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Recombinant Human TGF-beta 1 Protein, CF

(828 Publications)

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Equivalent bioactivity of CHO-derived (Catalog # 240-B/CF) and HEK293-derived (7754-BH) Recombinant Human TGF‑ beta 1 as measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cell. (orange, green, respectively).

Equivalent bioactivity of CHO-derived (Catalog # 240-B/CF) and HEK293-derived (7754-BH) Recombinant Human TGF‑ beta 1 as measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cell. ...read more

Product Details

Summary

Reactivity	HuSpecies Glossary
Applications	Bioactivity
Format	Carrier-Free

Order Details

View Available Formulations

Catalog# & Formulation	Size	Price
Standard Formulation 240-B-002

Carrier Free 240-B-001MG/CF

Carrier Free 240-B-010/CF

Carrier Free 240-B-500/CF

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Recombinant Human TGF-beta 1 Protein, CF Summary

Details of Functionality	Measured by its ability to inhibit the IL-4-dependent proliferation of HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED₅₀ for this effect is 0.0400-0.200 ng/mL.
Source	Chinese Hamster Ovary cell line, CHO-derived human TGF-beta 1 protein Ala279-Ser390
Accession #	P01137.2
N-terminal Sequence	Ala279
Structure / Form	Disulfide-linked homodimer
Protein/Peptide Type	Recombinant Proteins
Gene	TGFB1
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note	<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions

Bioactivity

Theoretical MW

12.8 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

SDS-PAGE

12 kDa, reducing conditions
24 kDa, non-reducing conditions

Publications

Read Publications using
240-B/CF in the following applications:

Bioassay
727 publications
Cell Culture
51 publications
Differentiation
4 publications
ELISA (Standard)
7 publications
ELISA Capture
1 publication
ELISA Developmet
1 publication
ELISA Standard
2 publications
IHC-P
1 publication
In Vivo
17 publications
Stimulation
6 publications
Surface Plasmon Resonance (SPR
1 publication
Tissue Culture
1 publication
Western Blot
4 publications

Packaging, Storage & Formulations

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Purity	>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions	Reconstitute 2 µg vials at 20 µg/mL in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin. Reconstitute 10 µg or larger vials at 100 µg/mL in sterile 4 mM HCl.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TGF-beta 1 Protein, CF

CEDLAP
DPD1
latency-associated peptide
TGF beta
TGF beta1
TGFB
TGFB1
TGF-beta 1 protein
TGFbeta 1
TGF-beta 1
TGFbeta
TGF-beta-1
transforming growth factor beta-1
transforming growth factor, beta 1

Background

TGF-beta 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure (1‑7). TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition (1‑4). Each TGF-beta isoform has some non‑redundant functions; for TGF-beta 1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation, and die of overwhelming inflammation (2). Human TGF‑ beta 1 cDNA encodes a 390 amino acid (aa) precursor that contains a 29 aa signal peptide and a 361 aa proprotein (8). A furin‑like convertase processes the proprotein to generate an N‑terminal 249 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 1 (8, 9). Disulfide‑linked homodimers of LAP and TGF‑ beta 1 remain non‑covalently associated after secretion, forming the small latent TGF‑ beta 1 complex (8‑10). Covalent linkage of LAP to one of three latent TGF‑ beta binding proteins (LTBPs) creates a large latent complex that may interact with the extracellular matrix (9, 10). TGF‑ beta is activated from latency by pathways that include actions of the protease plasmin, matrix metalloproteases, thrombospondin 1 and a subset of integrins (10). Mature human TGF‑ beta 1 shares 100% aa identity with pig, dog and cow TGF‑ beta 1, and 99% aa identity with mouse, rat and horse TGF‑ beta 1. It demonstrates cross‑species activity (1). TGF‑ beta 1 signaling begins with high‑affinity binding to a type II ser/thr kinase receptor termed TGF‑ beta RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF‑ beta RI (also called activin receptor‑like kinase (ALK) ‑5), or alternatively, ALK‑1. This complex phosphorylates and activates Smad proteins that regulate transcription (3, 11, 12). Contributions of the accessory receptors betaglycan (also known as TGF‑ beta RIII) and endoglin, or use of Smad‑independent signaling pathways, allow for disparate actions observed in response to TGF‑ beta in different contexts (11).

Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29.
Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982.
Wahl, S.M. (2006) Immunol. Rev. 213:213.
Chang, H. et al. (2002) Endocr. Rev. 23:787.
Lin, J.S. et al. (2006) Reproduction 132:179.
Hinck, A.P. et al. (1996) Biochemistry 35:8517.
Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261.
Derynck, R. et al. (1985) Nature 316:701.
Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407.
Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601.
de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1.
Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.

Publications for TGF-beta 1 (240-B/CF)(828)

We have publications tested in 14 confirmed species: Human, Mouse, Rat, Bovine, Canine, Chicken, Equine, Feline, Fish, Mink, Porcine, Rabbit, Transgenic Mouse, Virus.

We have publications tested in 13 applications: Bioassay, Cell Culture, Differentiation, ELISA (Standard), ELISA Capture, ELISA Developmet, ELISA Standard, IHC-P, In Vivo, Stimulation, Surface Plasmon Resonance (SPR, Tissue Culture, Western Blot.

Showing Publications 1 - 10 of 828. Show All 828 Publications.

