578131] (Bioassay, Human)	Bioassay	Human
Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells. Int J Oncol, 2014-02-21;44(5):1643-51. 2014-02-21 [PMID: 24573038] (Bioassay, Human)	Bioassay	Human
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Diepenbruck , Maren, Waldmeier , Lorenz, Ivanek , Robert, Berninger , Philipp, Arnold , Phil, van Nimwegen , Erik, Christofori , Gerhard Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. J Cell Sci, 2014-02-19;127(0):1523-36. 2014-02-19 [PMID: 24554433] (Bioassay, Mouse)	Bioassay	Mouse
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Oliveira W, Ribeiro L, Schrieffer A, Machado P, Carvalho E, Bacellar O The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine, 2014-01-30;66(2):127-32. 2014-01-30 [PMID: 24485388] (Bioassay, Human)	Bioassay	Human
Du , Lili, Yu , Yanqiu, Ma , Haiying, Lu , Xiaomei, Ma , Ling, Jin , Yunan, Zhang , Haipeng Hypoxia enhances protective effect of placental-derived mesenchymal stem cells on damaged intestinal epithelial cells by promoting secretion of insulin-like growth factor-1. Int J Mol Sci, 2014-01-27;15(2):1983-2002. 2014-01-27 [PMID: 24473145] (Bioassay, Human)	Bioassay	Human
Ratnayake M, Ploger F, Santibanez-Koref M, Loughlin J Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLoS ONE, 2014-01-21;9(1):e86590. 2014-01-21 [PMID: 24466161] (Bioassay, Human)	Bioassay	Human
Wang X, Gui L, Zhang Y, Zhang J, Shi J, Xu G Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-beta signaling pathway. Int J Oncol, 2014-01-21;44(4):1099-106. 2014-01-21 [PMID: 24452274] (Bioassay, Human)	Bioassay	Human
Miller M, Petty C, Tompkins M, Fogle J CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism. Virol J, 2014-01-18;11(0):7. 2014-01-18 [PMID: 24438223] (Bioassay, Feline)	Bioassay	Feline
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Axpe E, Lopez-Euba T, Castellanos-Rubio A, Merida D, Garcia J, Plaza-Izurieta L, Fernandez-Jimenez N, Plazaola F, Bilbao J Detection of atomic scale changes in the free volume void size of three-dimensional colorectal cancer cell culture using positron annihilation lifetime spectroscopy. PLoS ONE, 2014-01-02;9(1):e83838. 2014-01-02 [PMID: 24392097] (Bioassay, Human)	Bioassay	Human
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Leung L, Radulovich N, Zhu C, Wang D, To C, Ibrahimov E, Tsao M Loss of canonical Smad4 signaling promotes KRAS driven malignant transformation of human pancreatic duct epithelial cells and metastasis. PLoS ONE, 2013-12-27;8(12):e84366. 2013-12-27 [PMID: 24386371] (Bioassay, Human)	Bioassay	Human
Gong J, Cho I, Shin D, Han S, Park S, Kang Y Inhibition of airway epithelial-to-mesenchymal transition and fibrosis by kaempferol in endotoxin-induced epithelial cells and ovalbumin-sensitized mice. Lab Invest, 2013-12-30;94(3):297-308. 2013-12-30 [PMID: 24378645] (Stimulation, Human)	Stimulation	Human
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Tammaro A, Stroo I, Rampanelli E, Blank F, Butter L, Claessen N, Takai T, Colonna M, Leemans J, Florquin S, Dessing M Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy. PLoS ONE, 2013-12-16;8(12):e82498. 2013-12-16 [PMID: 24358193] (Bioassay, Mouse)	Bioassay	Mouse
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O'Connor J, Gomez E Cell adhesion and shape regulate TGF-beta1-induced epithelial-myofibroblast transition via MRTF-A signaling. PLoS ONE, 2013-12-10;8(12):e83188. 2013-12-10 [PMID: 24340092] (Bioassay, Mouse)	Bioassay	Mouse
