OPA1 Antibody - BSA Free

OPA1 (optic atrophy-1) is a member of dynamin family of large GTPases and is a major player in fusion of the inner mitochondrial membrane and maintenance of cristae architecture, events which are orchestrated through oligomerization of differentially processed forms of OPA1. It exists as a single-pass membrane protein in the mitochondrion inner membrane as well as in soluble forms in mitochondrion intermembrane space, and is expressed in retina, brain, testis, heart, skeletal muscles etc. It binds with PARL and interacts with CHCHD3 as well as IMMT (preferentially with soluble OPA1 forms). Proteolytic processing in response to intrinsic apoptotic signals may lead to disassembly of OPA1 oligomers and release of the caspase activator cytochrome C (CYCS) into mitochondrial intermembrane space. OPA1 form S1: inactive form produced by cleavage at S1 position by OMA1 following stress conditions that induce loss of mitochondrial membrane potential, leading to negative regulation of mitochondrial fusion. Defects in OPA1 have been linked to optic atrophy type 1 (OPA1) and dominant optic atrophy plus syndrome (DOA+).

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Porcine, Zebrafish.

We have publications tested in 8 applications: ICC/IF, IF/IHC, IHC-P, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Simple Western, WB, Western Blot.

Showing Publications 1 - 10 of 49. Show All 49 Publications. Collapse Publications.

