Recombinant Human/Mouse/Rat Activin A Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Activin and Inhibin are members of the TGF-beta superfamily of cytokines and are involved in a wide range of biological processes including tissue morphogenesis and repair, fibrosis, inflammation, neural development, hematopoiesis, reproductive system function, and carcinogenesis (1‑7). Activin and Inhibin are produced as precursor proteins. Their amino terminal propeptides are proteolytically cleaved and facilitate formation of disulfide-linked dimers of the bioactive proteins (8, 9). Activins are nonglycosylated homodimers or heterodimers of various beta subunits ( beta A, beta B, beta C, and beta E in mammals), while Inhibins are heterodimers of a unique alpha subunit and one of the beta subunits. Activin A is a widely expressed homodimer of two beta A chains. The beta A subunit can also heterodimerize with a beta B or beta C subunit to form Activin AB and Activin AC, respectively (10). The 14 kDa mature human beta A chain shares 100% amino acid sequence identity with bovine, feline, mouse, porcine, and rat beta A. Activin A exerts its biological activities by binding to the type 2 serine/threonine kinase Activin RIIA which then noncovalently associates with the type 1 serine/threonine kinase Activin RIB/ALK-4 (7, 11). Signaling through this receptor complex leads to Smad activation and regulation of activin-responsive gene transcription (7, 11). The bioactivity of Activin A is regulated by a variety of mechanisms (11). BAMBI, Betaglycan, and Cripto are cell‑associated molecules that function as decoy receptors or limit the ability of Activin A to induce receptor complex assembly (12‑14). The intracellular formation of Activin A can be prevented by the incorporation of the beta A subunit into Activin AC or Inhibin A (3, 10). And the bioavailability of Activin A is restricted by its incorporation into inactive complexes with alpha 2-Macroglobulin, Follistatin, and FLRG (15, 16). Activin A is involved in the differentiation of various cell and tissue types. The induction of definitive endoderm by Activin A is required in differentiation protocols of induced pluripotent stem cells (iPSCs) (17, 18). In vitro models of human gametogenesis use prolonged Activin A supplementation to human embryonic stem cells for differentiation into human primordial germ cell-like cells (19). Activin A can also be used to maintain cells in vitro, as is the case for iPSC-derived nephron cells that can then be used in disease modeling, drug screening and in regenerative medicine (20). Activin A is an important factor for tumor cells to evade the immune system as Activin A can act on surrounding immune cells to decrease their antitumor activity (21). Activin A also promotes migration and growth of tumors, making it a target for cancer therapies (22). Specifically, research has shown that interfering with Activin A activity can assist in overcoming CD8 T-cell exclusion and immunotherapy resistance (23). In bone marrow-derived stem cell transplants for treatment of diabetes, Activin A enhances migration and homing of stem cells towards pancreatic lineage (24).

We have publications tested in 15 confirmed species: Human, Mouse, Rat, Bovine, Chicken, Feline, Goat, Hamster, Ovine, Porcine, Primate - Callitrix jacchus (Common Marmoset), Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque), Primate - Macaca mulatta (Rhesus Macaque), Transgenic Mouse, Xenopus.

We have publications tested in 10 applications: Bioassay, Cell Culture, Differentiation, ELISA (Standard), Flow Cytometry, In Vivo, Stimulation, Surface Plasmon Resonance, Tissue Culture, Western Blot.

Showing Publications 1 - 10 of 513. Show All 513 Publications. Collapse Publications.

Publications using 338-AC/CF	Applications	Species
Lin, Y;Wu, TY;Chen, X;Wan, S;Chao, B;Xin, J;Yang, JYH;Wong, WH;Wang, YXR; scTIE: data integration and inference of gene regulation using single-cell temporal multimodal data bioRxiv : the preprint server for biology 2023-05-22 [PMID: 37292801] (Bioassay, Mouse)	Bioassay	Mouse
S Li, CS Wang, A Montel-Hag, HC Chen, S Lopez, O Zhou, K Dai, S Tsai, W Satyadi, C Botero, C Wong, D Casero, GM Crooks, CS Seet Strength of CAR signaling determines T�cell versus ILC differentiation from pluripotent stem cells Cell Reports, 2023-03-11;42(3):112241. 2023-03-11 [PMID: 36906850] (Bioassay, Human)	Bioassay	Human
AR Dicks, GI Maksaev, Z Harissa, A Savadipour, R Tang, N Steward, W Liedtke, CG Nichols, CL Wu, F Guilak Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes Elife, 2023-02-22;12(0):. 2023-02-22 [PMID: 36810131] (Bioassay, Human)	Bioassay	Human
E Ugur, A de la Port, W Qin, S Bultmann, A Ivanova, M Drukker, M Mann, M Wierer, H Leonhardt Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components Nucleic Acids Research, 2023-04-11;0(0):. 2023-04-11 [PMID: 36806742] (Bioassay, Mouse)	Bioassay	Mouse
EB Choi, M Vodnala, P Saini, S Anugula, M Zerbato, JJ Ho, J Wang, SJ Ho Sui, J Yoon, M Roels, C Inouye, YW Fong Transcription factor SOX15 regulates stem cell pluripotency and promotes neural fate during differentiation by activating the neurogenic gene Hes5 The Journal of Biological Chemistry, 2023-02-09;0(0):102996. 2023-02-09 [PMID: 36764520] (Bioassay, Mouse)	Bioassay	Mouse
A Landshamme, A Bolondi, H Kretzmer, C Much, R Buschow, A Rose, HJ Wu, SD Mackowiak, B Braendl, P Giesselman, R Tornisiell, KM Parsi, J Huey, T Mielke, D Meierhofer, R Maehr, D Hnisz, F Michor, JL Rinn, A Meissner T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation Elife, 2023-01-31;12(0):. 2023-01-31 [PMID: 36719724] (Bioassay, Human)	Bioassay	Human
P Madrigal, S Deng, Y Feng, S Militi, KJ Goh, R Nibhani, R Grandy, A Osnato, D Ortmann, S Brown, S Pauklin Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation Nature Communications, 2023-01-25;14(1):405. 2023-01-25 [PMID: 36697417] (Bioassay, Human)	Bioassay	Human
PP Shah, KC Keough, K Gjoni, GT Santini, RJ Abdill, NM Wickramasi, CE Dundes, A Karnay, A Chen, REA Salomon, PJ Walsh, SC Nguyen, S Whalen, EF Joyce, KM Loh, N Dubois, KS Pollard, R Jain An atlas of lamina-associated chromatin across twelve human cell types reveals an intermediate chromatin subtype Genome Biology, 2023-01-23;24(1):16. 2023-01-23 [PMID: 36691074] (Bioassay, Human)	Bioassay	Human
S Taniguchi, T Matsui, K Kimura, S Funaki, Y Miyamoto, Y Uchida, T Sudo, J Kikuta, T Hara, D Motooka, YC Liu, D Okuzaki, E Morii, N Emoto, Y Shintani, M Ishii In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma Nature Communications, 2023-01-17;14(1):143. 2023-01-17 [PMID: 36650150] (Bioassay, Mouse)	Bioassay	Mouse
Q Liu, Z Liu, H Gu, Y Ge, X Wu, F Zuo, Q Du, Y Lei, Z Wang, H Lin Comparative study of differentiating human pluripotent stem cells into vascular smooth muscle cells in hydrogel-based culture methods Regenerative Therapy, 2022-12-21;22(0):39-49. 2022-12-21 [PMID: 36618488] (Bioassay, Human)	Bioassay	Human
KL Reader, S John-McHaf, S Zellhuber-, T Jowett, DG Mottershea, HE Cunliffe, EJ Gold Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth Cancers, 2022-12-27;15(1):. 2022-12-27 [PMID: 36612143] (Bioassay, Human)	Bioassay	Human
F Chen, X Zhu Activin A Reduces Porcine Granulosa Cells Apoptosis via ERbeta-Dependent ROS Modulation Veterinary sciences, 2022-12-18;9(12):. 2022-12-18 [PMID: 36548865] (Bioassay, Porcine)	Bioassay	Porcine
AJ Stevens, AR Harris, J Gerdts, KH Kim, C Trentesaux, JT Ramirez, WL McKeithan, F Fattahi, OD Klein, DA Fletcher, WA Lim Programming Multicellular Assembly with Synthetic Cell Adhesion Molecules Nature, 2022-12-12;0(0):. 2022-12-12 [PMID: 36509107] (Bioassay, Human)	Bioassay	Human
AJ Stevens, AR Harris, J Gerdts, KH Kim, C Trentesaux, JT Ramirez, WL McKeithan, F Fattahi, OD Klein, DA Fletcher, WA Lim Programming Multicellular Assembly with Synthetic Cell Adhesion Molecules Nature, 2022;0(0):. 2022 [PMID: 36509107] (Bioassay, Human)	Bioassay	Human
TM Triolo, JQ Matuschek, R Castro-Gut, AH Shilleh, SPM Williams, MS Hansen, K McDaniel, JM Barra, A Michels, HA Russ Stem-Cell-Derived beta-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity Cells, 2022-11-30;11(23):. 2022-11-30 [PMID: 36497105] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
Ö Karabiyik, GD Nozhatzade, A Tuncer, G Torun Köse, E Hacihasano, F Sahin, E Aysan Production of parathyroid-like cells from thyroid stem cells in co-culture environment Medicine, 2022-12-02;101(48):e32009. 2022-12-02 [PMID: 36482540] (Bioassay, Human)	Bioassay	Human
D Shang, T Lan, Y Wang, X Li, Q Liu, H Dong, B Xu, H Cheng, R Zhou PGCLCs of human 45,XO reveal pathogenetic pathways of neurocognitive and psychosocial disorders Cell & bioscience, 2022-12-01;12(1):194. 2022-12-01 [PMID: 36457060] (Cell Culture, Human)	Cell Culture	Human
JA Watts, C Grunseich, Y Rodriguez, Y Liu, D Li, JT Burdick, A Bruzel, RJ Crouch, RW Mahley, SH Wilson, VG Cheung A common transcriptional mechanism involving R-loop and RNA abasic site regulates an enhancer RNA of APOE Nucleic Acids Research, 2022-11-28;0(0):. 2022-11-28 [PMID: 36453989] (Bioassay, Human)	Bioassay	Human
AB Menéndez, Z Du, TPP van den Bo, A Othman, N Gaio, C Silvestri, W Quirós, H Lin, S Korevaar, A Merino, J Mulder, MJ Hoogduijn Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system Scientific Reports, 2022-11-30;12(1):20699. 2022-11-30 [PMID: 36450835] (Bioassay, Human)	Bioassay	Human
ESY Ng, N Kady, J Hu, A Dave, Z Jiang, J Pei, MB Gorin, A Matynia, RA Radu Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration Cells, 2022-11-02;11(21):. 2022-11-02 [PMID: 36359858] (Bioassay, Human)	Bioassay	Human
R Lesage, MN Ferrao Bla, R Narcisi, T Welting, GJVM van Osch, L Geris An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis Bmc Biology, 2022-11-09;20(1):253. 2022-11-09 [PMID: 36352408] (Bioassay, Mouse)	Bioassay	Mouse
S Raad, A David, M Sagniez, B Paré, Z Orfi, NA Dumont, MA Smith, C Faure iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage Disease Models & Mechanisms, 2022-11-28;0(0):. 2022-11-28 [PMID: 36317486] (Bioassay, Human)	Bioassay	Human
YS Yang, JM Kim, J Xie, S Chaugule, C Lin, H Ma, E Hsiao, J Hong, H Chun, EM Shore, FS Kaplan, G Gao, JH Shim Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery Oncogene, 2022-10-19;13(1):6175. 2022-10-19 [PMID: 36258013] (Bioassay, Human)	Bioassay	Human
