Name: LAP (TGF-beta 1) Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF-246-NA
Rating: 3.7 (3 reviews)

- COVID-19 Research Tools
  
  Antibodies
  Primary Antibodies
  Conjugated Antibodies
  
  Sample Size Antibodies
  
  KO Validated Antibodies
  
  Recombinant Antibodies
  
  Antibody Sampler Packs
  
  Antibody Pairs
  
  Secondary Antibodies
  
  Isotype Control Antibodies
  
  Proteins and Peptides
  Peptides & Proteins
  
  Blocking Peptides
  
  Biologically Active Proteins
  
  Lysates and Cell Lines
  Lysates
  
  Stem Cell Lines
- Kits
  Antibody Labeling Kits
  
  ChIP Kits
  
  ELISA Kits
  
  Flow Cytometry Kits
  
  Activators and Inhibitors
  Inhibitors
  
  Activators
  
  Support Products
  Exosome Isolation
  
  Flow Cytometry Beads
  
  IHC Tissue Slides
  
  IHC Microarrays
  
  Western Blot Gels & Buffers
  
  Western Blot Membranes
  
  All Support Products
  
  Bulk and Custom
Products
Our Protocols
- Resources
  Protocols
  
  Video Protocols
  
  Troubleshooting Guides
  
  Posters and Literature
  
  Handbooks and Guides
  
  Calculators
  
  FAQs
  
  Blogs
  
  Diseases
  
  Whitepapers
  
  Antibody Concierge
  
  Webinars
- Tools
  Spectra Viewer
  
  Flow Cytometry Panel Builder
  
  Application
  ELISA
  
  Flow Cytometry
  
  Mass Cytometry (CyTOF)
  
  ICC
  
  IHC
  
  Western Blotting
  
  Interviews
  Faculty
  
  Postdoc
Resources
View Pathways
- By Research Area
  Apoptosis
  
  Autophagy
  
  Cancer
  
  Cell Biology
  
  Cellular Markers
  
  Epigenetics
  
  Epitope Tags
  
  Exosomes Research
  
  Hypoxia
  
  Immunology
  
  Microbiology
  
  Neuroscience
  
  Stem Cells
- By Pathway
  AKT
  
  Apoptosis
  
  Autophagy
  
  ERK1/2/5 Pathway
  
  Hedgehog
  
  Hippo
  
  JNK Pathway
  
  mTOR
  
  Necroptosis
  
  NFKB Signaling
  
  p38 Signaling
  
  TGF Beta
  
  TLR
Research Areas
Get Rewards
- Customer Care
  100% Guarantee
  
  Risk Free Testing
  
  Novus Rewards Program
  
  Publication Rewards Program
  
  New Lab Discount
  
  Scholarship
  
  Travel Grants
  
  Promotions
Customer Care
Novus Careers
- About us
  Careers
  
  Collaborations
  
  Events
  
  Novus Story
  
  Our Team
  
  Philanthropy
  
  Press Releases
  
  Why choose Novus
About Us
- Contact Us
  Customer Service
  
  Distributors
  
  Technical Support
Contact

At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, Simple Western, B/N, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Biotin BAF246

Catalog# & Formulation	Size	Price
Carrier Free AF-246-SP

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF246

LAP (TGF-beta 1) Antibody [Unconjugated]

Species Glossary

Images

Product Details

Order Details

LAP (TGF-beta 1) Antibody [Unconjugated] Summary

Applications/Dilutions

Packaging, Storage & Formulations

Notes

Alternate Names for LAP (TGF-beta 1) Antibody [Unconjugated]

Background

Limitations

Customers Who Viewed This Item Also Viewed...

Publications for LAP (TGF-beta 1) Antibody (AF-246-NA)(34)

Reviews for LAP (TGF-beta 1) Antibody (AF-246-NA) (3) 3.73

Summary

Summary

Summary

Product General Protocols

Video Protocols

FAQs for LAP (TGF-beta 1) Antibody (AF-246-NA) (0)

Secondary Antibodies

Isotype Controls

Additional LAP (TGF-beta 1) Products

Blogs on LAP (TGF-beta 1)

