Notch-1 Antibody (mN1A) - BSA Free

Notch1, also known as neurogenic locus notch homolog protein 1, is a single-pass transmembrane protein that serves as the receptor for the Delta1, Jagged1 and Jagged2 ligands. Activation of Notch1 causes the cytoplasmic domain to be cleaved, releasing the notch intracellular domain (NICD) which forms a complex with RBPJ/RBPSUH and subsequently influences transcription of its target genes. Because the majority of Notch1 ligands are transmembrane proteins, Notch1 is primarily triggered by cell-to-cell contact and employs lateral inhibition mechanisms to influence local populations of cells. The Notch1 pathway plays a pivotal role in development, including cell-fate determination, proliferation, and cell contact-dependent signaling. Aberrant activation of the Notch1 pathway has been associated with numerous diseases such as bicuspid aortic valve and cancer - in particular certain leukemias.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 5 applications: ICC/IF, IF/IHC, IHC-Fr, IP, WB.

Showing Publications 1 - 10 of 10.

Publications using NB100-78486	Applications	Species
Alghamdi TA, Krentz NAJ, Smith N et al. Zmiz1 is required for mature B-cell function and mass expansion upon high fat feeding Molecular metabolism 2022-10-25 [PMID: 36307047] (WB, Mouse) Details: Dilution used in WB 1:200	WB	Mouse
Gong M, Yan F, Yu L, Li F A dopamine-methacrylated hyaluronic acid hydrogel as an effective carrier for stem cells in skin regeneration therapy Cell death & disease 2022-08-27 [PMID: 36030275] (IHC-Fr, WB, Mouse) Details: WB Dilutions: 1:1000; ICC/IF Dilutions: 1:100	IHC-Fr, WB	Mouse
Bai J, Khajavi M, Sui L et al. Angiogenic responses in a 3D micro-engineered environment of primary endothelial cells and pericytes Angiogenesis 2020-09-21 [PMID: 32955682] (ICC/IF)	ICC/IF
Kang H, Yang K, Xiao L et al. Osteoblast Hypoxia-Inducible Factor-1a Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway. Front Immunol. 2017-10-31 [PMID: 29085370] (WB, Mouse)	WB	Mouse
Singh NK, Kotla S, Kumar R, Rao GN Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling. EBioMedicine 2015-11-01 [PMID: 26870802]
Qiu, H, Tang, X Et al. Notch1 Autoactivation via Transcriptional Regulation of Furin, Which Sustains Notch1 Signaling by Processing Notch1-Activating Proteases ADAM10 and Membrane Type 1 Matrix Metalloproteinase. Mol Cell Biol 2015-11-01 [PMID: 26283728] (IF/IHC, Mouse)	IF/IHC	Mouse
Jundt F et al. Leukemia. 22:1587. 2008-01-01 [PMID: 18449208] (IF/IHC)	IF/IHC
Sun H et al. J. Cell Biol. 177:647. 2007-01-01 [PMID: 17502421] (IF/IHC)	IF/IHC
De Strooper B, Annaert W, Cupers P et al. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 1999-04-08 [PMID: 10206645] (WB, Mouse)	WB	Mouse
Ray WJ, Yao M, Nowotny P et al. Evidence for a physical interaction between presenilin and Notch. Proc Natl Acad Sci U S A. 1999-03-16 [PMID: 10077672] (WB, IP, Human)	WB, IP	Human

Images	Ratings	Applications	Species	Date	Details
	5 reviewed by: Verified Customer	WB	Mouse	12/07/2021	View Summary Application Western Blot Sample Tested Vascular Smooth Muscle Cells Species Mouse Lot NR1C2
	5 reviewed by: Shyam Gudey	WB	Other	01/10/2014	View Summary Application Western Blot Species Other Lot Lot B 134275

Array NB100-78486

• Notch-1 Antibodies
• Notch-1 ELISA Kits
• Notch-1 Lysate
• Notch-1 Proteins
• Notch-1 Proteins and Enzymes
• Notch-1 ELISA