Y Han, L Tan, T Zhou, L Yang, L Carrau, LA Lacko, M Saeed, J Zhu, Z Zhao, BE Nilsson-Pa, FT Lira Neto, C Cahir, AM Giani, JC Chai, Y Li, X Dong, D Moroziewic, NYSCF Glob, D Paull, T Zhang, S Koo, C Tan, R Danziger, Q Ba, L Feng, Z Chen, A Zhong, GJ Wise, JZ Xiang, H Wang, RE Schwartz, BR tenOever, SA Noggle, CM Rice, Q Qi, T Evans, S Chen A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants Cell Stem Cell, 2022-10-06;29(10):1475-1490.e6. 2022-10-06 [PMID: 36206731] (Bioassay, Human)	Bioassay	Human
A Beucher, I Miguel-Esc, D Balboa, MG De Vas, MA Maestro, J Garcia-Hur, A Bernal, R Gonzalez-F, P Vargiu, H Heyn, P Ravassard, S Ortega, J Ferrer The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A Nature Cell Biology, 2022-10-06;0(0):. 2022-10-06 [PMID: 36202974] (Bioassay, Human)	Bioassay	Human
Z Wang, R Fan, A Russo, FM Cernilogar, A Nuber, S Schirge, I Shcherbako, I Dzhilyanov, E Ugur, T Anton, L Richter, H Leonhardt, H Lickert, G Schotta Dominant role of DNA methylation over H3K9me3 for IAP silencing in endoderm Nature Communications, 2022-09-19;13(1):5447. 2022-09-19 [PMID: 36123357] (Bioassay, Mouse)	Bioassay	Mouse
D Yang, J Gomez-Garc, S Funakoshi, T Tran, I Fernandes, GD Bader, MA Laflamme, GM Keller Modeling human multi-lineage heart field development with pluripotent stem cells Cell Stem Cell, 2022-09-01;29(9):1382-1401.e8. 2022-09-01 [PMID: 36055193] (Bioassay, Human)	Bioassay	Human
A Rössig, K Hill, W Nörenberg, S Weidenbach, S Zierler, M Schaefer, T Gudermann, V Chubanov Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7 Cell Calcium, 2022-08-17;106(0):102640. 2022-08-17 [PMID: 36030694] (Cell Culture, Human)	Cell Culture	Human
SH Kim, M Lee, KH Choi, J Jeong, DK Lee, JN Oh, GC Choe, CK Lee Species-Specific Enhancer Activity of OCT4 in Porcine Pluripotency: The Porcine OCT4 Reporter System Could Monitor Pluripotency in Porcine Embryo Development and Embryonic Stem Cells Stem Cells International, 2022-06-11;2022(0):6337532. 2022-06-11 [PMID: 35846983] (Bioassay, Porcine)	Bioassay	Porcine
D Ávila-Gonz, W Portillo, CP Barragán-Á, G Hernandez-, E Flores-Gar, A Molina-Her, NE Díaz-Martí, NF Díaz The human amniotic epithelium confers a bias to differentiate toward the neuroectoderm lineage in human embryonic stem cells Elife, 2022-07-11;11(0):. 2022-07-11 [PMID: 35815953] (Bioassay, Human)	Bioassay	Human
S Pulcrano, R De Gregori, C De Sanctis, L Lahti, C Perrone-Ca, D Ponti, U di Porzio, T Perlmann, M Caiazzo, F Volpicelli, GC Bellenchi Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation International Journal of Molecular Sciences, 2022-06-23;23(13):. 2022-06-23 [PMID: 35805964] (Bioassay, Mouse)	Bioassay	Mouse
K Tan, MF Wilkinson Regulation of both transcription and RNA turnover contribute to germline specification Oncogene, 2022-07-22;0(0):. 2022-07-22 [PMID: 35776114] (Bioassay, Mouse)	Bioassay	Mouse
Y Tsujisaka, T Hatani, C Okubo, R Ito, A Kimura, M Narita, K Chonabayas, S Funakoshi, A Lucena-Cac, T Toyoda, K Osafune, T Kimura, H Saito, Y Yoshida Purification of human iPSC-derived cells at large scale using microRNA switch and magnetic-activated cell sorting Stem Cell Reports, 2022-06-09;0(0):. 2022-06-09 [PMID: 35688152] (Bioassay, Human)	Bioassay	Human
DL Marvin, L You, L Bornes, M van Dinthe, N Peters, H Dang, SK Hakuno, M Hornsveld, O Kranenburg, J van Rheene, JHT Rohling, MP Chien, P Ten Dijke, L Ritsma Dynamic Visualization of TGF-beta/SMAD3 Transcriptional Responses in Single Living Cells Cancers, 2022-05-19;14(10):. 2022-05-19 [PMID: 35626109] (Bioassay, Mouse)	Bioassay	Mouse
H Kadokawa, R Yoshino, R Saito, T Hirokawa Chemosynthetic ethanolamine plasmalogen stimulates gonadotropin secretion from bovine gonadotrophs by acting as a potential GPR61 agonist Animal reproduction science, 2022-05-13;241(0):106992. 2022-05-13 [PMID: 35580407] (Bioassay, Bovine)	Bioassay	Bovine
AK Nair, M Traurig, JR Sutherland, YL Muller, ED Grellinger, L Saporito, RG Nelson, C Bogardus, LJ Baier Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians Cells, 2022-04-25;11(9):. 2022-04-25 [PMID: 35563754] (Bioassay, Human)	Bioassay	Human
MK Samanta, S Gayen, C Harris, E Maclary, Y Murata-Nak, RM Malcore, RS Porter, PM Garay, CN Vallianato, PB Samollow, S Iwase, S Kalantry Activation of Xist by an evolutionarily conserved function of KDM5C demethylase Nature Communications, 2022-05-11;13(1):2602. 2022-05-11 [PMID: 35545632] (Bioassay, Mouse)	Bioassay	Mouse
WS Fagg, N Liu, U Braunschwe, KL Pereira de, X Chen, FS Ditmars, SG Widen, JP Donohue, K Modis, WK Russell, JH Fair, MT Weirauch, BJ Blencowe, MA Garcia-Bla Definition of germ layer cell lineage alternative splicing programs reveals a critical role for Quaking in specifying cardiac cell fate Nucleic Acids Research, 2022-05-20;50(9):5313-5334. 2022-05-20 [PMID: 35544276] (Bioassay, Human)	Bioassay	Human
M Cloutier, S Kumar, E Buttigieg, L Keller, B Lee, A Williams, S Mojica-Per, I Erliandri, AMD Rocha, K Cadigan, GD Smith, S Kalantry Preventing erosion of X-chromosome inactivation in human embryonic stem cells Nature Communications, 2022-05-06;13(1):2516. 2022-05-06 [PMID: 35523820] (Bioassay, Mouse)	Bioassay	Mouse
SA Luff, JP Creamer, S Valsoni, C Dege, R Scarfò, A Dacunto, S Cascione, LN Randolph, E Cavalca, I Merelli, SA Morris, A Ditadi, CM Sturgeon Identification of a retinoic acid-dependent haemogenic endothelial progenitor from human pluripotent stem cells Nature Cell Biology, 2022-04-28;0(0):. 2022-04-28 [PMID: 35484246] (Bioassay, Human)	Bioassay	Human
H Kojima, H Yagi, H Kushige, Y Toda, K Takayama, S Masuda, T Morisaku, T Tsuchida, K Kuroda, K Hirukawa, J Inui, K Nishi, Y Nakano, M Tanaka, S Hori, Y Hasegawa, Y Abe, M Kitago, S Adachi, M Tomi, K Matsuura, H Mizuguchi, Y Kitagawa Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes Cells, 2022-04-07;11(8):. 2022-04-07 [PMID: 35455938] (Bioassay, Human)	Bioassay	Human
J Li, X Liu, Q Yang, J Huang, W Zhou, Z Tan, Z Li, D Zhou The effect of docetaxel on retinal pigment epithelial cells Toxicology reports, 2022-03-22;9(0):670-678. 2022-03-22 [PMID: 35433274] (Bioassay, Human)	Bioassay	Human
V Calvanese, S Capellera-, F Ma, I Fares, S Liebscher, ES Ng, S Ekstrand, J Aguadé-Gor, A Vavilina, D Lefaudeux, B Nadel, JY Li, Y Wang, LK Lee, R Ardehali, ML Iruela-Ari, M Pellegrini, EG Stanley, AG Elefanty, K Schenke-La, HKA Mikkola Mapping human haematopoietic stem cells from haemogenic endothelium to birth Nature, 2022-04-13;604(7906):534-540. 2022-04-13 [PMID: 35418685] (Bioassay, Human)	Bioassay	Human
BK Gage, S Merlin, C Olgasi, A Follenzi, GM Keller Therapeutic correction of hemophilia A by transplantation of hPSC-derived liver sinusoidal endothelial cell progenitors Cell Reports, 2022-04-05;39(1):110621. 2022-04-05 [PMID: 35385743] (Bioassay, Human)	Bioassay	Human
CL Jiang, Y Goyal, N Jain, Q Wang, RE Truitt, AJ Coté, B Emert, IA Mellis, K Kiani, W Yang, R Jain, A Raj Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells Genome Biology, 2022-04-05;23(1):90. 2022-04-05 [PMID: 35382863] (Cell Culture, Human)	Cell Culture	Human
S Kim, S Min, YS Choi, SH Jo, JH Jung, K Han, J Kim, S An, YW Ji, YG Kim, SW Cho Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids Nature Communications, 2022-03-30;13(1):1692. 2022-03-30 [PMID: 35354790] (Bioassay, Human)	Bioassay	Human
Y Zhu, LGPL Prata, EOW Gerdes, JME Netto, T Pirtskhala, N Giorgadze, U Tripathi, CL Inman, KO Johnson, A Xue, AK Palmer, T Chen, K Schaefer, JN Justice, AM Nambiar, N Musi, SB Kritchevsk, J Chen, S Khosla, D Jurk, MJ Schafer, T Tchkonia, JL Kirkland Orally-active, clinically-translatable senolytics restore alpha-Klotho in mice and humans EBioMedicine, 2022-03-13;0(0):103912. 2022-03-13 [PMID: 35292270] (Cell Culture, Human)	Cell Culture	Human
Z Wang, HP McWilliams, H Reza, JR Ostberg, W Chen, X Wang, C Huynh, V Vyas, WC Chang, R Starr, JR Wagner, B Aguilar, X Yang, X Wu, J Wang, W Chen, E Koelker-Wo, CS Seet, A Montel-Hag, GM Crooks, SJ Forman, CE Brown 3D-organoid culture supports differentiation of human CAR+ iPSCs into highly functional CAR T�cells Cell Stem Cell, 2022-03-11;0(0):. 2022-03-11 [PMID: 35278370] (Bioassay, Human)	Bioassay	Human
H Kim, BW Song, SJ Park, SW Choi, H Moon, KC Hwang, SW Kang, SH Moon, Y Yang, IC Kwon, SH Kim Ultraefficient extracellular vesicle-guided direct reprogramming of fibroblasts into functional cardiomyocytes Science Advances, 2022-02-25;8(8):eabj6621. 2022-02-25 [PMID: 35213232] (Bioassay, Mouse)	Bioassay	Mouse
HY Kim, JM Seok, SY Jung, MJ Lee, AN Tran, SJ Yeo, SA Park, HS Kim Development of Surgically Transplantable Parathyroid Hormone-Releasing Microbeads Biomedicines, 2022-02-14;10(2):. 2022-02-14 [PMID: 35203648] (Bioassay, Human)	Bioassay	Human
MM Capeling, S Huang, CJ Childs, JH Wu, YH Tsai, A Wu, N Garg, EM Holloway, N Sundaram, C Bouffi, M Helmrath, JR Spence Suspension culture promotes serosal mesothelial development in human intestinal organoids Cell Reports, 2022-02-15;38(7):110379. 2022-02-15 [PMID: 35172130] (Bioassay, Human)	Bioassay	Human
K Zhao, Y Shi, J Yu, L Yu, A Mael, Y Li, A Kolton, T Joyce, J Odorico, PO Berggren, SN Yang Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells Cell Transplantation, 2022-01-01;31(0):9636897211066. 2022-01-01 [PMID: 35156411] (Bioassay, Human)	Bioassay	Human
XJ Li, C Morgan, LA Goff, A Doetzlhofe Follistatin promotes LIN28B-mediated supporting cell reprogramming and hair cell regeneration in the murine cochlea Science Advances, 2022-02-11;8(6):eabj7651. 2022-02-11 [PMID: 35148175] (Bioassay, Mouse)	Bioassay	Mouse
C Raggi, MA M'Callum, QT Pham, P Gaub, S Selleri, NV Baratang, CL Mangahas, G Cagnone, B Reversade, JS Joyal, M Paganelli Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes Stem Cell Reports, 2022-02-03;0(0):. 2022-02-03 [PMID: 35120625] (Bioassay, Human)	Bioassay	Human
T Tada, H Ohnishi, N Yamamoto, F Kuwata, Y Hayashi, H Okuyama, T Morino, Y Kasai, H Kojima, K Omori Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats Regenerative Therapy, 2022-01-14;19(0):77-87. 2022-01-14 [PMID: 35097166] (Bioassay, Human)	Bioassay	Human
JY Kim, S Park, SY Oh, YH Nam, YM Choi, Y Choi, HY Kim, SY Jung, HS Kim, I Jo, SC Jung Density-Dependent Differentiation of Tonsil-Derived Mesenchymal Stem Cells into Parathyroid-Hormone-Releasing Cells International Journal of Molecular Sciences, 2022-01-10;23(2):. 2022-01-10 [PMID: 35054901] (Bioassay, Human)	Bioassay	Human
HQ Xian, C Blanco, K Bonham, HR Snodgrass Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes Toxicology and Applied Pharmacology, 2022-01-15;437(0):115886. 2022-01-15 [PMID: 35041852] (Bioassay, Human)	Bioassay	Human
X Hu, H Wang, GG Tian, C Hou, B Xu, X Zhao, Y Zhao, Q Fang, X Li, L He, X Chen, S Li, J Wu Offspring production of haploid spermatid-like cells derived from mouse female germline stem cells with chromatin condensation Cell & bioscience, 2022-01-04;12(1):5. 2022-01-04 [PMID: 34983631] (Bioassay, Mouse)	Bioassay	Mouse