Publications using 240-B/CF	Applications	Species
Ma, HY;Li, Q;Wong, WR;N'Diaye, EN;Caplazi, P;Bender, H;Huang, Z;Arlantico, A;Jeet, S;Wong, A;Emson, C;Brightbill, H;Tam, L;Newman, R;Roose-Girma, M;Sandoval, W;Ding, N; LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung Science advances 2023-05-26 [PMID: 37235663] (Bioassay, Human)	Bioassay	Human
Min, K;Yenilmez, B;Kelly, M;Echeverria, D;Elleby, M;Lifshitz, LM;Raymond, N;Tsagkaraki, E;Harney, SM;DiMarzio, C;McHugh, N;Bramato, B;Morrision, B;Rothstein, JD;Khvorova, A;Czech, MP; Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis bioRxiv : the preprint server for biology 2023-05-03 [PMID: 37205462] (Bioassay, Human)	Bioassay	Human
O Anannya, W Huang, A August ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway bioRxiv : the preprint server for biology, 2023-04-03;0(0):. 2023-04-03 [PMID: 37066370] (Bioassay, Mouse)	Bioassay	Mouse
N Fakatava, H Mitarai, A Yuda, A Haraguchi, H Wada, D Hasegawa, H Maeda, N Wada Actin alpha 2, smooth muscle, a transforming growth factor-beta1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway Journal of dental sciences, 2023;18(2):567-576. 2023 [PMID: 37021273] (Cell Culture, Human)	Cell Culture	Human
N Fakatava, H Mitarai, A Yuda, A Haraguchi, H Wada, D Hasegawa, H Maeda, N Wada Actin alpha 2, smooth muscle, a transforming growth factor-beta1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway Journal of dental sciences, 2022-09-16;18(2):567-576. 2022-09-16 [PMID: 37021273] (Cell Culture, Human)	Cell Culture	Human
J Sidhaye, P Trepte, N Sepke, M Novatchkov, M Schutzbier, G Dürnberger, K Mechtler, JA Knoblich Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids Elife, 2023-03-29;12(0):. 2023-03-29 [PMID: 36989136] (Bioassay, Human)	Bioassay	Human
AM Refaat, M Nakata, A Husain, H Kosako, T Honjo, NA Begum HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression Cell Reports, 2023-03-20;42(3):112284. 2023-03-20 [PMID: 36943867] (Bioassay, Mouse)	Bioassay	Mouse
Z Wang, J Lauko, AW Kijas, EP Gilbert, P Turunen, R Yegappan, D Zou, J Mata, AE Rowan Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation Nature Communications, 2023-02-23;14(1):1029. 2023-02-23 [PMID: 36823141] (Bioassay, Human)	Bioassay	Human
S Matsuda, A Revandkar, TD Dubash, A Ravi, BS Wittner, M Lin, R Morris, R Burr, H Guo, K Seeger, A Szabolcs, D Che, L Nieman, GA Getz, DT Ting, MS Lawrence, J Gainor, DA Haber, S Maheswaran TGF-beta in the microenvironment induces a physiologically occurring immune-suppressive senescent state Cell Reports, 2023-02-22;42(3):112129. 2023-02-22 [PMID: 36821441] (Bioassay, Human)	Bioassay	Human
Y Horii, S Matsuda, C Toyota, T Morinaga, T Nakaya, S Tsuchiya, M Ohmuraya, T Hironaka, R Yoshiki, K Kasai, Y Yamauchi, N Takizawa, A Nagasaka, A Tanaka, H Kosako, M Nakaya VGLL3 is a mechanosensitive protein that promotes cardiac fibrosis through liquid-liquid phase separation Nature Communications, 2023-02-08;14(1):550. 2023-02-08 [PMID: 36754961] (Bioassay, Rat)	Bioassay	Rat
S Kang, R Yasuhara, R Tokumasu, T Funatsu, K Mishima Adipose-derived mesenchymal stem cells promote salivary duct regeneration via a paracrine effect Journal of oral biosciences, 2023-02-01;0(0):. 2023-02-01 [PMID: 36736698] (Bioassay, Human)	Bioassay	Human
B Zadran, PD Sudhindar, D Wainwright, Y Bury, S Luli, R Howarth, MV McCain, R Watson, H Huet, F Palinkas, RB Palmini, J Casement, DA Mann, F Oakley, J Lunec, H Reeves, GJ Faulkner, R Shukla Impact of retrotransposon protein L1 ORF1p expression on oncogenic pathways in hepatocellular carcinoma: the role of cytoplasmic PIN1 upregulation British Journal of Cancer, 2023-01-27;0(0):. 2023-01-27 [PMID: 36707636] (Bioassay, Human)	Bioassay	Human
S Wenhua, T Tsunematsu, M Umeda, H Tawara, N Fujiwara, Y Mouri, R Arakaki, N Ishimaru, Y Kudo Cancer cell-derived novel periostin isoform promotes invasion in head and neck squamous cell carcinoma Cancer Medicine, 2023-01-23;0(0):. 2023-01-23 [PMID: 36691359] (Bioassay, Human)	Bioassay	Human
T Hironaka, N Takizawa, Y Yamauchi, Y Horii, M Nakaya The well-developed actin cytoskeleton and Cthrc1 expression by actin-binding protein drebrin in myofibroblasts promote cardiac and hepatic fibrosis The Journal of Biological Chemistry, 2023-01-20;0(0):102934. 2023-01-20 [PMID: 36690273] (Human)		Human
SJ Coeyman, Y Zhang, CF Baicu, MR Zile, AD Bradshaw, WJ Richardson In vitro bioreactor for mechanical control and characterization of tissue constructs Journal of biomechanics, 2023-01-18;147(0):111458. 2023-01-18 [PMID: 36682211] (Bioassay, Mouse)	Bioassay	Mouse
Z Itah, S Chaudhry, S Raju Ponny, O Aydemir, A Lee, J Cavanagh-K, C Tournier, WJ Muller, RJ Davis HER2-driven breast cancer suppression by the JNK signaling pathway Proceedings of the National Academy of Sciences of the United States of America, 2023-01-19;120(4):e2218373120. 2023-01-19 [PMID: 36656864] (Bioassay, Human)	Bioassay	Human
Y Wang, X Liu, Q Xu, W Xu, X Zhou, Z Lin CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development JCI Insight, 2023-01-10;8(1):. 2023-01-10 [PMID: 36625347] (Bioassay, Human)	Bioassay	Human
R Wang, AB Bhatt, BA Minden-Bir, OK Travis, S Tiwari, H Jia, W Rosikiewic, O Martinot, E Childs, R Loesch, G Tossou, S Jamieson, D Finkelstei, B Xu, M Labelle ZBTB18 restricts chromatin accessibility and prevents transcriptional adaptations that drive metastasis Science Advances, 2023-01-06;9(1):eabq3951. 2023-01-06 [PMID: 36608120] (Bioassay, Human)	Bioassay	Human
R Guo, M Jiang, G Wang, B Li, X Jia, Y Ai, S Chen, P Tang, A Liu, Q Yuan, X Xie IL6 supports long-term expansion of hepatocytes in vitro Nature Communications, 2022-11-29;13(1):7345. 2022-11-29 [PMID: 36446858] (Bioassay, Mouse)	Bioassay	Mouse
R Varol, Z Karaveliog, S Omeroglu, G Aydemir, A Karadag, HE Meco, AA Demircali, A Yilmaz, GC Kocal, G Gencoglan, ME Oruc, GB Esmer, Y Basbinar, SK Ozdemir, H Uvet Acousto-holographic reconstruction of whole-cell stiffness maps Nature Communications, 2022-11-29;13(1):7351. 2022-11-29 [PMID: 36446776] (Bioassay, Human)	Bioassay	Human
SMT Rahman, M Aqdas, EW Martin, F Tomassoni, P Songkiatis, KS Oh, S Uderhardt, S Yun, QC Claybourne, RA McDevitt, V Greco, RN Germain, L Tessarollo, MH Sung Double knockin mice show NF-kappaB trajectories in immune signaling and aging Cell Reports, 2022-11-22;41(8):111682. 2022-11-22 [PMID: 36417863] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
Y Geng, L Li, J Yan, K Liu, A Yang, L Zhang, Y Shen, H Gao, X Wu, I Noth, Y Huang, J Liu, X Fan PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis Nature Communications, 2022-11-19;13(1):7114. 2022-11-19 [PMID: 36402779] (Bioassay, Human)	Bioassay	Human
L Mlakar, SM Garrett, T Watanabe, M Sanderson, T Nishimoto, J Heywood, KL Helke, JM Pilewski, EL Herzog, C Feghali-Bo Ameliorating Fibrosis in Murine and Human Tissues with END55, an Endostatin-Derived Fusion Protein Made in Plants Biomedicines, 2022-11-09;10(11):. 2022-11-09 [PMID: 36359382] (Cell Culture, Human)	Cell Culture	Human
S Xu, X Yang, Q Chen, Z Liu, Y Chen, X Yao, A Xiao, J Tian, L Xie, M Zhou, Z Hu, F Zhu, X Xu, F Hou, J Nie Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis EBioMedicine, 2022-11-04;86(0):104312. 2022-11-04 [PMID: 36335669] (Bioassay, Mouse, Rat)	Bioassay	Mouse, Rat
X Hu, Y Zou, DA Copland, LP Schewitz-B, Y Li, PJP Lait, M Stimpson, Z Zhang, S Guo, J Liang, T Chen, JJ Li, S Yuan, S Li, P Zhou, Y Liu, AD Dick, X Wen, RWJ Lee, L Wei Epigenetic drug screen identified IOX1 as an inhibitor of Th17-mediated inflammation through targeting TET2 EBioMedicine, 2022-11-03;86(0):104333. 2022-11-03 [PMID: 36335665] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
D Cai, SY Chen Nanoparticle endothelial delivery of PGC-1alpha attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling Redox Biology, 2022-10-28;58(0):102524. 2022-10-28 [PMID: 36334380] (Bioassay, Human)	Bioassay	Human
Q Ye, SJ Taleb, H Wang, NL Parinandi, DJ Kass, M Rojas, C Wang, Q Ma, J Zhao, Y Zhao Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis Biomolecules, 2022-10-21;12(10):. 2022-10-21 [PMID: 36291740] (Cell Culture, Human)	Cell Culture	Human
VR Herrera Mi, B Canciani, L Mangiavini, JFS Filipe, L Aidos, M Pallaoro, GM Peretti, P Pocar, SC Modina, A Di Giancam Endostatin in 3D Fibrin Hydrogel Scaffolds Promotes Chondrogenic Differentiation in Swine Neonatal Meniscal Cells Biomedicines, 2022-09-27;10(10):. 2022-09-27 [PMID: 36289678] (Bioassay, Porcine)	Bioassay	Porcine
SA Park, YJ Lim, WL Ku, D Zhang, K Cui, LY Tang, C Chia, P Zanvit, Z Chen, W Jin, D Wang, J Xu, O Liu, F Wang, A Cain, N Guo, H Nakatsukas, C Wu, YE Zhang, K Zhao, W Chen Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation Nature Communications, 2022-10-14;13(1):6069. 2022-10-14 [PMID: 36241625] (Bioassay, Human)	Bioassay	Human
A Filliol, Y Saito, A Nair, DH Dapito, LX Yu, A Ravichandr, S Bhattachar, S Affo, N Fujiwara, H Su, Q Sun, TM Savage, JR Wilson-Kan, JM Caviglia, L Chin, D Chen, X Wang, S Caruso, JK Kang, AD Amin, S Wallace, R Dobie, D Yin, OM Rodriguez-, C Yin, A Mehal, B Izar, RA Friedman, RG Wells, UB Pajvani, Y Hoshida, HE Remotti, N Arpaia, J Zucman-Ros, M Karin, NC Henderson, I Tabas, RF Schwabe Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis Nature, 2022-10-05;0(0):. 2022-10-05 [PMID: 36198802] (Bioassay, Human)	Bioassay	Human
K Santerre, S Cortez Ghi, S Proulx TGF-beta-Mediated Modulation of Cell-Cell Interactions in Postconfluent Maturing Corneal Endothelial Cells Investigative Ophthalmology & Visual Science, 2022-10-03;63(11):3. 2022-10-03 [PMID: 36194422] (Bioassay, Human)	Bioassay	Human
Z Shen, W Luo, B Tan, K Nie, M Deng, S Wu, M Xiao, X Wu, X Meng, T Tong, C Zhang, K Ma, Y Liao, J Xu, X Wang Roseburia intestinalis stimulates TLR5-dependent intestinal immunity against Crohn's disease EBioMedicine, 2022-09-28;85(0):104285. 2022-09-28 [PMID: 36182776] (Bioassay, Human)	Bioassay	Human
Watanabe M, Buth J, Haney J, Vishlaghi N, Turcios F, Elahi L, Gu W, Pearson C, Kurdian A, Baliaouri N, Collier A, Miranda O, Dunn N, Chen D, Sabri S, Torre-Ubieta L, Clark A, Plath K, Christofk H, Kornblum H, Gandal M, Novitch B TGFbeta superfamily signaling regulates the state of human stem cell pluripotency and capacity to create well-structured telencephalic organoids. Stem Cell Reports, 2022-09-29;17(10):2220-2238. 2022-09-29 [PMID: 36179695] (Bioassay, Human)	Bioassay	Human
X Li, W Li, Z Zhang, W Wang, H Huang SIRT6 overexpression retards renal interstitial fibrosis through targeting HIPK2 in chronic kidney disease Frontiers in Pharmacology, 2022-09-12;13(0):1007168. 2022-09-12 [PMID: 36172184] (Bioassay, Human)	Bioassay	Human
WE Jiao, S Xu, YL Qiao, YG Kong, L Sun, YQ Deng, R Yang, ZZ Tao, QQ Hua, SM Chen Notch2-dependent GATA3+ Treg cells alleviate allergic rhinitis by suppressing the Th2 cell response International immunopharmacology, 2022-09-22;112(0):109261. 2022-09-22 [PMID: 36155282] (Bioassay, Human)	Bioassay	Human
C Bengtson, N Silswal, N Baumlin, M Yoshida, J Dennis, S Yerrathota, M Kim, M Salathe The CFTR Amplifier Nesolicaftor Rescues TGF-beta1 Inhibition of Modulator-Corrected F508del CFTR Function International Journal of Molecular Sciences, 2022-09-19;23(18):. 2022-09-19 [PMID: 36142862] (Cell Culture, Human)	Cell Culture	Human
A Martisova, L Sommerova, A Krejci, I Selingerov, T Kolarova, F Zavadil Ko, M Holanek, J Podhorec, T Kazda, R Hrstka Identification of AGR2 Gene-Specific Expression Patterns Associated with Epithelial-Mesenchymal Transition International Journal of Molecular Sciences, 2022-09-16;23(18):. 2022-09-16 [PMID: 36142758] (Bioassay, Human)	Bioassay	Human
E Gómez-Marí, M Posavec-Ma, L Zarzuela, L Basurto-Ca, JA Guerrero-M, G Arribas, R Yerbes, M Ceballos-C, M Rodríguez-, M Tomé, RV Durán, M Buschbeck, JC Reyes The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFbeta and Hippo pathways Nucleic Acids Research, 2022-09-23;50(17):9838-9857. 2022-09-23 [PMID: 36124662] (Bioassay, Transgenic Mouse)	Bioassay	Transgenic Mouse
T Ohhata, M Suzuki, S Sakai, K Ota, H Yokota, C Uchida, H Niida, M Kitagawa CCIVR facilitates comprehensive identification of cis-natural antisense transcripts with their structural characteristics and expression profiles Scientific Reports, 2022-09-15;12(1):15525. 2022-09-15 [PMID: 36109624] (Cell Culture, Human)	Cell Culture	Human
HJ Lee Therapeutic Potential of the Combination of Pentoxifylline and Vitamin-E in Inflammatory Bowel Disease: Inhibition of Intestinal Fibrosis Journal of Clinical Medicine, 2022-08-12;11(16):. 2022-08-12 [PMID: 36012952] (Bioassay, Human)	Bioassay	Human
V Catalán, P Domench, J Gómez-Ambr, B Ramírez, S Becerril, A Mentxaka, A Rodríguez, V Valentí, R Moncada, J Baixauli, C Silva, J Escalada, G Frühbeck Dermatopontin Influences the Development of Obesity-Associated Colon Cancer by Changes in the Expression of Extracellular Matrix Proteins International Journal of Molecular Sciences, 2022-08-17;23(16):. 2022-08-17 [PMID: 36012487] (Stimulation, Human)	Stimulation	Human
AKO Rode, TB Buus, V Mraz, FAH Al-Jaberi, DV Lopez, SL Ford, S Hennen, IP Eliasen, IV Klewe, L Gharehdagh, A Dragan, MM Rosenkilde, A Woetmann, L Skov, N Ødum, CM Bonefeld, M Kongsbak-W, C Geisler Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 Receptor Cells, 2022-08-19;11(16):. 2022-08-19 [PMID: 36010663] (Stimulation, Human)	Stimulation	Human
K Kitsugi, H Noritake, M Matsumoto, T Hanaoka, M Umemura, M Yamashita, S Takatori, J Ito, K Ohta, T Chida, B Ulmasov, BA Neuschwand, T Suda, K Kawata Arg-Gly-Asp-binding integrins activate hepatic stellate cells via the hippo signaling pathway Cellular Signalling, 2022-08-12;99(0):110437. 2022-08-12 [PMID: 35970425] (Bioassay, Human)	Bioassay	Human
XQ Fang, M Lee, WJ Lim, S Lee, CH Lim, JH Lim PGC1alpha Cooperates with FOXA1 to Regulate Epithelial Mesenchymal Transition through the TCF4-TWIST1 International Journal of Molecular Sciences, 2022-07-26;23(15):. 2022-07-26 [PMID: 35897813] (Bioassay, Human)	Bioassay	Human
N Ju, H Hayashi, M Shimamura, S Baba, S Yoshida, R Morishita, H Rakugi, H Nakagami Prevention of bleomycin-induced pulmonary fibrosis by a RANKL peptide in mice Scientific Reports, 2022-07-21;12(1):12474. 2022-07-21 [PMID: 35864207] (Bioassay, Human)	Bioassay	Human
MC Mezger, C Conzelmann, T Weil, P von Maltit, DPJ Albers, J Münch, T Stamminger, EM Schilling Inhibitors of Activin Receptor-like Kinase 5 Interfere with SARS-CoV-2 S-Protein Processing and Spike-Mediated Cell Fusion via Attenuation of Furin Expression Viruses, 2022-06-15;14(6):. 2022-06-15 [PMID: 35746781] (Bioassay, Human)	Bioassay	Human
S Sawamura, K Makino, M Ide, S Shimada, I Kajihara, T Makino, M Jinnin, S Fukushima Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis International Journal of Molecular Sciences, 2022-06-18;23(12):. 2022-06-18 [PMID: 35743254] (Bioassay, Human)	Bioassay	Human
D Thumkeo, S Punyawatth, S Prasongtan, R Matsuura, K Arima, H Nie, R Yamamoto, N Aoyama, H Hamaguchi, S Sugahara, S Takeda, V Charoensaw, A Tanaka, S Sakaguchi, S Narumiya PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment Cell Reports, 2022-06-07;39(10):110914. 2022-06-07 [PMID: 35675777] (Bioassay, Mouse)	Bioassay	Mouse
DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells Cancers, 2022-05-19;14(10):. 2022-05-19 [PMID: 35626109] (Bioassay, Human)	Bioassay	Human
