Recombinant Mouse Activin B Protein, CF

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Activin and Inhibin, members of the TGF-beta superfamily of cytokines, are involved in a range of biological processes including neural development, stem cell differentiation, reproductive physiology, inflammation, tissue morphogenesis and bone remodeling (1-5). Activins function as either a homodimer or heterodimer of non-glycosylated beta subunit proteins ( beta A, beta B, beta C, and beta E in mammals). Inhibins are heterodimers consisting of a unique alpha  subunit and any one beta  subunit. The alpha - and beta -subunits are produced as precursor proteins with an amino-terminal propeptide that is cleaved to release a carboxy-terminal monomeric subunit that becomes bioactive upon disulfide linkage with another Activin monomer (6, 7). The bioactive Activin B dimeric protein consists of two beta B subunits. The 13 kDa mature mouse Activin beta B subunit shares 99% and 98% amino acid sequence identity with rat and human Activin beta B, respectively. Activin B exerts its biological function upon binding to the type 2 serine/threonine kinase Activin receptor (Act RIIA). This receptor-ligand complex noncovalently associates and transphosphorylates the type 1 Activin receptor (ActRI) to initiate intracellular SMAD activation and the subsequent regulation of Activin-responsive gene transcription (8). BAMBI, Betaglycan, and Cripto, regulate the bioactivity of Activin B by restricting its ability to induce receptor complex assembly. Alternatively, bioavailability of Activin B is modulated through sequestration into inactive complexes with alpha 2-Macroglobulin, Follstatin, and FLRG (9-12).

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: Bioassay.

Showing Publications 1 - 5 of 5.

Publications using 8260-AB/CF	Applications	Species
T Yamamoto, Z Diao, M Murakami, F Shimokawa, T Matsui, M Funaba Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells Cytokine, 2022-06-20;157(0):155936. 2022-06-20 [PMID: 35738051] (Bioassay, Mouse)	Bioassay	Mouse
X Wang, P Tang, F Guo, M Zhang, Y Yan, M Huang, Y Chen, L Zhang, L Zhang mDia1 and Cdc42 regulate Activin B-induced migration of bone marrow-derived mesenchymal stromal cells Stem Cells, 2018-11-09;0(0):. 2018-11-09 [PMID: 30358011] (Bioassay, Mouse)	Bioassay	Mouse
BC Goh, V Singhal, AJ Herrera, RE Tomlinson, S Kim, MC Faugere, EL Germain-Le, TL Clemens, SJ Lee, DJ DiGirolamo Activin Receptor Type IIA (ACVR2A) Functions Directly in Osteoblasts as a Negative Regulator of Bone Mass J. Biol. Chem., 2017-06-28;0(0):. 2017-06-28 [PMID: 28659341] (Bioassay, Mouse)	Bioassay	Mouse
L Zhang, P Xu, X Wang, M Zhang, Y Yan, Y Chen, L Zhang, L Zhang Activin B regulates adipose-derived mesenchymal stem cells to promote skin wound healing via activation of the MAPK signaling pathway Int. J. Biochem. Cell Biol., 2017-04-08;87(0):69-76. 2017-04-08 [PMID: 28396222] (Bioassay, Mouse)	Bioassay	Mouse
Guo T, Marmol P, Moliner A, Bjornholm M, Zhang C, Shokat K, Ibanez C Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife, 2014-08-25;3(0):e03245. 2014-08-25 [PMID: 25161195] (Bioassay, Mouse)	Bioassay	Mouse

Array 8260-AB/CF

• Activin B/Inhibin beta B Antibodies
• Activin B/Inhibin beta B ELISA Kit
• Activin B/Inhibin beta B Lysate
• Activin B/Inhibin beta B Proteins and Enzymes