IGF-I/IGF-1 Antibody (SPM406)

Purified human IGF-I/IGF-1 protein (Uniprot: P05019)

Cytoplasmic (Secreted)

This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

IgG1 Kappa

Monoclonal

Mouse

IGF1

Protein A or G purified

Test in a species/application not listed above to receive a full credit towards a future purchase.

ELISA: For coating, purchase antibody without BSA.
Immunohistochemistry (Formalin-fixed): 1-2ug/ml for 30 min at RT.
In-vitro Neutralization of Biological Activity of IGF-I/IGF-1: Order Ab without Azide.
Optimal dilution for a specific application should be determined.

7.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.