X Wang, H Ye, S Yang, X Sha, X Wang, T Zhang, R Chen, W Xiao, H Yang Disulfiram Exerts Antifibrotic and Anti-Inflammatory Therapeutic Effects on Perimysial Orbital Fibroblasts in Graves' Orbitopathy International Journal of Molecular Sciences, 2022-05-09;23(9):. 2022-05-09 [PMID: 35563653] (Bioassay, Human)	Bioassay	Human
GN Yin, DK Kim, JI Kang, Y Im, DS Lee, AR Han, J Ock, MJ Choi, MH Kwon, A Limanjaya, SB Jung, J Yang, KW Min, J Yun, Y Koh, JE Park, D Hwang, JK Suh, JK Ryu, HM Kim Latrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function Experimental & Molecular Medicine, 2022-05-13;0(0):. 2022-05-13 [PMID: 35562586] (Bioassay, Human)	Bioassay	Human
M Wang, S Lin, K Mequanint Electrospun Biodegradable alpha-Amino Acid-Substituted Poly(organophosphazene) Fiber Mats for Stem Cell Differentiation towards Vascular Smooth Muscle Cells Polymers, 2022-04-11;14(8):. 2022-04-11 [PMID: 35458303] (Cell Culture, Human)	Cell Culture	Human
P Arora, W Li, X Huang, W Yu, R Huang, Q Jiang, C Chen Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs International Journal of Molecular Sciences, 2022-04-06;23(7):. 2022-04-06 [PMID: 35409397] (Cell Culture, Human)	Cell Culture	Human
YC Chen, HJ Liao, YM Hsu, YS Shen, CH Chang Delivery of Mesenchymal Stem Cell in Dialdehyde Methylcellulose-Succinyl-Chitosan Hydrogel Promotes Chondrogenesis in a Porcine Model Polymers, 2022-04-05;14(7):. 2022-04-05 [PMID: 35406348] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
Y Liu, S Chen, L Yu, Y Deng, D Li, X Yu, D Chen, Y Lu, S Liu, R Chen Pemafibrate attenuates pulmonary fibrosis by inhibiting myofibroblast differentiation International immunopharmacology, 2022-04-06;108(0):108728. 2022-04-06 [PMID: 35397395] (Bioassay, Human)	Bioassay	Human
PM Van Hoose, L Yang, M Kraemer, M Ubele, AJ Morris, SS Smyth Lipid phosphate phosphatase 3 in smooth muscle cells regulates angiotensin II-induced abdominal aortic aneurysm formation Scientific Reports, 2022-04-05;12(1):5664. 2022-04-05 [PMID: 35383201] (Bioassay, Human)	Bioassay	Human
KE Ying, W Feng, WZ Ying, X Li, D Xing, Y Sun, Y Chen, PW Sanders Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4 Redox Biology, 2022-03-24;52(0):102296. 2022-03-24 [PMID: 35378363] (Cell Culture, Rat)	Cell Culture	Rat
KI Jeon, A Kumar, KT Wozniak, K Nehrke, KR Huxlin Defining the Role of Mitochondrial Fission in Corneal Myofibroblast Differentiation Investigative Ophthalmology & Visual Science, 2022-04-01;63(4):2. 2022-04-01 [PMID: 35377925] (Bioassay, Feline)	Bioassay	Feline
D Chen, H Tang, H Jiang, L Sun, W Zhao, F Qian ACPA Alleviates Bleomycin-Induced Pulmonary Fibrosis by Inhibiting TGF-beta-Smad2/3 Signaling-Mediated Lung Fibroblast Activation Frontiers in Pharmacology, 2022-03-09;13(0):835979. 2022-03-09 [PMID: 35355726] (Bioassay, Mouse)	Bioassay	Mouse
V Narayan, JS Barber-Rot, IY Jung, SF Lacey, AJ Rech, MM Davis, WT Hwang, P Lal, EL Carpenter, SL Maude, G Plesa, N Vapiwala, A Chew, M Moniak, RA Sebro, MD Farwell, A Marshall, J Gilmore, L Lledo, K Dengel, SE Church, TD Hether, J Xu, M Gohil, TH Buckingham, SS Yee, VE Gonzalez, I Kulikovska, F Chen, L Tian, K Tien, W Gladney, CL Nobles, HE Raymond, Prostate C, EO Hexner, DL Siegel, FD Bushman, CH June, JA Fraietta, NB Haas PSMA-targeting TGFbeta-insensitive armored CAR T?cells in metastatic castration-resistant prostate cancer: a phase 1 trial Nature Medicine, 2022-03-21;0(0):. 2022-03-21 [PMID: 35314843] (Stimulation, Human)	Stimulation	Human
S Ma, SA Patel, Y Abe, N Chen, PR Patel, BS Cho, N Abbasi, S Zeng, B Schnabl, JT Chang, WJM Huang RORgammat phosphorylation protects against Tï¿½cell-mediated inflammation Cell Reports, 2022-03-15;38(11):110520. 2022-03-15 [PMID: 35294872] (Cell Culture, Mouse)	Cell Culture	Mouse
C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun, Q Kuang, J Zhao, L Wang, J Liu, B Wang, M Xu Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling Redox Biology, 2022-02-24;51(0):102274. 2022-02-24 [PMID: 35240537] (Bioassay, Human)	Bioassay	Human
CJ Brereton, L Yao, ER Davies, Y Zhou, M Vukmirovic, JA Bell, S Wang, RA Ridley, LSN Dean, OG Andriotis, F Conforti, L Brewitz, S Mohammed, T Wallis, A Tavassoli, RM Ewing, A Alzetani, BG Marshall, SV Fletcher, PJ Thurner, A Fabre, N Kaminski, L Richeldi, A Bhaskar, CJ Schofield, M Loxham, DE Davies, Y Wang, MG Jones Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis Elife, 2022-02-21;11(0):. 2022-02-21 [PMID: 35188460] (Bioassay, Human)	Bioassay	Human
J Burk, A Sassmann, C Kasper, A Nimptsch, S Schubert Extracellular Matrix Synthesis and Remodeling by Mesenchymal Stromal Cells Is Context-Sensitive International Journal of Molecular Sciences, 2022-02-03;23(3):. 2022-02-03 [PMID: 35163683] (Stimulation, Human)	Stimulation	Human
M Archer, P Dasari, D Walsh, KL Britt, A Evdokiou, WV Ingman Immune Regulation of Mammary Fibroblasts and the Impact of Mammographic Density Journal of Clinical Medicine, 2022-02-02;11(3):. 2022-02-02 [PMID: 35160252] (Bioassay, Human)	Bioassay	Human
Q Yuan, Q Ren, L Li, H Tan, M Lu, Y Tian, L Huang, B Zhao, H Fu, FF Hou, L Zhou, Y Liu A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-beta signaling Nature Communications, 2022-01-21;13(1):438. 2022-01-21 [PMID: 35064106] (Bioassay, Rat)	Bioassay	Rat
YH Chen, RH Liu, YZ Cui, A Hettinghou, WY Fu, L Zhang, C Zhang, CJ Liu Penfluridol targets acid sphingomyelinase to inhibit TNF signaling and is therapeutic against inflammatory autoimmune diseases Arthritis Research & Therapy, 2022-01-19;24(1):27. 2022-01-19 [PMID: 35045889] (Bioassay, Mouse)	Bioassay	Mouse
YJ Park, DM Kim, HB Choi, MH Jeong, SH Kwon, HR Kim, JH Kwak, KH Chung Dendropanoxide, a Triterpenoid from Dendropanax morbifera, Ameliorates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells through Autophagy Inhibition Nutrients, 2021-12-27;14(1):. 2021-12-27 [PMID: 35010975] (Bioassay, Human)	Bioassay	Human
Q Ding, Q Wei, G Sheng, S Wang, S Jing, T Ma, R Zhang, T Wang, W Li, X Tang, H Wu, C Liu The Preventive Effect of Decorin on Epidural Fibrosis and Epidural Adhesions After Laminectomy Frontiers in Pharmacology, 2021-12-16;12(0):774316. 2021-12-16 [PMID: 34975478] (Bioassay, Human)	Bioassay	Human
J Li, B Xu, M He, X Zong, T Cunningham, C Sha, Y Fan, R Cross, JH Hanna, Y Feng Control of Foxp3 induction and maintenance by sequential histone acetylation and DNA demethylation Cell Reports, 2021-12-14;37(11):110124. 2021-12-14 [PMID: 34910919] (Bioassay, Mouse, Transgenic Mouse)	Bioassay	Mouse, Transgenic Mouse
W Cheng, HL Li, SY Xi, XF Zhang, Y Zhu, Le Xing, YX Mo, MM Li, FE Kong, WJ Zhu, XG Chen, HQ Cui, ZM Cao, YF Gong, YQ Tang, Y Zhang, XY Guan, NF Ma, M Liu Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma Nature Communications, 2021-12-08;12(1):7142. 2021-12-08 [PMID: 34880251] (Bioassay, Human)	Bioassay	Human
PM Munne, L Martikaine, I Räty, K Bertula, Nonappa, J Ruuska, H Ala-Hongis, A Peura, B Hollmann, L Euro, K Yavuz, L Patrikaine, M Salmela, J Pokki, M Kivento, J Väänänen, T Suomi, L Nevalaita, M Mutka, P Kovanen, M Leidenius, T Meretoja, K Hukkinen, O Monni, J Pouwels, B Sahu, J Mattson, H Joensuu, P Heikkilä, LL Elo, C Metcalfe, MR Junttila, O Ikkala, J Klefström Compressive stress-mediated p38 activation required for ERalpha?+?phenotype in breast cancer Nature Communications, 2021-11-29;12(1):6967. 2021-11-29 [PMID: 34845227] (Bioassay, Human)	Bioassay	Human
HM Shen, R Wuerffel, JF Cantillo, S Priyadarsh, X Lei, J Liang, YL Wu, AL Kenter Loop extrusion promotes an alternate pathway for isotype switching Cell Reports, 2021-11-23;37(8):110059. 2021-11-23 [PMID: 34818547] (Bioassay, Mouse)	Bioassay	Mouse
V Janbandhu, V Tallapraga, R Patrick, Y Li, D Abeygunawa, DT Humphreys, EMMA Martin, AO Ward, O Contreras, N Farbehi, E Yao, J Du, SL Dunwoodie, N Bursac, RP Harvey Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction Cell Stem Cell, 2021-11-10;0(0):. 2021-11-10 [PMID: 34762860] (Bioassay, Mouse)	Bioassay	Mouse
SA Saenz, A Local, T Carr, A Shakya, S Koul, H Hu, L Chourb, J Stedman, J Malley, LA D'Agostino, V Shanmugasu, J Malona, CE Schwartz, L Beebe, M Clements, G Rajaraman, J Cho, L Jiang, A Dubrovskiy, M Kreilein, R Shimanovic, LG Hamann, L Escoubet, JM Ellis Small molecule allosteric inhibitors of RORgammat block Th17-dependent inflammation and associated gene expression in vivo PLoS ONE, 2021-11-09;16(11):e0248034. 2021-11-09 [PMID: 34752458] (Bioassay, Human)	Bioassay	Human
P Prakhar, J Alvarez-De, H Keller, A Crossman, X Tai, YK Park, JH Park The small intestine epithelium exempts Foxp3+ Tregs from their IL-2 requirement for homeostasis and effector function JCI Insight, 2021-11-08;6(21):. 2021-11-08 [PMID: 34747370] (Bioassay, Mouse)	Bioassay	Mouse
MI Matias, CS Yong, A Foroushani, C Goldsmith, C Mongellaz, E Sezgin, KR Levental, A Talebi, J Perrault, A Rivière, J Dehairs, O Delos, J Bertand-Mi, JC Portais, M Wong, JC Marie, A Kelekar, S Kinet, VS Zimmermann, I Levental, L Yvan-Charv, JV Swinnen, SA Muljo, H Hernandez-, S Tardito, N Taylor, V Dardalhon Regulatory Tï¿½cell differentiation is controlled by alphaKG-induced alterations in mitochondrial metabolism and lipid homeostasis Cell Reports, 2021-11-02;37(5):109911. 2021-11-02 [PMID: 34731632] (Bioassay, Human)	Bioassay	Human
NM Wong, E Frias, FD Sigoillot, JH Letendre, M Hild, WW Wong Engineering digitizer circuits for chemical and genetic screens in human cells Nature Communications, 2021-10-22;12(1):6150. 2021-10-22 [PMID: 34686672] (Bioassay, Human)	Bioassay	Human
L Salvadori, S Chiappalup, I Arato, F Mancuso, M Calvitti, MC Marchetti, F Riuzzi, R Calafiore, G Luca, G Sorci Sertoli Cells Improve Myogenic Differentiation, Reduce Fibrogenic Markers, and Induce Utrophin Expression in Human DMD Myoblasts Biomolecules, 2021-10-12;11(10):. 2021-10-12 [PMID: 34680138] (Bioassay, Mouse)	Bioassay	Mouse
E Håland, IN Moen, E Veidal, H Hella, K Misund, TS Slørdahl, KK Starheim TAK1-inhibitors are cytotoxic for multiple myeloma cells alone and in combination with melphalan Oncotarget, 2021-10-12;12(21):2158-2168. 2021-10-12 [PMID: 34676048] (Cell Culture, Human)	Cell Culture	Human
M Bruschi, E La Porta, I Panfoli, G Candiano, A Petretto, E Vidal, X Kajana, M Bartolucci, S Granata, GM Ghiggeri, G Zaza, E Verrina Proteomic profile of mesothelial exosomes isolated from peritoneal dialysis effluent of children with focal segmental glomerulosclerosis Scientific Reports, 2021-10-21;11(1):20807. 2021-10-21 [PMID: 34675284] (Cell Culture, Human)	Cell Culture	Human
RE Carlisle, Z Mohammed-A, C Lu, T Yousof, V Tat, S Nademi, ME MacDonald, RC Austin, JG Dickhout TDAG51 induces renal interstitial fibrosis through modulation of TGF-beta receptor 1 in chronic kidney disease Cell Death & Disease, 2021-10-08;12(10):921. 2021-10-08 [PMID: 34625532] (Cell Culture, Human)	Cell Culture	Human
P Jiang, Y Zhang, B Ru, Y Yang, T Vu, R Paul, A Mirza, G Altan-Bonn, L Liu, E Ruppin, L Wakefield, KW Wucherpfen Systematic investigation of cytokine signaling activity at the tissue and single-cell levels Nature methods, 2021-09-30;18(10):1181-1191. 2021-09-30 [PMID: 34594031] (Bioassay, Human)	Bioassay	Human
MH Shihan, SG Novo, Y Wang, D Sheppard, A Atakilit, TD Arnold, NM Rossi, AP Faranda, MK Duncan alphaVbeta8 integrin targeting to prevent posterior capsular opacification (PCO) JCI Insight, 2021-11-08;0(0):. 2021-11-08 [PMID: 34554928] (In Vivo, Mouse)	In Vivo	Mouse
X Chi, W Jin, X Bai, X Zhao, J Shao, J Li, Q Sun, B Su, X Wang, XO Yang, C Dong RORalpha is critical for mTORC1 activity in Tï¿½cell-mediated colitis Cell Reports, 2021-09-14;36(11):109682. 2021-09-14 [PMID: 34525365] (Bioassay, Human)	Bioassay	Human
L Dai, Q Wang, X Lv, F Gao, Z Chen, Y Shen Elevated beta-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease Brain, Behavior, and Immunity, 2021-09-06;98(0):337-348. 2021-09-06 [PMID: 34500034] (Bioassay, Mouse)	Bioassay	Mouse
I Malenica, J Adam, S Corgnac, L Mezquita, E Auclin, I Damei, L Grynszpan, G Gros, V de Montpré, D Planchard, N Théret, B Besse, F Mami-Choua Integrin-alphaV-mediated activation of TGF-beta regulates anti-tumour CD8 T cell immunity and response to PD-1 blockade Nature Communications, 2021-09-01;12(1):5209. 2021-09-01 [PMID: 34471106] (Cell Culture, Human)	Cell Culture	Human
T Bluhmki, S Traub, AK Müller, S Bitzer, E Schruf, MT Bammert, M Leist, F Gantner, JP Garnett, R Heilker Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96?Transwell air-liquid interface model Scientific Reports, 2021-08-23;11(1):17028. 2021-08-23 [PMID: 34426605] (Bioassay, Human)	Bioassay	Human
AG Kunihiro, JA Brickey, JB Frye, JN Cheng, PB Luis, C Schneider, JL Funk Curcumin Inhibition of TGFbeta signaling in bone metastatic breast cancer cells and the possible role of oxidative metabolites The Journal of nutritional biochemistry, 2021-08-15;0(0):108842. 2021-08-15 [PMID: 34407450] (Bioassay, Human)	Bioassay	Human
J Lee, JA Choi, HH Ju, JE Kim, SY Paik, PV Rao Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells Scientific Reports, 2021-07-22;11(1):14950. 2021-07-22 [PMID: 34294770] (Bioassay, Human)	Bioassay	Human
T Katsuyama, VR Moulton Splicing factor SRSF1 is indispensable for regulatory Tï¿½cell homeostasis and function Cell Reports, 2021-07-06;36(1):109339. 2021-07-06 [PMID: 34233194] (Bioassay, Mouse)	Bioassay	Mouse
A Kumar-Sing, MM Parniewska, N Giotopoulo, J Javadi, W Sun, T Szatmári, K Dobra, A Hjerpe, J Fuxe Nuclear Syndecan-1 Regulates Epithelial-Mesenchymal Plasticity in Tumor Cells Biology, 2021-06-11;10(6):. 2021-06-11 [PMID: 34208075] (Bioassay, Human)	Bioassay	Human
L Zhang, J Chen, L Yan, Q He, H Xie, M Chen Resveratrol Ameliorates Cardiac Remodeling in a Murine Model of Heart Failure With Preserved Ejection Fraction Frontiers in Pharmacology, 2021-06-10;12(0):646240. 2021-06-10 [PMID: 34177571] (Bioassay, Mouse)	Bioassay	Mouse
L Sun, X Zhao, X Liu, B Zhong, H Tang, W Jin, H Clevers, H Wang, X Wang, C Dong Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription Cell Reports, 2021-06-01;35(9):109188. 2021-06-01 [PMID: 34077723] (Bioassay, Mouse)	Bioassay	Mouse
S Naik, AR Wood, M Ongenaert, P Saidiyan, ED Elstak, HL Lanz, J Stallen, R Janssen, E Smythe, KS Erdmann A 3D Renal Proximal Tubule on Chip Model Phenocopies Lowe Syndrome and Dent II Disease Tubulopathy International Journal of Molecular Sciences, 2021-05-19;22(10):. 2021-05-19 [PMID: 34069732] (Bioassay, Human)	Bioassay	Human
HJ Kang, KJ Lee, J Woo, J Kim, YK Kim, CH Lee, CG Yoo, KH Lee Cereblon contributes to the development of pulmonary fibrosis via inactivation of adenosine monophosphate-activated protein kinase &alpha1 Experimental & Molecular Medicine, 2021-05-17;0(0):. 2021-05-17 [PMID: 34002012] (Bioassay, Human)	Bioassay	Human
V Zyulina, KK Yan, B Ju, E Schwarzenb, C Passegger, C Tam-Amersd, Q Pan, T Sconocchia, C Pollack, B Shaner, A Zebisch, J Easton, J Yu, JM Silva, H Strobl The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-&beta signaling Cell Reports, 2021-04-27;35(4):109049. 2021-04-27 [PMID: 33910004] (Bioassay, Human)	Bioassay	Human
X Zhu, Y Du, D Li, J Xu, Q Wu, W He, K Zhang, J Zhu, L Guo, M Qi, A Liu, J Qi, G Wang, J Meng, Z Yang, K Zhang, Y Lu Aberrant TGF-&beta1 signaling activation by MAF underlies pathological lens growth in high myopia Nature Communications, 2021-04-08;12(1):2102. 2021-04-08 [PMID: 33833231] (Cell Culture, Human)	Cell Culture	Human
