Human IGFBP-3 Quantikine ELISA Kit

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBP, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. ALS (Acid Labile Subunit) is a liver-derived protein that exists in a ternary complex with Insulin-like Growth Factor (IGF)-binding Protein-3 (IGFBP-3) or IGFBP-5, and either IGF-I or IGF-II. ALS increases the half-life of IGF/IGFBP complexes in circulation.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ELISA Capture.

Showing Publications 1 - 10 of 46. Show All 46 Publications. Collapse Publications.

Publications using DGB300	Applications	Species
Bakhashab, S;O'Neill, J;Barber, R;Arden, C;Weaver, JU; Upregulation of Anti-Angiogenic miR-106b-3p Correlates Negatively with IGF-1 and Vascular Health Parameters in a Model of Subclinical Cardiovascular Disease: Study with Metformin Therapy Biomedicines 2024-01-12 [PMID: 38255276] (Human)		Human
Alrashid, MH;Al-Serri, AE;Hussain, RF;Al-Bustan, SA;Al-Barrak, J; Association Study of IGF-1 rs35767 and rs6214 Gene Polymorphisms with Cancer Susceptibility and Circulating Levels of IGF-1, IGFBP-2, and IGFBP-3 in Colorectal Cancer Patients Biomedicines 2023-11-28 [PMID: 38137390] (Human)		Human
Gil-Martínez, M;Lorente-Sorolla, C;Rodrigo-Muñoz, JM;Naharro, S;García-de Castro, Z;Sastre, J;Valverde-Monge, M;Quirce, S;Caballero, ML;Olaguibel, JM;Del Pozo, V; Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis International journal of molecular sciences 2023-07-18 [PMID: 37511378] (Human)		Human
Strzelczyk, J;Wójcik-Giertuga, M;Strzelczyk, JK;Seńkowska, AP;Biernacki, K;Kos-Kudła, B; Selected Parameters of Bone Turnover in Neuroendocrine Tumors-A Potential Clinical Use? Journal of clinical medicine 2023-07-11 [PMID: 37510722] (Human)		Human
MK ?widerska, A Mostowska, D Skrypnik, PP Jagodzi?sk, P Bogda?ski, AE Grzegorzew Energy Homeostasis Gene Nucleotide Variants and Survival of Hemodialysis Patients-A Genetic Cohort Study Journal of Clinical Medicine, 2022-09-18;11(18):. 2022-09-18 [PMID: 36143124] (Human)		Human
WL Stuard, MK Guner, DM Robertson IGFBP-3 Regulates Mitochondrial Hyperfusion and Metabolic Activity in Ocular Surface Epithelia during Hyperosmolar Stress International Journal of Molecular Sciences, 2022-04-06;23(7):. 2022-04-06 [PMID: 35409425] (Human)		Human
JA Goldsmith, RE Lai, RS Garten, Q Chen, EJ Lesnefsky, RA Perera, AS Gorgey Visceral Adiposity, Inflammation, and Testosterone Predict Skeletal Muscle Mitochondrial Mass and Activity in Chronic Spinal Cord Injury Frontiers in Physiology, 2022-02-10;13(0):809845. 2022-02-10 [PMID: 35222077] (Human)		Human
ED Bogdan, WL Stuard, R Titone, DM Robertson IGFBP-3 Mediates Metabolic Homeostasis During Hyperosmolar Stress in the Corneal Epithelium Investigative Ophthalmology & Visual Science, 2021-06-01;62(7):11. 2021-06-01 [PMID: 34100890] (Human)		Human
J Yang, C Yang, H Shen, W Wu, Z Tian, Q Xu, C Cao, S Ye, L Ban, X Tong, J Mei Discovery and validation of PZP as a novel serum biomarker for screening lung adenocarcinoma in type 2 diabetes mellitus patients Cancer Cell International, 2021-03-10;21(1):162. 2021-03-10 [PMID: 33691685] (Human)		Human