Matsuhashi S, Hamajima H, Xia J, Zhang H, Mizuta T, Anzai K, Ozaki I Control of a tumor suppressor PDCD4: Degradation mechanisms of the protein in hepatocellular carcinoma cells. Cell Signal, 2013-12-12;26(3):603-10. 2013-12-12 [PMID: 24334270] (Bioassay, Human)	Bioassay	Human
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Karki S, Surolia R, Hock T, Guroji P, Zolak J, Duggal R, Ye T, Thannickal V, Antony V Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis. FASEB J, 2013-11-21;28(3):1122-31. 2013-11-21 [PMID: 24265486] (Bioassay, Human)	Bioassay	Human
Rojo J, Ojeda G, Acosta Y, Montes-Casado M, Criado G, Portoles P Characteristics of TCR/CD3 complex CD3{varepsilon} chains of regulatory CD4+ T (Treg) lymphocytes: role in Treg differentiation in vitro and impact on Treg in vivo. J Leukoc Biol, 2013-11-08;95(3):441-50. 2013-11-08 [PMID: 24212096] (Bioassay, Mouse)	Bioassay	Mouse
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Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis. Stem Cells Dev, 2013-12-04;23(5):541-54. 2013-12-04 [PMID: 24172175] (Bioassay, Human)	Bioassay	Human
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Wang X, Hu Y, Charpentier T, Lamarre A, Qi S, Wu J, Luo H TNF-like ligand 1A (TL1A) gene knockout leads to ameliorated collagen-induced arthritis in mice: implication of TL1A in humoral immune responses. J Immunol, 2013-10-18;191(11):5420-9. 2013-10-18 [PMID: 24140642] (Bioassay, Mouse)	Bioassay	Mouse
Sun H, Sun C, Xiao W Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations. Cytokine, 2013-10-15;65(1):33-41. 2013-10-15 [PMID: 24139237] (Bioassay, Human)	Bioassay	Human
Zheng J, Wu C, Lin Z, Guo Y, Shi L, Dong P, Lu Z, Gao S, Liao Y, Chen B, Yu F Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis. FEBS J, 2013-11-05;281(1):88-103. 2013-11-05 [PMID: 24138392] (Bioassay, Rat)	Bioassay	Rat
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Cheng J, Chang H, Leung P Transforming growth factor-beta1 inhibits trophoblast cell invasion by inducing Snail-mediated down-regulation of vascular endothelial-cadherin protein. J Biol Chem, 2013-10-08;288(46):33181-92. 2013-10-08 [PMID: 24106276] (Bioassay, Human)	Bioassay	Human
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Lin Y, Zhang B, Liang H, Lu Y, Ai X, Zhang B, Chen X JNK inhibitor SP600125 enhances TGF-beta-induced apoptosis of RBE human cholangiocarcinoma cells in a Smad-dependent manner. Mol Med Rep, 2013-10-02;8(6):1623-9. 2013-10-02 [PMID: 24100678] (Bioassay, Human)	Bioassay	Human
Xu Z, Zhang Q, Li H Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-beta1 and platelet-derived growth factor BB. Mol Med Rep, 2013-09-27;8(6):1715-21. 2013-09-27 [PMID: 24084832] (Bioassay, Human)	Bioassay	Human
Zhou Q, Hu Y, Howard O, Oppenheim J, Chen X In vitro generated Th17 cells support the expansion and phenotypic stability of CD4(+)Foxp3(+) regulatory T cells in vivo. Cytokine, 2013-09-27;65(1):56-64. 2013-09-27 [PMID: 24080164] (Bioassay, Mouse)	Bioassay	Mouse
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Hanieh H, Alzahrani A MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration. Eur J Immunol, 2013-10-01;43(10):2771-82. 2013-10-01 [PMID: 23780851] (Bioassay, Mouse)	Bioassay	Mouse
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Ammann J, Cooke A, Trowsdale J Butyrophilin Btn2a2 inhibits TCR activation and phosphatidylinositol 3-kinase/Akt pathway signaling and induces Foxp3 expression in T lymphocytes. J Immunol, 2013-04-15;190(10):5030-6. 2013-04-15 [PMID: 23589618] (Bioassay, Mouse)	Bioassay	Mouse