A Tellegen, M Beukers, I Rudnik-Jan, N van Klaver, KL How, N Woike, G Mihov, J Thies, E Teske, L Creemers, M Tryfonidou, B Meij Intra-Articular Slow-Release Triamcinolone Acetonide from Polyesteramide Microspheres as a Treatment for Osteoarthritis Pharmaceutics, 2021-03-11;13(3):. 2021-03-11 [PMID: 33799665] (Canine)		Canine
X Zhou, LJ Backman, P Danielson Activation of NF-&kapppaB signaling via cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA common deletion Scientific Reports, 2021-04-01;11(1):7360. 2021-04-01 [PMID: 33795727] (Bioassay, Human)	Bioassay	Human
Li Q, Ming Y, Jia H, Wang G Poricoic acid A suppresses TGF-beta1-induced renal fibrosis and proliferation via the PDGF-C, Smad3 and MAPK pathways. Exp Ther Med, 2021-01-27;21(4):289. 2021-01-27 [PMID: 33717232] (Bioassay, Rat)	Bioassay	Rat
J Calder, A Nagelberg, J Luu, D Lu, WW Lockwood Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4 Oncogenesis, 2021-03-12;10(3):27. 2021-03-12 [PMID: 33712563] (Bioassay, Human)	Bioassay	Human
MR Patel, AM Weaver Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-&beta signaling Cell Reports, 2021-03-09;34(10):108829. 2021-03-09 [PMID: 33691102] (Bioassay, Rat)	Bioassay	Rat
RB Bressan, B Southgate, KM Ferguson, C Blin, V Grant, N Alfazema, JC Wills, MA Marques-To, GM Morrison, J Ashmore, F Robertson, CAC Williams, L Bradley, A von Kriegs, RA Anderson, SR Tomlinson, SM Pollard Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants Cell Stem Cell, 2021-02-24;0(0):. 2021-02-24 [PMID: 33631116] (Bioassay, Human)	Bioassay	Human
D Wang, N Rabhi, SF Yet, SR Farmer, MD Layne Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A Scientific Reports, 2021-02-17;11(1):3948. 2021-02-17 [PMID: 33597582] (Bioassay, Mouse)	Bioassay	Mouse
Y Jiang, Y Dong, Y Luo, S Jiang, FL Meng, M Tan, J Li, Y Zang AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ Cell Reports, 2021-02-16;34(7):108713. 2021-02-16 [PMID: 33596428] (Bioassay, Mouse)	Bioassay	Mouse
C Türlü, N Willumsen, D Marando, P Schjerling, E Biskup, J Hannibal, LN Jorgensen, MS Ågren A Human Cellular Model for Colorectal Anastomotic Repair: The Effect of Localization and Transforming Growth Factor-&beta1 Treatment on Collagen Deposition and Biomarkers International Journal of Molecular Sciences, 2021-02-05;22(4):. 2021-02-05 [PMID: 33562728] (Bioassay, Human)	Bioassay	Human
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S Jadhav, S Tripathi, A Chandrekar, SS Waikar, LL Hsiao A novel antibody for the detection of alternatively spliced secreted KLOTHO isoform in human plasma PLoS ONE, 2021-01-22;16(1):e0245614. 2021-01-22 [PMID: 33481901] (ELISA Capture, Human)	ELISA Capture	Human
J Behary, N Amorim, XT Jiang, A Raposo, L Gong, E McGovern, R Ibrahim, F Chu, C Stephens, H Jebeili, V Fragomeli, YC Koay, M Jackson, J O'Sullivan, M Weltman, G McCaughan, E El-Omar, A Zekry Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma Nature Communications, 2021-01-08;12(1):187. 2021-01-08 [PMID: 33420074] (Bioassay, Human)	Bioassay	Human
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JA Guerrero-M, M Ceballos-C, F Koehler, S Peiró, JC Reyes TGF&beta promotes widespread enhancer chromatin opening and operates on genomic regulatory domains Nature Communications, 2020-12-03;11(1):6196. 2020-12-03 [PMID: 33273453] (Cell Culture, Human)	Cell Culture	Human
T Li, X Weng, S Cheng, D Wang, G Cheng, H Gao, Y Li Wnt3a upregulation is involved in TGF&beta1-induced cardiac hypertrophy Cytokine, 2020-11-23;0(0):155376. 2020-11-23 [PMID: 33243628] (Cell Culture, Rat)	Cell Culture	Rat
Y Koike, M Yozaki, A Utani, H Murota Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process Sci Rep, 2020-10-29;10(1):18545. 2020-10-29 [PMID: 33122782] (Cell Culture, Human)	Cell Culture	Human
S Li, M Liu, MH Do, C Chou, EG Stamatiade, BG Nixon, W Shi, X Zhang, P Li, S Gao, KJ Capistrano, H Xu, NV Cheung, MO Li Cancer immunotherapy via targeted TGF-&beta signalling blockade in TH cells Nature, 2020-10-21;0(0):. 2020-10-21 [PMID: 33087933] (Mouse)		Mouse
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F Chen, Q Gao, A Wei, X Chen, Y Shi, H Wang, W Cao Histone deacetylase 3 aberration inhibits Klotho transcription and promotes renal fibrosis Cell Death Differ, 2020-10-06;0(0):. 2020-10-06 [PMID: 33024274] (Bioassay, Human)	Bioassay	Human
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S Khazaei, N De Jay, S Deshmukh, LD Hendrikse, W Jawhar, CCL Chen, LG Mikael, D Faury, DM Marchione, J Lanoix, É Bonneil, T Ishii, SU Jain, K Rossokhata, TS Sihota, R Eveleigh, V Lisi, AS Harutyunya, S Jung, J Karamchand, BC Dickson, R Turcotte, JS Wunder, P Thibault, PW Lewis, BA Garcia, SC Mack, MD Taylor, L Garzia, CL Kleinman, N Jabado H3.3 G34W Promotes Growth and Impedes Differentiation of Osteoblast-Like Mesenchymal Progenitors in Giant Cell Tumor of Bone Cancer Discovery, 2020-09-23;10(12):1968-1987. 2020-09-23 [PMID: 32967858] (Bioassay, Human)	Bioassay	Human
MV Guijarro, LS Danielson, M Cañamero, A Nawab, C Abrahan, E Hernando, GD Palmer Tsc1 Regulates the Proliferation Capacity of Bone-Marrow Derived Mesenchymal Stem Cells Cells, 2020-09-10;9(9):. 2020-09-10 [PMID: 32927859] (Bioassay, Human)	Bioassay	Human
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L Berning, L Scharf, E Aplak, D Stucki, C von Montfo, AS Reichert, W Stahl, P Brenneisen In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis PLoS ONE, 2019-09-25;14(9):e0222267. 2019-09-25 [PMID: 31553748] (Bioassay, Human)	Bioassay	Human
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CL Hammond, E Roztocil, RP Phipps, SE Feldon, CF Woeller Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor PLoS ONE, 2019-09-19;14(9):e0222779. 2019-09-19 [PMID: 31536596] (Bioassay, Human)	Bioassay	Human
J Du, L Yan, R Torres, X Gong, H Bian, C Marugán, K Boehnke, C Baquero, YH Hui, SC Chapman, Y Yang, Y Zeng, SM Bogner, RT Foreman, A Capen, GP Donoho, RD Van Horn, DS Barnard, JA Dempsey, RP Beckmann, MS Marshall, LC Chio, Y Qian, YW Webster, A Aggarwal, S Chu, S Bhattachar, LF Stancato, MS Dowless, PW Iversen, JR Manro, JL Walgren, BW Halstead, MZ Dieter, R Martinez, SV Bhagwat, EL Kreklau, MJ Lallena, XS Ye, BKR Patel, C Reinhard, GD Plowman, DA Barda, JR Henry, SG Buchanan, RM Campbell Aurora A selective inhibitor LY3295668 leads to dominant mitotic arrest, apoptosis in cancer cells and shows potent preclinical antitumor efficacy Mol. Cancer Ther., 2019-09-17;0(0):. 2019-09-17 [PMID: 31530649] (Bioassay, Human)	Bioassay	Human
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YC Kim, KH Kim, S Lee, JW Jo, JY Park, MS Park, B Tsogbadrak, JP Lee, JW Lee, DK Kim, KH Oh, IJ Jang, YS Kim, RH Cha, SH Yang ST2 blockade mitigates peritoneal fibrosis induced by TGF-beta and high glucose J. Cell. Mol. Med., 2019-08-09;23(10):6872-6884. 2019-08-09 [PMID: 31397957] (Bioassay, Human)	Bioassay	Human
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DR Myers, E Norlin, Y Vercoulen, JP Roose Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells Cell Rep, 2019-05-07;27(6):1858-1874.e6. 2019-05-07 [PMID: 31067469] (Bioassay, Mouse)	Bioassay	Mouse
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HC Lien, YH Lee, YL Juang, YT Lu Fibrillin-1, a novel TGF-beta-induced factor, is preferentially expressed in metaplastic carcinoma with spindle sarcomatous metaplasia Pathology, 2019-04-19;0(0):. 2019-04-19 [PMID: 31010590] (Bioassay, Human)	Bioassay	Human
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JS Park, Y Oh, YJ Park, O Park, H Yang, S Slania, LK Hummers, AA Shah, HT An, J Jang, MR Horton, J Shin, HC Dietz, E Song, DH Na, EJ Park, K Kim, KC Lee, VV Roschke, J Hanes, MG Pomper, S Lee Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma Nat Commun, 2019-03-08;10(1):1128. 2019-03-08 [PMID: 30850660] (Bioassay, Human)	Bioassay	Human
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W Chen, MS Nyuydzefe, JM Weiss, J Zhang, SD Waksal, A Zanin-Zhor ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells Sci Rep, 2018-11-09;8(1):16636. 2018-11-09 [PMID: 30413785] (Bioassay, Human)	Bioassay	Human
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MR Conith, Y Hu, AJ Conith, MA Maginnis, JF Webb, RC Albertson Genetic and developmental origins of a unique foraging adaptation in a Lake Malawi cichlid genus Proc. Natl. Acad. Sci. U.S.A., 2018-06-18;0(0):. 2018-06-18 [PMID: 29915062] (In Vivo, Fish)	In Vivo	Fish
FC Bach, AR Tellegen, M Beukers, A Miranda-Be, M Teunissen, WAM de Jong, SAH de Vries, LB Creemers, K Benz, BP Meij, K Ito, MA Tryfonidou Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: from bench towards bedside Oncotarget, 2018-05-29;9(41):26507-26526. 2018-05-29 [PMID: 29899873] (Bioassay, Canine, Human)	Bioassay	Canine, Human
YW Liao, CC Yu, PL Hsieh, YC Chang miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2 J. Cell. Mol. Med., 2018-06-12;0(0):. 2018-06-12 [PMID: 29893466] (Bioassay, Human)	Bioassay	Human
A Kunita, S Morita, TU Irisa, A Goto, T Niki, D Takai, J Nakajima, M Fukayama MicroRNA-21 in cancer-associated fibroblasts supportsï¿½lung adenocarcinoma progression Sci Rep, 2018-06-11;8(1):8838. 2018-06-11 [PMID: 29892003] (Bioassay, Human)	Bioassay	Human
Z Qin, GJ Fisher, JJ Voorhees, T Quan Actin cytoskeleton assembly regulates collagen production via TGF-? type II receptor in human skin fibroblasts J. Cell. Mol. Med., 2018-06-11;0(0):. 2018-06-11 [PMID: 29888864] (Bioassay, Human)	Bioassay	Human
F Ghodrati, M Mehrabian, D Williams, O Halgas, MEC Bourkas, JC Watts, EF Pai, G Schmitt-Ul The prion protein is embedded in a molecular environment that modulates transforming growth factor ? and integrin signaling Sci Rep, 2018-06-05;8(1):8654. 2018-06-05 [PMID: 29872131] (Bioassay, Mouse)	Bioassay	Mouse
Z Al Shareef, H Kardooni, V Murillo-Ga, G Domenici, E Stylianaki, JH Steel, M Rabano, I Gorroño-Et, I Zabalza, M dM Vivanco, J Waxman, RM Kypta Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1 Oncogene, 2018-06-01;0(0):. 2018-06-01 [PMID: 29858602] (Bioassay, Human)	Bioassay	Human
S Tiwary, JE Morales, SC Kwiatkowsk, FF Lang, G Rao, JH McCarty Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a Sci Rep, 2018-05-29;8(1):8267. 2018-05-29 [PMID: 29844613] (Bioassay, Human)	Bioassay	Human
X Feng, Z Li, J Wei, Z Feng, W Wu, Y Zhao Injectable cartilaginous template transformed BMSCs into vascularized bone Sci Rep, 2018-05-29;8(1):8244. 2018-05-29 [PMID: 29844536] (Bioassay, Rabbit)	Bioassay	Rabbit
CF Hung, CL Wilson, YH Chow, LM Schnapp Role of integrin alpha8 in murine model of lung fibrosis PLoS ONE, 2018-05-29;13(5):e0197937. 2018-05-29 [PMID: 29813125] (Bioassay, Mouse)	Bioassay	Mouse
CB Cummins, X Wang, O Nunez Lope, G Graham, HY Tie, J Zhou, RS Radhakrish Luteolin-Mediated Inhibition of Hepatic Stellate Cell Activation via Suppression of the STAT3 Pathway Int J Mol Sci, 2018-05-24;19(6):. 2018-05-24 [PMID: 29795016] (Bioassay, Human)	Bioassay	Human
YH Chung, YH Huang, TH Chu, CL Chen, PR Lin, SC Huang, DC Wu, CC Huang, TH Hu, YH Kao, MH Tai BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-?1 signaling Lab. Invest., 2018-05-22;0(0):. 2018-05-22 [PMID: 29789683] (Bioassay, Rat)	Bioassay	Rat
S Lively, D Lam, R Wong, LC Schlichter Comparing Effects of Transforming Growth Factor ?1 on Microglia From Rat and Mouse: Transcriptional Profiles and Potassium Channels Front Cell Neurosci, 2018-05-03;12(0):115. 2018-05-03 [PMID: 29780305] (Bioassay, Rat)	Bioassay	Rat
K Schlereth, D Weichenhan, T Bauer, T Heumann, E Giannakour, D Lipka, S Jaeger, M Schlesner, P Aloy, R Eils, C Plass, HG Augustin The transcriptomic and epigenetic map of vascular quiescence in the continuous lung endothelium Elife, 2018-05-11;7(0):. 2018-05-11 [PMID: 29749927] (Bioassay, Human)	Bioassay	Human
L Huang, J Deng, W Xu, H Wang, L Shi, F Wu, D Wu, W Nei, M Zhao, P Mao, X Zhou CD8+ T cells with high TGF??1 expression cause lymph node fibrosis following HIV infection Mol Med Rep, 2018-05-03;0(0):. 2018-05-03 [PMID: 29749506] (Bioassay, Human)	Bioassay	Human
S Ottaviani, J Stebbing, AE Frampton, S Zagorac, J Krell, A de Giorgio, SM Trabulo, VTM Nguyen, L Magnani, H Feng, E Giovannett, N Funel, TM Gress, LR Jiao, Y Lombardo, NR Lemoine, C Heeschen, L Castellano TGF-? induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression Nat Commun, 2018-05-10;9(1):1845. 2018-05-10 [PMID: 29748571] (Bioassay, Human)	Bioassay	Human
CC Tsai, SB Wu, HC Kau, YH Wei Essential role of connective tissue growth factor (CTGF) in transforming growth factor-?1 (TGF-?1)-induced myofibroblast transdifferentiation from Graves' orbital fibroblasts Sci Rep, 2018-05-08;8(1):7276. 2018-05-08 [PMID: 29739987] (Bioassay, ELISA (Standard), Human)	Bioassay, ELISA (Standard)	Human
C Deng, YX Lin, XK Qi, GP He, Y Zhang, HJ Zhang, M Xu, QS Feng, JX Bei, YX Zeng, L Feng TNFRSF19 inhibits TGF? signaling through interaction with TGF? receptor type I to promote tumorigenesis Cancer Res., 2018-05-07;0(0):. 2018-05-07 [PMID: 29735548] (Bioassay, Human)	Bioassay	Human
LR Penke, JM Speth, VL Dommeti, ES White, IL Bergin, M Peters-Gol FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis J. Clin. Invest., 2018-05-07;0(0):. 2018-05-07 [PMID: 29733296] (Bioassay, Human)	Bioassay	Human
A Schmidt, F Marabita, NA Kiani, CC Gross, HJ Johansson, S Éliás, S Rautio, M Eriksson, SJ Fernandes, G Silberberg, U Ullah, U Bhatia, H Lähdesmäki, J Lehtiö, D Gomez-Cabr, H Wiendl, R Lahesmaa, J Tegnér Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3 BMC Biol., 2018-05-07;16(1):47. 2018-05-07 [PMID: 29730990] (Bioassay, Human)	Bioassay	Human
S Deshpande, M Abdollahi, M Wang, L Lanting, M Kato, R Natarajan Reduced Autophagy by a microRNA-mediated Signaling Cascade in Diabetes-induced Renal Glomerular Hypertrophy Sci Rep, 2018-05-03;8(1):6954. 2018-05-03 [PMID: 29725042] (Bioassay, Mouse)	Bioassay	Mouse
V Zaiatz-Bit, DK Finlay, CM Gardiner Canonical TGF-? Signaling Pathway Represses Human NK Cell Metabolism J. Immunol., 2018-05-02;0(0):. 2018-05-02 [PMID: 29720425] (Bioassay, Human)	Bioassay	Human
V Murillo-Ga, I Gorroño-Et, M Åkerfelt, MC Puustinen, L Sistonen, M Nees, J Carton, J Waxman, RM Kypta Frizzled-8 integrates Wnt-11 and transforming growth factor-? signaling in prostate cancer Nat Commun, 2018-05-01;9(1):1747. 2018-05-01 [PMID: 29717114] (Bioassay, Human)	Bioassay	Human
R Rekik, M Smiti Khan, T Larbi, I Zamali, A Beldi-Ferc, O Kammoun, S Marzouki, S Hamzaoui, S Mrad, MR Barbouche, MH Houman, M Ben Ahmed Impaired TGF-? signaling in patients with active systemic lupus erythematosus is associated with an overexpression of IL-22 Cytokine, 2018-04-21;108(0):182-189. 2018-04-21 [PMID: 29684755] (Bioassay, Human)	Bioassay	Human
F Liu, C Chu, Q Wei, J Shi, H Li, N Dong Metformin ameliorates TGF-Î²1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting Î²-catenin signaling Biochem. Biophys. Res. Commun., 2018-04-22;0(0):. 2018-04-22 [PMID: 29679571] (Bioassay, Human)	Bioassay	Human
M Wang, DQ Chen, L Chen, G Cao, H Zhao, D Liu, ND Vaziri, Y Guo, YY Zhao Novel inhibitors of the cellular RAS components, Poricoic acids, target Smad3 phosphorylation and Wnt/Î²-catenin pathway against renal fibrosis Br. J. Pharmacol., 2018-05-22;0(0):. 2018-05-22 [PMID: 29679507] (Cell Culture, Human)	Cell Culture	Human
L Knüppel, K Heinzelman, M Lindner, R Hatz, J Behr, O Eickelberg, CA Staab-Weij FK506-binding protein 10 (FKBP10) regulates lung fibroblast migration via collagen VI synthesis Respir. Res., 2018-04-19;19(1):67. 2018-04-19 [PMID: 29673351] (Bioassay, Human)	Bioassay	Human
