PD-1 Antibody - BSA Free

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 6 applications: EM, FLOW, ICC/IF, IHC, IHC-P, WB.

Showing Publications 1 - 5 of 5.

Publications using NBP1-77276	Applications	Species
Meng Y, Zhao Q, Sang Y et al. GPNMB+ Gal-3+ hepatic parenchymal cells promote immunosuppression and hepatocellular carcinogenesis The EMBO journal 2023-11-27 [PMID: 38009297] (FLOW, Rat)	FLOW	Rat
Xie C, You X, Zhang H et al. A Nanovaccine Based on Adjuvant Peptide FK-13 and l-Phenylalanine Poly(ester amide) Enhances CD8(+) T Cell-Mediated Antitumor Immunity Advanced Science 2023-07-01 [PMID: 37162249] (EM, ICC/IF, IHC, FLOW)	EM, ICC/IF, IHC, FLOW
Lu CH, Chung WM, Tsai CH et al. In vitro characterization of a small molecule PD-1 inhibitor that targets the PD-l/PD-L1 interaction Scientific reports 2022-01-07 [PMID: 34996924] (WB, Human)	WB	Human
Agina HA, Ehsan NA, Abd-Elaziz TA et al. Hepatic expression of programmed death-1 (PD-1) and its ligand, PD-L1, in children with autoimmune hepatitis: relation to treatment response Clin Exp Hepatol. 2019-09-05 [PMID: 31598564] (IHC-P, Human)	IHC-P	Human
CCR4 Blockade Depletes Regulatory T cells and Prolongs Survival in a Canine Model of Bladder Cancer. Maeda S, Murakami K, Inoue A et al. Cancer Immunol Res [PMID: 31160277]

Array NBP1-77276

• PD-1 Antibodies
• PD-1 Antibody Pair
• PD-1 Lysate
• PD-1 Proteins
• PD-1 ELISAs
• PD-1 Proteins and Enzymes