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Recent Reviews

Bioinformatics

Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived and Chinese hamster ovary cell line CHO-derived recombinant human LAP TGF‑ beta 1 Leu30-Ser390 Accession # P01137
Specificity	Detects human LAP TGF‑ beta 1 in direct ELISAs and Western blots.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	TGFB1
Purity Statement	Antigen Affinity-purified
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF-246-NA	Applications	Species
N Subramania, K Hofwimmer, B Tavira, L Massier, DP Andersson, P Arner, J Laurenciki Adipose tissue specific CCL18 associates with cardiometabolic diseases in non-obese individuals implicating CD4+ T cells Cardiovascular Diabetology, 2023-04-12;22(1):84. 2023-04-12 [PMID: 37046242] (Neutralization, Human)	Neutralization	Human
GK Annarapu, D Nolfi-Done, M Reynolds, Y Wang, L Kohut, B Zuckerbrau, S Shiva Heme stimulates platelet mitochondrial oxidant production to induce targeted granule secretion Redox Biology, 2021-12-05;48(0):102205. 2021-12-05 [PMID: 34891098] (Dot Blot, Human)	Dot Blot	Human
C Shen, J Liu, L Wang, Z Liang, H Niu, Y Wang Identification of metabolism-associated genes and construction of a prognostic signature in bladder cancer Cancer Cell International, 2020-11-04;20(1):538. 11/4/2020 [PMID: 33292266]
William D Stuart, Minzhe Guo, Iris M Fink-Baldauf, Alan M Coleman, John P Clancy, Marcus A Mall et al. CRISPRi-mediated functional analysis of lung disease-associated loci at non-coding regions NAR Genomics and Bioinformatics 6/1/2020 [PMID: 32500120]
Xiao-Sun Liu, Xian-Ke Lin, Ying Mei, Sabir Ahmad, Chong-Xian Yan, Hai-Long Jin et al. Regulatory T Cells Promote Overexpression of Lgr5 on Gastric Cancer Cells via TGF-beta1 and Confer Poor Prognosis in Gastric Cancer Frontiers in Immunology 7/30/2019 [PMID: 31417548]
D van de Vle, J Demmers, XX Nguyen, Y Campos, E Machado, I Annunziata, H Hu, E Gomero, X Qiu, A Bongiovann, CA Feghali-Bo, A d'Azzo Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis Sci Adv, 2019-07-17;5(7):eaav3270. 2019-07-17 [PMID: 31328155] (Western Blot, Mouse)	Western Blot	Mouse
Ratnakar Tripathi, Elizabeth A. Giuliano, Hannah B. Gafen, Suneel Gupta, Lynn M. Martin, Prashant R. Sinha et al. Is sex a biological variable in corneal wound healing? Experimental Eye Research 10/1/2019 [PMID: 31226339]
Xi Ou, Jing Guan, Jing‑Sen Chen, Jie‑Cao Ying, Xiao‑Ping Liu, Pei‑Kai Tian et al. LAP+CD4+ T cells are elevated among the peripheral blood mononuclear cells and tumor tissue of patients with hepatocellular carcinoma Experimental and Therapeutic Medicine 5/29/2018 [PMID: 30116333]
H Ohtani, T Terashima, E Sato Immune cell expression of TGF?1 in cancer with lymphoid stroma: dendritic cell and regulatory T cell contact Virchows Arch., 2018-03-28;0(0):. 2018-03-28 [PMID: 29594353] (IHC-P, Human)	IHC-P	Human
DL Coutu, KD Kokkaliari, L Kunz, T Schroeder Multicolor quantitative confocal imaging cytometry Nat. Methods, 2017-11-13;15(1):39-46. 2017-11-13 [PMID: 29320487] (IHC, Mouse)	IHC	Mouse
E Ventura, M Weller, I Burghardt Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-? and Furin in Glioma-Initiating Cells J. Immunol., 2017-05-08;0(0):. 2017-05-08 [PMID: 28484053] (Western Blot, Human)	Western Blot	Human
O Miroshnych, WT Chang, JL Dragoo The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration Am J Sports Med, 2016-12-27;45(4):945-953. 2016-12-27 [PMID: 28027451] (Western Blot, Human)	Western Blot	Human
Boris Hinz MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells Nat Mater, 2016-10-31;0(0):. 2016-10-31 [PMID: 27798620] (Western Blot, Rat)	Western Blot	Rat
D C Koch, H S Jang, E F O'Donnell, S Punj, P R Kopparapu, W H Bisson et al. Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated induction of transforming growth factor-beta 1 Oncogene 12/10/2015 [PMID: 25867062]
Cesar Cilento Ponce, Maria Maria de Lourdes Lopes Ferrari Chauffaille, Silvia Saiuli Miki Ihara, Maria Regina Regis Silva Increased angiogenesis in primary myelofibrosis: latent transforming growth factor-beta as a possible angiogenic factor Revista Brasileira de Hematologia e Hemoterapia 9/1/2014 [PMID: 25305163]
Jessica Kast, Patrizia Hanecker, Nathalie Beaufort, Armin Giese, Anne Joutel, Martin Dichgans et al. Sequestration of latent TGF-beta binding protein 1 into CADASIL-related Notch3-ECD deposits Acta Neuropathologica Communications 12/1/2014 [PMID: 25190493]