KR Monson, M Goldberg, HC Wu, RM Santella, WK Chung, MB Terry Circulating growth factor concentrations and breast cancer risk: a nested case-control study of IGF-1, IGFBP-3, and breast cancer in a family-based cohort Breast Cancer Res, 2020-10-22;22(1):109. 2020-10-22 [PMID: 33092613] (Human)		Human
F Buckinx, LP Carvalho, V Marcangeli, M Dulac, G Hajj Boutr, G Gouspillou, P Gaudreau, P Noirez, M Aubertin-L High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults Exp. Gerontol., 2020-07-25;0(0):111036. 2020-07-25 [PMID: 32721549] (Human)		Human
P Fahlbusch, B Knebel, T Hörbelt, DM Barbosa, A Nikolic, S Jacob, H Al-Hasani, F Van de Vel, Y Van Nieuwe, D Müller-Wie, B Lapauw, DM Ouwens, J Kotzka Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men Int J Mol Sci, 2020-06-10;21(11):. 2020-06-10 [PMID: 32532003] (Human)		Human
Z Zeng, X Huo, Q Wang, C Wang, MN Hylkema, X Xu PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height Environ Int, 2020-03-18;138(0):105660. 2020-03-18 [PMID: 32199227] (Human)		Human
J Sakata, A Hirosue, R Yoshida, Y Matsuoka, K Kawahara, H Arita, H Nakashima, T Yamamoto, M Nagata, S Kawaguchi, S Gohara, Y Nagao, K Yamana, R Toya, R Murakami, Y Kuwahara, M Fukumoto, H Nakayama Enhanced Expression of IGFBP-3 Reduces Radiosensitivity and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Cancers (Basel), 2020-02-20;12(2):. 2020-02-20 [PMID: 32093285] (Human)		Human
A Malin Igra, M Vahter, R Raqib, M Kippler Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children Environ. Health Perspect., 2019-03-01;127(3):37003. 2019-03-01 [PMID: 30848671] (Human)		Human
RH Bartels, E Chimwezi, V Watson, L Pei, I Potani, B Allubha, K Chidzalo, D Wang, Q Dube, M Mallewa, A Allen, RHJ Bandsma, WP Voskuijl, SJ Allen Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi Sci Rep, 2019-02-19;9(1):2304. 2019-02-19 [PMID: 30783173] (Human)		Human
M Krause, D Crognale, K Cogan, S Contarelli, B Egan, P Newsholme, G De Vito The effects of a combined bodyweight-based and elastic bands resistance training, with or without protein supplementation, on muscle mass, signaling and heat shock response in healthy older people Exp. Gerontol., 2018-12-05;115(0):104-113. 2018-12-05 [PMID: 30529477] (Human)		Human
MD DeBoer, AM Lee, K Herbert, J Long, M Thayu, LM Griffin, RN Baldassano, LA Denson, BS Zemel, MR Denburg, R Herskovitz, MB Leonard Increases in IGF-1 after Anti-TNF-? Therapy are Associated with Bone and Muscle Accrual in Pediatric Crohn's Disease J. Clin. Endocrinol. Metab., 2018-03-01;0(0):. 2018-03-01 [PMID: 29329430] (Human)		Human
G Annibalini, F Lucertini, D Agostini, L Vallorani, A Gioacchini, E Barbieri, M Guescini, L Casadei, A Passalia, M Del Sal, G Piccoli, M Andreani, A Federici, V Stocchi Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients Oxid Med Cell Longev, 2017-06-21;2017(0):3937842. 2017-06-21 [PMID: 28713486] (Human)		Human
JR Gee, DR Saltzstein, K Kim, JM Kolesar, W Huang, TC Havighurst, BW Wollmer, J Stublaski, T Downs, H Mukhtar, M House, HL Parnes, HH Bailey A phase II randomized, double-blind, presurgical trial of Polyphenon E in bladder cancer patients to evaluate pharmacodynamics and bladder tissue biomarkers Cancer Prev Res (Phila), 2017-03-21;0(0):. 2017-03-21 [PMID: 28325826] (Human)		Human
