Name: IGF-I R/IGF1R Antibody (33255) [Unconjugated]
Brand: Novus Biologicals
SKU: MAB391
Price: 499 USD

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At	=	A. thaliana	SyHa	=	Golden Syrian Hamster
All	=	All Species	Ha	=	Hamster
An	=	Animal	Hu	=	Human
ArHa	=	Armenian Hamster	I	=	Insect
Av	=	Avian	Ll	=	Llama
Bb	=	Baboon	Ma	=	Mammal
Ba	=	Bacteria	Mk	=	Monkey
Bv	=	Bovine	Mu	=	Mouse
Ca	=	Canine	Multi	=	Multi-species
Ce	=	C. Elegans	NA	=	Non-species specific
Ch	=	Chicken	Or	=	Orangutan
ChHa	=	Chinese Hamster	Pl	=	Plant
Cm	=	Cynomolgus Monkey	Pm	=	Primate
Do	=	Donkey	Po	=	Porcine
Dr	=	Drosophilia	Rb	=	Rabbit
Ec	=	E. Coli	Rt	=	Rat
Eq	=	Equine	RM	=	Rhesus Macaque
Fe	=	Feline	Sh	=	Sheep
Ft	=	Ferret	Vb	=	Vertebrate
Fi	=	Fish	Vi	=	Virus
Fu	=	Fungi	Xp	=	Xenopus
Ge	=	Gerbil	Ye	=	Yeast
GP	=	Guinea Pig	Ze	=	Zebrafish
Gt	=	Goat

Reactivity	Hu, MuSpecies Glossary
Applications	WB, Flow, IHC, B/N, ELISA(Cap), ICC/IF
Clone	33255
Clonality	Monoclonal
Host	Mouse
Conjugate	Unconjugated