P Mallikarju, RT Sitaram, M Landström, B Ljungberg VHL status regulates transforming growth factor-? signaling pathways in renal cell carcinoma Oncotarget, 2018-03-27;9(23):16297-16310. 2018-03-27 [PMID: 29662646] (Bioassay, Human)	Bioassay	Human
L Corsuto, S Rother, L Koehler, E Bedini, S Moeller, M Schnabelra, V Hintze, C Schiraldi, D Scharnwebe Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response Carbohydr Polym, 2018-03-01;191(0):53-64. 2018-03-01 [PMID: 29661321] (ELISA Standard, Human)	ELISA Standard	Human
D Wu, P Lu, X Mi, J Miao Exosomal miR-214 from endometrial stromal cells inhibits endometriosis fibrosis Mol. Hum. Reprod., 2018-07-01;0(0):. 2018-07-01 [PMID: 29660008] (Bioassay, Human)	Bioassay	Human
Y Nakayama, S Matsui, K Noda, M Yamazaki, Y Iwai, B Ganss, Y Ogata TGF?1-induced Amelotin gene expression is downregulated by Bax expression in mouse gingival epithelial cells J Oral Sci, 2018-04-16;0(0):. 2018-04-16 [PMID: 29657250] (Bioassay, Mouse)	Bioassay	Mouse
R Gupta, K Somyajit, T Narita, E Maskey, A Stanlie, M Kremer, D Typas, M Lammers, N Mailand, A Nussenzwei, J Lukas, C Choudhary DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity Cell, 2018-04-12;0(0):. 2018-04-12 [PMID: 29656893] (Bioassay, Mouse)	Bioassay	Mouse
Y Jiang, Y Liu, H Lu, SC Sun, W Jin, X Wang, C Dong Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28 Nat Commun, 2018-04-12;9(1):1424. 2018-04-12 [PMID: 29651155] (Bioassay, Mouse)	Bioassay	Mouse
E Groppa, S Brkic, A Uccelli, G Wirth, P Korpisalo-, M Filippova, B Dasen, V Sacchi, MG Muraro, M Trani, S Reginato, R Gianni-Bar, S Ylä-Herttu, A Banfi EphrinB2/EphB4 signaling regulates non-sprouting angiogenesis by VEGF EMBO Rep., 2018-04-11;0(0):. 2018-04-11 [PMID: 29643120] (Bioassay, Human)	Bioassay	Human
S Park, KM Yang, Y Park, E Hong, CP Hong, J Park, K Pang, J Lee, B Park, S Lee, H An, MK Kwak, J Kim, JM Kang, P Kim, Y Xiao, G Nie, A Ooshima, SJ Kim Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation J Cancer Prev, 2018-03-30;23(1):1-9. 2018-03-30 [PMID: 29629343] (Bioassay, Human)	Bioassay	Human
PD Leiphrakpa, MG Brattain, JD Black, JJ Wang TGF? and IGF1R signaling activate protein kinase A through differential regulation of ezrin phosphorylation in colon cancerï¿½cells J. Biol. Chem., 2018-03-29;0(0):. 2018-03-29 [PMID: 29599290] (Bioassay, Human)	Bioassay	Human
DJ Sharkey, DJ Glynn, JE Schjenken, KP Tremellen, SA Robertson Interferon-gamma inhibits seminal plasma induction of colony stimulating factor 2 in mouse and human reproductive tract epithelial cells Biol. Reprod., 2018-09-01;0(0):. 2018-09-01 [PMID: 29596569] (Bioassay, Human)	Bioassay	Human
S Nowsheen, K Aziz, A Aziz, M Deng, B Qin, K Luo, KB Jeganathan, H Zhang, T Liu, J Yu, Y Deng, J Yuan, W Ding, JM van Deurse, Z Lou L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage Nat. Cell Biol., 2018-03-26;20(4):455-464. 2018-03-26 [PMID: 29581593] (Bioassay, Mouse)	Bioassay	Mouse
L Geng, X Tang, K Zhou, D Wang, S Wang, G Yao, W Chen, X Gao, W Chen, S Shi, N Shen, X Feng, L Sun MicroRNA-663 induces immune dysregulation by inhibiting TGF-?1 production in bone marrow-derived mesenchymal stem cells in patients with systemic lupus erythematosus Cell. Mol. Immunol., 2018-01-01;0(0):. 2018-01-01 [PMID: 29578533] (Bioassay, Human)	Bioassay	Human
R Thome, AP Bonfanti, J Rasouli, ER Mari, GX Zhang, A Rostami, L Verinaud Chloroquine-treated dendritic cells require STAT1 signaling for their tolerogenic activity Eur. J. Immunol., 2018-04-17;0(0):. 2018-04-17 [PMID: 29572810] (Bioassay, Human)	Bioassay	Human
B Zhang, W Niu, HY Dong, ML Liu, Y Luo, ZC Li Hypoxia induces endothelial?mesenchymal transition in pulmonary vascular remodeling Int. J. Mol. Med., 2018-03-22;0(0):. 2018-03-22 [PMID: 29568878] (Bioassay, Rat)	Bioassay	Rat
H Fraser, N Safinia, N Grageda, S Thirkell, K Lowe, LJ Fry, C Scottá, A Hope, C Fisher, R Hilton, D Game, P Harden, A Bushell, K Wood, RI Lechler, G Lombardi A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials Mol Ther Methods Clin Dev, 2018-01-31;8(0):198-209. 2018-01-31 [PMID: 29552576] (Bioassay, Human)	Bioassay	Human
X Hu, H Kan, A Boye, Y Jiang, C Wu, Y Yang Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells Oncol Lett, 2018-02-02;15(4):4867-4872. 2018-02-02 [PMID: 29552126] (Bioassay, Human)	Bioassay	Human
N Zila, A Bileck, B Muqaku, L Janker, OM Eichhoff, PF Cheng, R Dummer, MP Levesque, C Gerner, V Paulitschk Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases Clin Proteomics, 2018-03-09;15(0):13. 2018-03-09 [PMID: 29541007] (Bioassay, Human)	Bioassay	Human
V Beaulieu L, O Roy, K Santerre, S Proulx TGF-?1 promotes cell barrier function upon maturation of corneal endothelial cells Sci Rep, 2018-03-13;8(1):4438. 2018-03-13 [PMID: 29535350] (Bioassay, Human)	Bioassay	Human
S Liu, J Iaria, RJ Simpson, HJ Zhu Ras enhances TGF-? signaling by decreasing cellular protein levels of its type II receptor negative regulator SPSB1 Cell Commun. Signal, 2018-03-13;16(1):10. 2018-03-13 [PMID: 29534718] (Bioassay, Canine)	Bioassay	Canine
R Yang, T Yu, D Liu, S Shi, Y Zhou Hydrogen sulfide promotes immunomodulation of gingiva-derived mesenchymal stem cells via the Fas/FasL coupling pathway Stem Cell Res Ther, 2018-03-09;9(1):62. 2018-03-09 [PMID: 29523215] (Bioassay, Mouse)	Bioassay	Mouse
H Sugiura, A Matsushita, M Futaya, A Teraoka, KI Akiyama, N Usui, N Nagano, K Nitta, K Tsuchiya Fibroblast growth factor 23 is upregulated in the kidney in a chronic kidney disease rat model PLoS ONE, 2018-03-08;13(3):e0191706. 2018-03-08 [PMID: 29518087] (Bioassay, Human)	Bioassay	Human
J Wang, A Faiz, Q Ge, CJ Vermeulen, J Van der Ve, KJ Snibson, R van de Vel, S Sawant, D Xenaki, B Oliver, W Timens, N Ten Hacken, M van den Be, A James, JG Elliot, L Dong, JK Burgess, AW Ashton Unique mechanisms of connective tissue growth factor regulation in airway smooth muscle in asthma: Relationship with airway remodelling J. Cell. Mol. Med., 2018-03-07;0(0):. 2018-03-07 [PMID: 29516637] (Bioassay, Human)	Bioassay	Human
P Bozatzi, KS Dingwell, KZ Wu, F Cooper, TD Cummins, LD Hutchinson, J Vogt, NT Wood, TJ Macartney, J Varghese, R Gourlay, DG Campbell, JC Smith, GP Sapkota PAWS1 controls Wnt signalling through association with casein kinase 1? EMBO Rep., 2018-03-07;0(0):. 2018-03-07 [PMID: 29514862] (Bioassay, Human)	Bioassay	Human
A Merdrignac, G Angenard, C Allain, K Petitjean, D Bergeat, P Bellaud, A Fautrel, B Turlin, B Clément, S Dooley, L Sulpice, K Boudjema, C Coulouarn A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma Hepatol Commun, 2018-01-30;2(3):254-269. 2018-01-30 [PMID: 29507901] (Bioassay, Human)	Bioassay	Human
K Kobayashi, T Yoshioka, J Miyauchi, A Nakazawa, N Kiyokawa, T Maihara, I Usami Role of monocyte chemoattractant protein-1 in liver fibrosis with transient myeloproliferative disorder in down syndrome Hepatol Commun, 2018-02-01;2(3):230-236. 2018-02-01 [PMID: 29507898] (Cell Culture, Human)	Cell Culture	Human
MM Pleumeeker, L Nimeskern, JLM Koevoet, M Karperien, KS Stok, GJVM van Osch Trophic effects of adipose-tissue-derived and bone-marrow-derived mesenchymal stem cells enhance cartilage generation by chondrocytes in co-culture PLoS ONE, 2018-02-28;13(2):e0190744. 2018-02-28 [PMID: 29489829] (Bioassay, Human)	Bioassay	Human
S Patalano, J Rodríguez-, C Colaneri, J Cotellessa, D Almanza, A Zhilin-Rot, T Riley, J Macoska CXCL12/CXCR4-Mediated Procollagen Secretion Is Coupled To Cullin-RING Ubiquitin Ligase Activation Sci Rep, 2018-02-22;8(1):3499. 2018-02-22 [PMID: 29472636] (Bioassay, Human)	Bioassay	Human
R Wang, T Fu, K You, S Li, N Zhao, J Yang, SM Zhuang Identification of a TGF-?-miR-195 positive feedback loop in hepatocytes and its deregulation in hepatoma cells FASEB J., 2018-02-20;0(0):fj201701199R. 2018-02-20 [PMID: 29465312] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
JM Dave, T Mirabella, SD Weatherbee, DM Greif Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain Dev. Cell, 2018-02-15;0(0):. 2018-02-15 [PMID: 29456135] (Bioassay, Human)	Bioassay	Human
A Löfdahl, C Wenglén, K Rydell-Tör, G Westergren, AK Larsson-Ca Effects of 5-HT2receptor antagonists on bronchoconstriction and pulmonary remodeling processes Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454752] (Bioassay, Human)	Bioassay	Human
L Gagnon, M Leduc, JF Thibodeau, MZ Zhang, B Grouix, F Sarra-Bour, W Gagnon, K Hince, M Tremblay, L Geerts, CRJ Kennedy, RL Hébert, A Gutsol, CE Holterman, E Kamto, L Gervais, J Ouboudinar, J Richard, A Felton, A Laverdure, JC Simard, S Létourneau, MP Cloutier, FA Leblond, SD Abbott, C Penney, JS Duceppe, B Zacharie, J Dupuis, A Calderone, QT Nguyen, RC Harris, P Laurin A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84 Am. J. Pathol., 2018-02-16;0(0):. 2018-02-16 [PMID: 29454750] (Cell Culture, Mouse)	Cell Culture	Mouse
M Desancé, R Contentin, L Bertoni, T Gomez-Ledu, T Branly, S Jacquet, JM Betsch, A Batho, F Legendre, F Audigié, P Galéra, M Demoor Chondrogenic Differentiation of Defined Equine Mesenchymal Stem Cells Derived from Umbilical Cord Blood for Use in Cartilage Repair Therapy Int J Mol Sci, 2018-02-10;19(2):. 2018-02-10 [PMID: 29439436] (Bioassay, Equine)	Bioassay	Equine
M Losa, M Risolino, B Li, J Hart, L Quintana, I Grishina, H Yang, IF Choi, P Lewicki, S Khan, R Aho, J Feenstra, CT Vincent, AMC Brown, E Ferretti, T Williams, L Selleri Face morphogenesis is promoted by Pbx-dependent EMT via regulation ofduring frontonasal prominence fusion Development, 2018-03-01;0(0):. 2018-03-01 [PMID: 29437830] (Bioassay, Mouse)	Bioassay	Mouse
VNS Garikipati, SP Singh, Y Mohanram, AK Gupta, D Kapoor, S Nityanand Isolation and characterization of mesenchymal stem cells from human fetus heart PLoS ONE, 2018-02-08;13(2):e0192244. 2018-02-08 [PMID: 29420637] (Bioassay, Human)	Bioassay	Human
F Wang, V Zachar, CP Pennisi, T Fink, Y Maeda, J Emmersen Hypoxia Enhances Differentiation of Adipose Tissue-Derived Stem Cells toward the Smooth Muscle Phenotype Int J Mol Sci, 2018-02-08;19(2):. 2018-02-08 [PMID: 29419805] (Bioassay, Human)	Bioassay	Human
M Imamura, JS Moon, KP Chung, K Nakahira, T Muthukumar, R Shingarev, SW Ryter, AM Choi, ME Choi RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase JCI Insight, 2018-02-08;3(3):. 2018-02-08 [PMID: 29415885] (Bioassay, Human)	Bioassay	Human
L Chen, J Li, Q Li, X Li, Y Gao, X Hua, B Zhou, J Li Overexpression of LncRNA AC067945.2 Down-Regulates Collagen Expression in Skin Fibroblasts and Possibly Correlates with the VEGF and Wnt Signalling Pathways Cell. Physiol. Biochem., 2018-02-01;45(2):761-771. 2018-02-01 [PMID: 29414824] (Bioassay, Human)	Bioassay	Human
H Tian, JJ Huang, C Golzio, X Gao, M Hector-Gre, N Katsanis, GC Blobe Endoglin interacts with VEGFR2 to promote angiogenesis FASEB J., 2018-01-11;0(0):fj201700867RR. 2018-01-11 [PMID: 29401587] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
T Rosengren, LJ Larsen, LB Pedersen, ST Christense, LB Møller TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms Cell. Mol. Life Sci., 2018-02-02;0(0):. 2018-02-02 [PMID: 29396625] (Bioassay, Mouse)	Bioassay	Mouse
R Zhang, Y Wu, F Xie, Y Zhong, Y Wang, M Xu, J Feng, J Charish, PP Monnier, X Qin RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke Cell Death Differ., 2018-02-02;0(0):. 2018-02-02 [PMID: 29396549] (Bioassay, Rat)	Bioassay	Rat
G Zhou, H Jiang, Z Yin, Y Liu, Q Zhang, C Zhang, B Pan, J Zhou, X Zhou, H Sun, D Li, A He, Z Zhang, W Zhang, W Liu, Y Cao In Vitro Regeneration of Patient-specific Ear-shaped Cartilage and Its First Clinical Application for Auricular Reconstruction EBioMedicine, 2018-01-13;28(0):287-302. 2018-01-13 [PMID: 29396297] (Bioassay, Human)	Bioassay	Human
O Kodet, B Dvo?ánková, B Bendlová, V Sýkorová, I Krajsová, J Štork, J Ku?era, P Szabo, H Strnad, M Kolá?, ? Vl?ek, K Smetana, L Lacina Microenvironment?driven resistance to B?Raf inhibition in a melanoma patient is accompanied by broad changes of gene methylation and expression in distal fibroblasts Int. J. Mol. Med., 2018-02-01;0(0):. 2018-02-01 [PMID: 29393387] (Bioassay, Human)	Bioassay	Human
L Jia, Y Tian, Y Chen, G Zhang The silencing of LncRNA-H19 decreases chemoresistance of human glioma cells to temozolomide by suppressing epithelial-mesenchymal transition via the Wnt/?-Catenin pathway Onco Targets Ther, 2018-01-11;11(0):313-321. 2018-01-11 [PMID: 29391808] (Bioassay, Human)	Bioassay	Human
J Nishida, K Miyazono, S Ehata Decreased TGFBR3/betaglycan expression enhances the metastatic abilities of renal cell carcinoma cells through TGF-?-dependent and -independent mechanisms Oncogene, 2018-02-02;0(0):. 2018-02-02 [PMID: 29391598] (Bioassay, Human)	Bioassay	Human
PS Bellaye, C Shimbori, T Yanagihara, DA Carlson, P Hughes, C Upagupta, S Sato, N Wheildon, T Haystead, K Ask, M Kolb Synergistic role of HSP90? and HSP90? to promote myofibroblast persistence in lung fibrosis Eur. Respir. J., 2018-01-31;51(2):. 2018-01-31 [PMID: 29386344] (Bioassay, Human)	Bioassay	Human
F Zhang, G Liu, D Li, C Wei, J Hao DDIT4 and Associated lncDDIT4 Modulate Th17 Differentiation through the DDIT4/TSC/mTOR Pathway J. Immunol., 2018-01-29;0(0):. 2018-01-29 [PMID: 29378913] (Bioassay, Human)	Bioassay	Human
T Yamakawa, H Ohigashi, D Hashimoto, E Hayase, S Takahashi, M Miyazaki, K Minomi, M Onozawa, Y Niitsu, T Teshima Vitamin A-coupled liposomes containing siRNA against HSP47 ameliorate skin fibrosis in chronic graft-versus-host disease Blood, 2018-01-23;0(0):. 2018-01-23 [PMID: 29363541] (Cell Culture, Mouse)	Cell Culture	Mouse
JT Chen, CY Wang, MH Chen Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts J. Formos. Med. Assoc., 2018-01-17;0(0):. 2018-01-17 [PMID: 29339038] (Bioassay, Human)	Bioassay	Human
L Lin, M Li, L Lin, X Xu, G Jiang, L Wu FPPS mediates TGF-?1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway Biochem. Biophys. Res. Commun., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337059] (Bioassay, Human)	Bioassay	Human
SJ Han, JK Jung, SS Im, SR Lee, BC Jang, KM Park, JI Kim Deficiency of primary cilia in kidney epithelial cells induces epithelial to mesenchymal transition Biochem. Biophys. Res. Commun., 2018-01-11;0(0):. 2018-01-11 [PMID: 29337054] (Bioassay, Canine)	Bioassay	Canine
J Zhu, Z Zhang, Y Zhang, W Li, W Zheng, J Yu, B Wang, L Chen, Q Zhuo, L Chen, J Zhang, J Liu MicroRNA-212 activates hepatic stellate cells and promotes liver fibrosis via targeting SMAD7 Biochem. Biophys. Res. Commun., 2018-01-04;0(0):. 2018-01-04 [PMID: 29307832] (Bioassay, Human)	Bioassay	Human
J Choi, DR Pease, S Chen, B Zhang, H Phee P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells Immunology, 2018-02-02;0(0):. 2018-02-02 [PMID: 29297928] (Bioassay, Mouse)	Bioassay	Mouse
JC Cheng, Y Yi, HM Chang, PCK Leung TGF-?1 up-regulates cadherin-11 expression through Snail: A potential mechanism for human trophoblast cell differentiation Cell. Signal., 2017-12-18;43(0):55-61. 2017-12-18 [PMID: 29269046] (Bioassay, Human)	Bioassay	Human
EM Reyes-Reye, I Aispuro, MA Tavera-Gar, M Field, S Moore, I Ramos, KS Ramos LINE-1 couples EMT programming with acquisition of oncogenic phenotypes in human bronchial epithelial cells Oncotarget, 2017-10-23;8(61):103828-103842. 2017-10-23 [PMID: 29262603] (Bioassay, Human)	Bioassay	Human
SD Hardy, A Shinde, WH Wang, MK Wendt, RL Geahlen Regulation of epithelial-mesenchymal transition and metastasis by TGF-?, P-bodies, and autophagy Oncotarget, 2017-10-17;8(61):103302-103314. 2017-10-17 [PMID: 29262563] (Bioassay, Mouse)	Bioassay	Mouse
