Name: IGF-I/IGF-1 Antibody [Unconjugated]
Brand: Novus Biologicals
SKU: AF-291-NA
Rating: 4.5 (2 reviews)

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	HuSpecies Glossary
Applications	WB, Simple Western, IHC, B/N, ICC/IF
Clonality	Polyclonal
Host	Goat
Conjugate	Unconjugated
Concentration	LYOPH

Catalog# & Conjugate	Size	Price
Biotin BAF291

Catalog# & Formulation	Size	Price
Carrier Free BAF291

Carrier Free AF-291-SP

Conjugate	Catalog #	Availability	Size	Price
Biotin	BAF291

IGF-I/IGF-1 Antibody [Unconjugated]

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IGF-I/IGF-1 Antibody [Unconjugated] Summary

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Publications for IGF-I/IGF-1 Antibody (AF-291-NA)(42)

Reviews for IGF-I/IGF-1 Antibody (AF-291-NA) (2) 4.52

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Immunogen	E. coli-derived recombinant human IGF-I/IGF-1
Specificity	Detects human IGF-I/IGF-1 in direct ELISAs and Western blots. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse IGF-I/IGF-1 and recombinant rat IGF-I/IGF-1 is observed.
Source	N/A
Isotype	IgG
Clonality	Polyclonal
Host	Goat
Gene	IGF1
Purity Statement	Antigen Affinity-purified
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Concentration	LYOPH
Reconstitution Instructions	Reconstitute at 0.2 mg/mL in sterile PBS.

