Human Total Insulin R DuoSet IC ELISA, 2 Plate

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Insulin Receptor (INSR, CD220) is a type I transmembrane glycoprotein in the Insulin/IGF Receptor family of receptor tyrosine kinases. The mature receptor contains an extracellular alpha subunit and an extracellular/transmembrane/cytoplasmic beta subunit. Alternative splicing generates A and B isoforms which may homodimerize or heterodimerize with the IGF-I receptor. All receptor combinations bind Insulin, IGF-I, or IGF-II, but with differing affinities. Insulin R signaling regulates glucose uptake and metabolism but also contributes to cell growth, differentiation and apoptosis. Mutations in INSR have been linked to severe insulin resistance (type A and Rabson-Mendenhall syndrome), type II diabetes mellitus, and leprechaunism (Donohue syndrome).

We have publications tested in 1 confirmed species: Human.

Showing Publications 1 - 2 of 2.

Publications using DYC1544-2	Applications	Species
Varewijck A, Brugts M, Frystyk J, Goudzwaard J, Uitterlinden P, Waaijers A, Feng Y, Dimitrov D, Lamberts S, Hofland L, Janssen J Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling. Mol Cell Endocrinol, 2012-09-07;365(1):17-24. 2012-09-07 [PMID: 22982059] (Human)		Human
Holm L, Haslund ML, Robach P, van Hall G, Calbet JA, Saltin B, Lundby C Skeletal muscle myofibrillar and sarcoplasmic protein synthesis rates are affected differently by altitude-induced hypoxia in native lowlanders. PLoS ONE, 2010-12-20;5(12):e15606. 2010-12-20 [PMID: 21187972] (Human)		Human

Array DYC1544-2

• Insulin R/CD220 Antibodies
• Insulin R/CD220 ELISA Kits
• Insulin R/CD220 Protein
• Insulin R/CD220 Proteins and Enzymes
• Insulin R/CD220 ELISAs