Catalog# & Conjugate	Size	Price
Alexa Fluor 350 FAB391U-100UG

Alexa Fluor 405 FAB391V-100UG

Alexa Fluor 488 FAB391G-100UG

Alexa Fluor 532 FAB391X

Alexa Fluor 594 FAB391T-100UG

Alexa Fluor 647 FAB391R-100UG

Alexa Fluor 700 FAB391N-100UG

Alexa Fluor 750 FAB391S-100UG

Allophycocyanin FAB391A

Allophycocyanin/Cy7 FAB391APCCY7

Biotin FAB391B

CoraFluor 1 FAB391CL1

DyLight 350 FAB391D

DyLight 405 FAB391E

DyLight 488 FAB391K

DyLight 550 FAB391L

DyLight 594 FAB391M

DyLight 650 FAB391W

DyLight 680 FAB391Y

DyLight 755 FAB391Z

Fluorescein FAB391F-025

Fluorescein FAB391F-100

HRP FAB391H

Janelia Fluor 525 FAB391JF525

Janelia Fluor 549 FAB391I

Janelia Fluor 646 FAB391J

Janelia Fluor 669 FAB391JF669

PE/Atto594 FAB391PEATT594

PE/Cy5.5 FAB391PECY55

PE/Cy7 FAB391PECY7

Phycoerythrin FAB391P-100

Phycoerythrin FAB391P-025

mFluor Violet 450 SE FAB391MFV450

mFluor Violet 500 SE FAB391MFV500

mFluor Violet 610 SE FAB391MFV610

Catalog# & Formulation	Size	Price
Carrier Free MAB391-SP

Carrier Free FAB391F-100

Carrier Free FAB391F-025

Carrier Free FAB391P-100

Carrier Free FAB391P-025

Carrier Free MAB391-500

Carrier Free FAB391V-100UG

Carrier Free FAB391U-100UG

Carrier Free FAB391T-100UG

Carrier Free FAB391S-100UG

Carrier Free FAB391R-100UG

Carrier Free FAB391N-100UG

Carrier Free FAB391G-100UG

Conjugate	Catalog #	Availability	Size	Price
Alexa Fluor 350	FAB391U-100UG
Alexa Fluor 405	FAB391V-100UG
Alexa Fluor 488	FAB391G-100UG
Alexa Fluor 532	FAB391X
Alexa Fluor 594	FAB391T-100UG
Alexa Fluor 647	FAB391R-100UG
Alexa Fluor 700	FAB391N-100UG
Alexa Fluor 750	FAB391S-100UG
Allophycocyanin	FAB391A
Allophycocyanin/Cy7	FAB391APCCY7
Biotin	FAB391B
CoraFluor 1	FAB391CL1
DyLight 350	FAB391D
DyLight 405	FAB391E
DyLight 488	FAB391K
DyLight 550	FAB391L
DyLight 594	FAB391M
DyLight 650	FAB391W
DyLight 680	FAB391Y
DyLight 755	FAB391Z
Fluorescein	FAB391F-025
Fluorescein	FAB391F-100
HRP	FAB391H
Janelia Fluor 525	FAB391JF525
Janelia Fluor 549	FAB391I
Janelia Fluor 646	FAB391J
Janelia Fluor 669	FAB391JF669
PE/Atto594	FAB391PEATT594
PE/Cy5.5	FAB391PECY55
PE/Cy7	FAB391PECY7
Phycoerythrin	FAB391P-100
Phycoerythrin	FAB391P-025
mFluor Violet 450 SE	FAB391MFV450
mFluor Violet 500 SE	FAB391MFV500
mFluor Violet 610 SE	FAB391MFV610

IGF-I R/IGF1R Antibody (33255) [Unconjugated]

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IGF-I R/IGF1R Antibody (33255) [Unconjugated] Summary

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Alternate Names for IGF-I R/IGF1R Antibody (33255) [Unconjugated]

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Publications for IGF-I R/IGF1R Antibody (MAB391)(32)

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Bioinformatics

Immunogen	S. frugiperda insect ovarian cell line Sf 21-derived recombinant human IGF-I R/IGF1R Glu31-Asn932 Accession # P08069
Specificity	Detects human IGF-I R/IGF1R in sandwich ELISAs and Western blots. Detects mouse IGF-I R/IGF1R in Immunohistochemistry. In sandwich immunoassays, less than 0.15% cross-reactivity or interference was observed with recombinant human (rh) IGF-I, rhIGF‑II, rhIL‑3 R alpha , rhIL‑9 R, and rhTGF‑ beta RII.
Source	N/A
Isotype	IgG1
Clonality	Monoclonal
Host	Mouse
Gene	IGF1R
Purity Statement	Protein A or G purified from hybridoma culture supernatant
Endotoxin Note	<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase. Learn about the Innovator's Reward

Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer	Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative	No Preservative
Reconstitution Instructions	Reconstitute at 0.5 mg/mL in sterile PBS.