Publications using NB110-55290	Applications	Species
Gomez-Valades Ag, Pozo M, Varela L Et Al. Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis Cell metabolism 2021-07-27 [PMID: 34343501]
Chidipi B, Shah SI, Reiser M et al. All-Trans Retinoic Acid Increases DRP1 Levels and Promotes Mitochondrial Fission Cells 2021-05-14 [PMID: 34068960] (WB, Human, Mouse)	WB	Human, Mouse
Yue M, Hinkle KM, Davies P et al. Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice Neurobiol. Dis. 2015-03-31 [PMID: 25836420] (WB, Mouse)	WB	Mouse
Bus C, Geisler S, Feldkaemper M, Flores-Romero H PINK1 Regulates Dopamine and Lipids at Mitochondria to Maintain Synapses and Neuronal Function bioRxiv 2019-10-22 (WB, Mouse)	WB	Mouse
Ren Z, Guo C, He H et al. Effects of deoxynivalenol on mitochondrial dynamics and autophagy in pig spleen lymphocytes Food Chem. Toxicol. 2020-04-14 [PMID: 32302720] (WB, Porcine)	WB	Porcine
Raynor JL, Liu C, Dhungana Y et al. Hippo/Mst signaling coordinates cellular quiescence with terminal maturation in iNKT cell development and fate decisions J. Exp. Med. 2020-06-01 [PMID: 32289155] (WB, Mouse)	WB	Mouse
Zakarya R, Sapkota A, Chan YL et al. Nitroxides affect neurological deficits and lesion size induced by a rat model of traumatic brain injury Nitric Oxide 2020-04-01 [PMID: 32061903] (WB, Rat)	WB	Rat
Chao T, Burmeister D M et al. Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 2019-01-06 [PMID: 30920884] (WB, Porcine)	WB	Porcine
Sikorski K, Mehta A et al. A high-throughput pipeline for validation of antibodies. Nat Methods 2018-01-11 [PMID: 30377371] (Human) Details: Antibody validation based on denaturing gel electrophoresis of biotinylated cell lysates (PAGE) followed by mass spectrometry (MS) and antibody array analysis (MAP).		Human
Sakiyama H, Li L, Kuwahara-Otani S et al. A lack of ChREBP inhibits mitochondrial cristae formation in brown adipose tissue Molecular and cellular biochemistry 2021-05-21 [PMID: 34021470]
e Silva AC Neuro-Resilient Function of PRMT8 Against Cellular Stress Thesis 2021-01-01
Wang D, Kuang Y, Wan Z et al. Aspartate Alleviates Colonic Epithelial Damage by Regulating Intestinal Stem Cell Proliferation and Differentiation via Mitochondrial Dynamics Molecular nutrition & food research 2022-10-30 [PMID: 36310136] (WB)	WB
Yao J, Takenaga K, Koshikawa N et al. Anticancer effect of a pyrrole-imidazole polyamide-triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells International journal of cancer 2022-10-10 [PMID: 36214789]
Trewin AJ, Silver J, Dillon HT et al. Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle BMC biology 2022-07-18 [PMID: 35850762] (WB, Mouse)	WB	Mouse
Ramasubramanian B, Griffith C, Hanson M et al. Protective Effects of Chaya against Mitochondrial and Synaptic Toxicities in the Type 2 Diabetes Mouse Model TallyHO Cells 2022-02-21 [PMID: 35203393] (IF/IHC, WB, Mouse)	IF/IHC, WB	Mouse
Li J, Zhang Z, Wang L et al. Maresin 1 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting NOX4/ROS/NF-kappaB Pathway Frontiers in pharmacology 2021-12-10 [PMID: 34955852]
Chidipi B, Angulo MB, Shah SI et al. The dynamin-related protein 1 is decreased and the mitochondrial network is altered in Friedreich's ataxia cardiomyopathy The international journal of biochemistry & cell biology 2021-12-16 [PMID: 34923139] (ICC/IF, WB, Human)	ICC/IF, WB	Human
Senthil K, Morgan R, Hefti M et al. Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model Resusc Plus 2021-07-05 [PMID: 34223382]
SA Harper, JR Bassler, S Peramsetty, Y Yang, LM Roberts, D Drummer, RT Mankowski, C Leeuwenbur, K Ricart, RP Patel, MM Bamman, SD Anton, BC Jaeger, TW Buford Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial Exp Gerontol, 2020-10-15;0(0):111111. 2020-10-15 [PMID: 33068691] (Simple Western, Human)	Simple Western	Human
Li G, Chan Y. L, et al. E-cigarettes damage the liver and alter nutrient metabolism in pregnant mice and their offspring. Ann N Y Acad Sci 2020-09-01 [PMID: 32557680] (WB, Mouse)	WB	Mouse
Ge Y, Shi X, Boopathy S et al. Two forms of Opa1 cooperate to complete fusion of the mitochondrial inner-membrane Elife 2020-01-11 [PMID: 31922487]
Chao T, Gomez BI, Heard TC et al. Burn-Induced Reductions in Mitochondrial Abundance and Efficiency are More Pronounced with Small Volumes of Colloids in Swine Am. J. Physiol., Cell Physiol. 2019-09-18 [PMID: 31532719] (WB, Porcine)	WB	Porcine
Chen H, Chan YL, Linnane C et al. L-Carnitine and extendin-4 improve outcomes following moderate brain contusion injury. Sci Rep 2018-07-25 [PMID: 30046063] (WB, Rat)	WB	Rat
Yoon Y, Kim S, Han Y et al. Protect TUDCA stimulated CKD-derived hMSCs against the CKD-Ischemic disease via upregulation of PrPC. bioRxiv 2018-08-28 (WB, Human)	WB	Human
Mariacristina Filice, Alfonsina Gattuso, Sandra Imbrogno, Rosa Mazza, Daniela Amelio, Alessia Caferro, Claudio Agnisola, José Manuel Icardo, Maria Carmela Cerra Functional, structural, and molecular remodelling of the goldfish ( Carassius auratus) heart under moderate hypoxia Fish Physiology and Biochemistry 2024-01-10 [PMID: 38198074]
Saito ER, Warren CE, Hanegan CM et al. A Novel Ketone-Supplemented Diet Improves Recognition Memory and Hippocampal Mitochondrial Efficiency in Healthy Adult Mice Metabolites 2022-10-25 [PMID: 36355101] (WB, Mouse)	WB	Mouse