S Xia, Z Bozóky, M Di Paola, O Laselva, S Ahmadi, JX Jiang, AL Pitstick, C Jiang, D Rotin, CN Mayhew, NL Jones, CE Bear High-Throughput Functional Analysis of CFTR and Other Apically Localized Proteins in iPSC-Derived Human Intestinal Organoids Cells, 2021-12-04;10(12):. 2021-12-04 [PMID: 34943927] (Bioassay, Human)	Bioassay	Human
R Sharma, A George, M Nimmagadda, D Ortolan, BS Karla, Z Qureshy, D Bose, R Dejene, G Liang, Q Wan, J Chang, BS Jha, O Memon, KJ Miyagishim, A Rising, M Lal, E Hanson, R King, MM Campos, M Ferrer, J Amaral, D McGaughey, K Bharti Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model Nature Communications, 2021-12-15;12(1):7293. 2021-12-15 [PMID: 34911940] (Bioassay, Human)	Bioassay	Human
V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage Cell Reports, 2021-12-14;37(11):110068. 2021-12-14 [PMID: 34910915] (Bioassay, Human)	Bioassay	Human
E Brûlé, Y Wang, Y Li, YF Lin, X Zhou, L Ongaro, CAI Alonso, ERS Buddle, AL Schneyer, CH Byeon, CS Hinck, N Mendelev, JP Russell, M Cowan, U Boehm, F Ruf-Zamojs, M Zamojski, CL Andoniadou, SC Sealfon, CA Harrison, KL Walton, AP Hinck, DJ Bernard TGFBR3L is an inhibin B co-receptor that regulates female fertility Science Advances, 2021-12-15;7(51):eabl4391. 2021-12-15 [PMID: 34910520] (Bioassay, Hamster)	Bioassay	Hamster
Y Lan, KM Banks, H Pan, N Verma, GR Dixon, T Zhou, B Ding, O Elemento, S Chen, D Huangfu, T Evans Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation Cell Reports, 2021-12-07;37(10):110095. 2021-12-07 [PMID: 34879277] (Bioassay, Human)	Bioassay	Human
F Xu, C Deng, Z Ren, L Sun, Y Meng, W Liu, J Wan, G Chen Lysophosphatidic acid shifts metabolic and transcriptional landscapes to induce a distinct cellular state in human pluripotent stem cells Cell Reports, 2021-11-30;37(9):110063. 2021-11-30 [PMID: 34852227] (Bioassay, Human)	Bioassay	Human
R Ungricht, L Guibbal, MC Lasbennes, V Orsini, M Beibel, A Waldt, R Cuttat, W Carbone, A Basler, G Roma, F Nigsch, JS Tchorz, D Hoepfner, PS Hoppe Genome-wide screening in human kidney organoids identifies developmental and disease-related aspects of nephrogenesis Cell Stem Cell, 2021-11-29;0(0):. 2021-11-29 [PMID: 34847364] (Bioassay, Human)	Bioassay	Human
AF de Souza, FF Bressan, NCG Pieri, RC Botigelli, T Revay, SK Haddad, DT Covas, ES Ramos, WA King, FV Meirelles Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients Cells, 2021-11-10;10(11):. 2021-11-10 [PMID: 34831322] (Bioassay, Human)	Bioassay	Human
C Gil-Recio, S Montori, S Al Demour, MA Ababneh, E Ferrés-Pad, C Marti, E Ferrés-Ama, M Barajas, A Al Madhoun, M Atari Chemically Defined Conditions Mediate an Efficient Induction of Dental Pulp Pluripotent-Like Stem Cells into Hepatocyte-Like Cells Stem Cells International, 2021-11-08;2021(0):5212852. 2021-11-08 [PMID: 34795766] (Bioassay, Human)	Bioassay	Human
RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors Nature Communications, 2021-11-17;12(1):6636. 2021-11-17 [PMID: 34789735] (Bioassay, Human)	Bioassay	Human
JOR Hernandez, X Wang, M Vazquez-Se, M Lopez-Marf, MF Sobral-Rey, A Moran-Horo, M Sundberg, DO Lopez-Cant, CK Probst, GU Ruiz-Espar, K Giannikou, R Abdi, EP Henske, DJ Kwiatkowsk, M Sahin, DR Lemos A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo Nature Communications, 2021-11-11;12(1):6496. 2021-11-11 [PMID: 34764250] (Bioassay, Human)	Bioassay	Human
JR Valcourt, RE Huang, S Kundu, D Venkatasub, RE Kingston, S Ramanathan Modulating mesendoderm competence during human germ layer differentiation Cell Reports, 2021-11-09;37(6):109990. 2021-11-09 [PMID: 34758327] (Bioassay, Human)	Bioassay	Human
C Schaniel, P Dhanan, B Hu, Y Xiong, T Raghunanda, DM Gonzalez, R Dariolli, SL D'Souza, AS Yadaw, J Hansen, G Jayaraman, B Mathew, M Machado, SI Berger, J Tripodig, V Najfeld, J Garg, M Miller, CS Surlyn, KC Michelis, NC Tangirala, H Weerahandi, DC Thomas, KG Beaumont, R Sebra, M Mahajan, E Schadt, D Vidovic, SC Schürer, J Goldfarb, EU Azeloglu, MR Birtwistle, EA Sobie, JC Kovacic, NC Dubois, R Iyengar A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals Stem Cell Reports, 2021-11-04;0(0):. 2021-11-04 [PMID: 34739849] (Bioassay, Human)	Bioassay	Human
X Duan, X Tang, MS Nair, T Zhang, Y Qiu, W Zhang, P Wang, Y Huang, J Xiang, H Wang, RE Schwartz, DD Ho, T Evans, S Chen An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection Cell Reports, 2021-10-15;37(6):109920. 2021-10-15 [PMID: 34731648] (Bioassay, Human)	Bioassay	Human
MNT Le, M Takahi, K Ohnuma Auto/paracrine factors and early Wnt inhibition promote cardiomyocyte differentiation from human induced pluripotent stem cells at initial low cell density Scientific Reports, 2021-11-02;11(1):21426. 2021-11-02 [PMID: 34728657] (Bioassay, Human)	Bioassay	Human
N Hosaka, S Kanda, T Shimono, T Nishiyama Induction of gammadeltaT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells Journal of Cellular and Molecular Medicine, 2021-10-23;0(0):. 2021-10-23 [PMID: 34687276] (Cell Culture, Mouse)	Cell Culture	Mouse
J Lim, E Sakai, F Sakurai, H Mizuguchi miR-27b antagonizes BMP signaling in early differentiation of human induced pluripotent stem cells Scientific Reports, 2021-10-06;11(1):19820. 2021-10-06 [PMID: 34615950] (Bioassay, Human)	Bioassay	Human
Y Aghazadeh, F Poon, F Sarangi, FTM Wong, ST Khan, X Sun, R Hatkar, BJ Cox, SS Nunes, MC Nostro Microvessels support engraftment and functionality of human islets and hESC-derived pancreatic progenitors in diabetes models Cell Stem Cell, 2021-09-03;0(0):. 2021-09-03 [PMID: 34480863] (Bioassay, Human)	Bioassay	Human
M Wei, J Zhang, J Liu, C Zhao, S Cao, X Yan, B Wu, S Bao Derivation of Mouse Parthenogenetic Advanced Stem Cells International Journal of Molecular Sciences, 2021-08-20;22(16):. 2021-08-20 [PMID: 34445681] (Bioassay, Mouse)	Bioassay	Mouse
M Martin-Ina, M Ferreira, J Taelman, C Eguizabal, SM Chuva De S Improving In Vitro Culture of Human Male Fetal Germ Cells Cells, 2021-08-09;10(8):. 2021-08-09 [PMID: 34440801] (Bioassay, Human)	Bioassay	Human
AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection Cell Reports, 2021-08-17;36(7):109538. 2021-08-17 [PMID: 34407395] (Bioassay, Human)	Bioassay	Human
NJ Hogrebe, KG Maxwell, P Augsornwor, JR Millman Generation of insulin-producing pancreatic beta cells from multiple human stem cell lines Nature Protocols, 2021-08-04;0(0):. 2021-08-04 [PMID: 34349281] (Bioassay, Human)	Bioassay	Human
T Grancharov, KA Gerbin, AB Rosenberg, CM Roco, JE Arakaki, CM DeLizo, SQ Dinh, RM Donovan-Ma, M Hirano, AM Nelson, J Tang, JA Theriot, C Yan, V Menon, SP Palecek, G Seelig, RN Gunawardan A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes Scientific Reports, 2021-08-04;11(1):15845. 2021-08-04 [PMID: 34349150] (Bioassay, Human)	Bioassay	Human
MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells Nature Communications, 2021-07-23;12(1):4492. 2021-07-23 [PMID: 34301945] (Bioassay, Human)	Bioassay	Human
K Sattler, I El-Battraw, L Cyganek, S Lang, H Lan, X Li, Z Zhao, J Utikal, T Wieland, M Borggrefe, X Zhou, I Akin TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes Scientific Reports, 2021-07-19;11(1):14689. 2021-07-19 [PMID: 34282193] (Bioassay, Human)	Bioassay	Human
EJ Grow, BD Weaver, CM Smith, J Guo, P Stein, SC Shadle, PG Hendrickso, NE Johnson, RJ Butterfiel, R Menafra, SL Kloet, SM van der Ma, CJ Williams, BR Cairns p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models Nature Genetics, 2021-07-15;0(0):. 2021-07-15 [PMID: 34267371] (Bioassay, Mouse)	Bioassay	Mouse
H Iseoka, S Miyagawa, Y Sakai, Y Sawa Cardiac fibrosis models using human induced pluripotent stem cell-derived cardiac tissues allow anti-fibrotic drug screening in vitro Stem Cell Research, 2021-06-11;54(0):102420. 2021-06-11 [PMID: 34126557] (Bioassay, Human)	Bioassay	Human
O Kwon, KB Jung, KR Lee, YS Son, H Lee, JJ Kim, K Kim, S Lee, YK Song, J Jung, K Park, DS Kim, MJ Son, MO Lee, TS Han, HS Cho, SJ Oh, H Chung, SH Kim, KS Chung, J Kim, CR Jung, MY Son The development of a functional human small intestinal epithelium model for drug absorption Science Advances, 2021-06-02;7(23):. 2021-06-02 [PMID: 34078609] (Bioassay, Human)	Bioassay	Human
S Mishra, J Taelman, YW Chang, A Boel, P De Sutter, B Heindryckx, SM Chuva De S Sex-Specific Isolation and Propagation of Human Premeiotic Fetal Germ Cells and Germ Cell-Like Cells Cells, 2021-05-16;10(5):. 2021-05-16 [PMID: 34065661] (Cell Culture, Human)	Cell Culture	Human
E Zahmatkesh, MH Ghanian, I Zarkesh, Z Farzaneh, M Halvaei, Z Heydari, F Moeinvazir, A Othman, M Ruo beta , A Piryaei, R Gramignoli, S Yakhkeshi, A Nüssler, M Najimi, H Baharvand, M Vosough Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes Cells, 2021-05-21;10(6):. 2021-05-21 [PMID: 34063948] (Bioassay, Human)	Bioassay	Human
DA Soto, M Navarro, C Zheng, MM Halstead, C Zhou, C Guiltinan, J Wu, PJ Ross Simplification of culture conditions and feeder-free expansion of bovine embryonic stem cells Scientific Reports, 2021-05-26;11(1):11045. 2021-05-26 [PMID: 34040070] (Bioassay, Bovine)	Bioassay	Bovine
S Funakoshi, I Fernandes, O Mastikhina, D Wilkinson, T Tran, W Dhahri, A Mazine, D Yang, B Burnett, J Lee, S Protze, GD Bader, SS Nunes, M Laflamme, G Keller Generation of mature compact ventricular cardiomyocytes from human pluripotent stem cells Nature Communications, 2021-05-26;12(1):3155. 2021-05-26 [PMID: 34039977] (Bioassay, Human)	Bioassay	Human
M Huang, Z Liao, X Li, Z Yang, X Fan, Y Li, Z Zhao, S Lang, L Cyganek, X Zhou, I Akin, M Borggrefe, I El-Battraw Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1 Frontiers in Pharmacology, 2021-05-07;12(0):675003. 2021-05-07 [PMID: 34025432] (Bioassay, Human)	Bioassay	Human
F Ruf-Zamojs, Z Zhang, M Zamojski, GR Smith, N Mendelev, H Liu, G Nudelman, M Moriwaki, H Pincas, RG Castanon, VD Nair, N Seenarine, MAS Amper, X Zhou, L Ongaro, C Toufaily, G Schang, JR Nery, A Bartlett, A Aldridge, N Jain, GV Childs, OG Troyanskay, JR Ecker, JL Turgeon, CK Welt, DJ Bernard, SC Sealfon Single nucleus multi-omics regulatory landscape of the murine pituitary Nature Communications, 2021-05-11;12(1):2677. 2021-05-11 [PMID: 33976139] (Bioassay, Mouse)	Bioassay	Mouse
Y Yamamura, K Furuichi, Y Murakawa, S Hirabayash, M Yoshihara, K Sako, S Kitajima, T Toyama, Y Iwata, N Sakai, K Hosomichi, PM Murphy, A Tajima, K Okita, K Osafune, S Kaneko, T Wada Identification of candidate PAX2-regulated genes implicated in human kidney development Scientific Reports, 2021-04-27;11(1):9123. 2021-04-27 [PMID: 33907292] (Bioassay, Human)	Bioassay	Human
