Please differentiate to me between PPAR and PGC clearly. I am confused with the difference between these two

Name: PGC1 alpha Antibody
Brand: Novus Biologicals
SKU: NB100-1750
Price: 499 USD

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Thank you very much for contacting Novus Biologicals technical support team and sharing your query on the differences between PGC-1 alpha and PPAR. These are two different proteins encoded by their respective genes and serves different functions. PGC-1 alpha (PGC1A or PPAR gamma coactivator 1-alpha) is a transcriptional co-activator for steroid receptors and nuclear receptors, and it regulates diverse aspects of cellular physiology. It up-regulates the transcriptional activity of PPAR-gamma /thyroid hormone receptor on the uncoupling protein promoter; regulates the key mitochondrial genes involved in adaptive thermogenesis; implicates in the metabolic reprogramming in response to nutrients availability through the coordination of the expression of a wide array of genes involved in the regulation of glucose and fatty acid metabolism. Among our PGC-1 alpha antibodies, NBP1-04676 is our best selling product with nice customer feedback and citations in at least 13 research publications. PPAR (PPAR alpha) on the other hand is a ligand-activated transcription factor which gets activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine, and oleylethanolamide (a naturally occurring lipid that regulates satiety), and acts as a key regulator of lipid metabolism. It also acts as a receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. It regulates the peroxisomal beta-oxidation pathway of fatty acids, and also functions as transcription activator for the ACOX1 and P450 genes. We have a variety of PPAR alpha antibodies. I hope you will find this information helpful but please let me know if I can support you with anything else from my end. Thank you very much for choosing Novus Biologicals as your quality reagent supplier and we wish you the best with your research projects.

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, MuSpecies Glossary
Applications	WB, IHC
Clonality	Polyclonal
Host	Rabbit
Conjugate	Unconjugated
Concentration	0.25 mg/ml

Immunogen	The immunogen recognized by this PGC1 alpha Antibody maps to a region between residue 250 and 300 of human peroxisome proliferative activated receptor, gamma, coactivator 1, alpha using the numbering given in SwissProt entry Q9UBK2 (Gene ID 10891).
Specificity	The epitope recognized by PGC1 alpha Antibody maps to a region between residue 250 and 300 of human PGC1 alpha using the numbering given in SwissProt entry Q9UBK2 (Gene ID: 10891).
Isotype	IgG
Clonality	Polyclonal
Host	Rabbit
Gene	PPARGC1A
Purity	Immunogen affinity purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Store at 4C. Do not freeze.
Buffer	TBS and 0.1% BSA
Preservative	0.09% Sodium Azide
Concentration	0.25 mg/ml
Purity	Immunogen affinity purified

Publications using NB100-1750	Applications	Species
Gioscia-Ryan RA, Battson ML, Cuevas LM et al. Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice. Aging (Albany NY). 2016-11-22 [PMID: 27875805] (WB, Mouse)	WB	Mouse
Feigerlova E, Demarquet L, Melhem H et al. Methyl donor deficiency impairs bone development via peroxisome proliferator-activated receptor-gamma coactivator-1 alpha -dependent vitamin D receptor pathway FASEB J. 2016-07-19 [PMID: 27435264]
Ivanova MM, Radde BN, Son J, Mehta FF et al. Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus. Society for Endocronology. 2010-09-10 [PMID: 23892277] (IF/IHC, Mouse)	IF/IHC	Mouse

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Gene Symbol	PPARGC1A
Entrez	10891(Human)
Uniprot	Q9UBK2(Human)