Publications using AF-291-NA	Applications	Species
Guan, H;Yonemitsu, I;Ikeda, Y;Ono, T; Reversible Effects of Functional Mandibular Lateral Shift on Masticatory Muscles in Growing Rats Biomedicines 2023-07-27 [PMID: 37626623] (IHC, Rat)	IHC	Rat
Tu, X;Jain, A;Parra Bueno, P;Decker, H;Liu, X;Yasuda, R; Local autocrine plasticity signaling in single dendritic spines by insulin-like growth factors Science advances 2023-08-02 [PMID: 37531435] (IHC, Mouse)	IHC	Mouse
Guillaume Fonteneau, Alexandra Redding, Hannah Hoag-Lee, Edward S. Sim, Stefan Heinrich, Matthias M. Gaida et al. Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer Cancer Discovery 2022-08-05 [PMID: 35674408]
KM Lugo-Cintr, JM Ayuso, M Humayun, MM Gong, SC Kerr, SM Ponik, PM Harari, M Virumbrale, DJ Beebe Primary Head and Neck Tumour-Derived Fibroblasts Promote Lymphangiogenesis in a Lymphatic Organotypic Co-culture Model EBioMedicine, 2021-10-18;73(0):103634. 2021-10-18 [PMID: 34673450] (Neutralization, Human)	Neutralization	Human
P Uruski, J Miku?a-Pie, M Paku?a, S Budkiewicz, M Drzewiecki, AN Gaiday, M Wierzowiec, E Naumowicz, R Moszy?ski, A Tykarski, K Ksi??ek Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts International Journal of Molecular Sciences, 2021-04-19;22(8):. 4/19/2021 [PMID: 33921783]
Q Zhang, T Li, Z Wang, X Kuang, N Shao, Y Lin lncRNA NR2F1-AS1 promotes breast cancer angiogenesis through activating IGF-1/IGF-1R/ERK pathway J. Cell. Mol. Med., 2020-06-17;0(0):. 2020-06-17 [PMID: 32548873] (Western Blot, Human)	Western Blot	Human
F Alvarez-Ri, A Rey-Rico, JK Venkatesan, L Diaz-Gomez, M Cucchiarin, A Concheiro, C Alvarez-Lo Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy Pharmaceutics, 2020-04-09;12(4):. 2020-04-09 [PMID: 32283694] (IHC, Human)	IHC	Human
Natalie J Haywood, Thomas A Slater, Michael Drozd, Nele Warmke, Connor Matthews, Paul A Cordell et al. IGFBP-1 in Cardiometabolic Pathophysiology—Insights From Loss-of-Function and Gain-of-Function Studies in Male Mice Journal of the Endocrine Society 2020-01-01 [PMID: 32190801]
S Lie, BR Vieira, S Arruda, M Simões, LM Ashander, JM Furtado, JR Smith Molecular Basis of The Retinal Pigment Epithelial Changes That Characterize The Ocular Lesion in Toxoplasmosis Microorganisms, 2019-09-29;7(10):. 2019-09-29 [PMID: 31569536] (Neutralization, Human)	Neutralization	Human
Stephanie Morscheid, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Magali Cucchiarini Remodeling of Human Osteochondral Defects via rAAV-Mediated Co-Overexpression of TGF-beta and IGF-I from Implanted Human Bone Marrow-Derived Mesenchymal Stromal Cells Journal of Clinical Medicine 2019-08-28 [PMID: 31466339]
S Morscheid, A Rey-Rico, G Schmitt, H Madry, M Cucchiarin, JK Venkatesan Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-? and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells Int J Mol Sci, 2019-05-27;20(10):. 2019-05-27 [PMID: 31137788] (IHC-P, Human)	IHC-P	Human
M Paku?a, P Uruski, A Niklas, A Wo?niak, D Szpurek, A Tykarski, J Miku?a-Pie, K Ksi??ek A Unique Pattern of Mesothelial-Mesenchymal Transition Induced in the Normal Peritoneal Mesothelium by High-Grade Serous Ovarian Cancer Cancers (Basel), 2019-05-13;11(5):. 2019-05-13 [PMID: 31086083] (Neutralization, Human)	Neutralization	Human
A Pristerà, C Blomeley, E Lopes, S Threlfell, E Merlini, D Burdakov, S Cragg, F Guillemot, SL Ang Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration Proc. Natl. Acad. Sci. U.S.A., 2019-02-11;116(9):3817-3826. 2019-02-11 [PMID: 30808767] (IHC, Mouse)	IHC	Mouse
M Paku?a, J Miku?a-Pie, A Witucka, K Kostka-Jez, P Uruski, R Moszy?ski, E Naumowicz, S Sajdak, A Tykarski, K Ksi??ek The Epithelial-Mesenchymal Transition Initiated by Malignant Ascites Underlies the Transmesothelial Invasion of Ovarian Cancer Cells Int J Mol Sci, 2019-01-02;20(1):. 2019-01-02 [PMID: 30609691] (Neutralization, Human)	Neutralization	Human