G Mancinelli, C Torres, N Krett, J Bauer, K Castellano, R McKinney, D Dawson, G Guzman, R Hwang, S Grimaldo, P Grippo, B Jung Role of stromal activin A in human pancreatic cancer and metastasis in mice Scientific Reports, 2021-04-12;11(1):7986. 2021-04-12 [PMID: 33846512] (Bioassay, Human)	Bioassay	Human
S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima Capturing human trophoblast development with naive pluripotent stem cells in�vitro Cell Stem Cell, 2021-04-07;28(6):1023-1039.e13. 2021-04-07 [PMID: 33831365] (Bioassay, Human)	Bioassay	Human
M Chiara Per, N Bellitto, ERS Maylem, F Caloni, LJ Spicer Effects of selected hormones and their combination on progesterone and estradiol production and proliferation of feline granulosa cells cultured in�vitro Theriogenology, 2021-03-28;168(0):1-12. 2021-03-28 [PMID: 33826978] (Bioassay, Feline)	Bioassay	Feline
CS Lee, HJ Cho, JW Lee, H Son, J Chai, HS Kim Adhesion GPCR Latrophilin-2 Specifies Cardiac Lineage Commitment through CDK5, Src, and P38MAPK Stem Cell Reports, 2021-04-01;0(0):. 2021-04-01 [PMID: 33798451] (Bioassay, Human)	Bioassay	Human
L Preisler, A Habib, G Shapira, L Kuznitsov-, Y Mayshar, I Carmel-Gro, M Malcov, F Azem, N Shomron, R Kariv, D Hershkovit, D Ben-Yosef Heterozygous APC germline mutations impart predisposition to colorectal cancer Scientific Reports, 2021-03-04;11(1):5113. 2021-03-04 [PMID: 33664379] (Bioassay, Human)	Bioassay	Human
AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D Nature Protocols, 2021-03-01;0(0):. 2021-03-01 [PMID: 33649566] (Bioassay, Human)	Bioassay	Human
H Kadokawa, M Kotaniguch, O Kereilwe, S Kitamura Reduced gonadotroph stimulation by ethanolamine plasmalogens in old bovine brains Scientific Reports, 2021-02-26;11(1):4757. 2021-02-26 [PMID: 33637828] (Bioassay, Bovine)	Bioassay	Bovine
N Katagiri, H Hitomi, SI Mae, M Kotaka, L Lei, T Yamamoto, A Nishiyama, K Osafune Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells Scientific Reports, 2021-02-16;11(1):3936. 2021-02-16 [PMID: 33594180] (Bioassay, Human)	Bioassay	Human
A Mischler, V Karakis, J Mahinthaku, CK Carberry, A San Miguel, JE Rager, RC Fry, BM Rao Two distinct trophectoderm lineage stem cells from human pluripotent stem cells The Journal of Biological Chemistry, 2021-02-05;0(0):100386. 2021-02-05 [PMID: 33556374] (Bioassay, Human)	Bioassay	Human
PP Shah, W Lv, JH Rhoades, A Poleshko, D Abbey, MA Caporizzo, R Linares-Sa, JG Heffler, N Sayed, D Thomas, Q Wang, LJ Stanton, K Bedi, MP Morley, TP Cappola, AT Owens, KB Margulies, DB Frank, JC Wu, DJ Rader, W Yang, BL Prosser, K Musunuru, R Jain Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes Cell Stem Cell, 2021-02-01;0(0):. 2021-02-01 [PMID: 33529599] (Bioassay, Human)	Bioassay	Human
Q Yan, Y Zhang, X Fang, B Liu, TL Wong, L Gong, S Liu, D Yu, M Liu, L Jiang, X Wang, T Wei, Y Jia, L Li, L Sun, Y Tang, N Zhou, YF Yuan, Y Li, S Ma, XY Guan PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors Cell Death and Differentiation, 2021-01-26;0(0):. 2021-01-26 [PMID: 33500560] (Bioassay, Human)	Bioassay	Human
CL Wu, A Dicks, N Steward, R Tang, DB Katz, YR Choi, F Guilak Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis Nature Communications, 2021-01-13;12(1):362. 2021-01-13 [PMID: 33441552] (Bioassay, Human)	Bioassay	Human
M Souidi, Y Sleiman, I Acimovic, J Pribyl, A Charrabi, V Baecker, V Scheuerman, M Pesl, S Jelinkova, P Skladal, P Dvorak, A Lacampagne, V Rotrekl, AC Meli Oxygen Is an Ambivalent Factor for the Differentiation of Human Pluripotent Stem Cells in Cardiac 2D Monolayer and 3D Cardiac Spheroids International Journal of Molecular Sciences, 2021-01-11;22(2):. 2021-01-11 [PMID: 33440843] (Bioassay, Human)	Bioassay	Human
LTG Harland, CS Simon, AD Senft, I Costello, L Greder, I Imaz-Rossh, B Göttgens, JC Marioni, EK Bikoff, C Porcher, MFTR de Bruijn, EJ Robertson The T-box transcription factor Eomesodermin governs haemogenic competence of yolk sac mesodermal progenitors Nature Cell Biology, 2021-01-08;23(1):61-74. 2021-01-08 [PMID: 33420489] (Bioassay, Mouse)	Bioassay	Mouse
H Fang, S Geng, M Hao, Q Chen, M Liu, C Liu, Z Tian, C Wang, T Takebe, JL Guan, Y Chen, Z Guo, W He, J Diao Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells Nature Communications, 2021-01-04;12(1):109. 2021-01-04 [PMID: 33397937] (Bioassay, Human)	Bioassay	Human
S Barbeau, R Desprat, B Eymard, C Martinat, JM Lemaitre, C Legay Generation of a human induced pluripotent stem cell line (iPSC) from peripheral blood mononuclear cells of a patient with a myasthenic syndrome due to mutation in COLQ Stem Cell Research, 2020-12-02;49(0):102106. 2020-12-02 [PMID: 33370874] (Bioassay, Human)	Bioassay	Human
K Uchimura, H Wu, Y Yoshimura, BD Humphreys Human Pluripotent Stem Cell-Derived Kidney Organoids with Improved Collecting Duct Maturation and Injury Modeling Cell Reports, 2020-12-15;33(11):108514. 2020-12-15 [PMID: 33326782] (Bioassay, Human)	Bioassay	Human
Y Zheng, Y Shao, J Fu A microfluidics-based stem cell model of early post-implantation human development Nature Protocols, 2020-12-11;0(0):. 2020-12-11 [PMID: 33311712] (Bioassay, Human)	Bioassay	Human
F Michielin, GG Giobbe, C Luni, Q Hu, I Maroni, MR Orford, A Manfredi, L Di Filippo, AL David, D Cacchiarel, P De Coppi, S Eaton, N Elvassore The Microfluidic Environment Reveals a Hidden Role of Self-Organizing Extracellular Matrix in Hepatic Commitment and Organoid Formation of hiPSCs Cell Rep, 2020-12-01;33(9):108453. 2020-12-01 [PMID: 33264615] (Bioassay, Human)	Bioassay	Human
A Hagg, S Kharoud, G Goodchild, CA Goodman, JL Chen, RE Thomson, H Qian, P Gregorevic, CA Harrison, KL Walton TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass Front Physiol, 2020-11-04;11(0):560225. 2020-11-04 [PMID: 33250771] (Bioassay, Human)	Bioassay	Human
L Jiang, B Liu, Y Qi, L Zhu, X Cui, Z Liu Antagonistic effects of activin A and TNF-&alpha on the activation of L929 fibroblast cells via Smad3-independent signaling Sci Rep, 2020-11-26;10(1):20623. 2020-11-26 [PMID: 33244088] (Cell Culture, Mouse)	Cell Culture	Mouse
CB Mulholland, A Nishiyama, J Ryan, R Nakamura, M Yi?it, IM Glück, C Trummer, W Qin, MD Bartoschek, FR Traube, E Parsa, E Ugur, M Modic, A Acharya, P Stolz, C Ziegenhain, M Wierer, W Enard, T Carell, DC Lamb, H Takeda, M Nakanishi, S Bultmann, H Leonhardt Recent evolution of a TET-controlled and DPPA3/STELLA-driven pathway of passive DNA demethylation in mammals Nature Communications, 2020-11-24;11(1):5972. 2020-11-24 [PMID: 33235224] (Cell Culture, Mouse)	Cell Culture	Mouse
RM Samuel, H Majd, MN Richter, Z Ghazizadeh, SM Zekavat, A Navickas, JT Ramirez, H Asgharian, CR Simoneau, LR Bonser, KD Koh, M Garcia-Kni, M Tassetto, S Sunshine, S Farahvashi, A Kalantari, W Liu, R Andino, H Zhao, P Natarajan, DJ Erle, M Ott, H Goodarzi, F Fattahi Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men Cell Stem Cell, 2020-11-17;27(6):876-889.e12. 2020-11-17 [PMID: 33232663] (Bioassay, Human)	Bioassay	Human
M Gartz, CW Lin, MA Sussman, MW Lawlor, JL Strande Duchenne muscular dystrophy (DMD) cardiomyocyte-secreted exosomes promote the pathogenesis of DMD-associated cardiomyopathy Dis Model Mech, 2020-11-13;13(11):. 2020-11-13 [PMID: 33188007] (Cell Culture, Human)	Cell Culture	Human
P Mandal, D De, DU Im, SH Um, KK Kim Exosome-Mediated Differentiation of Mouse Embryonic Fibroblasts and Exocrine Cells into &beta-Like Cells and the Identification of Key miRNAs for Differentiation Biomedicines, 2020-11-09;8(11):. 2020-11-09 [PMID: 33182285] (Bioassay, Mouse)	Bioassay	Mouse
YS Hwang, S Suzuki, Y Seita, J Ito, Y Sakata, H Aso, K Sato, BP Hermann, K Sasaki Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells Nat Commun, 2020-11-09;11(1):5656. 2020-11-09 [PMID: 33168808] (Cell Culture, Human)	Cell Culture	Human
H Fukushima, M Yoshioka, M Kawatou, V López-Dávi, M Takeda, Y Kanda, Y Sekino, Y Yoshida, JK Yamashita Specific induction and long-term maintenance of high purity ventricular cardiomyocytes from human induced pluripotent stem cells PLoS ONE, 2020-11-02;15(11):e0241287. 2020-11-02 [PMID: 33137106] (Bioassay, Human)	Bioassay	Human
H Hwang, R Liu, JT Maxwell, J Yang, C Xu Machine learning identifies abnormal Ca2+ transients in human induced pluripotent stem cell-derived cardiomyocytes Sci Rep, 2020-10-12;10(1):16977. 2020-10-12 [PMID: 33046816] (Bioassay, Human)	Bioassay	Human
EI Crosse, S Gordon-Key, S Rybtsov, A Binagui-Ca, H Felchle, NC Nnadi, K Kirschner, T Chandra, S Tamagno, DJ Webb, F Rossi, RA Anderson, A Medvinsky Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development Cell Stem Cell, 2020-09-17;0(0):. 2020-09-17 [PMID: 32946788] (Bioassay, Human)	Bioassay	Human
Y Kiyokawa, M Sato, H Noguchi, E Inada, Y Iwase, N Kubota, T Sawami, M Terunuma, T Maeda, H Hayasaki, I Saitoh Drug-Induced Na�ve iPS Cells Exhibit Better Performance than Primed iPS Cells with Respect to the Ability to Differentiate into Pancreatic &beta-Cell Lineage Journal of Clinical Medicine, 2020-09-02;9(9):. 2020-09-02 [PMID: 32887316] (Bioassay, Human)	Bioassay	Human
F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2 Res Sq, 2020-09-15;0(0):. 2020-09-15 [PMID: 32839764] (Bioassay, Human)	Bioassay	Human
T Arita, J Kondo, Y Kaneko, M Tsutsumi, M Kanemaru, M Matsui, Y Arakawa, N Katoh, M Inoue, J Asai Novel ex vivo disease model for extramammary Paget�s disease using the cancer tissue-originated spheroid method J. Dermatol. Sci., 2020-08-05;0(0):. 2020-08-05 [PMID: 32800410] (Bioassay, Human)	Bioassay	Human
M Chen, M Maimaitili, M Habekost, KP Gill, N Mermet-Jor, S Nabavi, F Febbraro, M Denham Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells Stem Cell Res, 2020-08-03;48(0):101945. 2020-08-03 [PMID: 32791483] (Bioassay, Cell Culture, Human)	Bioassay, Cell Culture	Human
L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State Cell Stem Cell, 2020-08-11;0(0):. 2020-08-11 [PMID: 32783886] (Bioassay, Human)	Bioassay	Human
SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential Cell Rep, 2020-07-28;32(4):107963. 2020-07-28 [PMID: 32726627] (Bioassay, Human)	Bioassay	Human
NC Leite, E Sintov, TB Meissner, MA Brehm, DL Greiner, DM Harlan, DA Melton Modeling Type 1 Diabetes In�Vitro Using Human Pluripotent Stem Cells Cell Rep, 2020-07-14;32(2):107894. 2020-07-14 [PMID: 32668238] (Cell Culture, Human)	Cell Culture	Human
K Takahashi, Y Akatsu, KA Podyma-Ino, T Matsumoto, H Takahashi, Y Yoshimatsu, D Koinuma, M Shirouzu, K Miyazono, T Watabe Targeting all transforming growth factor-&beta isoforms with a Fc chimeric receptor impairs tumor growth and angiogenesis of oral squamous cell cancer J. Biol. Chem., 2020-07-06;0(0):. 2020-07-06 [PMID: 32631954] (Cell Culture, Human)	Cell Culture	Human
