Reactivity | MuSpecies Glossary |
Applications | Flow |
Clone | 1168B |
Clonality | Monoclonal |
Host | Rabbit |
Conjugate | Phycoerythrin |
Additional Information | Recombinant Monoclonal Antibody. |
Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Pref-1/DLK1/FA1 Ala24-Gln305 Accession # Q09163 |
Specificity | Detects mouse Pref-1/DLK1/FA1 in direct ELISAs. |
Source | N/A |
Isotype | IgG |
Clonality | Monoclonal |
Host | Rabbit |
Gene | DLK1 |
Purity Statement | Protein A or G purified from cell culture supernatant |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Storage | Protect from light. Do not freeze.
|
Buffer | Supplied in a saline solution containing BSA and Sodium Azide. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS. |
Preservative | Sodium Azide |
Pref-1 (Preadipocyte factor 1), also known as Protein delta homolog 1, DLK1, FA1 and Fetal antigen 1, is a 45-60 kDa transmembrane glycoprotein that is highly expressed in fetal liver, placenta, adult adrenal gland, brain, testis and ovary. Expression of Pref-1 is elevated in liver after birth but starts to decline around postnatal day 16. Mature mouse Pref-1 is a 362 amino acid (aa) type I transmembrane N- and O-linked glycoprotein. It contains a 282 aa extracellular region (aa 24-305), a 24 aa transmembrane segment (aa 306-329), and a 56 aa cytoplasmic domain (aa 330-385). It contains 6 EGF-like domains and is involved in embryonic skeletal system development. Pref-1 inhibits preadipocyte proliferation by regulating their entry into G1/S-phase and represses preadipocyte differentiation. It is a master regulator of preadipocyte homeostasis and adipose tissue expansion. Pref-1 manipulation may, therefore, be utilized in obesity treatments. Mouse Pref-1 shares 85% and 94% aa identity with human and rat Pref-1, respectively.
Secondary Antibodies |
Isotype Controls |
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