L Dou, Y Zheng, L Li, X Gui, Y Chen, M Yu, Y Guo The effect of cinnamon on polycystic ovary syndrome in a mouse model Reprod. Biol. Endocrinol., 2018-10-19;16(1):99. 2018-10-19 [PMID: 30340496] (IHC, Mouse)	IHC	Mouse
Julien Daubriac, Shiwei Han, Jelena Grahovac, Eve Smith, Abdel Hosein, Marguerite Buchanan et al. The crosstalk between breast carcinoma-associated fibroblasts and cancer cells promotes RhoA-dependent invasion via IGF-1 and PAI-1 Oncotarget 2018-02-13 [PMID: 29535813]
D Wang, C Liu, J Wang, Y Jia, X Hu, H Jiang, ZM Shao, YA Zeng Protein C receptor stimulates multiple signaling pathways in breast cancer cells J. Biol. Chem., 2017-12-07;0(0):. 2017-12-07 [PMID: 29217770] (Neutralization, Human)	Neutralization	Human
L Song, Z Sun, DS Kim, W Gou, C Strange, H Dong, W Cui, G Gilkeson, KA Morgan, DB Adams, H Wang Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function Stem Cell Res Ther, 2017-08-30;8(1):192. 2017-08-30 [PMID: 28854965] (Neutralization, Mouse)	Neutralization	Mouse
J Frisch, P Orth, A Rey-Rico, JK Venkatesan, G Schmitt, H Madry, D Kohn, M Cucchiarin Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes J. Cell. Mol. Med., 2017-05-03;0(0):. 2017-05-03 [PMID: 28467017] (ICC, Human)	ICC	Human
Amina El El Ayadi, Michael J. Zigmond, Amanda D. Smith IGF-1 protects dopamine neurons against oxidative stress: association with changes in phosphokinases Experimental Brain Research 2016-07-01 [PMID: 26894890]
J Frisch, A Rey-Rico, J K Venkatesan, G Schmitt, H Madry, M Cucchiarini rAAV-mediated overexpression of sox9, TGF-beta and IGF-I in minipig bone marrow aspirates to enhance the chondrogenic processes for cartilage repair Gene Therapy 2016-03-01 [PMID: 26583804]
Magali Cucchiarin Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I Tissue Eng Part A, 2015-07-22;21(17):2460-71. 2015-07-22 [PMID: 26123891] (IHC-P, Human)	IHC-P	Human
Janina Frisch, Jagadeesh Kumar Venkatesan, Ana Rey-Rico, Gertrud Schmitt, Henning Madry, Magali Cucchiarini Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells Stem Cell Research & Therapy 2014-12-01 [PMID: 25163769]
Benabbou N, Mirshahi P, Bordu C, Faussat A, Tang R, Therwath A, Soria J, Marie J, Mirshahi M A subset of bone marrow stromal cells regulate ATP-binding cassette gene expression via insulin-like growth factor-I in a leukemia cell line. Int J Oncol, 2014-07-29;45(4):1372-80. 2014-07-29 [PMID: 25095896] (ICC, Human)	ICC	Human
Cucchiarini M, Madry H Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo. Gene Ther, 2014-07-03;21(9):811-9. 7/3/2014 [PMID: 24989812]
Luo X, Suzuki M, Ghandhi S, Amundson S, Boothman D ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PLoS ONE, 2014-06-17;9(6):e99983. 2014-06-17 [PMID: 24937130] (ELISA Development (Detection), Human)	ELISA Development (Detection)	Human
Du , Lili, Yu , Yanqiu, Ma , Haiying, Lu , Xiaomei, Ma , Ling, Jin , Yunan, Zhang , Haipeng Hypoxia enhances protective effect of placental-derived mesenchymal stem cells on damaged intestinal epithelial cells by promoting secretion of insulin-like growth factor-1. Int J Mol Sci, 2014-01-27;15(2):1983-2002. 2014-01-27 [PMID: 24473145] (Neutralization, Human)	Neutralization	Human
Elias G. Elias, Joanne H. Hasskamp, Bhuvnesh K. Sharma Cytokines and Growth Factors Expressed by Human Cutaneous Melanoma Cancers (Basel) 2010-05-07 [PMID: 24281094]
H Madry, Centre of Experimental Orthopaedics, Medical Faculty, Building 37, Saarland University, D-66421 Homburg, Germany, G Kaul, D Zurakowski, G Vunjak-Novakovic, M Cucchiarini Cartilage constructs engineered from chondrocytes overexpressing IGF-I improve the repair of osteochondral defects in a rabbit model European Cells and Materials 2013-04-16 [PMID: 23588785]