A Olszanecka, A Dragan, K Kawecka-Ja, D Fedak, D Czarnecka Relationships of insulin-like growth factor-1, its binding proteins, and cardiometabolic risk in hypertensive perimenopausal women Metab. Clin. Exp., 2017-01-12;69(0):96-106. 2017-01-12 [PMID: 28285656] (Human)		Human
S Sakimoto, V Marchetti, E Aguilar, K Lee, Y Usui, S Murinello, F Bucher, JK Trombley, R Fallon, R Wagey, C Peters, EL Scheppke, PD Westenskow, M Friedlande CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect JCI Insight, 2017-01-26;2(2):e89906. 2017-01-26 [PMID: 28138561] (Human)		Human
Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population Sci Rep, 2016-12-15;6(0):39014. 2016-12-15 [PMID: 27976731] (Human)		Human
Ge Sheng Cheng Bone marrow-derived mesenchymal stem cells modified with IGFBP-3 inhibit the proliferation of pulmonary artery smooth muscle cells Int. J. Mol. Med, 2016-12-07;39(1):223-230. 2016-12-07 [PMID: 27959432] (Human)		Human
Howard H Bailey Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D3) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy Am J Clin Exp Urol, 2016-09-20;4(2):17-27. 2016-09-20 [PMID: 27766277] (Human)		Human
Matthew P Rowan, Darrick J Beckman, Julie A Rizzo, Claire L Isbell, Christopher E White, Stephen M Cohn, Kevin K Chung Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2016-10-04;0(0):1757-7241. 2016-10-04 [PMID: 27716276] (ELISA Capture, Human)	ELISA Capture	Human
The Differential Hormonal Milieu of Morning versus Evening May Have an Impact on Muscle Hypertrophic Potential PLoS ONE, 2016-09-01;11(9):e0161500. 2016-09-01 [PMID: 27583459] (Human)		Human
Matthew N Svalina IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma Sci Rep, 2016-06-03;6(0):27012. 2016-06-03 [PMID: 27255663] (Human)		Human
Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodome A, Hase T, Hosoi E, Yoshida H Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial. PLoS ONE, 2015-02-06;10(2):e0116256. 2015-02-06 [PMID: 25659147] (Human)		Human
Nguyen K, Yao X, Erickson A, Mishra S, Nyomba B Glucose intolerance in aging male IGFBP-3 transgenic mice: differential effects of human IGFBP-3 and its mutant IGFBP-3 devoid of IGF binding ability. Endocrinology, 2014-12-09;156(2):462-74. 2014-12-09 [PMID: 25490144] (Human)		Human
Choi Y, Park G, Rho J, Kim S, So G, Kim H, Choi C, Lee J Role of IGF-binding protein 3 in the resistance of EGFR mutant lung cancer cells to EGFR-tyrosine kinase inhibitors. PLoS ONE, 2013-12-05;8(12):e81393. 2013-12-05 [PMID: 24339922] (Human)		Human
Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy. Cytokine, 2013-02-14;61(3):755-8. 2013-02-14 [PMID: 23415672] (Human)		Human
Imamura , Yusuke, Sakamoto , Shinichi, Endo , Takumi, Utsumi , Takanobu, Fuse , Miki, Suyama , Takahito, Kawamura , Koji, Imamoto , Takashi, Yano , Kojiro, Uzawa , Katsuhir, Nihei , Naoki, Suzuki , Hiroyosh, Mizokami , Atsushi, Ueda , Takeshi, Seki , Naohiko, Tanzawa , Hideki, Ichikawa , Tomohiko FOXA1 promotes tumor progression in prostate cancer via the insulin-like growth factor binding protein 3 pathway. PLoS ONE, 2012-08-03;7(8):e42456. 2012-08-03 [PMID: 22879989] (Human)		Human