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JH Kim, JH Kim, LA Sutikno, SB Lee, DH Jin, YK Hong, YS Kim, HJ Jin Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals PLoS ONE, 2019-04-18;14(4):e0215298. 2019-04-18 [PMID: 30998775] (Bioassay, Human)	Bioassay	Human
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K Ito, K Matsuura, Y Mihara, Y Sakamoto, K Hasegawa, N Kokudo, T Shimizu Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant Sci Rep, 2019-04-11;9(1):5922. 2019-04-11 [PMID: 30976035] (Bioassay, Human)	Bioassay	Human
B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019-04-09;27(2):599-615.e12. 2019-04-09 [PMID: 30970261] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
EA Rosado-Oli, K Anderson, JH Kenty, DA Melton YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing ? cells Nat Commun, 2019-04-01;10(1):1464. 2019-04-01 [PMID: 30931946] (Bioassay, Human)	Bioassay	Human
X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert Point mutations in the PDX1 transactivation domain impair human ?-cell development and function Mol Metab, 2019-03-20;0(0):. 2019-03-20 [PMID: 30930126] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
H Xu, B Wang, M Ono, A Kagita, K Fujii, N Sasakawa, T Ueda, P Gee, M Nishikawa, M Nomura, F Kitaoka, T Takahashi, K Okita, Y Yoshida, S Kaneko, A Hotta Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility Cell Stem Cell, 2019-03-07;0(0):. 2019-03-07 [PMID: 30853558] (Bioassay, Human)	Bioassay	Human
Y Toba, A Kiso, S Nakamae, F Sakurai, K Takayama, H Mizuguchi FGF signal is not required for hepatoblast differentiation of human iPS cells Sci Rep, 2019-03-06;9(1):3713. 2019-03-06 [PMID: 30842525] (Bioassay, Human)	Bioassay	Human
T Colunga, M Hayworth, S Kre beta , DM Reynolds, L Chen, KL Nazor, J Baur, AM Singh, JF Loring, M Metzger, S Dalton Human Pluripotent Stem Cell-Derived Multipotent Vascular Progenitors of the Mesothelium Lineage Have Utility in Tissue Engineering and Repair Cell Rep, 2019-03-05;26(10):2566-2579.e10. 2019-03-05 [PMID: 30840882] (Bioassay, Human)	Bioassay	Human
H Noguchi, C Miyagi-Shi, Y Nakashima, T Kinjo, N Kobayashi, I Saitoh, M Watanabe, AMJ Shapiro, T Kin Induction of Expandable Tissue-Specific Progenitor Cells from Human Pancreatic Tissue through Transient Expression of Defined Factors Mol Ther Methods Clin Dev, 2019-01-29;13(0):243-252. 2019-01-29 [PMID: 30828587] (Bioassay, Human)	Bioassay	Human
E Ito, S Miyagawa, M Takeda, A Kawamura, A Harada, H Iseoka, S Yajima, N Sougawa, N Mochizuki-, S Yasuda, Y Sato, Y Sawa Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application Sci Rep, 2019-02-13;9(1):1881. 2019-02-13 [PMID: 30760836] (Bioassay, Human)	Bioassay	Human
P Rentsch, S Stayte, GP Morris, B Vissel Time dependent degeneration of the nigrostriatal tract in mice with 6-OHDA lesioned medial forebrain bundle and the effect of activin A on L-Dopa induced dyskinesia BMC Neurosci, 2019-02-13;20(1):5. 2019-02-13 [PMID: 30760214] (In Vivo, Mouse)	In Vivo	Mouse
S Matsui, M Ochiai, K Yasuda, SI Mae, M Kotaka, T Toyoda, T Yamamoto, K Osafune Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line Stem Cell Res, 2019-01-31;35(0):101400. 2019-01-31 [PMID: 30735882] (Bioassay, Human)	Bioassay	Human
V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed Excess growth hormone suppresses DNA damage repair in epithelial cells JCI Insight, 2019-02-07;4(3):. 2019-02-07 [PMID: 30728323] (Bioassay, Human)	Bioassay	Human
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L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos Nat Commun, 2019-01-21;10(1):364. 2019-01-21 [PMID: 30664750] (Bioassay, Human)	Bioassay	Human
AJ Miller, BR Dye, D Ferrer-Tor, DR Hill, AW Overeem, LD Shea, JR Spence Generation of lung organoids from human pluripotent stem cells in vitro Nat Protoc, 2019-02-01;14(2):518-540. 2019-02-01 [PMID: 30664680] (Bioassay, Human)	Bioassay	Human
A Montel-Hag, CS Seet, S Li, B Chick, Y Zhu, P Chang, S Tsai, V Sun, S Lopez, HC Chen, C He, CJ Chin, D Casero, GM Crooks Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells Cell Stem Cell, 2019-01-17;0(0):. 2019-01-17 [PMID: 30661959] (Bioassay, Human)	Bioassay	Human
TW Lin, Y Chien, YY Lin, ML Wang, AA Yarmishyn, YP Yang, DK Hwang, CH Peng, CC Hsu, SJ Chen, KH Chien Establishing Liposome-Immobilized Dexamethasone-Releasing PDMS Membrane for the Cultivation of Retinal Pigment Epithelial Cells and Suppression of Neovascularization Int J Mol Sci, 2019-01-09;20(2):. 2019-01-09 [PMID: 30634448] (Bioassay, Human)	Bioassay	Human
MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA Cell Rep, 2018-12-26;25(13):3811-3827.e7. 2018-12-26 [PMID: 30590051] (Bioassay, Human)	Bioassay	Human
J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family PLoS ONE, 2018-12-12;13(12):e0208110. 2018-12-12 [PMID: 30540809] (Bioassay, Human)	Bioassay	Human
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T Azami, K Matsumoto, H Jeon, T Waku, M Muratani, H Niwa, S Takahashi, M Ema Klf5 suppresses ERK signaling in mouse pluripotent stem cells PLoS ONE, 2018-11-19;13(11):e0207321. 2018-11-19 [PMID: 30452437] (Bioassay, Mouse)	Bioassay	Mouse
H Wu, K Uchimura, EL Donnelly, Y Kirita, SA Morris, BD Humphreys Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics Cell Stem Cell, 2018-11-15;0(0):. 2018-11-15 [PMID: 30449713] (Bioassay, Human)	Bioassay	Human
A Jørgensen, J Macdonald, JE Nielsen, KR Kilcoyne, S Perlman, L Lundvall, L Langhoff T, K Juul Hare, H Frederikse, AM Andersson, NE Skakkebæk, A Juul, RM Sharpe, E Rajpert-De, RT Mitchell Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis Cell Rep, 2018-11-13;25(7):1924-1937.e4. 2018-11-13 [PMID: 30428358] (Bioassay, Human)	Bioassay	Human
T Tezuka, A Ota, S Karnan, K Matsuura, K Yokoo, Y Hosokawa, D Vigetti, A Passi, S Hatano, K Umezawa, H Watanabe The plant alkaloid conophylline inhibits matrix formation of fibroblasts J. Biol. Chem., 2018-10-30;0(0):. 2018-10-30 [PMID: 30377255] (Stimulation, Human)	Stimulation	Human
H Ida, T Akiyama, K Ishiguro, SK Goparaju, Y Nakatake, N Chikazawa-, S Sato, H Kimura, Y Yokoyama, M Nagino, MSH Ko, SBH Ko Establishment of a rapid and footprint-free protocol for differentiation of human embryonic stem cells into pancreatic endocrine cells with synthetic mRNAs encoding transcription factors Stem Cell Res Ther, 2018-10-25;9(1):277. 2018-10-25 [PMID: 30359326] (Bioassay, Human)	Bioassay	Human
A Yoney, F Etoc, A Ruzo, T Carroll, JJ Metzger, I Martyn, S Li, C Kirst, ED Siggia, AH Brivanlou WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids Elife, 2018-10-12;7(0):. 2018-10-12 [PMID: 30311909] (Bioassay, Human)	Bioassay	Human
D Huang, L Wang, NC Talbot, C Huang, L Pu, X Zhao, X Tian, M Zhang, Y Tang Analyzing bovine OCT4 and NANOG enhancer activity in pluripotent stem cells using fluorescent protein reporters PLoS ONE, 2018-10-05;13(10):e0203923. 2018-10-05 [PMID: 30289916] (Bioassay, Mouse)	Bioassay	Mouse
Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling Cell Stem Cell, 2018-09-20;0(0):. 2018-09-20 [PMID: 30244870] (Bioassay, Human)	Bioassay	Human
A Skrzypczyk, S Kehr, I Krystel, SH Bernhart, S Giri, A Bader, PF Stadler Noncoding RNA Transcripts during Differentiation of Induced Pluripotent Stem Cells into Hepatocytes Stem Cells Int, 2018-08-19;2018(0):5692840. 2018-08-19 [PMID: 30210551] (Bioassay, Human)	Bioassay	Human
Bajaj P, Rodrigues A, Steppan C, Engle S, Mathialagan S, Schroeter T Human Pluripotent Stem Cell-Derived Kidney Model for Nephrotoxicity Studies. Drug Metab Dispos, 2018-08-31;46(11):1703-1711. 2018-08-31 [PMID: 30171163] (Bioassay, Human)	Bioassay	Human
YY Lin, Y Chien, JH Chuang, CC Chang, YP Yang, YH Lai, WL Lo, KH Chien, TI Huo, CY Wang Development of a Graphene Oxide-Incorporated Polydimethylsiloxane Membrane with Hexagonal Micropillars Int J Mol Sci, 2018-08-25;19(9):. 2018-08-25 [PMID: 30149618] (Bioassay, Human)	Bioassay	Human
MA Scavuzzo, MC Hill, J Chmielowie, D Yang, J Teaw, K Sheng, Y Kong, M Bettini, C Zong, JF Martin, M Borowiak Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis Nat Commun, 2018-08-22;9(1):3356. 2018-08-22 [PMID: 30135482] (Bioassay, Human)	Bioassay	Human
C Miyagi-Shi, Y Nakashima, N Kobayashi, I Saitoh, M Watanabe, H Noguchi Characterization of induced tissue-specific stem cells from pancreas by a synthetic self-replicative RNA Sci Rep, 2018-08-17;8(1):12341. 2018-08-17 [PMID: 30120295] (Bioassay, Mouse)	Bioassay	Mouse
A Spangler, EY Su, AM Craft, P Cahan A single cell transcriptional portrait of embryoid body differentiation and comparison to progenitors of the developing embryo Stem Cell Res, 2018-07-29;31(0):201-215. 2018-07-29 [PMID: 30118958] (Bioassay, Mouse)	Bioassay	Mouse
S Yamada, Y Kubo, D Yamazaki, Y Sekino, Y Nomura, S Yoshida, Y Kanda Tributyltin Inhibits Neural Induction of Human Induced Pluripotent Stem Cells Sci Rep, 2018-08-14;8(1):12155. 2018-08-14 [PMID: 30108368] (Bioassay, Human)	Bioassay	Human
A Di Baldass, MA D'Amico, P Izzicupo, G Gaggi, S Guarnieri, MA Mariggiò, I Antonucci, B Corneo, D Sirabella, L Stuppia, B Ghinassi Cardiomyocytes Derived from Human CardiopoieticAmniotic Fluids Sci Rep, 2018-08-13;8(1):12028. 2018-08-13 [PMID: 30104705] (Bioassay, Human)	Bioassay	Human
Z Xu, X He, X Shi, Y Xia, X Liu, H Wu, P Li, H Zhang, W Yin, X Du, L Li, Y Li Analysis of differentially expressed genes among human hair follicle-derived iPSCs, induced hepatocyte-like cells, and primary hepatocytes Stem Cell Res Ther, 2018-08-09;9(1):211. 2018-08-09 [PMID: 30092828] (Bioassay, Human)	Bioassay	Human
P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon Precardiac organoids form two heart fields via Bmp/Wnt signaling Nat Commun, 2018-08-07;9(1):3140. 2018-08-07 [PMID: 30087351] (Bioassay, Mouse)	Bioassay	Mouse
M Shoji, H Minato, S Ogaki, M Seki, Y Suzuki, S Kume, T Kuzuhara Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells PLoS ONE, 2018-07-26;13(7):e0201239. 2018-07-26 [PMID: 30048506] (Bioassay, Human)	Bioassay	Human
E Magro-Lope, C Palmer, J Manso, I Liste, A Zambrano Effects of lung and airway epithelial maturation cocktail on the structure of lung bud organoids Stem Cell Res Ther, 2018-07-11;9(1):186. 2018-07-11 [PMID: 29996941] (Bioassay, Human)	Bioassay	Human
K Koefoed, J Skat-Rørda, P Andersen, CB Warzecha, M Pye, TA Andersen, KD Ajbro, E Bendsen, M Narimatsu, F Vilhardt, LB Pedersen, JL Wrana, RH Anderson, K Møllgård, ST Christense, LA Larsen The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development Sci Rep, 2018-06-22;8(1):9542. 2018-06-22 [PMID: 29934521] (Bioassay, Human)	Bioassay	Human
Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips. Cellular and Molecular Gastroenterology and Hepatology, 2017-12-29;0(0):2352-345X. 2017-12-29 [PMID: 29930984] (Bioassay, Human)	Bioassay	Human
F Zambelli, J Mertens, D Dziedzicka, J Sterckx, C Markouli, A Keller, P Tropel, L Jung, S Viville, H Van de Vel, M Geens, S Seneca, K Sermon, C Spits Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem�Cells Stem Cell Reports, 2018-06-14;0(0):. 2018-06-14 [PMID: 29910126] (Bioassay, Human)	Bioassay	Human
J Li, F Xing, F Chen, L He, KF So, Y Liu, J Xiao Functional 3D Human Liver Bud Assembled from MSC-Derived Multiple Liver Cell Lineages Cell Transplant, 2018-06-13;0(0):9636897187803. 2018-06-13 [PMID: 29895168] (Bioassay, Human)	Bioassay	Human
RP Russell, Y Fu, Y Liu, P Maye Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage Stem Cell Res, 2018-05-22;30(0):85-95. 2018-05-22 [PMID: 29807258] (Bioassay, Mouse)	Bioassay	Mouse
X Guo, Y Xu, Z Wang, Y Wu, J Chen, G Wang, C Lu, W Jia, J Xi, S Zhu, Z Jiapaer, X Wan, Z Liu, S Gao, J Kang A Linc1405/Eomes Complex Promotes Cardiac Mesoderm Specification and Cardiogenesis Cell Stem Cell, 2018-05-10;0(0):. 2018-05-10 [PMID: 29754779] (Bioassay, Mouse)	Bioassay	Mouse
J Zhou, A Plagge, P Murray Functional comparison of distinct Brachyury+ states in a renal differentiation assay Biol Open, 2018-05-17;0(0):. 2018-05-17 [PMID: 29666052] (Bioassay, Mouse)	Bioassay	Mouse
R Okamoto, K Takayama, N Akita, Y Nagamoto, D Hosokawa, S Iizuka, F Sakurai, H Suemizu, K Ohashi, H Mizuguchi Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B Cell Transplant, 2018-02-01;27(2):299-309. 2018-02-01 [PMID: 29637813] (Bioassay, Human)	Bioassay	Human
MA Deutsch, SA Doppler, X Li, H Lahm, G Santamaria, G Cuda, S Eichhorn, T Ratschille, E Dzilic, M Dre beta en, A Eckart, K Stark, S Massberg, A Bartels, C Rischpler, R Gilsbach, L Hein, BK Fleischman, SM Wu, R Lange, M Krane Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis Cardiovasc. Res., 2018-07-01;0(0):. 2018-07-01 [PMID: 29579159] (Bioassay, Mouse)	Bioassay	Mouse
Y Jin, Y Liu, Z Li, K Santostefa, J Shi, X Zhang, D Wu, Z Cheng, W Wu, N Terada, S Jin, F Bai Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery PLoS ONE, 2018-03-26;13(3):e0194895. 2018-03-26 [PMID: 29579079] (Bioassay, Human)	Bioassay	Human
J Tu, G Tian, HH Cheung, W Wei, TL Lee Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells Stem Cell Res Ther, 2018-03-21;9(1):71. 2018-03-21 [PMID: 29562912] (Bioassay, Mouse)	Bioassay	Mouse
A Yoshida, JK Lee, S Tomoyama, K Miwa, K Shirakawa, S Hamanaka, T Yamaguchi, H Nakauchi, S Miyagawa, Y Sawa, I Komuro, Y Sakata In vitro platform of allogeneic stem cell-derived cardiomyocyte transplantation for cardiac conduction defects Europace, 2018-09-01;0(0):. 2018-09-01 [PMID: 29554331] (Bioassay, Rat)	Bioassay	Rat
L Galvan, L Francelle, MC Gaillard, L de Longpre, MA Carrillo-d, G Liot, K Cambon, L Stimmer, S Luccantoni, J Flament, J Valette, M de Chaldée, G Auregan, M Guillermie, C Joséphine, F Petit, C Jan, M Jarrige, N Dufour, G Bonvento, S Humbert, F Saudou, P Hantraye, K Merienne, AP Bemelmans, AL Perrier, N Déglon, E Brouillet The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin Brain, 2018-05-01;0(0):. 2018-05-01 [PMID: 29534157] (Bioassay, Human)	Bioassay	Human
YY Sin, LL Ballantyne, CR Richmond, CD Funk Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice Mol Ther Nucleic Acids, 2017-12-01;10(0):122-130. 2017-12-01 [PMID: 29499927] (Bioassay, Mouse)	Bioassay	Mouse
A Schöbel, K Rösch, E Herker Functional innate immunity restricts Hepatitis C Virus infection in induced pluripotent stem cell-derived hepatocytes Sci Rep, 2018-03-01;8(1):3893. 2018-03-01 [PMID: 29497123] (Bioassay, Human)	Bioassay	Human
X Yang, R Wang, X Wang, G Cai, Y Qian, S Feng, F Tan, K Chen, K Tang, X Huang, N Jing, Y Qiao TGF? signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs J Mol Cell Biol, 2018-06-01;0(0):. 2018-06-01 [PMID: 29481611] (Bioassay, Mouse)	Bioassay	Mouse
M Chen, SH Laursen, M Habekost, CH Knudsen, SH Buchholdt, J Huang, F Xu, X Liu, L Bolund, Y Luo, P Nissen, F Febbraro, M Denham Central and Peripheral Nervous System Progenitors Derived from Human Pluripotent Stem Cells Reveal a Unique Temporal and Cell-Type Specific Expression of PMCAs Front Cell Dev Biol, 2018-02-06;6(0):5. 2018-02-06 [PMID: 29468158] (Cell Culture, Human)	Cell Culture	Human
EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen Beta-Catenin maintains lung epithelial progenitors after lung specification Development, 2018-03-09;0(0):. 2018-03-09 [PMID: 29440304] (Bioassay, Human)	Bioassay	Human
RR Zhang, M Koido, T Tadokoro, R Ouchi, T Matsuno, Y Ueno, K Sekine, T Takebe, H Taniguchi Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids Stem Cell Reports, 2018-02-08;0(0):. 2018-02-08 [PMID: 29429958] (Bioassay, Human)	Bioassay	Human
T Yamashita, K Takayama, F Sakurai, H Mizuguchi Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells Biochem. Biophys. Res. Commun., 2018-02-01;0(0):. 2018-02-01 [PMID: 29409945] (Differentiation, Differentiation, Human)	Differentiation, Differentiation	Human
C Long, H Li, M Tiburcy, C Rodriguez-, V Kyrychenko, H Zhou, Y Zhang, YL Min, JM Shelton, PPA Mammen, NY Liaw, WH Zimmermann, R Bassel-Dub, JW Schneider, EN Olson Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing Sci Adv, 2018-01-31;4(1):eaap9004. 2018-01-31 [PMID: 29404407] (Bioassay, Human)	Bioassay	Human
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JB Lees-Shepa, M Yamamoto, AA Biswas, SJ Stoessel, SE Nicholas, CA Cogswell, PM Devarakond, MJ Schneider, SM Cummins, NP Legendre, S Yamamoto, V Kaartinen, JW Hunter, DJ Goldhamer Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva Nat Commun, 2018-02-02;9(1):471. 2018-02-02 [PMID: 29396429] (In Vivo, Mouse)	In Vivo	Mouse
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WS Fagg, N Liu, MJ Yang, K Cheng, E Chung, JS Kim, G Wu, J Fair Magnetic Targeting of Stem Cell Derivatives Enhances Hepatic Engraftment into Structurally Normal Liver Cell Transplant, 2017-12-01;26(12):1868-1877. 2017-12-01 [PMID: 29390880] (Bioassay, Mouse)	Bioassay	Mouse
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KE Tumelty, N Higginson-, X Fan, P Bajaj, KM Knowlton, M Shamashkin, AJ Coyle, W Lu, SP Berasi Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways J. Biol. Chem., 2018-01-09;0(0):. 2018-01-09 [PMID: 29317497] (Bioassay, Human)	Bioassay	Human
MG Perino, S Yamanaka, DR Riordon, Y Tarasova, KR Boheler Ascorbic acid promotes cardiomyogenesis through SMAD1 signaling in differentiating mouse embryonic stem cells PLoS ONE, 2017-12-12;12(12):e0188569. 2017-12-12 [PMID: 29232368] (Bioassay, Mouse)	Bioassay	Mouse
M Kotaka, T Toyoda, K Yasuda, Y Kitano, C Okada, A Ohta, A Watanabe, M Uesugi, K Osafune Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells Sci Rep, 2017-12-01;7(1):16734. 2017-12-01 [PMID: 29196668] (Bioassay, Human)	Bioassay	Human
JP Matson, R Dumitru, P Coryell, RM Baxley, W Chen, K Twaroski, BR Webber, J Tolar, AK Bielinsky, JE Purvis, JG Cook Rapid DNA replication origin licensing protects stem cell pluripotency Elife, 2017-11-17;6(0):. 2017-11-17 [PMID: 29148972] (Bioassay, Human)	Bioassay	Human
DS Varghese, S Parween, MT Ardah, BS Emerald, SA Ansari Effects of Aminoglycoside Antibiotics on Human Embryonic Stem Cell Viability during Differentiation In Vitro Stem Cells Int, 2017-09-24;2017(0):2451927. 2017-09-24 [PMID: 29147115] (Bioassay, Human)	Bioassay	Human
A Taguchi, R Nishinakam Higher-Order Kidney Organogenesis from Pluripotent Stem Cells Cell Stem Cell, 2017-11-09;0(0):. 2017-11-09 [PMID: 29129523] (Bioassay, Human)	Bioassay	Human
S Bao, WW Tang, B Wu, S Kim, J Li, L Li, T Kobayashi, C Lee, Y Chen, M Wei, S Li, S Dietmann, F Tang, X Li, MA Surani Derivation of hypermethylated pluripotent embryonic stem cells with high potency Cell Res., 2017-10-27;0(0):. 2017-10-27 [PMID: 29076502] (Bioassay, Mouse)	Bioassay	Mouse
K Sakamoto, Y Kanematsu-, Y Kamada, M Oka, T Ohnishi, M Miwa, T Asami, H Inooka Identification of ligand-selective peptidic ActRIIB-antagonists using phage display technology Biochem Biophys Rep, 2017-06-10;11(0):33-39. 2017-06-10 [PMID: 28955765] (Bioassay, Human)	Bioassay	Human
N Merienne, G Vachey, L de Longpre, C Meunier, V Zimmer, G Perriard, M Canales, A Mathias, L Herrgott, T Beltramine, A Maulet, T Dequesne, C Pythoud, M Rey, L Pellerin, E Brouillet, AL Perrier, R du Pasquie, N Déglon The Self-Inactivating KamiCas9 System for the Editing of CNS Disease Genes Cell Rep, 2017-09-19;20(12):2980-2991. 2017-09-19 [PMID: 28930690] (Bioassay, Human)	Bioassay	Human
M Ito, S Sun, T Fukuhara, R Suzuki, M Tamai, T Yamauchi, K Nakashima, YI Tagawa, S Okazaki, Y Matsuura, T Wakita, T Suzuki Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation Oncotarget, 2017-07-08;8(33):53899-53915. 2017-07-08 [PMID: 28903311] (Bioassay, Human)	Bioassay	Human
ZQ He, BL Xia, YK Wang, J Li, GH Feng, LL Zhang, YH Li, HF Wan, TD Li, K Xu, XW Yuan, YF Li, XX Zhang, Y Zhang, L Wang, W Li, Q Zhou Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening Cell Rep, 2017-08-29;20(9):2227-2237. 2017-08-29 [PMID: 28854370] (Bioassay, Mouse)	Bioassay	Mouse
KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors Nat Commun, 2017-08-24;8(1):331. 2017-08-24 [PMID: 28835709] (Bioassay, Human)	Bioassay	Human
NG Kooreman, PE de Almeida, JP Stack, RV Nelakanti, S Diecke, NY Shao, RJ Swijnenbur, V Sanchez-Fr, E Matsa, C Liu, AJ Connolly, JF Hamming, PHA Quax, MA Brehm, DL Greiner, LD Shultz, JC Wu Alloimmune Responses of Humanized Mice to Human Pluripotent Stem Cell Therapeutics Cell Rep, 2017-08-22;20(8):1978-1990. 2017-08-22 [PMID: 28834758] (Bioassay, Human)	Bioassay	Human
S Merfeld-Cl, H Lu, X Wu, KL March, DO Traktuev Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity J. Cell. Mol. Med., 2017-08-18;0(0):. 2017-08-18 [PMID: 28834227] (Bioassay, Human)	Bioassay	Human
J Xing, Y Cao, Y Yu, H Li, Z Song, H Yu In Vitro Micropatterned Human Pluripotent Stem Cell Test (�P-hPST) for Morphometric-Based Teratogen Screening Sci Rep, 2017-08-17;7(1):8491. 2017-08-17 [PMID: 28819231] (Bioassay, Human)	Bioassay	Human
NJ Palpant, Y Wang, B Hadland, RJ Zaunbreche, M Redd, D Jones, L Pabon, R Jain, J Epstein, WL Ruzzo, Y Zheng, I Bernstein, A Margolin, CE Murry Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis Cell Rep, 2017-08-15;20(7):1597-1608. 2017-08-15 [PMID: 28813672] (Bioassay, Human)	Bioassay	Human