Fumin Chang, Christopher A. Lemmon, Voraphoj Nilaratanakul, Varda Rotter, Lewis Romer Endothelial matrix assembly during capillary morphogenesis: insights from chimeric TagRFP-fibronectin matrix Journal of Histochemistry & Cytochemistry 11/1/2014 [PMID: 25063001]
Antoine François, Emmanuel Chatelus, Dominique Wachsmann, Jean Sibilia, Seiamak Bahram, Ghada Alsaleh et al. B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis Arthritis Research & Therapy 10/28/2013 [PMID: 24289101]
Yasmin N, Bauer T, Modak M, Wagner K, Schuster C, Koffel R, Seyerl M, Stockl J, Elbe-Burger A, Graf D, Strobl H Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation. J Exp Med, 2013-11-04;210(12):2597-610. 2013-11-04 [PMID: 24190429] (IHC-Fr, Human)	IHC-Fr	Human
Shahinian H, Loessner D, Biniossek M, Kizhakkedathu J, Clements J, Magdolen V, Schilling O Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFbeta-1 signaling in ovarian cancer cells. Mol Oncol, 2013-10-01;8(1):68-82. 2013-10-01 [PMID: 24120346] (IHC, Western Blot, Human, Mouse)	IHC, Western Blot	Human, Mouse
Brophy T, Coller B, Ahamed J Identification of the thiol isomerase-binding peptide, mastoparan, as a novel inhibitor of shear-induced transforming growth factor beta1 (TGF-beta1) activation. J Biol Chem, 2013-03-05;288(15):10628-39. 2013-03-05 [PMID: 23463512] (Western Blot, Human)	Western Blot	Human
Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini F, Andreeff M, Kuratsu J, Lang F TGF-beta mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells. Cancer Res, 2013-01-30;73(7):2333-44. 2013-01-30 [PMID: 23365134] (Neutralization, Human)	Neutralization	Human
Jasvir Kaur, Dieter P. Reinhardt Immobilized Metal Affinity Chromatography Co-Purifies TGF-beta 1 with Histidine-Tagged Recombinant Extracellular Proteins PLoS ONE 10/31/2012 [PMID: 23119075]
Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell, 2011-11-23;147(5):1146-58. 2011-11-23 [PMID: 22118468] (ICC, Mouse)	ICC	Mouse
Navin K. Kapur, Ce Bian, Edward Lin, Clayton B. Deming, Jason L. Sperry, Baranda S. Hansen et al. Inhibition of transforming growth factor-beta restores endothelial thromboresistance in vein grafts Journal of Vascular Surgery 10/1/2011 [PMID: 21803524]
Shen M, Siu S, Byrd S, Edelmann KH, Patel N, Ketchem RR, Mehlin C, Arnett HA, Hasegawa H Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31. Exp. Cell Res., 2010-12-21;317(7):976-93. 2010-12-21 [PMID: 21182835] (Western Blot, Human)	Western Blot	Human
Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis. Biol. Reprod., 2010-03-24;83(1):27-35. 2010-03-24 [PMID: 20335639] (Neutralization, Human)	Neutralization	Human
Popovic N, Bridenbaugh EA, Neiger JD, Hu JJ, Vannucci M, Mo Q, Trzeciakowski J, Miller MW, Fossum TW, Humphrey JD, Wilson E Transforming growth factor-beta signaling in hypertensive remodeling of porcine aorta. Am. J. Physiol. Heart Circ. Physiol., 2009-08-28;297(6):H2044-53. 2009-08-28 [PMID: 19717726] (IHC, Porcine)	IHC	Porcine
Hackett TL, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, Argentieri R, Kicic A, Stick SM, Bai TR, Knight DA Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1. Am. J. Respir. Crit. Care Med., 2009-04-30;180(2):122-33. 2009-04-30 [PMID: 19406982] (Neutralization, Human)	Neutralization	Human
Pierre-Jean Wipff, Daniel B. Rifkin, Jean-Jacques Meister, Boris Hinz Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix The Journal of Cell Biology 12/17/2007 [PMID: 18086923]
Shazia S. Chaudhry, Stuart A. Cain, Amanda Morgan, Sarah L. Dallas, C. Adrian Shuttleworth, Cay M. Kielty Fibrillin-1 regulates the bioavailability of TGFbeta1 The Journal of Cell Biology 1/29/2007 [PMID: 17242066]
Rose DM, Sydlaske AD, Agha-Babakhani A, Johnson K, Terkeltaub R Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils. Arthritis Rheum., 2006-10-01;54(10):3363-71. 2006-10-01 [PMID: 17009310] (Neutralization, Mouse)	Neutralization	Mouse
Unitt E, Rushbrook SM, Marshall A, Davies S, Gibbs P, Morris LS, Coleman N, Alexander GJ Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells. Hepatology, 2005-04-01;41(4):722-30. 2005-04-01 [PMID: 15791620] (IHC-P, Human)	IHC-P	Human
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood, 2004-09-16;105(2):750-8. 2004-09-16 [PMID: 15374887] (Neutralization, Human)	Neutralization	Human
Show All 34 Publications. Collapse Publications.

	Jeremie Raso 02/03/2020
Application:	WB
Species:	Rat

	Verified Customer 01/07/2015
Application:	WB
Species:	Other

	Verified Customer 01/07/2015
Application:	WB
Species:	Other

Gene Symbol	TGFB1
Uniprot	P01137(Human)