Elzi , David J, Lai , Yanlai, Song , Meihua, Hakala , Kevin, Weintraub , Susan T, Shiio , Yuzuru Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence. Proc Natl Acad Sci U S A, 2012-07-09;109(30):12052-7. 2012-07-09 [PMID: 22778398] (Human)		Human
Administration of omega-3 fatty acids and Raloxifene to women at high risk of breast cancer: interim feasibility and biomarkers analysis from a clinical trial. Eur J Clin Nutr, 2012-06-06;66(8):878-84. 2012-06-06 [PMID: 22669332] (Human)		Human
Higgins MF, Russell NE, Crossey PA, Nyhan KC, Brazil DP, McAuliffe FM Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy. PLoS ONE, 2012-02-17;7(2):e29164. 2012-02-17 [PMID: 22363400] (Human)		Human
Weimer A, Madry H, Venkatesan JK Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis. Mol. Med., 2012-05-09;18(1):346-58. 2012-05-09 [PMID: 22160392] (Human)		Human
Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S Prognostic significance of angiogenic factors in uterine cervical cancer. Anticancer Res., 2011-08-01;31(8):2589-95. 2011-08-01 [PMID: 21778309] (Human)		Human
Morgan K, Dennis NA, Ruffman T, Bilkey DK, McLennan IS The stature of boys is inversely correlated to the levels of their sertoli cell hormones: do the testes restrain the maturation of boys? PLoS ONE, 2011-06-02;6(6):e20533. 2011-06-02 [PMID: 21655101] (Human)		Human
Sesso R, Franco MC Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood. Am. J. Hypertens., 2009-11-05;23(1):6-11. 2009-11-05 [PMID: 19893495] (Human)		Human
Veraldi KL, Gibson BT, Yasuoka H, Myerburg MM, Kelly EA, Balzar S, Jarjour NN, Pilewski JM, Wenzel SE, Feghali-Bostwick CA Role of insulin-like growth factor binding protein-3 in allergic airway remodeling. Am. J. Respir. Crit. Care Med., 2009-07-16;180(7):611-7. 2009-07-16 [PMID: 19608721] (Human)		Human
Oy GF, Slipicevic A, Davidson B, Solberg Faye R, Maelandsmo GM, Florenes VA Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma. Int. J. Cancer, 2010-01-15;126(2):350-61. 2010-01-15 [PMID: 19588500] (Human)		Human
Akhtar S, Meeran SM, Katiyar N, Katiyar SK Grape seed proanthocyanidins inhibit the growth of human non-small cell lung cancer xenografts by targeting insulin-like growth factor binding protein-3, tumor cell proliferation, and angiogenic factors. Clin. Cancer Res., 2009-02-01;15(3):821-31. 2009-02-01 [PMID: 19188152] (Human)		Human
Schoyer KD, Liu HC, Witkin S, Rosenwaks Z, Spandorfer SD Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome. Fertil. Steril., 2007-02-22;88(1):139-44. 2007-02-22 [PMID: 17320874] (Human)		Human
Yin D, Vreeland F, Schaaf LJ, Millham R, Duncan BA, Sharma A Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy. Clin. Cancer Res., 2007-02-01;13(3):1000-9. 2007-02-01 [PMID: 17289896] (Human)		Human
Wang TH, Chang CL, Wu HM, Chiu YM, Chen CK, Wang HS Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development. Fertil. Steril., 2006-11-01;86(5):1392-401. 2006-11-01 [PMID: 17070193] (Human)		Human
Show All 46 Publications. Collapse Publications.

Array DGB300

• IGFBP-3 Antibodies
• IGFBP-3 Antibody Pair
• IGFBP-3 ELISA Kit
• IGFBP-3 Lysate
• IGFBP-3 Protein
• IGFBP-3 Proteins and Enzymes
• IGFBP-3 ELISAs