Soundararajan R, Hern�ndez-Cuervo H, Stearns TM et al. A-Kinase Anchor Protein 1 deficiency causes mitochondrial dysfunction in mouse model of hyperoxia induced acute lung injury Frontiers in Pharmacology 2022-10-03 [PMID: 36263130] (Western Blot)	Western Blot
Faiq MA, Sengupta T, Nath M et al. Ocular manifestations of central insulin resistance Neural Regeneration Research 2023-01-01 [PMID: 36255004] (Immunocytochemistry/ Immunofluorescence)	Immunocytochemistry/ Immunofluorescence
Wongkitikamjorn W, Hosomichi J, Wada E et al. Gestational Intermittent Hypoxia Induces Mitochondrial Impairment in the Geniohyoid Muscle of Offspring Rats Cureus 2022-05-17 [PMID: 35600069] (Immunohistochemistry, Western Blot)	Immunohistochemistry, Western Blot
L�n�rt K, Bank� C, Ujlaki G et al. Tissue Transglutaminase Knock-Out Preadipocytes and Beige Cells of Epididymal Fat Origin Possess Decreased Mitochondrial Functions Required for Thermogenesis International Journal of Molecular Sciences 2022-05-05 [PMID: 35563567] (Western Blot)	Western Blot
Meng Q, Zaharieva EK, Sasatani M, Kobayashi J. Possible relationship between mitochondrial changes and oxidative stress under low dose-rate irradiation Redox Report 2021-08-26 [PMID: 34435550] (Western Blot, Immunocytochemistry/ Immunofluorescence)	Western Blot, Immunocytochemistry/ Immunofluorescence
Philipp Portz, Michael K. Lee, Ilana Chefetz Menaker Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the alpha -Synuclein Pathology in a Transgenic Mouse Model of Parkinson’s Disease Cells 2021-04-13 [PMID: 33924585]
Douida A, Batista F, Boto P et al. Cells Lacking PA200 Adapt to Mitochondrial Dysfunction by Enhancing Glycolysis via Distinct Opa1 Processing International Journal of Molecular Sciences 2021-02-05 [PMID: 33562813]
Chang JC, Chang HS, Wu YC et al. Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer J. Exp. Clin. Cancer Res. 2019-01-23 [PMID: 30674338] (WB, Human)	WB	Human
Du X, Wen J, Wang Y et al. Hippo/Mst signalling couples metabolic state and immune function of CD8alpha+ dendritic cells Nature 2018-06-01 [PMID: 29849151] (WB, Mouse)	WB	Mouse
Chan YL, Saad S, Al-Odat I et al. Maternal L-Carnitine Supplementation Improves Brain Health in Offspring from Cigarette Smoke Exposed Mothers. Front Mol Neurosci. 2017-02-28 [PMID: 28243190] (WB, Mouse)	WB	Mouse
Tan LX, Toops KA, Lakkaraju A. Protective responses to sublytic complement in the retinal pigment epithelium Proc. Natl. Acad. Sci. U.S.A. 2016-08-02 [PMID: 27432952] (WB)	WB
Bohovych I, Fernandez MR, Rahn JJ et al. Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability. Sci Rep 2015-09-14 [PMID: 26365306] (WB, Zebrafish)	WB	Zebrafish
Lee KP, Jin Shin Y, Chun Cho S et al. Peroxiredoxin 3 has a Crucial Role in the Contractile Function of Skeletal Muscle via Regulating Mitochondrial Homeostasis. Free Radic. Biol. Med. 2014-09-12 [PMID: 25224038]
Lionetti L, Mollica MP, Donizzetti I et al. High-lard and high-fish-oil diets differ in their effects on function and dynamic behaviour of rat hepatic mitochondria. PLoS ONE 2014-03-25 [PMID: 24663492] (WB, IHC-P, Rat)	WB, IHC-P	Rat
Hara H, Araya J, Ito S et al. Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence. Am J Physiol Lung Cell Mol Physiol. 2013-11-01 [PMID: 24056969] (WB, Human)	WB	Human
Ussakli CH, Ebaee A, Binkley J et al. Mitochondria and Tumor Progression in Ulcerative Colitis. J Natl Cancer Inst 2013-07-12 [PMID: 23852949] (IF/IHC, Human)	IF/IHC	Human
Rahn JJ, Stackley KD, Chan SS. Opa1 is required for proper mitochondrial metabolism in early development PLoS One 2013-01-01 [PMID: 23516612] (WB, Zebrafish)	WB	Zebrafish
Trushina E, Nemutlu E, Zhang S et al. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer's disease. PLoS One. 2012-01-01 [PMID: 22393443] (WB, Mouse)	WB	Mouse
Johnson D, Allman E, Nehrke K. Regulation of acid-base transporters by reactive oxygen species following mitochondrial fragmentation. Am J Physiol Cell Physiol;302(7):C1045-54. 2012-04-01 [PMID: 22237403] (WB, Rat)	WB	Rat
Vallon M, Aubele P, Janssen K-P, Essler M. Thrombin-induced shedding of tumor endothelial marker 5 and exposure of its RGD motif are regulated by cell surface protein disulfide isomerase. The Biochemical Journal. 2011-10-20 [PMID: 22013897] (WB, Human)	WB	Human
Dai DF, Hsieh EJ, Liu Y, Chen T, Beyer RP, Chin MT, MacCoss MJ, Rabinovitch PS. Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress. Cardiovasc Res;93(1):79-88. 2012-01-01 [PMID: 22012956] (WB, Mouse)	WB	Mouse
Tang D, Kang R, Livesey KM et al. High-mobility group box 1 is essential for mitochondrial quality control Cell Metab 2011-06-01 [PMID: 21641551] (WB, Mouse)	WB	Mouse
Show All 49 Publications. Collapse Publications.

Images	Ratings	Applications	Species	Date	Details
Enlarge	5 reviewed by: Verified Customer	WB	Other	06/04/2015	View Summary Application Western Blot Sample Tested Retinal pigment epithelium lysate Species Other Lot D
	5 reviewed by: Verified Customer	WB	Other	01/19/2010	View Summary Application Western Blot Sample Tested COS-1 cell, Sample Amount: 30 ug Species Other Lot B1

Array NB110-55290

• OPA1 Antibodies
• OPA1 Lysates
• OPA1 Proteins