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Liu M, Wang H, Wang Z, Zhang Y, Chen Y, Zhu F, Zhang Y, Ma J, Li Z TGF-beta1 regulation of estrogen production in mature rat Leydig cells. PLoS ONE, 2013-03-29;8(3):e60197. 2013-03-29 [PMID: 23555924] (Bioassay, Rat)	Bioassay	Rat
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Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood, 2007-02-08;109(10):4272-9. 2007-02-08 [PMID: 17289812] (ELISA (Standard))	ELISA (Standard)
Zheng SG, Wang J, Wang P, Gray JD, Horwitz DA IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cells. J. Immunol., 2007-02-15;178(4):2018-27. 2007-02-15 [PMID: 17277105] (Bioassay, Mouse)	Bioassay	Mouse
Ungefroren H, Schniewind B, Groth S, Chen WB, Muerkoster SS, Kalthoff H, Fandrich F Antitumor activity of ALK1 in pancreatic carcinoma cells. Int. J. Cancer, 2007-04-15;120(8):1641-51. 2007-04-15 [PMID: 17230504] (Bioassay, Human)	Bioassay	Human
Ogawa K, Funaba M, Chen Y, Tsujimoto M Activin A functions as a Th2 cytokine in the promotion of the alternative activation of macrophages. J. Immunol., 2006-11-15;177(10):6787-94. 2006-11-15 [PMID: 17082592] (Bioassay, Mouse)	Bioassay	Mouse
Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex. Blood, 2006-11-02;109(5):2234-42. 2006-11-02 [PMID: 17082320] (Bioassay, Mouse)	Bioassay	Mouse
Andl CD, Fargnoli BB, Okawa T, Bowser M, Takaoka M, Nakagawa H, Klein-Szanto A, Hua X, Herlyn M, Rustgi AK Coordinated functions of E-cadherin and transforming growth factor beta receptor II in vitro and in vivo. Cancer Res., 2006-10-15;66(20):9878-85. 2006-10-15 [PMID: 17047049] (Bioassay, Human)	Bioassay	Human
Rose DM, Sydlaske AD, Agha-Babakhani A, Johnson K, Terkeltaub R Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils. Arthritis Rheum., 2006-10-01;54(10):3363-71. 2006-10-01 [PMID: 17009310] (Bioassay, Mouse)	Bioassay	Mouse
Mukhopadhyay A, Chan SY, Lim IJ, Phillips DJ, Phan TT The role of the activin system in keloid pathogenesis. Am. J. Physiol., Cell Physiol., 2006-09-13;292(4):C1331-8. 2006-09-13 [PMID: 16971493] (Bioassay, Human)	Bioassay	Human
Rosendahl AH, Forsberg G IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells. Kidney Int., 2006-09-13;70(9):1584-90. 2006-09-13 [PMID: 16969385] (Bioassay, Human)	Bioassay	Human
Letterio J, Rudikoff E, Voong N, Bauer SR Transforming growth factor-beta1 sensitivity is altered in Abl-Myc- and Raf-Myc-induced mouse pre-B-cell tumors. Stem Cells, 2006-08-31;24(12):2611-7. 2006-08-31 [PMID: 16945999] (Bioassay, Mouse)	Bioassay	Mouse
Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C Multipotent adult progenitor cells from swine bone marrow. Stem Cells, 2006-08-24;24(11):2355-66. 2006-08-24 [PMID: 16931778] (Bioassay, Porcine)	Bioassay	Porcine
Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am. J. Pathol., 2006-06-01;168(6):1879-88. 2006-06-01 [PMID: 16723703] (Bioassay, Human)	Bioassay	Human
Li Y, Fan J, Chen M, Li W, Woodley DT Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration. J. Invest. Dermatol., 2006-05-11;126(9):2096-105. 2006-05-11 [PMID: 16691197] (Bioassay, Human)	Bioassay	Human
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature, 2006-04-30;441(7090):235-8. 2006-04-30 [PMID: 16648838] (Bioassay, Mouse)	Bioassay	Mouse
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat)	Bioassay	Rat
Rhodes KE, Raivich G, Fawcett JW The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience, 2006-04-21;140(1):87-100. 2006-04-21 [PMID: 16631314] (In Vivo, Rat)	In Vivo	Rat
Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur. J. Immunol., 2006-05-01;36(5):1309-23. 2006-05-01 [PMID: 16619290] (Bioassay, Human)	Bioassay	Human
Nguyen AN, Stebbins EG, Henson M, O'Young G, Choi SJ, Quon D, Damm D, Reddy M, Ma JY, Haghnazari E, Kapoun AM, Medicherla S, Protter A, Schreiner GF, Kurihara N, Anderson J, Roodman GD, Navas TA, Higgins LS Normalizing the bone marrow microenvironment with p38 inhibitor reduces multiple myeloma cell proliferation and adhesion and suppresses osteoclast formation. Exp. Cell Res., 2006-04-04;312(10):1909-23. 2006-04-04 [PMID: 16600214] (Bioassay, Human)	Bioassay	Human
Neurohr C, Nishimura SL, Sheppard D Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am. J. Respir. Cell Mol. Biol., 2006-03-30;35(2):252-9. 2006-03-30 [PMID: 16574941] (Bioassay, Human)	Bioassay	Human
Létuvé S, Lajoie-Kadoch S, Audusseau S, Rothenberg ME, Fiset PO, Ludwig MS, Hamid Q IL-17E upregulates the expression of proinflammatory cytokines in lung fibroblasts. J. Allergy Clin. Immunol., 2006-02-08;117(3):590-6. 2006-02-08 [PMID: 16522458] (Bioassay, Human)	Bioassay	Human
Yue Z, Jiang TX, Widelitz RB, Chuong CM Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia. Proc. Natl. Acad. Sci. U.S.A., 2006-01-17;103(0):951-5. 2006-01-17 [PMID: 16418297] (In Vivo, Chicken)	In Vivo	Chicken
Puxeddu I, Bader R, Piliponsky AM, Reich R, Levi-Schaffer F, Berkman N The CC chemokine eotaxin/CCL11 has a selective profibrogenic effect on human lung fibroblasts. J. Allergy Clin. Immunol., 2005-12-02;117(1):103-10. 2005-12-02 [PMID: 16387592] (Bioassay, Human)	Bioassay	Human
Jung Y, Wang J, Schneider A, Sun YX, Koh-Paige AJ, Osman NI, McCauley LK, Taichman RS Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing. Bone, 2005-12-05;38(4):497-508. 2005-12-05 [PMID: 16337237] (Bioassay, Human)	Bioassay	Human
Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum., 2005-03-01;52(3):770-8. 2005-03-01 [PMID: 15751070] (Bioassay, Human)	Bioassay	Human
Pound JD, Batth BK, Johannessen I, Wood K Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma. J. Immunol., 2005-03-01;174(5):3015-23. 2005-03-01 [PMID: 15728515] (Bioassay, Human)	Bioassay	Human
Mesples B, Fontaine RH, Lelievre V, Launay JM, Gressens P Neuronal TGF-beta1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice. Neurobiol. Dis., 2005-02-01;18(1):193-205. 2005-02-01 [PMID: 15649710] (In Vivo, Mouse)	In Vivo	Mouse
Nagineni CN, Kutty V, Detrick B, Hooks JJ Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. J. Cell. Physiol., 2005-04-01;203(1):35-43. 2005-04-01 [PMID: 15368539] (Bioassay, Human)	Bioassay	Human
Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum., 2004-08-01;50(8):2521-30. 2004-08-01 [PMID: 15334466] (Bioassay, Human)	Bioassay	Human
Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R IL-22 increases the innate immunity of tissues. Immunity, 2004-08-01;21(2):241-54. 2004-08-01 [PMID: 15308104] (Bioassay, Human)	Bioassay	Human
Brenner N, Huning M, Stange R Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif. Tissue Int., 2004-04-01;74(4):388-97. 2004-04-01 [PMID: 15255077] (In Vivo, Rat)	In Vivo	Rat
Phillips TM Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis. Electrophoresis, 2004-06-01;25(10):1652-9. 2004-06-01 [PMID: 15188254]
Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats. Bone, 2004-05-01;34(5):862-8. 2004-05-01 [PMID: 15121018] (In Vivo, Rat)	In Vivo	Rat
Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am. J. Respir. Crit. Care Med., 2004-04-22;170(2):188-94. 2004-04-22 [PMID: 15105163] (Bioassay, Mink)	Bioassay	Mink
Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J. Immunol., 2004-05-01;172(9):5753-64. 2004-05-01 [PMID: 15100322] (Western Blot)	Western Blot
Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol., 2004-05-01;172(9):5213-21. 2004-05-01 [PMID: 15100259] (Bioassay, Human)	Bioassay	Human
Studer RK, Bergman R, Stubbs T, Decker K Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther., 2003-11-07;6(1):R56-R64. 2003-11-07 [PMID: 14979938] (Bioassay, Rabbit)	Bioassay	Rabbit
Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev. Biol., 2004-02-15;266(2):223-37. 2004-02-15 [PMID: 14738873] (Bioassay, Human)	Bioassay	Human
Chen , WanJun, Jin , Wenwen, Hardegen , Neil, Lei , Ke-Jian, Li , Li, Marinos , Nancy, McGrady , George, Wahl , Sharon M Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med, 2003-12-15;198(12):1875-86. 2003-12-15 [PMID: 14676299] (Bioassay, Mouse)	Bioassay	Mouse
Ashcroft GS, Mills SJ, Lei K, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J. Clin. Invest., 2003-05-01;111(9):1309-18. 2003-05-01 [PMID: 12727922] (In Vivo, Mouse)	In Vivo	Mouse
Khattri , Roli, Cox , Tom, Yasayko , Sue-Ann, Ramsdell , Fred An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol, 2003-03-03;4(4):337-42. 2003-03-03 [PMID: 12612581] (Bioassay, Mouse)	Bioassay	Mouse
Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Mouse)		Mouse
Scharstuhl A, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Ann. Rheum. Dis., 2002-12-01;61(12):1095-8. 2002-12-01 [PMID: 12429542] (In Vivo, Mouse)	In Vivo	Mouse
Huaux F, 107322, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms, 2002-09-01;169(5):2653-61. 2002-09-01 [PMID: 12193738] (Bioassay, Mouse)	Bioassay	Mouse
Zhao W, Kobayashi M, Ding W, Yuan L, Seth P, Cornain S, Wang J, Okada F, Hosokawa M Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II. Cancer Immunol. Immunother., 2002-06-25;51(7):381-8. 2002-06-25 [PMID: 12192538] (Bioassay, Rat)	Bioassay	Rat
Rosado E, 2019, Schwartz Z, Sylvia VL, Dean DD, Boyan BD Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. 91, 2002-06-12;1590(1):1-15. 2002-06-12 [PMID: 12063164] (Bioassay, Rat)	Bioassay	Rat
Schmidt A, 2019, Gopfert C, Vlodavsky I, Volker W, Buddecke E Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta. 101211, 2002-03-01;81(3):138-44. 2002-03-01 [PMID: 11998865] (Bioassay, Bovine)	Bioassay	Bovine
Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56. 2002-05-01 [PMID: 11943670] (ELISA (Standard))	ELISA (Standard)
Cashman J, Clark-Lewis I, Eaves A, Eaves C Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood, 2002-02-01;99(3):792-9. 2002-02-01 [PMID: 11806978] (Bioassay, Human)	Bioassay	Human
Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J. Immunol., 2000-05-15;164(10):5337-43. 2000-05-15 [PMID: 10799896] (ELISA (Standard))	ELISA (Standard)
Desfaits AC, 48971, Raymond J, Muizelaar JP Growth factors stimulate neointimal cells in vitro and increase the thickness of the neointima formed at the neck of porcine aneurysms treated by embolization. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions, 2000-02-01;31(0):498-507. 2000-02-01 [PMID: 10657429] (Bioassay, In Vivo, Canine, Porcine)	Bioassay, In Vivo	Canine, Porcine
Mozes MM, Hodics T, Kopp JB Isoform specificity of commercially-available anti-TGF-beta antibodies. J. Immunol. Methods, 1999-05-27;225(1):87-93. 1999-05-27 [PMID: 10365785] (Western Blot)	Western Blot
Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-09-01;58(17):4008-14. 1998-09-01 [PMID: 9731515] (Bioassay, Human)	Bioassay	Human
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