Publications using MAB391	Applications	Species
Ishihara, H;Otani, Y;Tanaka, K;Miyajima, H;Ngo, HX;Fujitani, M; Blocking insulin-like growth factor 1 receptor signaling pathway inhibits neuromuscular junction regeneration after botulinum toxin-A treatment Cell death & disease 2023-09-16 [PMID: 37717026] (In Vivo, Mouse)	In Vivo	Mouse
Miyagawa, K;Tenshin, H;Mulcrone, PL;Delgado-Calle, J;Subler, MA;Windle, JJ;Chirgwin, JM;Roodman, GD;Kurihara, N; Osteoclast-derived IGF1 induces RANKL production in osteocytes and contributes to Pagetic lesion formation JCI insight 2023-06-20 [PMID: 37338990] (Neutralization, Mouse)	Neutralization	Mouse
Sham Jdeed, Edina Erdős, Bálint L. Bálint, Iván P. Uray The Role of ARID1A in the Nonestrogenic Modulation of IGF-1 Signaling Molecular Cancer Research 2022-07-06 [PMID: 35320351]
T Khan, AM Seddon, AG Dalgleish, S Khelwatty, N Ioannou, S Mudan, H Modjtahedi Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancer Oncol Rep, 2020-10-22;0(0):. 2020-10-22 [PMID: 33125153] (Flow Cytometry, Human)	Flow Cytometry	Human
Priya Crosby, Ryan Hamnett, Marrit Putker, Nathaniel P. Hoyle, Martin Reed, Carolyn J. Karam et al. Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time Cell 2019-05-02 [PMID: 31030999]
Laura E. Ratcliffe, Irina Vázquez Villaseñor, Luke Jennings, Paul R. Heath, Heather Mortiboys, Aurelie Schwartzentruber et al. Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons Neuroscience 2018-10-15 [PMID: 30056117]
J Li, E Weber, S Guth-Gunde, M Schuleit, A Kuttler, C Halleux, N Accart, A Doelemeyer, A Basler, B Tigani, K Wuersch, M Fornaro, M Kneissel, A Stafford, BR Freedman, DJ Mooney Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs Adv Healthc Mater, 2018-02-14;0(0):. 2018-02-14 [PMID: 29441702] (ELISA Capture, Mouse)	ELISA Capture	Mouse
Y Neuzillet, E Chapeaubla, C Krucker, L De Koning, T Lebret, F Radvanyi, I Bernard-Pi IGF1R activation and the in vitro antiproliferative efficacy of IGF1R inhibitor are inversely correlated with IGFBP5 expression in bladder cancer BMC Cancer, 2017-09-07;17(1):636. 2017-09-07 [PMID: 28882129] (Neutralization, Human)	Neutralization	Human
Helmout Modjtahedi Impact of the putative cancer stem cell markers and growth factor receptor expression on the sensitivity of ovarian cancer cells to treatment with various forms of small molecule tyrosine kinase inhibitors and cytotoxic drugs Int. J. Oncol., 2016-09-05;49(5):1825-1838. 2016-09-05 [PMID: 27599579] (Flow Cytometry, Western Blot, Human)	Flow Cytometry, Western Blot	Human
Vionnie W.C. Yu, Stefania Lymperi, Toshihiko Oki, Alexandra Jones, Peter Swiatek, Radovan Vasic et al. Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow Stem Cell Reports 2016-08-01 [PMID: 27453006]
M Gschweitl, A Ulbricht, CA Barnes, RI Enchev, I Stoffel-St, N Meyer-Scha, J Huotari, Y Yamauchi, UF Greber, A Helenius, M Peter A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes Elife, 2016-03-23;5(0):. 2016-03-23 [PMID: 27008177] (Western Blot, Human)	Western Blot	Human
Jacob Thomsen, Rikke Hjortebjerg, Ulrick Espelund, Gitte Ørtoft, Poul Vestergaard, Nils E. Magnusson et al. PAPP-A proteolytic activity enhances IGF bioactivity in ascites from women with ovarian carcinoma Oncotarget 2015-08-24 [PMID: 26336825]
Garwood C, Ratcliffe L, Morgan S, Simpson J, Owens H, Vazquez-Villasenor I, Heath P, Romero I, Ince P, Wharton S Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors. Mol Brain, 2015-08-22;8(0):51. 2015-08-22 [PMID: 26297026] (Neutralization, Human)	Neutralization	Human
Christine M. Lovly, Nerina T. McDonald, Heidi Chen, Sandra Ortiz-Cuaran, Lukas C. Heukamp, Yingjun Yan et al. Rationale for co-targeting IGF-1R and ALK in ALK fusion–positive lung cancer Nature Medicine 2014-09-01 [PMID: 25173427]
Renna M, Bento CF, Fleming A et al. IGF-1 receptor antagonism inhibits autophagy. Hum Mol Genet. 7/10/2013 [PMID: 23804751]
A N Rettew, E D Young, D C Lev, E S Kleinerman, F W Abdul-Karim, P J Getty et al. Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines Oncogenesis 2012-11-19 [PMID: 23552467]