H Hanieh, K Masuda, H Metwally, JP Chalise, M Mohamed, KK Nyati, DM Standley, S Li, M Higa, MM Zaman, T Kishimoto Arid5a stabilizes OX40 mRNA in murine CD4+ T cells by recognizing a stem-loop structure in its 3'UTR Eur. J. Immunol., 2018-02-05;0(0):. 2018-02-05 [PMID: 29244194] (Bioassay, Mouse)	Bioassay	Mouse
W Shin, Y Jeon, I Choi, YJ Kim V-set and Ig domain-containing 4 (VSIG4)-expressing hepatic F4/80+ cells regulate oral antigen-specific responses in mouse Eur. J. Immunol., 2018-01-18;0(0):. 2018-01-18 [PMID: 29235119] (Bioassay, Mouse)	Bioassay	Mouse
Shyam Kumar Gudey, Reshma Sundar, Carl-Henrik Heldin, Anders Bergh, Marene Landström Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGF? stimulation in cancer. Oncotarget, 2017-08-09;0(0):1949-2553. 2017-08-09 [PMID: 29228645] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming Cell Stem Cell, 2017-11-22;0(0):. 2017-11-22 [PMID: 29174331] (Bioassay, Human)	Bioassay	Human
Chris J C Johnston, Danielle J Smyth, Ravindra B Kodali, Madeleine P J White, Yvonne Harcus, Kara J Filbey, James P Hewitson, Cynthia S Hinck, Alasdair Ivens, Andrea M Kemter, Anna O Kildemoes, Thierry Le Bihan, Dinesh C Soares, Stephen M Anderton, Thomas Brenn, Stephen J Wigmore, Hannah V Woodcock, Rachel C Chambers, Andrew P Hinck, Henry J McSorley, Rick M Maizels A structurally distinct TGF-? mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 2017-11-23;0(0):2041-1723. 2017-11-23 [PMID: 29170498] (Bioassay, Mouse)	Bioassay	Mouse
SK Sahu, N Tiwari, A Pataskar, Y Zhuang, M Borisova, M Diken, S Strand, P Beli, VK Tiwari FBXO32 promotes microenvironment underlying epithelial-mesenchymal transition via CtBP1 during tumour metastasis and brain development Nat Commun, 2017-11-15;8(1):1523. 2017-11-15 [PMID: 29142217] (Bioassay, Human)	Bioassay	Human
F Yu, B Chen, X Fan, G Li, P Dong, J Zheng Epigenetically-Regulated MicroRNA-9-5p Suppresses the Activation of Hepatic Stellate Cells via TGFBR1 and TGFBR2 Cell. Physiol. Biochem., 2017-10-27;43(6):2242-2252. 2017-10-27 [PMID: 29073595] (Bioassay, Human)	Bioassay	Human
A Shibata, M Kuno, R Adachi, Y Sato, H Hattori, A Matsuda, Y Okuzono, K Igaki, Y Tominari, T Takagi, M Yabuki, M Okaniwa Discovery and pharmacological characterization of a new class of prolyl-tRNA synthetase inhibitor for anti-fibrosis therapy PLoS ONE, 2017-10-24;12(10):e0186587. 2017-10-24 [PMID: 29065190] (Bioassay, Human)	Bioassay	Human
S Saito, Y Zhuang, B Shan, S Danchuk, F Luo, M Korfei, A Guenther, JA Lasky Tubastatin ameliorates pulmonary fibrosis by targeting the TGF?-PI3K-Akt pathway PLoS ONE, 2017-10-18;12(10):e0186615. 2017-10-18 [PMID: 29045477] (Bioassay, Human)	Bioassay	Human
W Wang, P Li, W Li, J Jiang, Y Cui, S Li, Z Wang Osteopontin activates mesenchymal stem cells to repair skin wound PLoS ONE, 2017-09-28;12(9):e0185346. 2017-09-28 [PMID: 28957406] (Bioassay, Mouse)	Bioassay	Mouse
SZ Wu, SJ Yang, HM Chen, FF Peng, H Yu, JC Kreprinsky, BF Zhang Dual roles of parathyroid hormone-related protein in TGF-?1 signaling and fibronectin upregulation in mesangial cells Biosci. Rep., 2017-10-27;0(0):. 2017-10-27 [PMID: 28954822] (Bioassay, Rat)	Bioassay	Rat
M Sato-Matsu, T Matsubara, A Daikoku, Y Okina, L Longato, K Rombouts, LTT Thuy, J Adachi, T Tomonaga, K Ikeda, K Yoshizato, M Pinzani, N Kawada Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling J. Biol. Chem., 2017-09-15;0(0):. 2017-09-15 [PMID: 28916723] (Bioassay, Human)	Bioassay	Human
M Turcotte, D Allard, D Mittal, Y Bareche, L Buisseret, V Jose, S Pommey, V Delisle, S Loi, H Joensuu, PL Kellokumpu, C Sotiriou, MJ Smyth, J Stagg CD73 promotes resistance to HER2/ErbB2 antibody therapy Cancer Res., 2017-08-30;0(0):. 2017-08-30 [PMID: 28855210] (Bioassay, Human)	Bioassay	Human
Y Qi, N Wang, Y He, J Zhang, H Zou, W Zhang, W Gu, Y Huang, X Lian, J Hu, J Zhao, X Cui, L Pang, F Li Transforming growth factor-?1 signaling promotes epithelial-mesenchymal transition-like phenomena, cell motility, and cell invasion in synovial sarcoma cells PLoS ONE, 2017-08-22;12(8):e0182680. 2017-08-22 [PMID: 28829837] (Bioassay, Human)	Bioassay	Human
Ying Chen, Dan-Dan Wang, Ye-Ping Wu, Dan Su, Tian-Yi Zhou, Ren-Hua Gai, Ying-Ying Fu, Lin Zheng, Qiao-Jun He, Hong Zhu, Bo Yang MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. British Journal of Cancer, 2017-08-17;0(0):1532-1827. 2017-08-17 [PMID: 28817834] (Bioassay, Human)	Bioassay	Human
VC Rodríguez-, P Martínez-R, F Català-Mol, J Rodríguez-, A Garcia-Gom, G Poorani-Su, L Ciudad, H Hernando, A Pérez-Garc, C Company, JM Urquiza, AR Ramiro, JM Di Noia, A Vaquero, E Ballestar Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites Sci Rep, 2017-08-08;7(1):7594. 2017-08-08 [PMID: 28790320] (Bioassay, Mouse)	Bioassay	Mouse
P Åström, K Juurikka, ES Hadler-Ols, G Svineng, NK Cervigne, RD Coletta, J Risteli, JH Kauppila, S Skarp, S Kuttner, A Oteiza, M Sutinen, T Salo The interplay of matrix metalloproteinase-8, transforming growth factor-?1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma Br. J. Cancer, 2017-08-03;117(7):1007-1016. 2017-08-03 [PMID: 28772283] (Bioassay, Human)	Bioassay	Human
S Lee, D Kim, J Kang, E Kim, W Kim, H Youn, B Youn Surfactant Protein B Suppresses Lung Cancer Progression by Inhibiting Secretory Phospholipase A2 Activity and Arachidonic Acid Production Cell. Physiol. Biochem., 2017-07-25;42(4):1684-1700. 2017-07-25 [PMID: 28743125] (Bioassay, Human)	Bioassay	Human
M Renard, L Muiño-Mosq, EC Manalo, S Tufa, EJ Carlson, DR Keene, J De Backer, LY Sakai Sex, pregnancy and aortic disease in Marfan syndrome PLoS ONE, 2017-07-14;12(7):e0181166. 2017-07-14 [PMID: 28708846] (Bioassay, Human)	Bioassay	Human
H Kamata, Y Tsukasaki, T Sakai, R Ikebe, J Wang, A Jeffers, J Boren, S Owens, T Suzuki, M Higashihar, S Idell, TA Tucker, M Ikebe KIF5A transports collagen vesicles of myofibroblasts during pleural fibrosis Sci Rep, 2017-07-04;7(1):4556. 2017-07-04 [PMID: 28676645] (Bioassay, Human)	Bioassay	Human
JC Cheng, CP Tseng, MH Liao, CY Peng, JS Yu, PH Chuang, JT Huang, JJW Chen Activation of hepatic stellate cells by the ubiquitin C-terminal hydrolase 1 protein secreted from hepatitis C virus-infected hepatocytes Sci Rep, 2017-06-30;7(1):4448. 2017-06-30 [PMID: 28667290] (Bioassay, Human)	Bioassay	Human
C Caër, C Rouault, T Le Roy, C Poitou, J Aron-Wisne, A Torcivia, JC Bichet, K Clément, M Guerre-Mil, S André Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue Sci Rep, 2017-06-07;7(1):3000. 2017-06-07 [PMID: 28592801] (Bioassay, Human)	Bioassay	Human
JB Koo, MO Nam, Y Jung, J Yoo, DH Kim, G Kim, SJ Shin, KM Lee, KB Hahm, JW Kim, SP Hong, KJ Lee, JH Yoo Anti-fibrogenic effect of PPAR-? agonists in human intestinal myofibroblasts BMC Gastroenterol, 2017-06-07;17(1):73. 2017-06-07 [PMID: 28592228] (Bioassay, Human)	Bioassay	Human
TP Nguyen, SF Sieg TGF-? inhibits IL-7-induced proliferation in memory but not naive human CD4(+) T cells J. Leukoc. Biol., 2017-06-06;0(0):. 2017-06-06 [PMID: 28588029] (Bioassay, Human)	Bioassay	Human
L Bai, HM Chang, JC Cheng, C Klausen, G Chu, PCK Leung, G Yang SMAD1/5 mediates bone morphogenetic protein 2-induced up-regulation of BAMBI expression in human granulosa-lutein cells Cell. Signal., 2017-05-31;37(0):52-61. 2017-05-31 [PMID: 28578012] (Bioassay, Human)	Bioassay	Human
S Khakipoor, C Ophoven, M Schrödl-Hä, M Feuerstein, B Heimrich, JW Deitmer, E Roussa TGF-? signaling directly regulates transcription and functional expression of the electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), via Smad4 in mouse astrocytes Glia, 2017-06-01;0(0):. 2017-06-01 [PMID: 28568893] (Bioassay, Mouse)	Bioassay	Mouse
EJ Kim, SG Seo, HS Shin, DJ Lee, JH Kim, DY Lee Platelet-Derived Growth Factor Receptor-Positive Pericytic Cells of White Adipose Tissue from Critical Limb Ischemia Patients Display Mesenchymal Stem Cell-Like Properties Clin Orthop Surg, 2017-05-08;9(2):239-248. 2017-05-08 [PMID: 28567229] (Bioassay, Human)	Bioassay	Human
Q Zhao, SN Harbour, R Kolde, IJ Latorre, HM Tun, TR Schoeb, H Turner, JJ Moon, E Khafipour, RJ Xavier, CT Weaver, CO Elson Selective Induction of Homeostatic Th17 Cells in the Murine Intestine by Cholera Toxin Interacting with the Microbiota J. Immunol., 2017-05-24;0(0):. 2017-05-24 [PMID: 28539431] (Bioassay, Mouse)	Bioassay	Mouse
J Geng, S Yu, H Zhao, X Sun, X Li, P Wang, X Xiong, L Hong, C Xie, J Gao, Y Shi, J Peng, RL Johnson, N Xiao, L Lu, J Han, D Zhou, L Chen The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells Nat. Immunol., 2017-05-15;0(0):. 2017-05-15 [PMID: 28504697] (Bioassay, Human)	Bioassay	Human
N Salvarani, A Maguy, SA De Simone, M Miragoli, F Jousset, S Rohr TGF-?1 (Transforming Growth Factor-?1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity Circ Arrhythm Electrophysiol, 2017-05-01;10(5):e004567. 2017-05-01 [PMID: 28500173] (Bioassay, Rat)	Bioassay	Rat
J Ko, MK Chae, JH Lee, EJ Lee, JS Yoon Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy Invest. Ophthalmol. Vis. Sci., 2017-05-01;58(5):2544-2553. 2017-05-01 [PMID: 28492873] (Bioassay, Human)	Bioassay	Human
L Calvier, P Chouvarine, E Legchenko, N Hoffmann, J Geldner, P Borchert, D Jonigk, MM Mozes, G Hansmann PPAR? Links BMP2 and TGF?1 Pathways in Vascular Smooth Muscle Cells, Regulating Cell Proliferation and Glucose Metabolism Cell Metab., 2017-05-02;25(5):1118-1134.e7. 2017-05-02 [PMID: 28467929] (Bioassay, Human)	Bioassay	Human
R Singh, T Miao, ALJ Symonds, B Omodho, S Li, P Wang Egr2 and 3 Inhibit T-bet-Mediated IFN-? Production in T Cells J. Immunol., 2017-04-28;0(0):. 2017-04-28 [PMID: 28455436] (Bioassay, Mouse)	Bioassay	Mouse
ZM Zhao, HL Liu, X Sun, T Guo, L Shen, YY Tao, CH Liu Levistilide A inhibits angiogenesis in liver fibrosis via vascular endothelial growth factor signaling pathway Exp. Biol. Med. (Maywood), 2017-03-22;242(9):974-985. 2017-03-22 [PMID: 28440736] (Bioassay, Human)	Bioassay	Human
Y Zhang Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling Biochem. Biophys. Res. Commun., 2017-04-17;0(0):. 2017-04-17 [PMID: 28427938] (Bioassay, Human)	Bioassay	Human
A Shiokawa, R Kotaki, T Takano, H Nakajima-A, S Hachimura Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cells highly induce regulatory T cells Immunology, 2017-06-01;0(0):. 2017-06-01 [PMID: 28423181] (Bioassay, Mouse)	Bioassay	Mouse
JJ Kathiriya, N Nakra, J Nixon, PS Patel, V Vaghasiya, A Alhassani, Z Tian, D Allen-Gips, V Davé Galectin-1 inhibition attenuates profibrotic signaling in hypoxia-induced pulmonary fibrosis Cell Death Discov, 2017-04-10;3(0):17010. 2017-04-10 [PMID: 28417017] (Bioassay, Human)	Bioassay	Human
KA Whelan, PM Chandramou, K Tanaka, M Natsuizaka, M Guha, S Srinivasan, DS Darling, Y Kita, S Natsugoe, JD Winkler, AJ Klein-Szan, RK Amaravadi, NG Avadhani, AK Rustgi, H Nakagawa Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance Oncogene, 2017-04-17;0(0):. 2017-04-17 [PMID: 28414310] (Bioassay, Human)	Bioassay	Human
D Zhou, L Zhang, W Sun, W Guan, Q Lin, W Ren, J Zhang, G Xu Cytidine monophosphate kinase is inhibited by the TGF-? signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer Cell. Signal., 2017-04-14;0(0):. 2017-04-14 [PMID: 28414100] (Bioassay, Human)	Bioassay	Human
Y Dimitrova, AJ Gruber, N Mittal, S Ghosh, B Dimitriade, D Mathow, WA Grandy, G Christofor, M Zavolan TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition Biol. Direct, 2017-04-17;12(1):8. 2017-04-17 [PMID: 28412966] (Bioassay, Mouse)	Bioassay	Mouse
S Ghatak, VC Hascall, RR Markwald, C Feghali-Bo, CM Artlett, M Gooz, GS Bogatkevic, I Atanelishv, RM Silver, J Wood, VJ Thannickal, S Misra TGF beta-1 induced CD44v6-NOX4 signaling in pathogenesis of idiopathic pulmonary fibrosis J. Biol. Chem., 2017-04-07;0(0):. 2017-04-07 [PMID: 28389561] (Bioassay, Human)	Bioassay	Human
F Pan, H Xiang, J Yan, L Hong, L Zhang, Y Liu, X Feng, C Cai Dendritic cells from rheumatoid arthritis patient peripheral blood induce Th17 cell differentiation via miR-363/Integrin ?v/TGF-? axis Scand. J. Immunol., 2017-06-01;0(0):. 2017-06-01 [PMID: 28376277] (Bioassay, Human)	Bioassay	Human
KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling Cell Stem Cell, 2017-03-30;0(0):. 2017-03-30 [PMID: 28366587] (Bioassay, Human)	Bioassay	Human
K Desai, R Aiyappa, JS Prabhu, MG Nair, PV Lawrence, A Korlimarla, A Ce, A Alexander, RS Kaluve, S Manjunath, M Correa, BS Srinath, S Patil, A Kalamdani, M Prasad, TS Sridhar HR+HER2- breast cancers with growth factor receptor-mediated EMT have a poor prognosis and lapatinib downregulates EMT in MCF-7 cells Tumour Biol, 2017-03-01;39(3):1010428317695. 2017-03-01 [PMID: 28349782] (Bioassay, Human)	Bioassay	Human
C Pagiatakis, D Sun, SW Tobin, T Miyake, JC McDermott TGF?-TAZ/SRF Signaling regulates vascular smooth muscle cell differentiation FEBS J, 2017-04-20;0(0):. 2017-04-20 [PMID: 28342289] (Bioassay, Mouse)	Bioassay	Mouse
A Siddiqui, ME Vazakidou, A Schwab, F Napoli, C Fernandez-, I Rapa, MP Stemmler, M Volante, T Brabletz, P Ceppi Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial-to-mesenchymal transition of cancer cells J. Pathol, 2017-06-01;0(0):. 2017-06-01 [PMID: 28337746] (Bioassay, Human)	Bioassay	Human
V Ruiz-Carpi, P Sandoval, A Aguilera, P Albar-Vizc, ML Perez-Loza, GT González-M, A Acuña-Ruiz, J García-Can, P Botías, MA Bajo, R Selgas, JA Sánchez-To, J Passlick-D, D Piecha, J Büchel, S Steppan, M López-Cabr Genomic reprograming analysis of the Mesothelial to Mesenchymal Transition identifies biomarkers in peritoneal dialysis patients Sci Rep, 2017-03-22;7(0):44941. 2017-03-22 [PMID: 28327551] (Bioassay, Human)	Bioassay	Human
K Kamio, A Azuma, J Usuki, K Matsuda, M Inomata, N Nishijima, S Itakura, H Hayashi, T Kashiwada, N Kokuho, K Atsumi, T Yamaguchi, K Fujita, Y Saito, S Abe, K Kubota, A Gemma XPLN is modulated by HDAC inhibitors and negatively regulates SPARC expression by targeting mTORC2 in human lung fibroblasts Pulm Pharmacol Ther, 2017-03-14;0(0):. 2017-03-14 [PMID: 28315487] (Bioassay, Human)	Bioassay	Human
D Iizuka, M Sasatani, MH Barcellos-, K Kamiya Hydrogen Peroxide Enhances TGF?-mediated Epithelial-to-Mesenchymal Transition in Human Mammary Epithelial MCF-10A Cells Anticancer Res, 2017-03-01;37(3):987-995. 2017-03-01 [PMID: 28314256] (Bioassay, Human)	Bioassay	Human
Y Tachida, N Izumi, T Sakurai, H Kobayashi Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells Biol Open, 2017-03-15;6(3):370-380. 2017-03-15 [PMID: 28298363] (Bioassay, Human)	Bioassay	Human
F Loayza-Puc, K Rooijers, J Zijlstra, B Moumbeini, EA Zaal, JF Oude Vriel, R Lopes, A Pineiro Ug, CR Berkers, R Agami TGF?1-induced leucine limitation uncovered by differential ribosome codon reading EMBO Rep, 2017-03-08;0(0):. 2017-03-08 [PMID: 28274951] (Bioassay, Human)	Bioassay	Human
DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-04-01;0(0):. 2017-04-01 [PMID: 28270449] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
KH Bae, JB Seo, YA Jung, HY Seo, SH Kang, HJ Jeon, JM Lee, S Lee, JG Kim, IK Lee, GS Jung, KG Park Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor ? Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice Endocrinol Metab (Seoul), 2017-02-28;0(0):. 2017-02-28 [PMID: 28256116] (Bioassay, Rat)	Bioassay	Rat