Ni , Fang, Sun , Rui, Fu , Binqing, Wang , Fuyan, Guo , Chuang, Tian , Zhigang, Wei , Haiming IGF-1 promotes the development and cytotoxic activity of human NK cells. Nat Commun, 2013-01-01;4(0):1479. 2013-01-01 [PMID: 23403580] (Neutralization, Human)	Neutralization	Human
H J Kang, Y W Yi, H J Kim, Y B Hong, Y S Seong, I Bae BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site Cell Death & Disease 2012-06-28 [PMID: 22739988]
Weimer A, Madry H, Venkatesan JK Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis. Mol. Med., 2012-05-09;18(1):346-58. 2012-05-09 [PMID: 22160392] (ICC, Western Blot, Human)	ICC, Western Blot	Human
Antero Macedo, Manuela Moriggi, Michele Vasso, Sara De Palma, Mauro Sturnega, Giorgio Friso et al. Enhanced Athletic Performance on Multisite AAV-IGF1 Gene Transfer Coincides with Massive Modification of the Muscle Proteome Human Gene Therapy 2012-02-01 [PMID: 22017471]
Rakesh K. Srivastava, Terry G. Unterman, Sharmila Shankar FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol Molecular and Cellular Biochemistry 2010-04-01 [PMID: 20012470]
Banziger-Tobler NE, Halin C, Kajiya K, Detmar M Growth hormone promotes lymphangiogenesis. Am. J. Pathol., 2008-06-26;173(2):586-97. 2008-06-26 [PMID: 18583315] (ELISA Development, Immunoprecipitation, Neutralization, Western Blot, Human)	ELISA Development, Immunoprecipitation, Neutralization, Western Blot	Human
Skibinski G, Elborn JS, Ennis M Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor. Am. J. Physiol. Lung Cell Mol. Physiol., 2007-03-23;293(1):L69-76. 2007-03-23 [PMID: 17384084] (Neutralization, Human)	Neutralization	Human
Yoon DM, Hawkins EC, Francke-Carroll S, Fisher JP Effect of construct properties on encapsulated chondrocyte expression of insulin-like growth factor-1. Biomaterials, 2006-09-18;28(2):299-306. 2006-09-18 [PMID: 16982090] (Western Blot, Bovine)	Western Blot	Bovine
Schnapp LM, Donohoe S, Chen J, Sunde DA, Kelly PM, Ruzinski J, Martin T, Goodlett DR Mining the acute respiratory distress syndrome proteome: identification of the insulin-like growth factor (IGF)/IGF-binding protein-3 pathway in acute lung injury. Am. J. Pathol., 2006-07-01;169(1):86-95. 2006-07-01 [PMID: 16816363] (Neutralization, Human)	Neutralization	Human
McCaig C, Duval C, Hemers E, Steele I, Pritchard DM, Przemeck S, Dimaline R, Ahmed S, Bodger K, Kerrigan DD, Wang TC, Dockray GJ, Varro A The role of matrix metalloproteinase-7 in redefining the gastric microenvironment in response to Helicobacter pylori. Gastroenterology, 2006-03-06;130(6):1754-63. 2006-03-06 [PMID: 16697739] (Western Blot, Human)	Western Blot	Human
Lee JH, Ryu IH, Kim EK, Lee JE, Hong S, Lee HK Induced expression of insulin-like growth factor-1 by amniotic membrane-conditioned medium in cultured human corneal epithelial cells. Invest. Ophthalmol. Vis. Sci., 2006-03-01;47(3):864-72. 2006-03-01 [PMID: 16505018] (Western Blot, Human)	Western Blot	Human
Wade KC, Guttentag SH, Gonzales LW, Maschhoff KL, Gonzales J, Kolla V, Singhal S, Ballard PL Gene induction during differentiation of human pulmonary type II cells in vitro. Am. J. Respir. Cell Mol. Biol., 2006-02-10;34(6):727-37. 2006-02-10 [PMID: 16474099] (IHC-Fr, Western Blot, Human)	IHC-Fr, Western Blot	Human
Brenner N, Huning M, Stange R Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif. Tissue Int., 2004-04-01;74(4):388-97. 2004-04-01 [PMID: 15255077] (IHC-P, Rat)	IHC-P	Rat
Show All 42 Publications. Collapse Publications.

	Verified Customer 01/07/2015
Application:	WB
Species:	Human

	Verified Customer 01/07/2015
Application:	WB
Species:	Human