Hemant K. Bid, Cheryl A. London, Jin Gao, Haihong Zhong, Robert E. Hollingsworth, Soledad Fernandez et al. Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and its Ligands as an Effective Anti-angiogenic Strategy Clinical Cancer Research 2013-06-01 [PMID: 23549869]
Cardillo T, Trisal P, Arrojo R, Goldenberg D, Chang C Targeting both IGF-1R and mTOR synergistically inhibits growth of renal cell carcinoma in vitro. BMC Cancer, 2013-04-01;13(0):170. 2013-04-01 [PMID: 23548153] (Flow Cytometry, Human)	Flow Cytometry	Human
Suh H, Zhao M, Derico L, Choi N, Lee S Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators. J Neuroinflammation, 2013-03-12;10(0):37. 2013-03-12 [PMID: 23497056] (ICC, Human)	ICC	Human
Chien-Hsing Chang, Yang Wang, Preeti Trisal, Rongxiu Li, Diane L. Rossi, Anju Nair et al. Evaluation of a Novel Hexavalent Humanized Anti-IGF-1R Antibody and Its Bivalent Parental IgG in Diverse Cancer Cell Lines PLoS ONE 2012-08-31 [PMID: 22952934]
Jacques C, Holzenberger M, Mladenovic Z Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity. J. Biol. Chem., 2012-03-07;287(18):15100-8. 2012-03-07 [PMID: 22399297] (Neutralization, Human)	Neutralization	Human
Massoner P, Ladurner Rennau M, Heidegger I, Kloss-Brandstatter A, Summerer M, Reichhart E, Schafer G, Klocker H Expression of the IGF axis is decreased in local prostate cancer but enhanced after benign prostate epithelial differentiation and TGF-beta treatment. Am. J. Pathol., 2011-10-06;179(6):2905-19. 2011-10-06 [PMID: 21983635] (IHC-P, Human)	IHC-P	Human
Deeksha Vishwamitra, Ping Shi, Desiree Wilson, Roxsan Manshouri, Francisco Vega, Ellen J Schlette et al. Expression and effects of inhibition of type I insulin-like growth factor receptor tyrosine kinase in mantle cell lymphoma Haematologica 2011-06-01 [PMID: 21330319]
Aleksic T, Chitnis MM, Perestenko OV et al. Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells. Cancer Res. 8/15/2010 [PMID: 20710042]
Ling Xu, Martin Hausmann, Wolfgang Dietmaier, Silvia Kellermeier, Theresa Pesch, Manuela Stieber-Gunckel et al. Expression of growth factor receptors and targeting of EGFR in cholangiocarcinoma cell lines BMC Cancer 2010-12-01 [PMID: 20565817]
Wang N, Fallavollita L, Nguyen L, Burnier J, Rafei M, Galipeau J, Yakar S, Brodt P Autologous bone marrow stromal cells genetically engineered to secrete an igf-I receptor decoy prevent the growth of liver metastases. Mol. Ther., 2009-04-14;17(7):1241-9. 2009-04-14 [PMID: 19367255] (ELISA Development, Human)	ELISA Development	Human
Back K, Arnqvist HJ Changes in insulin and IGF-I receptor expression during differentiation of human preadipocytes. Growth Horm. IGF Res., 2008-08-09;19(2):101-11. 2008-08-09 [PMID: 18693051] (ELISA Development, Human)	ELISA Development	Human
Riccioni R, Senese M, Diverio D, Riti V, Mariani G, Boe A, LoCoco F, Foa R, Peschle C, Sporn M, Testa U Resistance of acute myeloid leukemic cells to the triterpenoid CDDO-Imidazolide is associated with low caspase-8 and FADD levels. Leuk. Res., 2008-03-04;32(8):1244-58. 2008-03-04 [PMID: 18304628] (Flow Cytometry, Human)	Flow Cytometry	Human
Garderet L, Mazurier C, Chapel A, Ernou I, Boutin L, Holy X, Gorin NC, Lopez M, Doucet C, Lataillade JJ Mesenchymal stem cell abnormalities in patients with multiple myeloma. Leuk. Lymphoma, 2007-10-01;48(10):2032-41. 2007-10-01 [PMID: 17917971] (Flow Cytometry, Human)	Flow Cytometry	Human
Riccioni R, Diverio D, Mariani G, Buffolino S, Riti V, Saulle E, Petrucci E, Cedrone M, Lo-Coco F, Foa R, Peschle C, Testa U Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts. Stem Cells, 2007-04-19;25(8):1862-71. 2007-04-19 [PMID: 17446561] (Flow Cytometry, Human)	Flow Cytometry	Human
Spicer LJ, Aad PY Insulin-like growth factor (IGF) 2 stimulates steroidogenesis and mitosis of bovine granulosa cells through the IGF1 receptor: role of follicle-stimulating hormone and IGF2 receptor. Biol. Reprod., 2007-03-14;77(1):18-27. 2007-03-14 [PMID: 17360960] (Western Blot, Bovine)	Western Blot	Bovine
Quirk SM, Cowan RG, Harman RM The susceptibility of granulosa cells to apoptosis is influenced by oestradiol and the cell cycle. J. Endocrinol., 2006-06-01;189(3):441-53. 2006-06-01 [PMID: 16731776] (Neutralization, Bovine)	Neutralization	Bovine
Show All 32 Publications. Collapse Publications.

Gene Symbol	IGF1R
Uniprot	P08069()