W Zhao, J Yan, L Gao, J Zhao, C Zhao, C Gao, X Luo, X Zhu Cdk5 is required for the neuroprotective effect of transforming growth factor-?1 against cerebral ischemia-reperfusion Biochem. Biophys. Res. Commun, 2017-02-27;0(0):. 2017-02-27 [PMID: 28254431] (Bioassay, Rat)	Bioassay	Rat
D Pap, E Sziksz, Z Kiss, R Rokonay, A Veres-Szék, R Lippai, IM Takács, É Kis, A Fekete, G Reusz, A Vannay, AJ Szabó Microarray Analysis Reveals Increased Expression of Matrix Metalloproteases and Cytokines of Interleukin-20 Subfamily in the Kidneys of Neonate Rats Underwent Unilateral Ureteral Obstruction: A Potential Role of IL-24 in the Regulation of Inflammation and Tissue Remodeling Kidney Blood Press. Res, 2017-02-28;42(1):16-32. 2017-02-28 [PMID: 28253513] (Bioassay, Human)	Bioassay	Human
A Rynne-Vida, CL Au-Yeung, JA Jiménez-He, ML Pérez-Loza, L Cremades-J, C Bárcena, I Cristóbal-, C Fernández-, TL Yeung, SC Mok, P Sandoval, M López-Cabr Mesothelial-to-mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer J. Pathol, 2017-04-03;0(0):. 2017-04-03 [PMID: 28247413] (Bioassay, Human)	Bioassay	Human
G Mondanelli, R Bianchi, MT Pallotta, C Orabona, E Albini, A Iacono, ML Belladonna, C Vacca, F Fallarino, A Macchiarul, S Ugel, V Bronte, F Gevi, L Zolla, A Verhaar, M Peppelenbo, EM Mazza, S Bicciato, Y Laouar, L Santambrog, P Puccetti, C Volpi, U Grohmann A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells Immunity, 2017-02-14;46(2):233-244. 2017-02-14 [PMID: 28214225] (Bioassay, Mouse)	Bioassay	Mouse
BA Boswell, A Korol, JA West-Mays, LS Musil Dual function of TGF? in lens epithelial cell fate: implications for secondary cataract Mol. Biol. Cell, 2017-02-16;0(0):. 2017-02-16 [PMID: 28209733] (Bioassay, Chicken)	Bioassay	Chicken
A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells Oncotarget, 2017-04-11;8(15):24869-24881. 2017-04-11 [PMID: 28206960] (Bioassay, Human)	Bioassay	Human
Y Hu, L Lao, J Mao, W Jin, H Luo, T Charpentie, S Qi, J Peng, B Hu, MM Marcinkiew, A Lamarre, J Wu Armc5 deletion causes developmental defects and compromises T-cell immune responses Nat Commun, 2017-02-07;8(0):13834. 2017-02-07 [PMID: 28169274] (Bioassay, Mouse)	Bioassay	Mouse
K Sakaguchi, W Katagiri, M Osugi, T Kawai, Y Sugimura-W, H Hibi Periodontal tissue regeneration using the cytokine cocktail mimicking secretomes in the conditioned media from human mesenchymal stem cells Biochem. Biophys. Res. Commun, 2017-01-16;484(1):100-106. 2017-01-16 [PMID: 28104393] (Bioassay, Canine)	Bioassay	Canine
S Gopal, L Veracini, D Grall, C Butori, S Schaub, S Audebert, L Camoin, E Baudelet, A Radwanska, S Beghelli-d, SM Violette, PH Weinreb, S Rekima, M Ilie, A Sudaka, P Hofman, E Van Obberg Fibronectin-guided migration of carcinoma collectives Nat Commun, 2017-01-19;8(0):14105. 2017-01-19 [PMID: 28102238] (Bioassay, Human)	Bioassay	Human
D Brethour, M Mehrabian, D Williams, X Wang, F Ghodrati, S Ehsani, EA Rubie, JR Woodgett, J Sevalle, Z Xi, E Rogaeva, G Schmitt-Ul A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition Sci Rep, 2017-01-18;7(0):40313. 2017-01-18 [PMID: 28098160] (Bioassay, Human)	Bioassay	Human
MA L‚cuyer, O Saint-Laur, L BourbonniŠ, S Larouche, C Larochelle, L Michel, M Charabati, M Abadier, S Zandee, N Haghayegh, E Gowing, C Pittet, R Lyck, B Engelhardt, A Prat Dual role of ALCAM in neuroinflammation and blood-brain barrier homeostasis Proc. Natl. Acad. Sci. U.S.A, 2017-01-09;114(4):E524-E533. 2017-01-09 [PMID: 28069965] (Bioassay, Mouse)	Bioassay	Mouse
Claire Yu Decellularized adipose tissue microcarriers as a dynamic culture platform for human adipose-derived stem/stromal cell expansion Biomaterials, 2016-12-23;120(0):66-80. 2016-12-23 [PMID: 28038353] (Bioassay, Human)	Bioassay	Human
Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases Cell Death Dis, 2016-12-29;7(12):e2565. 2016-12-29 [PMID: 28032864] (Bioassay, Human)	Bioassay	Human
Loss of TRPV4 Function Suppresses Inflammatory Fibrosis Induced by Alkali-Burning Mouse Corneas PLoS ONE, 2016-12-28;11(12):e0167200. 2016-12-28 [PMID: 28030558] (Bioassay, Mouse)	Bioassay	Mouse
IL-10 production in murine IgM(+) CD138(hi) cells is driven by Blimp1 and downregulated in class-switched cells Eur. J. Immunol, 2017-01-10;0(0):. 2017-01-10 [PMID: 28012163] (Bioassay, Mouse)	Bioassay	Mouse
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MiR-133 modulates TGF-ÃŽÂ²1-induced bladder smooth muscle cell hypertrophic and fibrotic response: implication for a role of microRNA in bladder wall remodeling caused by bladder outlet obstruction. Cell Signal, 2014-11-11;27(2):215-27. 2014-11-11 [PMID: 25451078] (Bioassay, Human, Rat)	Bioassay	Human, Rat
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Eun S, Lee S, Xu Y, Croft M 4-1BB ligand signaling to T cells limits T cell activation. J Immunol, 2014-11-17;194(1):134-41. 2014-11-17 [PMID: 25404362] (Bioassay, Mouse)	Bioassay	Mouse
Li J, Ballim D, Rodriguez M, Cui R, Goding C, Teng H, Prince S The anti-proliferative function of the TGF-beta1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3. J Biol Chem, 2014-11-04;289(51):35633-43. 2014-11-04 [PMID: 25371204] (Bioassay, Human)	Bioassay	Human
Bohnsack R, Warejcka D, Wang L, Gillespie S, Bernstein A, Twining S, Dahms N Expression of insulin-like growth factor 2 receptor in corneal keratocytes during differentiation and in response to wound healing. Invest Ophthalmol Vis Sci, 2014-10-30;55(12):7697-708. 2014-10-30 [PMID: 25358730] (Bioassay, Human)	Bioassay	Human
Jolly L, Stavrou A, Vanderstoken G, Meliopoulos V, Habgood A, Tatler A, Porte J, Knox A, Weinreb P, Violette S, Hussell T, Kolb M, Stampfli M, Schultz-Cherry S, Jenkins G Influenza promotes collagen deposition via alphavbeta6 integrin-mediated transforming growth factor beta activation. J Biol Chem, 2014-10-22;289(51):35246-63. 2014-10-22 [PMID: 25339175] (Bioassay, Human)	Bioassay	Human
Kuang D, Xiao X, Zhao Q, Chen M, Li X, Liu R, Wei Y, Ouyang F, Chen D, Wu Y, Lao X, Deng H, Zheng L B7-H1-expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets. J Clin Invest, 2014-09-17;124(10):4657-67. 2014-09-17 [PMID: 25244097] (Bioassay, Human)	Bioassay	Human
Xiao , Guan-Yu, Liu , I-Hsuan, Cheng , Chun-Chu, Chang , Chia-Chu, Lee , Yen-Hua, Cheng , Winston, Wu , Shinn-Ch Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy. PLoS ONE, 2014-09-08;9(9):e106538. 2014-09-08 [PMID: 25198549] (Bioassay, Mouse)	Bioassay	Mouse
Chen K, Hsu H, Lee C, Yen T, Ko Y, Yang C, Hung C The AMPK agonist AICAR inhibits TGF-beta1 induced activation of kidney myofibroblasts. PLoS ONE, 2014-09-04;9(9):e106554. 2014-09-04 [PMID: 25188319] (Bioassay, Rat)	Bioassay	Rat
Normanton M, Alvarenga H, Hamerschlak N, Ribeiro A, Kondo A, Rizzo L, Marti L Interleukin 7 plays a role in T lymphocyte apoptosis inhibition driven by mesenchymal stem cell without favoring proliferation and cytokines secretion. PLoS ONE, 2014-09-03;9(9):e106673. 2014-09-03 [PMID: 25184791] (Bioassay, Human)	Bioassay	Human
Tobar N, Toyos M, Urra C, Mendez N, Arancibia R, Smith P, Martinez J c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells. BMC Cancer, 2014-08-30;14(0):640. 2014-08-30 [PMID: 25175743] (Bioassay, Human)	Bioassay	Human
Cheng T, Hu C, Yang H, Cao L, An J Transforming growth factor-beta-induced miR143 expression in regulation of non-small cell lung cancer cell viability and invasion capacity in vitro and in vivo. Int J Oncol, 2014-08-27;45(5):1977-88. 2014-08-27 [PMID: 25175415] (Bioassay, Human)	Bioassay	Human
Pessina P, Cabrera D, Morales M, Riquelme C, Gutierrez J, Serrano A, Brandan E, Munoz-Canoves P Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular Dystrophy. Skelet Muscle, 2014-08-25;4(0):7. 2014-08-25 [PMID: 25157321] (In Vivo, Mouse)	In Vivo	Mouse
Zhou Y, Xiong M, Niu J, Sun Q, Su W, Zen K, Dai C, Yang J Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney. J Cell Sci, 2014-08-08;127(0):4494-506. 2014-08-08 [PMID: 25107369] (Bioassay, Rat)	Bioassay	Rat
Scherz-Shouval R, Santagata S, Mendillo M, Sholl L, Ben-Aharon I, Beck A, Dias-Santagata D, Koeva M, Stemmer S, Whitesell L, Lindquist S The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy. Cell, 2014-07-31;158(3):564-78. 2014-07-31 [PMID: 25083868] (Bioassay, Human)	Bioassay	Human
Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi M, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kuhl A, Heimesaat M, Esser C, Im S, Radbruch A, Rutz S, Scheffold A Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med, 2014-07-29;211(9):1807-19. 2014-07-29 [PMID: 25073792] (Bioassay, Mouse)	Bioassay	Mouse
Speck S, Lim J, Shelake S, Matka M, Stoddard J, Farr A, Kuchroo V, Laouar Y TGF-beta signaling initiated in dendritic cells instructs suppressive effects on Th17 differentiation at the site of neuroinflammation. PLoS ONE, 2014-07-29;9(7):e102390. 2014-07-29 [PMID: 25072375] (Bioassay, Mouse)	Bioassay	Mouse
Han L, Yang J, Wang X, Wu Q, Yin S, Li Z, Zhang J, Xing Y, Chen Z, Tsun A, Li D, Piccioni M, Zhang Y, Guo Q, Jiang L, Bao L, Lv L, Li B The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor gammat (RORgammat) in Th17 cells. J Biol Chem, 2014-07-28;289(37):25546-55. 2014-07-28 [PMID: 25070893] (Bioassay, Human)	Bioassay	Human
Pan C, Kumar S, Shah N, Hoyt D, Hawinkels L, Mythreye K, Lee N Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis. J Biol Chem, 2014-07-28;289(37):25486-96. 2014-07-28 [PMID: 25070888] (Bioassay, Mouse)	Bioassay	Mouse
Okada Y, Shirai K, Reinach P, Kitano-Izutani A, Miyajima M, Flanders K, Jester J, Tominaga M, Saika S TRPA1 is required for TGF-beta signaling and its loss blocks inflammatory fibrosis in mouse corneal stroma. Lab Invest, 2014-07-28;94(9):1030-41. 2014-07-28 [PMID: 25068659] (Bioassay, Mouse)	Bioassay	Mouse
Chen L, Munoz-Antonia T, Cress W Trim28 contributes to EMT via regulation of E-cadherin and N-cadherin in lung cancer cell lines. PLoS ONE, 2014-07-01;9(7):e101040. 2014-07-01 [PMID: 24983967] (Bioassay, Human)	Bioassay	Human
Mercer F, Khaitan A, Kozhaya L, Aberg J, Unutmaz D Differentiation of IL-17-producing effector and regulatory human T cells from lineage-committed naive precursors. J Immunol, 2014-06-23;193(3):1047-54. 2014-06-23 [PMID: 24958901] (Bioassay, Human)	Bioassay	Human
Hardin H, Guo Z, Shan W, Montemayor-Garcia C, Asioli S, Yu X, Harrison A, Chen H, Lloyd R The roles of the epithelial-mesenchymal transition marker PRRX1 and miR-146b-5p in papillary thyroid carcinoma progression. Am J Pathol, 2014-06-17;184(8):2342-54. 2014-06-17 [PMID: 24946010] (Bioassay, Human)	Bioassay	Human
Lim M, Ahn J, Yi J, Kim M, Son A, Lee S, Lim D, Kim S, Kang M, Han Y, Song J Induction of galectin-1 by TGF-beta1 accelerates fibrosis through enhancing nuclear retention of Smad2. Exp Cell Res, 2014-06-11;326(1):125-35. 2014-06-11 [PMID: 24928277] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
Arts M, Baron M, Chokr N, Fritzler M, Servant M Systemic sclerosis immunoglobulin induces growth and a pro-fibrotic state in vascular smooth muscle cells through the epidermal growth factor receptor. PLoS ONE, 2014-06-13;9(6):e100035. 2014-06-13 [PMID: 24927197] (Bioassay, Human)	Bioassay	Human
Zhao C, Pavicic P, Datta S, Sun D, Novotny M, Hamilton T Cellular stress amplifies TLR3/4-induced CXCL1/2 gene transcription in mononuclear phagocytes via RIPK1. J Immunol, 2014-06-11;193(2):879-88. 2014-06-11 [PMID: 24920846] (Bioassay, Human)	Bioassay	Human
Santhekadur P, Akiel M, Emdad L, Gredler R, Srivastava J, Rajasekaran D, Robertson C, Mukhopadhyay N, Fisher P, Sarkar D Staphylococcal nuclease domain containing-1 (SND1) promotes migration and invasion via angiotensin II type 1 receptor (AT1R) and TGFbeta signaling. FEBS Open Bio, 2014-04-01;4(0):353-61. 2014-04-01 [PMID: 24918049] (Bioassay, Human)	Bioassay	Human
Liu Y, Kimura K, Orita T, Teranishi S, Suzuki K, Sonoda K Inhibition by all-trans-retinoic acid of transforming growth factor-beta-induced collagen gel contraction mediated by human tenon fibroblasts. Invest Ophthalmol Vis Sci, 2014-06-03;55(7):4199-205. 2014-06-03 [PMID: 24894398] (Bioassay, Human)	Bioassay	Human
Okabe H, Delgado E, Lee J, Yang J, Kinoshita H, Hayashi H, Tsung A, Behari J, Beppu T, Baba H, Monga S Role of leukocyte cell-derived chemotaxin 2 as a biomarker in hepatocellular carcinoma. PLoS ONE, 2014-06-03;9(6):e98817. 2014-06-03 [PMID: 24892551] (Bioassay, Human)	Bioassay	Human
Zafar A, Wu F, Hardy K, Li J, Tu W, McCuaig R, Harris J, Khanna K, Attema J, Gregory P, Goodall G, Harrington K, Dahlstrom J, Boulding T, Madden R, Tan A, Milburn P, Rao S Chromatinized protein kinase C-theta directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells. Mol Cell Biol, 2014-06-02;34(16):2961-80. 2014-06-02 [PMID: 24891615] (Bioassay, Human)	Bioassay	Human
Togashi , Yosuke, Sakamoto , Hiroki, Hayashi , Hidetosh, Terashima , Masato, de Velasco , Marco A, Fujita , Yoshihik, Kodera , Yasuo, Sakai , Kazuko, Tomida , Shuta, Kitano , Masayuki, Ito , Akihiko, Kudo , Masatosh, Nishio , Kazuto Homozygous deletion of the activin A receptor, type IB gene is associated with an aggressive cancer phenotype in pancreatic cancer. Mol Cancer, 2014-05-27;13(0):126. 2014-05-27 [PMID: 24886203] (Bioassay, Human)	Bioassay	Human
Salvo E, Garasa S, Dotor J, Morales X, Pelaez R, Altevogt P, Rouzaut A Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer. Mol Cancer, 2014-05-19;13(0):112. 2014-05-19 [PMID: 24884715] (Bioassay, Human)	Bioassay	Human
Matthews A, Husain S, Chaudhuri J Binding of AID to DNA does not correlate with mutator activity. J Immunol, 2014-05-30;193(1):252-7. 2014-05-30 [PMID: 24879790] (Bioassay, Mouse)	Bioassay	Mouse
Choi S, Kim B, Robinson J, Fink S, Yan M, Sporn M, Markowitz S, Letterio J Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J Clin Invest, 2014-05-16;124(6):2472-82. 2014-05-16 [PMID: 24837432] (Bioassay, Human)	Bioassay	Human
Desai L, Zhou Y, Estrada A, Ding Q, Cheng G, Collawn J, Thannickal V Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein. J Biol Chem, 2014-05-15;289(26):18270-8. 2014-05-15 [PMID: 24831009] (Bioassay, Human)	Bioassay	Human
Fehrholz M, Speer C, Kunzmann S Caffeine and rolipram affect Smad signalling and TGF-beta1 stimulated CTGF and transgelin expression in lung epithelial cells. PLoS ONE, 2014-05-14;9(5):e97357. 2014-05-14 [PMID: 24828686] (Bioassay, Human)	Bioassay	Human
Solomon J, Heitzer M, Liu T, Beumer J, Parise R, Normolle D, Leach D, Buchanan G, DeFranco D VDR activity is differentially affected by Hic-5 in prostate cancer and stromal cells. Mol Cancer Res, 2014-05-13;12(8):1166-80. 2014-05-13 [PMID: 24825850] (Bioassay, Human)	Bioassay	Human
Kirkegaard T, Yde C, Kveiborg M, Lykkesfeldt A The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines. Int J Oncol, 2014-05-09;45(1):393-400. 2014-05-09 [PMID: 24819550] (Bioassay, Human)	Bioassay	Human
Jakobsen R, Ostrup E, Zhang X, Mikkelsen T, Brinchmann J Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. PLoS ONE, 2014-05-09;9(5):e96615. 2014-05-09 [PMID: 24816923] (Bioassay, Human)	Bioassay	Human
Kofler D, Marson A, Dominguez-Villar M, Xiao S, Kuchroo V, Hafler D Decreased RORC-dependent silencing of prostaglandin receptor EP2 induces autoimmune Th17 cells. J Clin Invest, 2014-05-08;124(6):2513-22. 2014-05-08 [PMID: 24812667] (Human)		Human
Gobel K, Schuhmann M, Pankratz S, Stegner D, Herrmann A, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth S Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol, 2014-06-05;44(8):2295-305. 2014-06-05 [PMID: 24811005] (Bioassay, Mouse)	Bioassay	Mouse