Y Hosokawa, T Toyoda, K Fukui, MY Baden, M Funato, Y Kondo, T Sudo, H Iwahashi, M Kishida, C Okada, A Watanabe, I Asaka, K Osafune, A Imagawa, I Shimomura Insulin-producing cells derived from 'induced pluripotent stem cells' of patients with fulminant type 1 diabetes: vulnerability to cytokine insults and increased expression of apoptosis-related genes J Diabetes Investig, 2017-08-10;0(0):. 2017-08-10 [PMID: 28796422] (Bioassay, Human)	Bioassay	Human
Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu A pluripotent stem cell-based model for post-implantation human amniotic sac development Nat Commun, 2017-08-08;8(1):208. 2017-08-08 [PMID: 28785084] (Bioassay, Human)	Bioassay	Human
JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations Cell Stem Cell, 2017-08-03;21(2):179-194.e4. 2017-08-03 [PMID: 28777944] (Bioassay, Human)	Bioassay	Human
K Hino, K Horigome, M Nishio, S Komura, S Nagata, C Zhao, Y Jin, K Kawakami, Y Yamada, A Ohta, J Toguchida, M Ikeya Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva J. Clin. Invest., 2017-07-31;0(0):. 2017-07-31 [PMID: 28758906] (Bioassay, Human)	Bioassay	Human
C Sallon, I Callebaut, I Boulay, J Fontaine, D Logeart-Av, C Henriquet, M Pugnière, X Cayla, P Monget, G Harichaux, V Labas, S Canepa, C Taragnat Thrombospondin-1 (TSP-1), a new bone morphogenetic protein-2 and -4 (BMP-2/4) antagonist identified in pituitary cells J. Biol. Chem., 2017-07-26;0(0):. 2017-07-26 [PMID: 28747434] (Bioassay, Ovine)	Bioassay	Ovine
JJ Staudacher, J Bauer, A Jana, J Tian, T Carroll, G Mancinelli, Ö Özden, N Krett, G Guzman, D Kerr, P Grippo, B Jung Activin signaling is an essential component of the TGF-? induced pro-metastatic phenotype in colorectal cancer Sci Rep, 2017-07-17;7(1):5569. 2017-07-17 [PMID: 28717230] (Bioassay, Human)	Bioassay	Human
BC Goh, V Singhal, AJ Herrera, RE Tomlinson, S Kim, MC Faugere, EL Germain-Le, TL Clemens, SJ Lee, DJ DiGirolamo Activin Receptor Type IIA (ACVR2A) Functions Directly in Osteoblasts as a Negative Regulator of Bone Mass J. Biol. Chem., 2017-06-28;0(0):. 2017-06-28 [PMID: 28659341] (Bioassay, Mouse)	Bioassay	Mouse
AG Freire, A Waghray, F Soares-da-, TP Resende, DF Lee, CF Pereira, DS Nascimento, IR Lemischka, P Pinto-do-Ó Transient HES5 Activity Instructs Mesodermal Cells toward a Cardiac Fate Stem Cell Reports, 2017-06-22;0(0):. 2017-06-22 [PMID: 28648899] (Bioassay, Mouse)	Bioassay	Mouse
M Crespo, E Vilar, SY Tsai, K Chang, S Amin, T Srinivasan, T Zhang, NH Pipalia, HJ Chen, M Witherspoo, M Gordillo, JZ Xiang, FR Maxfield, S Lipkin, T Evans, S Chen Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing Nat. Med., 2017-06-19;0(0):. 2017-06-19 [PMID: 28628110] (Bioassay, Human)	Bioassay	Human
G Yücel, Z Zhao, I El-Battraw, H Lan, S Lang, X Li, F Buljubasic, WH Zimmermann, L Cyganek, J Utikal, U Ravens, T Wieland, M Borggrefe, XB Zhou, I Akin Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes Sci Rep, 2017-06-07;7(1):2935. 2017-06-07 [PMID: 28592841] (Bioassay, Human)	Bioassay	Human
A Arauchi, K Matsuura, T Shimizu, T Okano Functional Thyroid Follicular Cells Differentiation from Human-Induced Pluripotent Stem Cells in Suspension Culture Front Endocrinol (Lausanne), 2017-05-22;8(0):103. 2017-05-22 [PMID: 28588551] (Bioassay, Human)	Bioassay	Human
D Jeziorowsk, V Fontaine, C Jouve, E Villard, S Dussaud, D Akbar, V Letang, P Cervello, JM Itier, MP Pruniaux, JS Hulot Differential Sarcomere and Electrophysiological Maturation of Human iPSC-Derived Cardiac Myocytes in Monolayer vs. Aggregation-Based Differentiation Protocols Int J Mol Sci, 2017-06-01;18(6):. 2017-06-01 [PMID: 28587156] (Bioassay, Human)	Bioassay	Human
DD Seachrist, ST Sizemore, E Johnson, FW Abdul-Kari, KL Weber Bonk, RA Keri Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer Breast Cancer Res., 2017-06-05;19(1):66. 2017-06-05 [PMID: 28583174] (Bioassay, Human)	Bioassay	Human
YY Sin, PR Price, LL Ballantyne, CD Funk Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency Sci Rep, 2017-05-31;7(1):2585. 2017-05-31 [PMID: 28566761] (Bioassay, Mouse)	Bioassay	Mouse
Q Gu, J Wang, L Wang, ZX Liu, WW Zhu, YQ Tan, WF Han, J Wu, CJ Feng, JH Fang, L Liu, L Wang, W Li, XY Zhao, BY Hu, J Hao, Q Zhou Accreditation of Biosafe Clinical-Grade Human Embryonic Stem Cells According to Chinese Regulations Stem Cell Reports, 2017-05-11;0(0):. 2017-05-11 [PMID: 28506532] (Bioassay, Human)	Bioassay	Human
K Breckwoldt, D Letuffe-Br, I Mannhardt, T Schulze, B Ulmer, T Werner, A Benzin, B Klampe, MC Reinsch, S Laufer, A Shibamiya, M Prondzynsk, G Mearini, D Schade, S Fuchs, C Neuber, E Krämer, U Saleem, ML Schulze, ML Rodriguez, T Eschenhage, A Hansen Differentiation of cardiomyocytes and generation of human engineered heart tissue Nat Protoc, 2017-05-11;12(6):1177-1197. 2017-05-11 [PMID: 28492526] (Bioassay, Human)	Bioassay	Human
LK Bollum, K Huse, MP Oksvold, B Bai, VI Hilden, L Forfang, SO Yoon, S Wälchli, EB Smeland, JH Myklebust BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-? receptor type I ALK5 PLoS ONE, 2017-05-10;12(5):e0177188. 2017-05-10 [PMID: 28489883] (Bioassay, Human)	Bioassay	Human
M Sone, N Morone, T Nakamura, A Tanaka, K Okita, K Woltjen, M Nakagawa, JE Heuser, Y Yamada, S Yamanaka, T Yamamoto Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency Cell Metab., 2017-05-02;25(5):1103-1117.e6. 2017-05-02 [PMID: 28467928] (Bioassay, Mouse)	Bioassay	Mouse
S Mitani, K Takayama, Y Nagamoto, K Imagawa, F Sakurai, M Tachibana, R Sumazaki, H Mizuguchi Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling Mol. Ther., 2017-04-24;25(6):1420-1433. 2017-04-24 [PMID: 28462819] (Bioassay, Human)	Bioassay	Human
K Low, LY Wong, M Maldonado, C Manjunath, CB Horner, M Perez, NV Myung, J Nam Physico-electrochemical Characterization of Pluripotent Stem Cells during Self-Renewal or Differentiation by a Multi-modal Monitoring System Stem Cell Reports, 2017-04-27;0(0):. 2017-04-27 [PMID: 28457888] (Bioassay, Human)	Bioassay	Human
JA Heslop, R Kia, CS Pridgeon, RL Sison-Youn, T Liloglou, M Elmasry, SW Fenwick, JS Mills, NR Kitteringh, CE Goldring, BK Park Donor-Dependent and Other Nondefined Factors Have Greater Influence on the Hepatic Phenotype Than the Starting Cell Type in Induced Pluripotent Stem Cell Derived Hepatocyte-Like Cells Stem Cells Transl Med, 2017-05-01;6(5):1321-1331. 2017-05-01 [PMID: 28456008] (Bioassay, Human)	Bioassay	Human
E Latres, J Mastaitis, W Fury, L Miloscio, J Trejos, J Pangilinan, H Okamoto, K Cavino, E Na, A Papatheodo, T Willer, Y Bai, J Hae Kim, A Rafique, S Jaspers, T Stitt, AJ Murphy, GD Yancopoulo, J Gromada Activin A more prominently regulates muscle mass in primates than does GDF8 Nat Commun, 2017-04-28;8(0):15153. 2017-04-28 [PMID: 28452368] (Surface Plasmon Resonance, Human)	Surface Plasmon Resonance	Human
S Warrier, M Van der Je, G Duggal, L Tilleman, E Sutherland, J Taelman, M Popovic, S Lierman, S Chuva De S, A Van Soom, L Peelman, F Van Nieuwe, DIM De Coninck, B Menten, P Mestdagh, J Van de Som, D Deforce, P De Sutter, B Heindryckx Direct comparison of distinct naive pluripotent states in human embryonic stem cells Nat Commun, 2017-04-21;8(0):15055. 2017-04-21 [PMID: 28429706] (Bioassay, Human)	Bioassay	Human
K Hirano, S Konagaya, A Turner, Y Noda, S Kitamura, H Kotera, H Iwata Closed-channel culture system for efficient and reproducible differentiation of human pluripotent stem cells into islet cells Biochem. Biophys. Res. Commun., 2017-04-13;0(0):. 2017-04-13 [PMID: 28412348] (Bioassay, Human)	Bioassay	Human
EE Pashos, Y Park, X Wang, A Raghavan, W Yang, D Abbey, DT Peters, J Arbelaez, M Hernandez, N Kuperwasse, W Li, Z Lian, Y Liu, W Lv, SL Lytle-Gabb, DH Marchadier, P Rogov, J Shi, KJ Slovik, IM Stylianou, L Wang, R Yan, X Zhang, S Kathiresan, SA Duncan, TS Mikkelsen, EE Morrisey, DJ Rader, CD Brown, K Musunuru Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci Cell Stem Cell, 2017-04-06;20(4):558-570.e10. 2017-04-06 [PMID: 28388432] (Bioassay, Human)	Bioassay	Human
Y Li, S Tian, I Lei, L Liu, P Ma, Z Wang Transplantation of multipotent Isl1+ cardiac progenitor cells preserves infarcted heart function in mice Am J Transl Res, 2017-03-15;9(3):1530-1542. 2017-03-15 [PMID: 28386378] (Bioassay, Mouse)	Bioassay	Mouse
H Montacir, N Freyer, F Knoespel, T Urbaniak, T Dedova, M Berger, G Damm, R Tauber, K Zeilinger, V Blanchard The N-glycome of embryonic stem cells and thereof differentiated hepatic cells Chembiochem, 2017-05-15;0(0):. 2017-05-15 [PMID: 28370937] (Bioassay, Human)	Bioassay	Human
F Sampazioti, MC de Brito, I Geti, A Bertero, NR Hannan, L Vallier Directed differentiation of human induced pluripotent stem cells into functional cholangiocyte-like cells Nat Protoc, 2017-03-23;12(4):814-827. 2017-03-23 [PMID: 28333915] (Bioassay, Human)	Bioassay	Human
S Tousa, M Semitekolo, I Morianos, A Banos, AI Trochoutso, TM Brodie, N Poulos, K Samitas, M Kapasa, D Konstantop, G Paraskevop, M Gaga, CM Hawrylowic, F Sallusto, G Xanthou Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses Proc. Natl. Acad. Sci. U.S.A, 2017-03-20;0(0):. 2017-03-20 [PMID: 28320933] (Bioassay, Human)	Bioassay	Human
EY Yoshitoshi, T Toyoda, K Yasuda, M Kotaka, K Nomoto, K Okita, K Yasuchika, S Okamoto, N Takubo, T Nishikubo, T Soga, S Uemoto, K Osafune Modelling urea-cycle disorder citrullinemia type 1 with disease-specific iPSCs Biochem. Biophys. Res. Commun, 2017-03-14;0(0):. 2017-03-14 [PMID: 28302489] (Bioassay, Human)	Bioassay	Human
A Asai, E Aihara, C Watson, R Mourya, T Mizuochi, P Shivakumar, K Phelan, C Mayhew, M Helmrath, T Takebe, J Wells, JA Bezerra Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells Development, 2017-03-15;144(6):1056-1064. 2017-03-15 [PMID: 28275009] (Bioassay, Human)	Bioassay	Human
DW Hammers, M Merscham-B, JY Hsiao, S Engst, JJ Hartman, HL Sweeney Supraphysiological levels of GDF11 induce striated muscle atrophy EMBO Mol Med, 2017-04-01;0(0):. 2017-04-01 [PMID: 28270449] (Bioassay, Human, Mouse)	Bioassay	Human, Mouse
M García, R Barrio, M García-Lav, AR Garcia-Ren, A Escudero, E Díaz-Rodrí, D Gorbenko D, A Fernández, YB de Rijke, E Vallespín, J Nevado, P Lapunzina, V Matre, PM Hinkle, AC Hokken-Koe, MP de Miguel, JM Cameselle-, M Nistal, CV Alvarez, JC Moreno The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGF? and Activin pathways Sci Rep, 2017-03-06;7(0):42937. 2017-03-06 [PMID: 28262687] (Bioassay, Human)	Bioassay	Human
M Sambi, T Chow, J Whiteley, M Li, S Chua, V Raileanu, IM Rogers Acellular Mouse Kidney ECM can be Used as a Three-Dimensional Substrate to Test the Differentiation Potential of Embryonic Stem Cell Derived Renal Progenitors Stem Cell Rev, 2017-08-01;0(0):. 2017-08-01 [PMID: 28239758] (Bioassay, Mouse)	Bioassay	Mouse
K Yamamizu, M Iwasaki, H Takakubo, T Sakamoto, T Ikuno, M Miyoshi, T Kondo, Y Nakao, M Nakagawa, H Inoue, JK Yamashita In�Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling Stem Cell Reports, 2017-02-23;0(0):. 2017-02-23 [PMID: 28238797] (Bioassay, Human)	Bioassay	Human
B Ulmer, M Tingler, S Kurz, M Maerker, P Andre, D Mönch, M Campione, K Dei beta ler, M Lewandoski, T Thumberger, A Schweicker, A Fainsod, H Steinbei beta e, M Blum A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse Sci Rep, 2017-02-21;7(0):43010. 2017-02-21 [PMID: 28220837] (Bioassay, Mouse)	Bioassay	Mouse
H Koike, RR Zhang, Y Ueno, K Sekine, YW Zheng, T Takebe, H Taniguchi Nutritional modulation of mouse and human liver bud growth through a branched-amino acid metabolism Development, 2017-02-20;0(0):. 2017-02-20 [PMID: 28219950] (Bioassay, Human)	Bioassay	Human
G Valenti, HM Quinn, GJ Heynen, L Lan, JD Holland, R Vogel, A Wulf-Golde, W Birchmeier Cancer stem cells regulate cancer-associated fibroblasts via activation of Hedgehog signaling in mammary gland tumors Cancer Res, 2017-02-15;0(0):. 2017-02-15 [PMID: 28202523] (Bioassay, Mouse)	Bioassay	Mouse
N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2 Nat Commun, 2017-02-13;8(0):14127. 2017-02-13 [PMID: 28193997] (Bioassay, Mouse)	Bioassay	Mouse
HK Voges, RJ Mills, DA Elliott, RG Parton, ER Porrello, JE Hudson Development of a human cardiac organoid injury model reveals innate regenerative potential Development, 2017-02-07;0(0):. 2017-02-07 [PMID: 28174241] (Bioassay, Human)	Bioassay	Human
CS Simon, DJ Downes, ME Gosden, J Telenius, DR Higgs, JR Hughes, I Costello, EK Bikoff, EJ Robertson Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo Development, 2017-02-07;0(0):. 2017-02-07 [PMID: 28174238] (Bioassay, Mouse)	Bioassay	Mouse
M Tiburcy, JE Hudson, P Balfanz, S Schlick, T Meyer, ML Chang Liao, E Levent, F Raad, S Zeidler, E Wingender, J Riegler, M Wang, JD Gold, I Kehat, E Wettwer, U Ravens, P Dierickx, LW van Laake, MJ Goumans, S Khadjeh, K Toischer, G Hasenfuss, LA Couture, A Unger, WA Linke, T Araki, B Neel, G Keller, L Gepstein, JC Wu, WH Zimmermann Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair Circulation, 2017-02-06;135(19):1832-1847. 2017-02-06 [PMID: 28167635] (Bioassay, Human)	Bioassay	Human
JS Saini, B Corneo, JD Miller, TR Kiehl, Q Wang, NC Boles, TA Blenkinsop, JH Stern, S Temple Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration Cell Stem Cell, 2017-01-26;0(0):. 2017-01-26 [PMID: 28132833] (Bioassay, Human)	Bioassay	Human
S Stayte, P Rentsch, AR Tr”scher, M Bamberger, KM Li, B Vissel Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo PLoS ONE, 2017-01-25;12(1):e0167211. 2017-01-25 [PMID: 28121982] (In Vivo, Mouse)	In Vivo	Mouse
Y Choudhury, YC Toh, J Xing, Y Qu, J Poh, L Huan, HS Tan, R Kanesvaran, H Yu, MH Tan Patient-specific hepatocyte-like cells derived from induced pluripotent stem cells model pazopanib-mediated hepatotoxicity Sci Rep, 2017-01-25;7(0):41238. 2017-01-25 [PMID: 28120901] (Bioassay, Human)	Bioassay	Human
T Jiajie, Y Yanzhou, AC Hoi-Hung, C Zi-Jiang, C Wai-Yee Conserved miR-10 family represses proliferation and induces apoptosis in ovarian granulosa cells Sci Rep, 2017-01-23;7(0):41304. 2017-01-23 [PMID: 28112253] (Bioassay, Mouse)	Bioassay	Mouse
S Kadota, L Pabon, H Reinecke, CE Murry In�Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts Stem Cell Reports, 2017-01-05;0(0):. 2017-01-05 [PMID: 28065644] (Bioassay, Human)	Bioassay	Human
Generation of nephron progenitor cells and kidney organoids from human pluripotent stem cells Nat Protoc, 2016-12-22;12(1):195-207. 2016-12-22 [PMID: 28005067] (Bioassay, Human)	Bioassay	Human
Repressed SIRT1/PGC-1? pathway and mitochondrial disintegration in iPSC-derived RPE disease model of age-related macular degeneration J Transl Med, 2016-12-20;14(1):344. 2016-12-20 [PMID: 27998274] (Bioassay, Human)	Bioassay	Human
Yining Li SMAD3 Regulates Follicle-Stimulating Hormone Synthesis by Pituitary Gonadotrope Cells In Vivo J. Biol. Chem, 2016-12-19;0(0):. 2016-12-19 [PMID: 27994055] (Bioassay, Mouse)	Bioassay	Mouse
SW Lee, JU Chong, SO Min, SY Bak, KS Kim Are Adipose-Derived Stem Cells From Liver Falciform Ligaments Another Possible Source of Mesenchymal Stem Cells? Cell Transplant, 2016-11-24;26(5):855-866. 2016-11-24 [PMID: 27938473] (Bioassay, Human)	Bioassay	Human
Activin promotes skin carcinogenesis by attraction and reprogramming of macrophages EMBO Mol Med, 2017-01-01;0(0):. 2017-01-01 [PMID: 27932444] (Bioassay, Mouse)	Bioassay	Mouse
Silvia Parisi Lin28 is induced in primed embryonic stem cells and regulates let-7-independent events FASEB J, 2016-12-05;0(0):. 2016-12-05 [PMID: 27920151] (Bioassay, Mouse)	Bioassay	Mouse
Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells Nat Protoc, 2016-12-01;12(1):15-31. 2016-12-01 [PMID: 27906170] (Bioassay, Human)	Bioassay	Human
Joan Massagué The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells Cell Stem Cell, 2016-11-23;0(0):. 2016-11-23 [PMID: 27889317] (Bioassay, Mouse)	Bioassay	Mouse
Lilian T Kaufmann Nemo-like kinase 1 (Nlk1) and paraxial protocadherin (PAPC) cooperatively control Xenopus gastrulation through regulation of Wnt/planar cell polarity (PCP) signaling Differentiation, 2016-10-28;93(0):27-38. 2016-10-28 [PMID: 27875771] (Bioassay)	Bioassay
N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer Capturing the biology of disease severity in a PSC-based model of familial dysautonomia Nat. Med., 2016-11-14;22(12):1421-1427. 2016-11-14 [PMID: 27841875] (Bioassay, Human)	Bioassay	Human
Terry F Davies TAZ induction directs differentiation of thyroid follicular cells from human embryonic stem cells Thyroid, 2017-01-03;0(0):. 2017-01-03 [PMID: 27829313] (Human)		Human
Long-Xing Xue Activin A/Smads signaling pathway negatively regulates Oxygen Glucose Deprivation-induced autophagy via suppression of JNK and p38 MAPK pathways in neuronal PC12 cells Biochem. Biophys. Res. Commun, 2016-10-18;480(3):355-361. 2016-10-18 [PMID: 27769861] (Bioassay, Rat)	Bioassay	Rat
Transient RUNX1 Expression during Early Mesendodermal Differentiation of�hESCs Promotes Epithelial to Mesenchymal Transition through TGFB2 Signaling Stem Cell Reports, 2016-10-06;7(5):884-896. 2016-10-06 [PMID: 27720906] (Bioassay, Human)	Bioassay	Human
Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose PLoS ONE, 2016-09-23;11(9):e0163580. 2016-09-23 [PMID: 27662374] (Bioassay, Mouse)	Bioassay	Mouse
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McLean AB, D'Amour KA, Jones KL, Krishnamoorthy M, Kulik MJ, Reynolds DM, Sheppard AM, Liu H, Xu Y, Baetge EE, Dalton S Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells, 2007-01-01;25(1):29-38. 2007-01-01 [PMID: 17204604] (Bioassay, Human)	Bioassay	Human
Greber B, Lehrach H, Adjaye J Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal. Stem Cells, 2006-10-12;25(2):455-64. 2006-10-12 [PMID: 17038665] (ELISA (Standard))	ELISA (Standard)
Mukhopadhyay A, Chan SY, Lim IJ, Phillips DJ, Phan TT The role of the activin system in keloid pathogenesis. Am. J. Physiol., Cell Physiol., 2006-09-13;292(4):C1331-8. 2006-09-13 [PMID: 16971493] (Bioassay, Human)	Bioassay	Human
Kurita R, Sasaki E, Yokoo T, Hiroyama T, Takasugi K, Imoto H, Izawa K, Dong Y, Hashiguchi T, Soda Y, Maeda T, Suehiro Y, Tanioka Y, Nakazaki Y, Tani K Tal1/Scl gene transduction using a lentiviral vector stimulates highly efficient hematopoietic cell differentiation from common marmoset (Callithrix jacchus) embryonic stem cells. Stem Cells, 2006-05-25;24(9):2014-22. 2006-05-25 [PMID: 16728561] (Bioassay, Primate - Callitrix jacchus (Common Marmoset))	Bioassay	Primate - Callitrix jacchus (Common Marmoset)
Maeshima A, Vaughn DA, Choi Y, Nigam SK Activin A is an endogenous inhibitor of ureteric bud outgrowth from the Wolffian duct. Dev. Biol., 2006-04-27;295(2):473-85. 2006-04-27 [PMID: 16643884] (Bioassay, Rat)	Bioassay	Rat
Yao S, Chen S, Clark J, Hao E, Beattie GM, Hayek A, Ding S Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc. Natl. Acad. Sci. U.S.A., 2006-04-21;103(18):6907-12. 2006-04-21 [PMID: 16632596] (Bioassay, Human)	Bioassay	Human
Silva JR, Tharasanit T, Taverne MA, van der Weijden GC, Santos RR, Figueiredo JR, van den Hurk R The activin-follistatin system and in vitro early follicle development in goats. J. Endocrinol., 2006-04-01;189(1):113-25. 2006-04-01 [PMID: 16614386] (Bioassay, Goat)	Bioassay	Goat
Ng RK, Gurdon JB Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc. Natl. Acad. Sci. U.S.A., 2005-01-31;102(6):1957-62. 2005-01-31 [PMID: 15684086] (Bioassay, Xenopus)	Bioassay	Xenopus
Tardif G, Hum D, Pelletier JP, Boileau C, Ranger P, Martel-Pelletier J Differential gene expression and regulation of the bone morphogenetic protein antagonists follistatin and gremlin in normal and osteoarthritic human chondrocytes and synovial fibroblasts. Arthritis Rheum., 2004-08-01;50(8):2521-30. 2004-08-01 [PMID: 15334466] (Bioassay, Human)	Bioassay	Human
Gilchrist RB, Ritter LJ, Cranfield M, Jeffery LA, Amato F, Scott SJ, Myllymaa S, Kaivo-Oja N, Lankinen H, Mottershead DG, Groome NP, Ritvos O Immunoneutralization of growth differentiation factor 9 reveals it partially accounts for mouse oocyte mitogenic activity. Biol. Reprod., 2004-05-05;71(3):732-9. 2004-05-05 [PMID: 15128595] (Bioassay, Bovine, Mouse)	Bioassay	Bovine, Mouse
Oren A, Toporik A, Biton S, Almogy N, Eshel D, Bernstein J, Savitsky K, Rotman G hCHL2, a novel chordin-related gene, displays differential expression and complex alternative splicing in human tissues and during myoblast and osteoblast maturation. Gene, 2004-04-28;331(0):17-31. 2004-04-28 [PMID: 15094188] (Bioassay, Human)	Bioassay	Human
Grimm OH, 107326, Gurdon JB Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Knockdown of RhoQ, a member of Rho GTPase, accelerates TGF-beta-induced EMT in human lung adenocarcinoma, 2002-07-01;4(7):519-22. 2002-07-01 [PMID: 12068307] (Bioassay, Xenopus)	Bioassay	Xenopus
Kawakami S, 2019, Fujii Y, Okada Y, Winters SJ Paracrine regulation of FSH by follistatin in folliculostellate cell-enriched primate pituitary cell cultures. 101203, 2002-06-01;143(6):2250-8. 2002-06-01 [PMID: 12021189] (Bioassay, Primate - Macaca mulatta (Rhesus Macaque))	Bioassay	Primate - Macaca mulatta (Rhesus Macaque)
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Array 338-AC/CF

• Activin A Antibodies
• Activin A Lysate
• Activin A Protein
• Activin A ELISAs
• Activin A Proteins and Enzymes