Kongsbak M, von Essen M, Boding L, Levring T, Schjerling P, Lauritsen J, Woetmann A, Odum N, Bonefeld C, Geisler C Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells. PLoS ONE, 2014-05-02;9(5):e96695. 2014-05-02 [PMID: 24792400] (Bioassay, Human)	Bioassay	Human
Kasabova M, Joulin-Giet A, Lecaille F, Gilmore B, Marchand-Adam S, Saidi A, Lalmanach G Regulation of TGF-beta1-driven differentiation of human lung fibroblasts: emerging roles of cathepsin B and cystatin C. J Biol Chem, 2014-04-30;289(23):16239-51. 2014-04-30 [PMID: 24790080] (Bioassay, Human)	Bioassay	Human
Luo F, Zhuang Y, Sides M, Sanchez C, Shan B, White E, Lasky J Arsenic trioxide inhibits transforming growth factor-beta1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo. Respir Res, 2014-04-24;15(0):51. 2014-04-24 [PMID: 24762191] (Bioassay, Human)	Bioassay	Human
Li H, Fitchett C, Kozdon K, Jayaram H, Rose G, Bailly M, Ezra D Independent adipogenic and contractile properties of fibroblasts in Graves' orbitopathy: an in vitro model for the evaluation of treatments. PLoS ONE, 2014-04-21;9(4):e95586. 2014-04-21 [PMID: 24751986] (Bioassay, Human)	Bioassay	Human
Kumawat K, Menzen M, Slegtenhorst R, Halayko A, Schmidt M, Gosens R TGF-beta-activated kinase 1 (TAK1) signaling regulates TGF-beta-induced WNT-5A expression in airway smooth muscle cells via Sp1 and beta-catenin. PLoS ONE, 2014-04-11;9(4):e94801. 2014-04-11 [PMID: 24728340] (Bioassay, Human)	Bioassay	Human
Tulley S, Chen W Transcriptional regulation of seprase in invasive melanoma cells by transforming growth factor-beta signaling. J Biol Chem, 2014-04-13;289(22):15280-96. 2014-04-13 [PMID: 24727589] (Bioassay, Human)	Bioassay	Human
Villegas V, Rahman M, Fernandez-Barrena M, Diao Y, Liapi E, Sonkoly E, Stahle M, Pivarcsi A, Annaratone L, Sapino A, Ramirez Clavijo S, Burglin T, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico M, Zaphiropoulos P Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1. Mol Oncol, 2014-03-22;8(5):912-26. 2014-03-22 [PMID: 24726458] (Bioassay, Human)	Bioassay	Human
Wei D, Chiang V, Fyne E, Balakrishnan M, Barnes T, Graupe M, Hesselgesser J, Irrinki A, Murry J, Stepan G, Stray K, Tsai A, Yu H, Spindler J, Kearney M, Spina C, McMahon D, Lalezari J, Sloan D, Mellors J, Geleziunas R, Cihlar T Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing. PLoS Pathog, 2014-04-10;10(4):e1004071. 2014-04-10 [PMID: 24722454] (Bioassay, Human)	Bioassay	Human
Shi X, DiRenzo D, Guo L, Franco S, Wang B, Seedial S, Kent K TGF-beta/Smad3 stimulates stem cell/developmental gene expression and vascular smooth muscle cell de-differentiation. 2014-04-09;9(0):. 2014-04-09 [PMID: 24718260] (Bioassay, Rat)	Bioassay	Rat
Echeverria C, Montorfano I, Hermosilla T, Armisen R, Velasquez L, Cabello-Verrugio C, Varela D, Simon F Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS ONE, 2014-04-07;9(4):e94146. 2014-04-07 [PMID: 24710004] (Bioassay, Human)	Bioassay	Human
Yu Y, Yiang G, Chou P, Tseng H, Wu T, Hung Y, Lin P, Lin S, Liu H, Chang W, Wei C Dual role of acetaminophen in promoting hepatoma cell apoptosis and kidney fibroblast proliferation. Mol Med Rep, 2014-03-28;9(6):2077-84. 2014-03-28 [PMID: 24682227] (Bioassay, Rat)	Bioassay	Rat
Miller C, Haas U, Diaz R, Leeper N, Kundu R, Patlolla B, Assimes T, Kaiser F, Perisic L, Hedin U, Maegdefessel L, Schunkert H, Erdmann J, Quertermous T, Sczakiel G Coronary heart disease-associated variation in TCF21 disrupts a miR-224 binding site and miRNA-mediated regulation. PLoS Genet, 2014-03-27;10(3):e1004263. 2014-03-27 [PMID: 24676100] (Bioassay, Human)	Bioassay	Human
Kim S, Lee S, Wang Z, Ding Y, Haque N, Zhang J, Zhou J, Choi M TGF-beta-activated kinase 1 is crucial in podocyte differentiation and glomerular capillary formation. J Am Soc Nephrol, 2014-03-20;25(9):1966-78. 2014-03-20 [PMID: 24652804] (Bioassay, Human)	Bioassay	Human
Gurunathan S, Winkles J, Ghosh S, Hayden M Regulation of fibroblast growth factor-inducible 14 (Fn14) expression levels via ligand-independent lysosomal degradation. J Biol Chem, 2014-03-20;289(19):12976-88. 2014-03-20 [PMID: 24652288]
Aschner Y, Khalifah A, Briones N, Yamashita C, Dolgonos L, Young S, Campbell M, Riches D, Redente E, Janssen W, Henson P, Sap J, Vacaresse N, Kapus A, McCulloch C, Zemans R, Downey G Protein tyrosine phosphatase alpha mediates profibrotic signaling in lung fibroblasts through TGF-beta responsiveness. Am J Pathol, 2014-03-17;184(5):1489-502. 2014-03-17 [PMID: 24650563] (Bioassay, Mouse)	Bioassay	Mouse
Jeon K, Kulkarni A, Woeller C, Phipps R, Sime P, Hindman H, Huxlin K Inhibitory effects of PPARgamma ligands on TGF-beta1-induced corneal myofibroblast transformation. Am J Pathol, 2014-03-17;184(5):1429-45. 2014-03-17 [PMID: 24650561] (Bioassay, Feline)	Bioassay	Feline
Xu S, Zhu J, Wu Z Loss of Dab2 expression in breast cancer cells impairs their ability to deplete TGF-beta and induce Tregs development via TGF-beta. PLoS ONE, 2014-03-17;9(3):e91709. 2014-03-17 [PMID: 24638085] (Bioassay, Human)	Bioassay	Human
Olderoy M, Lilledahl M, Beckwith M, Melvik J, Reinholt F, Sikorski P, Brinchmann J Biochemical and structural characterization of neocartilage formed by mesenchymal stem cells in alginate hydrogels. PLoS ONE, 2014-03-13;9(3):e91662. 2014-03-13 [PMID: 24626259] (Bioassay, Human)	Bioassay	Human
Overstreet J, Samarakoon R, Meldrum K, Higgins P Redox control of p53 in the transcriptional regulation of TGF-beta1 target genes through SMAD cooperativity. Cell Signal, 2014-03-05;26(7):1427-36. 2014-03-05 [PMID: 24613410] (Bioassay, Human)	Bioassay	Human
Kudo-Saito C, Yura M, Yamamoto R, Kawakami Y Induction of immunoregulatory CD271+ cells by metastatic tumor cells that express human endogenous retrovirus H. Cancer Res, 2014-03-01;74(5):1361-70. 2014-03-01 [PMID: 24590808] (Bioassay, Human)	Bioassay	Human
Gao X, Cao Y, Staloch D, Gonzales M, Aronson J, Chao C, Hellmich M, Ko T Bone morphogenetic protein signaling protects against cerulein-induced pancreatic fibrosis. PLoS ONE, 2014-02-21;9(2):e89114. 2014-02-21 [PMID: 24586530] (Bioassay, Mouse)	Bioassay	Mouse
Mael-Ainin M, Abed A, Conway S, Dussaule J, Chatziantoniou C Inhibition of periostin expression protects against the development of renal inflammation and fibrosis. J Am Soc Nephrol, 2014-02-27;25(8):1724-36. 2014-02-27 [PMID: 24578131] (Bioassay, Human)	Bioassay	Human
Liu R, Zeng Y, Lei Z, Wang L, Yang H, Liu Z, Zhao J, Zhang H JAK/STAT3 signaling is required for TGF-beta-induced epithelial-mesenchymal transition in lung cancer cells. Int J Oncol, 2014-02-21;44(5):1643-51. 2014-02-21 [PMID: 24573038] (Bioassay, Human)	Bioassay	Human
Suresh Babu S, Valdez Y, Xu A, O'Byrne A, Calvo F, Lei V, Conway E TGFbeta-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells. BMC Cancer, 2014-02-20;14(0):113. 2014-02-20 [PMID: 24555435] (Bioassay, Mouse)	Bioassay	Mouse
Diepenbruck , Maren, Waldmeier , Lorenz, Ivanek , Robert, Berninger , Philipp, Arnold , Phil, van Nimwegen , Erik, Christofori , Gerhard Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. J Cell Sci, 2014-02-19;127(0):1523-36. 2014-02-19 [PMID: 24554433] (Bioassay, Mouse)	Bioassay	Mouse
Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation. Eur J Immunol, 2014-02-18;44(5):1330-40. 2014-02-18 [PMID: 24549985] (Bioassay, Human)	Bioassay	Human
Italiani , Paola, Mazza , Emilia M, Lucchesi , Davide, Cifola , Ingrid, Gemelli , Claudia, Grande , Alexis, Battaglia , Cristina, Bicciato , Silvio, Boraschi , Diana Transcriptomic profiling of the development of the inflammatory response in human monocytes in vitro. PLoS ONE, 2014-02-03;9(2):e87680. 2014-02-03 [PMID: 24498352] (Bioassay, Human)	Bioassay	Human
Mirkina I, Hadzijusufovic E, Krepler C, Mikula M, Mechtcheriakova D, Strommer S, Stella A, Jensen-Jarolim E, Holler C, Wacheck V, Pehamberger H, Valent P Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R. PLoS ONE, 2014-01-29;9(1):e84417. 2014-01-29 [PMID: 24489649] (Bioassay, Human)	Bioassay	Human
Oliveira W, Ribeiro L, Schrieffer A, Machado P, Carvalho E, Bacellar O The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of human tegumentary leishmaniasis. Cytokine, 2014-01-30;66(2):127-32. 2014-01-30 [PMID: 24485388] (Bioassay, Human)	Bioassay	Human
Du , Lili, Yu , Yanqiu, Ma , Haiying, Lu , Xiaomei, Ma , Ling, Jin , Yunan, Zhang , Haipeng Hypoxia enhances protective effect of placental-derived mesenchymal stem cells on damaged intestinal epithelial cells by promoting secretion of insulin-like growth factor-1. Int J Mol Sci, 2014-01-27;15(2):1983-2002. 2014-01-27 [PMID: 24473145] (Bioassay, Human)	Bioassay	Human
Ratnayake M, Ploger F, Santibanez-Koref M, Loughlin J Human chondrocytes respond discordantly to the protein encoded by the osteoarthritis susceptibility gene GDF5. PLoS ONE, 2014-01-21;9(1):e86590. 2014-01-21 [PMID: 24466161] (Bioassay, Human)	Bioassay	Human
Wang X, Gui L, Zhang Y, Zhang J, Shi J, Xu G Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-beta signaling pathway. Int J Oncol, 2014-01-21;44(4):1099-106. 2014-01-21 [PMID: 24452274] (Bioassay, Human)	Bioassay	Human
Miller M, Petty C, Tompkins M, Fogle J CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism. Virol J, 2014-01-18;11(0):7. 2014-01-18 [PMID: 24438223] (Bioassay, Feline)	Bioassay	Feline
Chen X, Yang Y, Zhou Q, Weiss J, Howard O, McPherson J, Wakefield L, Oppenheim J Effective chemoimmunotherapy with anti-TGFbeta antibody and cyclophosphamide in a mouse model of breast cancer. PLoS ONE, 2014-01-09;9(1):e85398. 2014-01-09 [PMID: 24416401] (Bioassay, Mouse)	Bioassay	Mouse
Rozycki M, Lodyga M, Lam J, Miranda M, Fatyol K, Speight P, Kapus A The fate of the primary cilium during myofibroblast transition. Mol Biol Cell, 2014-01-08;25(5):643-57. 2014-01-08 [PMID: 24403605] (Bioassay, Human)	Bioassay	Human
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Wildemann B, Bamdad P, Holmer Ch, Haas NP, Raschke M, Schmidmaier G Local delivery of growth factors from coated titanium plates increases osteotomy healing in rats. Bone, 2004-05-01;34(5):862-8. 2004-05-01 [PMID: 15121018] (In Vivo, Rat)	In Vivo	Rat
Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung. Am. J. Respir. Crit. Care Med., 2004-04-22;170(2):188-94. 2004-04-22 [PMID: 15105163] (Bioassay, Mink)	Bioassay	Mink
Torrealba JR, Katayama M, Fechner JH, Jankowska-Gan E, Kusaka S, Schultz JM, Hu H, Hamawy MM, Jonker M, Wubben J, Doxiadis G, Bontrop R, Burlingham WJ, Knechtle SJ Metastable tolerance to rhesus monkey renal transplants is correlated with allograft TGF-beta 1+CD4+ T regulatory cell infiltrates. J. Immunol., 2004-05-01;172(9):5753-64. 2004-05-01 [PMID: 15100322] (Western Blot)	Western Blot
Zheng SG, Wang JH, Gray JD, Soucier H, Horwitz DA Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10. J. Immunol., 2004-05-01;172(9):5213-21. 2004-05-01 [PMID: 15100259] (Bioassay, Human)	Bioassay	Human
Studer RK, Bergman R, Stubbs T, Decker K Chondrocyte response to growth factors is modulated by p38 mitogen-activated protein kinase inhibition. Arthritis Res. Ther., 2003-11-07;6(1):R56-R64. 2003-11-07 [PMID: 14979938] (Bioassay, Rabbit)	Bioassay	Rabbit
Leach RE, Kilburn B, Wang J, Liu Z, Romero R, Armant DR Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype. Dev. Biol., 2004-02-15;266(2):223-37. 2004-02-15 [PMID: 14738873] (Bioassay, Human)	Bioassay	Human
Chen , WanJun, Jin , Wenwen, Hardegen , Neil, Lei , Ke-Jian, Li , Li, Marinos , Nancy, McGrady , George, Wahl , Sharon M Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med, 2003-12-15;198(12):1875-86. 2003-12-15 [PMID: 14676299] (Bioassay, Mouse)	Bioassay	Mouse
Ashcroft GS, Mills SJ, Lei K, Gibbons L, Jeong MJ, Taniguchi M, Burow M, Horan MA, Wahl SM, Nakayama T Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor. J. Clin. Invest., 2003-05-01;111(9):1309-18. 2003-05-01 [PMID: 12727922] (In Vivo, Mouse)	In Vivo	Mouse
Khattri , Roli, Cox , Tom, Yasayko , Sue-Ann, Ramsdell , Fred An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol, 2003-03-03;4(4):337-42. 2003-03-03 [PMID: 12612581] (Bioassay, Mouse)	Bioassay	Mouse
Huaux F, Liu T, McGarry B, Ullenbruch M, Phan SH Dual roles of IL-4 in lung injury and fibrosis. Proteins containing BRCA1 C-terminal (BRCT) domains play crucial roles in response to and repair of DNA damage. Epithelial cell transforming factor ECT2 is a member of the BRCT protein family, but it , 2003-02-15;170(4):2083-92. 2003-02-15 [PMID: 12574379] (Mouse)		Mouse
Scharstuhl A, van Beuningen HM, Vitters EL, van der Kraan PM, van den Berg WB Loss of transforming growth factor counteraction on interleukin 1 mediated effects in cartilage of old mice. Ann. Rheum. Dis., 2002-12-01;61(12):1095-8. 2002-12-01 [PMID: 12429542] (In Vivo, Mouse)	In Vivo	Mouse
Huaux F, 107322, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier JP, Vink A, Phan SH, Renauld JC, Lison D A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms, 2002-09-01;169(5):2653-61. 2002-09-01 [PMID: 12193738] (Bioassay, Mouse)	Bioassay	Mouse
Zhao W, Kobayashi M, Ding W, Yuan L, Seth P, Cornain S, Wang J, Okada F, Hosokawa M Suppression of in vivo tumorigenicity of rat hepatoma cell line KDH-8 cells by soluble TGF-beta receptor type II. Cancer Immunol. Immunother., 2002-06-25;51(7):381-8. 2002-06-25 [PMID: 12192538] (Bioassay, Rat)	Bioassay	Rat
Rosado E, 2019, Schwartz Z, Sylvia VL, Dean DD, Boyan BD Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. 91, 2002-06-12;1590(1):1-15. 2002-06-12 [PMID: 12063164] (Bioassay, Rat)	Bioassay	Rat
Schmidt A, 2019, Gopfert C, Vlodavsky I, Volker W, Buddecke E Induction of a hypertrophic growth status of coronary smooth muscle cells is associated with an overexpression of TGF-beta. 101211, 2002-03-01;81(3):138-44. 2002-03-01 [PMID: 11998865] (Bioassay, Bovine)	Bioassay	Bovine
Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells. Am. J. Physiol. Lung Cell Mol. Physiol., 2002-05-01;282(5):L1049-56. 2002-05-01 [PMID: 11943670] (ELISA (Standard))	ELISA (Standard)
Cashman J, Clark-Lewis I, Eaves A, Eaves C Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood, 2002-02-01;99(3):792-9. 2002-02-01 [PMID: 11806978] (Bioassay, Human)	Bioassay	Human
Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4. J. Immunol., 2000-05-15;164(10):5337-43. 2000-05-15 [PMID: 10799896] (ELISA (Standard))	ELISA (Standard)
Desfaits AC, 48971, Raymond J, Muizelaar JP Growth factors stimulate neointimal cells in vitro and increase the thickness of the neointima formed at the neck of porcine aneurysms treated by embolization. Cigarette smoke attenuates phagocytic ability of macrophages through down-regulating Milk fat globule-EGF factor 8 (MFG-E8) expressions, 2000-02-01;31(0):498-507. 2000-02-01 [PMID: 10657429] (Bioassay, In Vivo, Canine, Porcine)	Bioassay, In Vivo	Canine, Porcine
Mozes MM, Hodics T, Kopp JB Isoform specificity of commercially-available anti-TGF-beta antibodies. J. Immunol. Methods, 1999-05-27;225(1):87-93. 1999-05-27 [PMID: 10365785] (Western Blot)	Western Blot
Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res., 1998-09-01;58(17):4008-14. 1998-09-01 [PMID: 9731515] (Bioassay, Human)	Bioassay	Human
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TGF-beta 1 - a versatile signaling molecule with roles in development and disease
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Gene Symbol	TGFB1
Uniprot	P01137.2()

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